1,469 research outputs found
Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants
Many Indonesian infants have an inadequate nutritional status, which may be due in part to inadequate maternal nutrition during pregnancy. This study was designed to investigate whether infant nutritional status could be improved by maternal vitamin A and Fe supplementation during gestation. Mothers of these infants from five villages had been randomly assigned on an individual basis, supervised and double-blind, to receive supplementation once weekly from approximately 18 weeks of pregnancy until delivery. Supplementation comprised 120 mg Fe and 500 ÎŒg folic acid with or without 4800 retinol equivalent vitamin A. Mothers of infants from four other villages who participated in the national Fe and folic acid supplementation programme were also recruited; intake of tablets was not supervised. Anthropometric and biochemical parameters of infants and their mothers were assessed approximately 4 months after delivery. Infants of mothers supplemented with vitamin A plus Fe had higher serum retinol concentrations than infants of mothers supplemented with Fe alone. However, the proportion of infants with serum retinol concentrations 70 n all groups. Maternal and infant serum retinol concentrations were correlated. Fe status, weight and length of infants were similar in all groups. Fe status of girls was better than that of boys, but boys were heavier and longer. We conclude that supplementation with vitamin A in conjunction with Fe supplementation of women during pregnancy benefits vitamin A status of their infants. However, considering the large proportion of infants with marginal serum retinol concentrations, it may still be necessary to increase their vitamin A intake
Field desorption ion source development for neutron generators
A new approach to deuterium ion sources for deuterium-tritium neutron
generators is being developed. The source is based upon the field desorption of
deuterium from the surfaces of metal tips. Field desorption studies of
microfabricated field emitter tip arrays have been conducted for the first
time. Maximum fields of 30 V/nm have been applied to the array tip surfaces to
date, although achieving fields of 20 V/nm to possibly 25 V/nm is more typical.
Both the desorption of atomic deuterium ions and the gas phase field ionization
of molecular deuterium has been observed at fields of roughly 20 V/nm and 20-30
V/nm, respectively, at room temperature. The desorption of common surface
adsorbates, such as hydrogen, carbon, water, and carbon monoxide is observed at
fields exceeding ~10 V/nm. In vacuo heating of the arrays to temperatures of
the order of 800 C can be effective in removing many of the surface
contaminants observed
Preliminary Results of Post-Disaster Archaeological Investigations at the Kasthamandap and within Hanuman Dhoka, Kathmandu Valley UNESCO World Heritage Property (Nepal)
Post-Disaster Rescue Archaeological Investigations, Evaluations and Interpretations in the Kathmandu Valley World Heritage Property (Nepal): Observations and Recommendations from a UNESCO mission in 2015
The association between dietary macronutrient intake and fibrogen growth factor 21 in a sample of White UK adults with elevated cardiometabolic risk markers
Increased levels of Fibrogen growth factor 21 (FGF21) is an emerging risk marker for cardiometabolic (CM) disease(1). Little detail is known about the impact of the human diet on FGF21 levels. The aim of this investigation was to assess potential associations between mean daily dietary macronutrient intake and FGF21 levels in a sample of 10 healthy normal-weight and overweight Caucasian adults aged 32â60 (80 % male) at increased CM risk(2). This pilot study received ethical approval from Liverpool John Moores University Research Ethics Committee (16/ELS/029) and was registered with ClinicalTrials.gov (Ref. NCT03257085).
Participants were randomly allocated to one of two groups and asked to either consume 50 % energy from CHO for a duration of 8 weeks. Blood plasma samples were col- lected at baseline (BL), interim point (IP) and endpoint (EP) after a 12-hour overnight fast, immediately processed and frozen at â80°C. Thawed plasma samples were analysed via QuantikineÂź enzyme-linked immunosorbent assay (ELISA) (R&D Systems) for FGF21 levels. Two-way mixed ANOVA and Pearsonâs partial correlation adjusted for estimated weekly moderate and vigorous activity was undertaken using IBM SPSS 24Âź.
There were no effects for diet between groups or over time (data not shown). Significant correlations between macronutrient intakes and FGF21 levels were found for both groups at IP, but not at BL or EP. Moderate and significant positive correlations were found in the overall group for intake (g/d) for glucose (rpartial = ·699, p = ·04) and fructose (rpartial = ·686, p = ·04) and strong and significant positive correlations for non-milk extrinsic sugars (rpartial = ·742, p = ·02). Strong and significant positive correlations were also found in the LC group for glucose intake (g/d) (rpartial = ·980, p = ·02) and fructose (rpartial = ·967, p = ·03) and for protein (rpartial =·998, p=·002) after adjusting for physical activity. Mean carbohydrate intake (g/d) was 160·0 (s.d. 124·5) overall and 44·2 (s.d. 14·9) in the LC group at IP. Mean protein intake (g/d) was 113·2 (21·4) 130·0 (s.d. 15·9) overall and in the LC group at IP. Mean FGF21 levels were 179·9 pg/mL (s.d. 144·9) in the overall group and 94.4 pg/ML (s.d. 48.6) in the LC group at IP.
