9 research outputs found
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
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- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
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- Luna Alejandro
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- Lysenko Tatyana
- Maclean Malcolm
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- Margaritov Viktor
- Markov Valentin
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- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
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- Patil Ashwini P
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- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
- Singh Narendra
- Sivalingam Kanagaratnam
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- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
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- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
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- Stankiewicz Andrzej
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- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
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- Taeschner Heidrun
- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
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- Cheol-Young Park
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- Chu P. -L.
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- Souhila Ounadjela
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- Srikanth Bellary
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- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world
- Author
- Abad Pedro
- Abbara Suhny
- Abbasi Taimur
- Abbott Brian
- Abdel Aziz Islam Shawky
- Abdulla Jawdat
- Abikhzer Gad
- Abohashem Shady
- Abougabal Mahasen
- Abramson Sandra
- Abrihan Paz
- Acuña Arturo Romero
- Affandi Erwin
- Afzal Muhammad Shehzad
- Agolti Mariela
- Agranovich Svetlana
- Aguadé-Bruix Santiago
- Aguero Roberto Nicolas
- Ahmed Hassan Mohamed Ismail
- Ahmed Taghreed
- Akhter Afroza
- Al Dhuhli Humoud
- Al Kindi Faiza
- Al-Abboud Tarek
- Al-Bulushi Naeema
- Al-Mallah Mouaz
- Alak Maria del Carmen
- Alam Edison
- Alaoui Nadia Ismaili
- Alasnag Mirvat
- Albadr Amjed
- Albalooshi Batool
- Albano Domenico
- Alberguina Lucia Graciela
- Albernaz Siqueira Maria Helena
- Alexanderson-Rosas Erick
- Alfaro Ana
- Ali Mohamed Mandour
- Alkadhi Hatem
- Alkandari Faridah
- Allam Adel
- Allarakha Mohammad Aaftaab
- Almeida Augusto
- Almousalli Omar
- Alongi Pierpaolo
- Alonso Omar
- Alves Togni Paulo Henrique
- Alves Wilson Furlan
- Ananthasubramaniam Karthikeyan
- Anderson Jill
- Andrade Jose Henrique
- Andrade Luciana
- Angelidis George
- Anselmi Carlos
- Ansheles Alexey
- Araújo Roberta
- Archontaki Aikaterini
- Arnone Gaspare
- Arnous Samer
- Arnson Yoav
- Arroñada Guillermo
- Arturo Harold
- Asano Hiroshi
- Ascani Sebastian Perez
- Asfour Ahmed
- Askew Jeffrey
- Assadi Majid
- Astesiano Alfredo
- Astesiano Andrea
- Attanasio Lea
- Atyani Said
- Ayala Sandra
- Ayetey Harold
- Ayodele Tolulope
- Azevedo Guilherme
- Bagatin Elisa
- Bailly Matthieu
- Baldari Sergio
- Balmer-Swain Mallory
- Bang Ji-In
- Banthia Nilesh
- Bar-Shalom Rachel
- Barette Rene
- Baric Ana
- Barneveld Peter
- Barragan Adriana Puente
- Barragan Erika
- Barroso Asela
- Basavaraj Ashok Gangasandra
- Batinic Tonci
- Batista Juan Felipe
- Batyrkhanov Daultai
- Bauckneht Matteo
- Baugh Dainia
- Bayer Richard R.
- Bedi Punit
- Bejai Shereen
- Ben-Rais Nozha
- Benedek Imre
- Benedek Theodora
- Benitez Luis
- Benlabgaa Rabie
- Bennie George
- Benteo Pablo
- Beretta Mario
- Berman Daniel S.
- Bernheim Adam
- Bertelli Paolo
- Bester Ria
- Bettencourt Nuno
- Better Nathan
- Better Nathan
- Beuzeville Scott
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- Wang Ellen
- Wang Jian
- Wang Ximing
- Wang Yifan
- Wang Yining
- Wang Zhao-Qian
- Ward Parker
- Wayne Victor
- Weihmuller Juan Sebastian
- Weir-Mccall Jonathan
- Weiss Konrad
- Weissman Gaby
- Wesbey George
- White James
- White Kelly
- Williams Michelle C.
