Pricing in the crisis? :an empirical analysis

In an empirical survey on pricing, teamsteffenhagen GmbH analyzed the impact of the financial and economic crisis 2008 / 2009 on the chemical industry. 80 pricing managers gave insights into the effects of the crisis, the concernment triggered by the crisis and the counter measures that were employed in the companies. The analysis uncovers success factors which promise successful pricing in times of crises. These include, among others, a high pricing performance already before the crisis, a clear structure of the pricing processes, a result-oriented alignment of the pricing, a good knowledge of the advantage of the own products in the processes of the customers and in the competitive environment, as well as pro-active pricing approaches.During the crisis, it is vital to gain more information on the financial situation of the customers to substantially invest in marketing and distribution, to limit abatements, and to ensure professionalismin pricing despite the turbulences of the crisis. In summary, these factors denote sufficient reasons for an increase of professionalism of the pricing

Account management 2.0:from silo thinking to integrated account development

Account management in combination with the successful, strategy-driven development of customers constitutes the nucleus of Marketing & Sales Excellence. This article introduces the Double Loop Process of account management. This process utilizes cultural-psychological factors of organizational development which have a massive impact on whether account management succeeds or fails. Nonetheless, these factors too often remain outside the scope of consciousness, and therefore, they cannot be controlled. Through the Double Loop Process, customer-based strategies are developed and profitably implemented by integrating all required internal functions and expertise in a collaborative and productive way. Thereby, the Double Loop Process sustainably contributes to the customer- and profit-oriented alignment of internal decision-making processes within a given corporate culture. It improves cross-functional collaboration, instead of letting silo thinking, departmental egoisms, management from the “ivory tower,” or the reference to “lack of time” and “exhaustion” jeopardize account-related profit potentials

Low-metallicity star formation: Relative impact of metals and magnetic fields

Low-metallicity star formation poses a central problem of cosmology, as it determines the characteristic mass scale and distribution for the first and second generations of stars forming in our Universe. Here, we present a comprehensive investigation assessing the relative impact of metals and magnetic fields, which may both be present during low-metallicity star formation. We show that the presence of magnetic fields generated via the small-scale dynamo stabilises the protostellar disc and provides some degree of support against fragmentation. In the absence of magnetic fields, the fragmentation timescale in our model decreases by a factor of ~10 at the transition from Z=0 to Z>0, with subsequently only a weak dependence on metallicity. Similarly, the accretion timescale of the cluster is set by the large-scale dynamics rather than the local thermodynamics. In the presence of magnetic fields, the primordial disc can become completely stable, therefore forming only one central fragment. At Z>0, the number of fragments is somewhat reduced in the presence of magnetic fields, though the shape of the mass spectrum is not strongly affected in the limits of the statistical uncertainties. The fragmentation timescale, however, increases by roughly a factor of 3 in the presence of magnetic fields. Indeed, our results indicate comparable fragmentation timescales in primordial runs without magnetic fields and Z>0 runs with magnetic fields.Comment: MNRAS in pres

The β-bungarotoxin-binding protein from chick brain: binding sites for different neuronal K+ channel ligands co-fractionate upon partial purification

Abstractβ-Bungarotoxin (β-Butx) is a presynaptically active neurotoxin which blocks neuronal A-type K+ channels. Here, the efficient solubilisation and about 300-fold purification of the β-Butx-binding protein from chick brain were achieved by detergent extraction at high ionic strength followed by chromatography on DEAE Affigel Blue, β-Butx Affigel 102 and wheat germ agglutinin Sepharose. Binding of 125I-labelled β-Butx to the purified protein was inhibited by two other K+ channel ligands, dendrotoxin I and mast cell-degranulating peptide. It is concluded that the β-Butx-binding protein is a member of a family of voltage-gated K+ channels which exhibit varying affinities for different polypeptide ligands

Micrometeoroid infall onto Saturn’s rings constrains their age to no more than a few hundred million years