%TE Intake (g/d)
PROT FAT CHO GLU FRU NMES PROT FAT rrrrrrrrrrr
â·214 ·623 ·635 â·326 â·491 ·448 ·699* ·686* ·742* â·606 â·496 ·143 ·637 ·937 ·427 â·059 ·722 ·980* ·967* ·919 ·998** â·080
Total
kcal CHO NMES
T LC
CHO-Total carbohydrates, FAT-Total fat, FRU-Fructose, GLUC-Glucose, LC-low-carbohydrate, high-fat group, NMES-non-milk extrinsic sugars, PROT-protein, T â total, %TE â percentage total energy, *p < ·05 **p < ·005.
In conclusion, low-carbohydrate diets provide the opportunity to assess responses to even small amounts of CHO, which are likely to be replaced in part by proteins. Despite low overall intakes of fructose and glucose in the LC group, strong and positive correlations with FGF21 levels were observed. The lower levels of FGF21 in the LC compared to the overall group are in line with findings that FGF21 levels are elevated with high-carbohydrate, low-protein diets with dietary fats having only minor impact(3). However, the majority of studies have still been undertaken using rodent models. The impact of dietary macronutrients on FGF21 levels as novel CMR marker in humans and the mechanism behind this relationship warrant further investigation.
1. Lakhani I, Gong M, Wong W et al. (2018) Metabolism 2018 Feb 1. pii: S0026-0495(18)30023-4. [Epub ahead of print]. 2. Jebb S, Lovegrove J, Griffin B et al. (2010) Am J Clin Nutr 92, 748â58.
3. Solon-Biet S, Cogger V, Pulpitel T et al. (2016) Cell Metab 24, 555â565
Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy
Maternal nutrition is important for fetal development, but its impact on the functional outcome of infants is still unclear. The present study investigated the effects of vitamin A and Fe supplementation during gestation on infant mental and psychomotor development. Mothers of infants from five villages in Indonesia were randomly assigned to supervised, double-blind supplementation once per week from approximately 18 weeks of pregnancy until delivery. Supplementation comprised 120 mg Fe + 500 ”g folic acid with (n 94) or without (n 94) 4800 ”g retinol in the form of retinyl acetate. Mothers of infants who participated in the national Fe+folic acid supplementation programme, but whose intake of supplements was not supervised, were recruited from four other villages (n 88). The mental and psychomotor development of infants was assessed, either at 6 or 12 months of age, using the Bayley Scales of Infant Development (BSID). We found no impact of vitamin A supplementation on mental or psychomotor development of infants. In addition, infants whose mothers had received weekly Fe supplementation had similar mental and psychomotor indices as those whose mothers had participated in the governmental Fe supplementation programme. The study population was moderately Fe and vitamin A deficient. The size of the treatment groups was large enough to detect a mean difference of 10 points on the BSID, which is less than 1 sd (15 points) of the average performance of an infant on the BSID. In conclusion, the present study did not find an impact of weekly supplementation of 4800 RE vitamin A in addition to Fe during gestation on functional development of Indonesian infants. However, smaller improvements in development may be seen if studied in a larger and/or more deficient population
Dietary carbohydrate intake, visceral adipose tissue and associated markers of cardiometabolic risk
Risk of cardiometabolic (CM) disease is characterised by elevated visceral adipose tissue (VAT) and a number of associated biomar- kers(1). Some dietary carbohydrates (CHO) have been found to contribute to VAT accumulation(2). Little is known about the impact of following a low-carbohydrate diet versus a high-carbohydrate diet on VAT, adiponectin (ADPN), leptin (LEPT) and leptin:adipo- nectin ratio (LAR). The aim of this investigation was to assess the impact of dietary carbohydrates (CHO) on VAT and emerging CM risk markers in a sample of 10 healthy normal-weight and overweight Caucasian adults aged 32â60 (80 % male) at increased CM risk(3). This pilot study received ethical approval from Liverpool John Moores University Research Ethics Committee (16/ELS/ 029) and was registered with ClinicalTrials.gov (Ref. NCT03257085).
Participants were randomly allocated to one of two groups and asked to either consume 50 % energy from CHO (high-carb (HC)) for a duration of 8 weeks. VAT was ana- lysed via bioelectrical impedance (SECA mBCA 515). Blood plasma samples were collected at baseline (BL), interim point (IP) and endpoint (EP) after a 12-hour overnight fast, immediately processed and frozen at -80°C. Thawed plasma samples were analysed via immunoassay technology (Randox Evidence InvestigatorTM Metabolic Syndrome Arrays I and II) for ADPN and LEPT levels. Statistical analysis was undertaken using IBM SPSS 24Ÿ.