- Williams Michelle C.
- Wilson Peter
- Winchester David
- Winchester David
- Wolcan Juan
- Wolinsky David
- Won Kyoung Sook
- Wong David
- Wong Kirby
- Wu Jiang
- Wu Zhifang
- Xia Liming
- Xiao Jiangxi
- Xu Lei
- Xu Zhuoran
- Yamada Shinichiro
- Yamazaki Shinya
- Yang Youyou
- Yew Min Sen
- Yin Wu
- Yoneyama Tatsuya
- Yost Sandra
- Young Calum
- Younger John
- Younis Muhammad Numair
- Yu Jianqun
- Yuan Li
- Zaid Eed Abu
- Zakavi Seyed Rasoul
- Zapparoli Marcello
- Zavadovsky Konstantin
- Zeffiro Susana
- Zeidán Nahla
- Zerahn Bo
- Zgaljardic Michael
- Zhang Longjiang
- Zhang Tong
- Zhang Xiaoli
- Zhang Yong-Gao
- Zhu Li
- Zhuravlev Kirill
- Zoboli Stefania
- Zukotynski Katherine
- Zuluaga Alejandro
- Øvrehus Kristian Altern
- Štalc Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality.
Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States.
Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis.
Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection
Intelligent Decision Support System
- Author
- Publication venue
- 'RS Global Sp. z O.O.'
- Publication date
- 01/01/2021
- Field of study
Here one of the new efficient approaches to solving problems of intelligent support of making decisions of a cooperate enterprise scale is analyzed, bearing in mind that the enterprise is oriented towards integration of two interconnected information technologies: a technology of constructing information storages and a technology of intelligent data analysis. A new conception of the role of informating-controlling systems in controlling and operating pipe manufacturing process is suggested. It broadens a traditional view over information systems just as if it were only an instrument of a computer data analysis. The role of the modern information systems in the manufacturing as an independent scientific and applied direction serving as a connecting link in the triad “raw product – ngineering process – end product” is substantiated. Some problems connected with plantation of the informating-controlling systems in the pipe manufacturing is formulated. It broadens a traditional view over information systems just as if it were only an instrument of a computer data analysis. The practical application of this product permits the operating personnel of the enterprise to control the engineering process, analyze the processes passing in each mill, adjust the PRP mills' engineering characteristics in the pipe-manufacturing process. The suggested approach influences quite strongly the production's quality improving and enables to work stably in the thin-walled pipe grades sphere
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- de Almeida Roberto Simões
- de Brito Claudia Moreira
- De Cosmo Salvatore
- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
- De Serres Sacha
- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
- Deak Laszlo
- Deboni Luciane Mônica
- Deck Kenneth
- Deepak Dewan
- del Campo Blanco Belia Martin
- Demian Luiza Despina
- Derosa Giuseppe
- Desouza Cyrus
- Dev Devasmita
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Di Tanna Gian Luca
- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Douthat Walter Guillermo
- Dran Ricardo Dario
- Drasnar Tomas
- Dreval Alexander
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dubé François
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- d’Avila Domingos
- Eder Frank
- Edwin Fernando M.
- Egido de los Rios Jesus
- El Kossi Mohsen
- El-Shahawy Mohamed
- Elosegui Ana Maria
- English Patrick
- Enriquez Sosa Favio Edmundo
- Ervin John
- Escalante Tonatiu Diaz
- Escobedo Rolando Zamarripa
- Esquenazi Alberto
- Evans John
- Faghih Markus
- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
- Fauvel Jean-Pierre
- Felício João Soares
- Ferariu Ioana Emilia
- Ferkl Richard
- Fernandez Maria Florencia
- Filho Roberto Pecoits
- Finkelstein Hernan
- Fishbane Steven
- Flores Fernando Jimenez
- Flota Cervera Luis Fernando
- Fragale Guillermo
- Fraige Filho Fadlo
- Franco Guadalupe Morales
- Franco Roberto Jorge da Silva
- Frascà Giovanni
- Fraser Donald
- Fraser Ian
- Fresnedo Gema Fernandez
- Fretes Jose Osvaldo
- Frias Juan
- Fuiano Giorgio
- Fulop Peter
- Fushtey Ivan
- Gajardo Victor Saavedra
- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Chye Lee
- Gan Shenglian
- Garcia Isabel
- Garcia Nestor Horacio
- Garcia Pere Alvarez
- Garibotto Giacomo
- Gastaldi Anibal
- Gaupsiene Egle
- Gelersztein Elizabeth
- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glenny Jorge Archibaldo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
- Gomez Rangel Jose David
- Gomez Olivert
- Gonzalez Martinez Francisco Javier
- Gonzalez Orellana Ronaldo Arturo
- Gonzalez Alexander
- Gonzalez Alfonso Soto
- Gonzalez Enrique
- Gonzalez Joaquin Pablo
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Górriz Jose L.