There is ongoing debate as to whether Saturn’s main rings are relatively young or ancient— having been formed shortly after Saturn or during the Late Heavy Bombardment. The rings are mostly water-ice but are polluted by non-icy material with a volume fraction ranging from ∼0.1 to 2%. Continuous bombardment by micrometeoroids exogenic to the Saturnian system is a source of this non-icy material. Knowledge of the incoming mass flux of these pollutants allows estimation of the rings’ exposure time, providing a limit on their age. Here we report the final measurements by Cassini’s Cosmic Dust Analyzer of the micrometeoroid flux into the Saturnian system. Several populations are present, but the flux is dominated by low-relative velocity objects such as from the Kuiper belt. We find a mass flux between 6.9 · 10−17 and 2.7 · 10−16 kg m−2s−1 from which we infer a ring exposure time ≲100 to 400 million years in support of recent ring formation scenarios

Rheology of different hydrocolloids-rice starch blends. Effect of successive heating-cooling cycles

10 pages, 3 figures, 5 tables.-- Available online 25 November 2010.Hydrocolloids are frequently used for modifying starch functionality. In the present study the possible interaction of three different hydrocolloids – guar gum, hydroxypropylmethylcellulose (HPMC) and xanthan gum – with rice starch was explored by determining the pasting, viscoelastic and swelling properties of the rice starch–hydrocolloids mixtures. The impact of successive heating–cooling cycles on the pasting, viscoelasticity and swelling was also determined. Hydrocolloids tested in the range 0.2–0.8% (w/w) significantly modified the pasting, viscoelastic and swelling properties of rice starch–hydrocolloid pastes (8%, w/w) and the extent of the effect was dependent on hydrocolloid concentration. Guar and xanthan gum mixtures with rice starch had the greatest effect on the pasting properties, whereas HPMC mixtures only changed the viscosity during cooling. The starch–hydrocolloids pastes formed weaker gels compared to those of the starch alone. Rheological results suggested the formation of composite network structures with high frequency dependence. Successive multiple-heating cycles allowed the gel to rearrange resulting in altered gel viscoelasticity and release of water soluble compounds that favour phase separation at the highest hydrocolloid level tested.Financial support from University of California-Davis, Ministry of Education and Science, Spanish Research National Council (CSIC) and Spanish Ministerio de Ciencia e Innovación (Project AGL2008-00092/ALI) is gratefully acknowledged. Dr. Rosell thanks the Spanish Ministry of Education and Science for her grant.Peer reviewe

A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogeneous ribonucleoprotein C on cleavage and polyadenylation

Alternative polyadenylation (APA) is a general mechanism of transcript diversification in mammals, which has been recently linked to proliferative states and cancer. Different 3' untranslated region (3' UTR) isoforms interact with different RNA-binding proteins (RBPs), which modify the stability, translation, and subcellular localization of the corresponding transcripts. Although the heterogeneity of pre-mRNA 3' end processing has been established with high-throughput approaches, the mechanisms that underlie systematic changes in 3' UTR lengths remain to be characterized. Through a uniform analysis of a large number of 3' end sequencing data sets, we have uncovered 18 signals, six of which are novel, whose positioning with respect to pre-mRNA cleavage sites indicates a role in pre-mRNA 3' end processing in both mouse and human. With 3' end sequencing we have demonstrated that the heterogeneous ribonucleoprotein C (HNRNPC), which binds the poly(U) motif whose frequency also peaks in the vicinity of polyadenylation (poly(A)) sites, has a genome-wide effect on poly(A) site usage. HNRNPC-regulated 3' UTRs are enriched in ELAV-like RBP 1 (ELAVL1) binding sites and include those of the CD47 gene, which participate in the recently discovered mechanism of 3' UTR-dependent protein localization (UDPL). Our study thus establishes an up-to-date, high-confidence catalog of 3' end processing sites and poly(A) signals, and it uncovers an important role of HNRNPC in regulating 3' end processing. It further suggests that U-rich elements mediate interactions with multiple RBPs that regulate different stages in a transcript's life cycle