Parametric data was analysed via two-way mixed ANOVA; non-parametric data was analysed via Mann-Whitney U test and Friedman test. Average daily carbohydrate intake in the LC group was 44·2 g at IP and 48·9 g at EP.
There were no significant differences between groups at any time point for ADPN, LEPT, LAR or VAT and no significant inter- actions for time or group*time for ADPN, LEPT or LAR. However, in the LC group VAT decreased significantly between baseline and endpoint by 15 % (p = ·015) Over the course of the intervention ADPN and LEPT decreased non- significantly (by 4 % and 70 % respectively) in the LC group, whilst increasing non-significantly in the HC group (9 % and 65 % respectively). LAR increased in the HC group throughout the study, whilst LAR in the LC group decreased albeit not significantly.
VAT (litre) ADPN (ng/mL) LEPT (ng/mL) LAR BL IP EP Median Median Median
M SD M SD M SD BL IP EP BL IP EP BL IP EP
LC 4·1a 1·2 3·8 1·3 3·5a 1·2 8·9 8·6 8·5 3·96 1·64 1·20 0·45 0·19 0·14 HC 2·7 0·1 1·6 0·3 2·5 0·1 11·3 13·4 12·3 0·97 1·1 1·60 0·07 0·07 0·46 ADPN = adiponectin, BL = baseline, EP = endpoint, HC = high-carbohydrate, moderate fat diet, IP = interim point, LAR = leptin:adiponectin ratio, LEPT = leptin, LC = low-carbohydrate, high-fat diet, VAT = visceral adipose tissue, ap = ·015. NB: interquartile ranges not provided for median values due to missing data.
Higher LAR has been found to be a marker of increased CM risk(4). In conclusion, while the significant reduction in VAT in the LC group corresponds with the reduction of LAR further evidence is required to corroborate these findings. Previous evidence for LC is supportive for improved CM health from various biomarkers(5); LAR should be considered as a useful endocrine addition for future LC studies.
1. Krasimira A, Mozaffarian D & Pischon T (2018) Clin Chem 64, 142â153.
2. RĂŒttgers D, Fischer K, Koch M et al. (2015) Br J Nutr 114, 1929â1940.
3. Jebb S, Lovegrove J, Griffin B et al. (2010) Am J Clin Nutr 92, 748â58.
4. LĂłpez-Jaramillo P, GĂłmez-ArbelĂĄez D, LĂłpez-LĂłpez J et al. (2014) Horm Mol Biol Clin Investig 18, 37â45. 5. Bazzano L, Hi T, Reynolds K et al. (2014) Ann Intern Med 161, 309â318
Evidence for a three-nucleon-force effect in proton-deuteron elastic scattering
Developments in spin-polarized internal targets for storage rings have
permitted measurements of 197 MeV polarized protons scattering from vector
polarized deuterons. This work presents measurements of the polarization
observables A_y, iT_11, and C_y,y in proton-deuteron elastic scattering. When
compared to calculations with and without three-nucleon forces, the
measurements indicate that three-nucleon forces make a significant contribution
to the observables. This work indicates that three-body forces derived from
static nuclear properties appear to be crucial to the description of dynamical
properties.Comment: 8 pages 2 figures Latex, submitted to Phys. Rev. Letter
Comment on "Resolving the 180-deg Ambiguity in Solar Vector Magnetic Field Data: Evaluating the Effects of Noise, Spatial Resolution, and Method Assumptions"
In a recent paper, Leka at al. (Solar Phys. 260, 83, 2009)constructed a
synthetic vector magnetogram representing a three-dimensional magnetic
structure defined only within a fraction of an arcsec in height. They rebinned
the magnetogram to simulate conditions of limited spatial resolution and then
compared the results of various azimuth disambiguation methods on the resampled
data. Methods relying on the physical calculation of potential and/or
non-potential magnetic fields failed in nearly the same, extended parts of the
field of view and Leka et al. (2009) attributed these failures to the limited
spatial resolution. This study shows that the failure of these methods is not
due to the limited spatial resolution but due to the narrowly defined test
data. Such narrow magnetic structures are not realistic in the real Sun.
Physics-based disambiguation methods, adapted for solar magnetic fields
extending to infinity, are not designed to handle such data; hence, they could
only fail this test. I demonstrate how an appropriate limited-resolution
disambiguation test can be performed by constructing a synthetic vector
magnetogram very similar to that of Leka et al. (2009) but representing a
structure defined in the semi-infinite space above the solar photosphere. For
this magnetogram I find that even a simple potential-field disambiguation
method manages to resolve the ambiguity very successfully, regardless of
limited spatial resolution. Therefore, despite the conclusions of Leka et al.
(2009), a proper limited-spatial-resolution test of azimuth disambiguation
methods is yet to be performed in order to identify the best ideas and
algorithms.Comment: Solar Physics, in press (19 pp., 5 figures, 2 tables
Remediation of PCB contaminated sediments using activated carbon: Assessing efficiency and robustness using equilibrium sampling
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