- Gracious Noble
- Greco Barbara
- Greene Tom
- Greloni Gustavo Cristian
- Grineva Elena
- Grubb Stephen
- Guerrero Rodolfo Andres Ahuad
- Guinsburg Adrian
- Gulati Rakesh
- Guldris Secundino Cigarran
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Guzman Juan Rosas
- Gyrina Olga
- Haase Franklin Paul
- Hachmann Jean Carlo Tibes
- Hadjadj Samy
- Halciakova Katarina
- Hall Timothy
- Haller Hermann
- Halmagyi Ildiko
- Hammoud Jamal
- Hancu Nicolae
- Handelsman Stuart
- Hanif Wasim
- Hansraj Alva
- Harcsa Eleonora
- Hartman Israel
- Hawley Carmel
- Hayashida Cesar Yoiti
- Heerspink Hiddo J. L.
- Heerspink Hiddo J. L.
- Heerspink Hiddo J. L.
- Henein Sam
- Hermida Sonia
- Herrera Jimenez Luis Enrique
- Hershon Kenneth
- Higuera Juan Diego
- Hiser Daniel
- Hissa Miguel Nasser
- Hon George
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
- Hsieh Chang-Hsun
- Hwang Shang-Jyh
- Hwang Shang-Jyh
- Iglesias Javier Nieto
- Iitsuka Tadashi
- Ilavska Adriana
- Irizar Santana Sergio Saul
- Ismail Mastura
- Jackson Alan
- Jacob Radu
- Jaime Maria
- Jain Dinesh
- Jamal Aamir
- Januszewicz Andrzej
- Jardine Meg
- Jardine Meg
- Jardine Meg J.
- Jeong In-Kyung
- Jerwan-Keim Reinhold
- Jha Vivekanand
- Ji Linong
- Jimeno Cecilia
- Jodar Gimeno Jose Esteban
- Johnson Andrew
- Johnson David
- Joseph Franklin
- Joshi Mukesh
- Juarez Erick Turcios
- Juncos Luis Isaias
- Junior Renan Montenegro
- Jurgens Jaco
- Kaczmarek Barbara
- Kadir Khalid Abdul
- Kajiyama Shizuo
- Kamenov Zdravko
- Kaminska Anna
- Kang Amy
- Kashine Susumu
- Kaupke Charles
- Kawada Toshio
- Kazmirchuk Anatoliy
- Keightley Gerald
- Keitel Elizete
- Keltai Katalin
- Kendereski Aleksandra
- Keresztesi Sandor
- Kern Elizabeth
- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
- Khitan Zeid
- Khullar Dinesh
- Kim Sin Gon
- Kim Sun
- Kim Yeong Hoon
- Kiss Krisztian
- Klein Alexandre
- Klokocnikova Vera
- Klyver Maria Isabel
- Kodera Takamoto
- Kohara Suely Keiko
- Kolesnyk Inna
- Kolesnyk Mykola
- Kolesnyk Mykola
- Kolmakova Elena
- Komisarenko Iuliia
- Kong Wei Yen
- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Kopyt Nelson
- Koroleva Tatiana
- Korzh Oleksii
- Koundurdjiev Atanas
- Kovar Richard
- Kovesdy Csaba
- Koyama Kazunori
- Kozloviene Dalia
- Kraft Florencia
- Krane Vera
- Kravchun Nonna
- Krishna Gopal
- Krishnan Singhan
- Kropp Jeffrey (Jay)
- Krynski Fernando
- Kumar Amrendra
- Kumar Jayant
- Kumar Neil
- Kumeda Yasuro
- Kumwenda Mick
- Kusnir Jorge
- Kvitkova Liudmila
- Kwon Hyuk-Sang
- Kwon Min Jeong
- Lalic Katarina
- Lalic Nebojsa
- Lallaine Ygpuara Ma. Dovie
- Lam Swee Win
- Lanchiotti Paulina Virginia
- Lane Wendy
- Lastuvka Jiri
- Latiff Gulam
- Lawrence Mary
- Lazuka Lech
- Le Meur Yannick
- Lee Byung-Wan
- Lee JungEun
- Lee Li Yuan
- Lee Moon-Kyu
- Legun Oleg
- Lehrner Lawrence
- Leiter Lawrence
- Lentz John
- Leon de la Fuente Ricardo Alfonso
- Levin Adeera
- Levin Adeera
- Levin Adeera
- Levin Adeera
- Levinson Dennis
- Lewis Derek
- Li Detian
- Li Nicole
- Li Wenge
- Li Xuemei
- Lim Soo Kun
- Lim Soo Kun
- Lim-Abrahan Mary Anne
- Lin Chih-Ching
- Lin Hongli
- Lisboa Hugo Roberto Kurtz
- Liss Kenneth
- Liu Jian
- Loh Chek Loong
- Lombard Landman
- Lopez Marta Dominguez
- Lozano Fernando Flores
- Lozanov Lachezar
- Lu Weiping
- Lu Yung- Chuan
- Lukac Martin
- Luna Ceballos Rosa Isela
- MacDougall Iain
- Maddux Andreas
- Madej Andrzej
- Madore François
- Mah Peak Mann
- Mahaffey Kenneth W.
- Mahaffey Kenneth W.
- Maheshwari Hiralal
- Major Lajos
- Malaver Natalia
- Malberti Fabio
- Mandayam Sreedhar
- Mandreoli Marcora
- Manisha Sahay
- Mankovskyy Borys
- Mannucci Edoardo
- Manocha Anita Bhajan
- Mao Hong
- Marar Isam
- Marasaev Viacheslav
- Marchetta Nora
- Margaritov Viktor
- Marin Tamara Malek
- Martinka Emil
- Martynyuk Liliya
- Maxeiner Stephan
- Mazur Stanislaw
- McMahon Alan
- Mehta Bhasker
- Meininger Gary
- Mele Pablo
- Mendoza Jose Luis Accini
- Mendoza Manuel Lopez
- Mercadal Luis Asmarats
- Mesa Juan Villagordoa
- Middleton John
- Milagres Rosângela
- Mileder Margit
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Mkrtumyan Ashot
- Mlodawska-Choluj Dorota
- Molina Hugo Laviada
- Molnar Marta
- Montenegro María Alicia Fernández
- Mookadam Mohamed
- Mordujovich Jorge
- Moreda Ramon
- Moreira Diaz Juan Pablo
- Moreno Loza Oscar Tarsicio
- Morugova Tatiana
- Mostovoy Yuriy
- Moustafa Moustafa
- Mucsi Janos
- Muirhead Norman
- Munar Vila Maria Antonia
- Munteanu Mircea
- Nagibovich Galina
- Nagibovich Oleg
- Nam Moon-Suk
- Narayanan Mohanram
- Narvarte Javier
- Nassar Tareq
- Navickas Antanas
- Neal Bruce
- Neal Bruce
- Nedogoda Sergei
- Negru Doru
- Neto Bruno Geloneze
- Newman George
- Ng Kee Sing
- Ngcakani Nomangesi
- Nichol Brian
- Nicholls Kathy
- Nicol Philip
- Nicolai Silvia
- Niiya Tetsuji
- Nisnisan Josier
- Nixon Paul
- Nonchev Boyan
- Noonan Paul
- Noronha Irene
- Nortje Hendrik
- Nossuli A. Kaldun
- Novoa Pablo Antonio
- Nowicki Michal
- Nowicki Michał
- O'Hare Joseph
- O'Shaughnessy Andrew
- Obialo Chamberlain
- Obrador Gregorio
- Ochodnicka Zuzana
- Oh Kook-Hwan
- Oishi Hiroko
- Olelewe Sarah
- Oliver Michael
- Onaca Adriana Gabriela
- Oosthuizen Helena
- Orio Silvia Ines
- Orlowska-Kowalik Grazyna
- Oroszlan Tamas
- Orsi Emanuela
- Ortiz Luis Hernando Garcia
- Ory Ivan
- Osipova Irina
- Ota Satoshi
- Otreras Fabian
- Oviedo Alejandra
- Packham David
- Padron John
- Panarotto Daniel
- Pankhaniya Rohit
- Papini Nelson Rodriguez
- Paragh Gyorgy
- Park Cheol- Young
- Park Sun-Hee
- Parker Reginald
- Paschen Björn
- Pashkovska Nataliia
- Patel Devesh
- Patel Gnyandev
- Patel Nina
- Pattzi Hiromi Rodriguez
- Pavon Humberto
- Pecoits-Filho Roberto
- Pella Daniel
- Penfornis Alfred
- Pereira Márcio Antônio
- Pererva Larysa
- Perez Armando
- Perez Carlos
- Perez Jonay Pantoja
- Peringat Jayameena
- Perkovic Vlado
- Perkovic Vlado
- Perlman Alan
- Pertseva Tetyana
- Pesickova Satu
- Peterfai Eva
- Peterka Karel
- Petrica Ligia
- Petro Gizella
- Petry Tarissa Beatrice Zanata
- Pettis Karlton
- Pharr Walter
- Philip Sam
- Phillips Andrea
- Piatti Piermarco
- Pichette Vincent
- Pillay-Ramaya Larisha
- Plassmann Georg
- Plaza Mercedes Velo
- Pollock Carol
- Pollock Carol
- Popa Amorin Remus
- Popenda Grazyna
- Popovic-Radinovic Vesna
- Portes Evandro de Souza
- Portillo Cristobal Morales
- Portoles Perez Jose M.
- Prasad Narayan
- Proietto Joseph
- Prozesky Hans
- Pumprla Jiri
- Purighalla Raman
- Quesada Simón María Angustias
- Quesada-Suarez Luis
- Rabasa-Lhoret Remi
- Raduan Roberto Abrão
- Raffaele Pablo
- Railey Mohamed
- Ramirez Roca Luis Alberto
- Ramos Cássio Slompo
- Ramos Jose Chevaile
- Ramtoola Shenaz
- Ranetti Aurelian-Emil
- Rangelov Rangel
- Ranjan Rajiv
- Raskina Tatiana
- Rastogi Sanjeev
- Ratnasingam Vanassa
- Reddy Jakkidi
- Reddy Jeevren
- Ren Yan
- Rendell Marc
- Resk Jorge Hector
- Revesz Katalin
- Rewerska Barbara
- Reyes Rosano Miguel Angel
- Rheeder Paul
- Rich Lisa
- Riera Manel Terns
- Rista Lucas
- Roberts Anthony
- Robinson Michael
- Rocha Cynthia Mustieles
- Rodriguez Hector
- Roger Simon
- Rosas Sylvia
- Rose Ludger
- Rosero Ricardo
- Rosivall László
- Roussel Ronan
- Rucker Joerg Isabel Erika
- Rychlik Ivan
- Rychlík Ivan
- Saavedra Sanchez Sandra Berenice
- Saba Fadi
- Sabbag Ângela Regina Nazario
- Sakakibara Terue
- Sala Jorgelina
- Salazar Melchor Alpizar
- Samoylov Oleksandr
- Samoylova Yulia
- Sanches Fernanda Cristina Camelo
- Sanchez Mijangos Jose Hector
- Sanchez Polo José Vicente
- Sankaram Rallabhandi
- Sanson Pablo Serrano
- Santoro Domenico
- Santos Florence
- Santos Florence
- Santos Juan Carlos
- Santos Lalaine Delos
- Saporito Wladmir
- Saraiva Jose Francisco Kerr
- Sarin Ravi
- Sasso Ferdinando Carlo
- Satyanarayana Rao K.
- Saudek Frantisek
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Sánchez Arenales Jose Antonio
- Schiavi Lilia Beatriz
- Schiller Adalbert
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Scotton Antonio Scafuto
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Antonio Galan
- Serviddio Gaetano
- Sessa Horacio
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Sheu Wayne H-H
- Shinkov Alexander
- Shudim Saiful Shahrizal Bin
- Shutemova Elena
- Shwartz Yuriy
- Simon Godwin
- Singh Baldev
- Smatanova Iveta
- Smirnov Ivan
- Smith Stephen
- Smyth Brendan
- Solomon Richard
- Song Weihong
- Soto Mario Burgos
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- Sreedhar Reddy
- Sreelatha Melemadathil
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
- Strzelecka Anna
- Suchinda Pusadee
- Sudhakar Bhimavarapu
- Sultan Senan
- Sun Jiao
- Sun Lin
- Surampudi Prasanth
- Sussman Sherry
- Svyshchenko Yevgeniya
- Symonds Rehan
- Takacs Robert
- Takai Masahiko
- Tamayo y Orozco Juan Alfredo
- Tan Anjanette
- Tan Gerry
- Tangri Navdeep
- Temelkova Margarita
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thomé Fernando
- Thompson Michael
- Tinahones Madueno Francisco Jose
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torres Manuel Muñoz
- Torshizi Ali
- Trenche Samuel Mujica
- Trespalacios Fernando
- Trevisan Roberto
- Triana Eric Hernandez
- Trippe Bruce
- Trueba Pilar
- Tryshchuk Nadiya
- Tsang Venessa
- Tseluyko Vira
- Tsujimoto Mitsuru
- Tu Ping
- Turatti Luiz Alberto Andreotti
- Turner Wayne
- Twahirwa Marcel
- Ulla Maria Rosa
- Updegrove John
- Urbanaviciene Egle
- Uriasyev Oleg
- Valdez Maria
- Valenzuela Alex
- Valis Martin
- Vallejos Augusto
- Van Buren Peter
- Vangel Sandor
- Vannorsdall Mark
- Vargas Alonso Ruben Dario
- Varghese Freemu
- Vasas Szilard
- Vazelov Evgueniy
- Vejar Margarita
- Velasquez-Mieyer Pedro
- Velichkova Ekaterina
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vera Gregorio Obrador
- Vera Merce Perez
- Veronelli Anna Maria
- Vêncio Sérgio Alberto Cunha
- Villarino Adriana
- Villegas Ivan
- Visco Virginia Esther
- Vizir Vadym
- Vlasenko Maryna
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
- Williams Michael
- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
Effect of SGLT2 Inhibitors on Stroke and Atrial Fibrillation in Diabetic Kidney Disease: Results From the CREDENCE Trial and Meta-Analysis
- Author
- (Jay) Kropp Jeffrey
- Abdul Kadir Khalid
- Abdullah Raied
- Abraham Oomman India:
- Abramowitz Matthew
- Acosta Idalia
- Africa: Fayzal Ahmed South
- Agra Jeimeen
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alappan Rajendran
- Alberto Andreotti Turatti Luiz
- Alberto Berli Mario
- Alberto Cuneo Carlos
- Alberto Cunha V\ueancio S\ue9rgio
- Alberto Ramirez Roca Luis
- Alexandra Terront Lozano Monica
- Alfonso Leon de la Fuente Ricardo
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Alina Agafyina Russia:
- Alpizar Salazar Melchor
- Alva Hansraj
- Alvarisqueta Andres
- Amodeo Celso
- Andres Ahuad Guerrero Rodolfo
- Angel Reyes Rosano Miguel
- Angelova Angelina
- Anghel Veronica
- Angustias Quesada Sim\uf3n Mar\ueda
- Ant\uf4nio Pereira M\ue1rcio
- Antonia Munar Vila Maria
- Antonio Novoa Pablo
- Antonio S\ue1nchez Arenales Jose
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Archibaldo Glenny Jorge
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Asmarats Mercadal Luis
- Atray Naveen
- Augusto Alves da Costa Fernando
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Baas Cruz Juan
- Badat Aysha
- Bajaj Harpreet
- Bakris George
- Barbarash Olga
- Barnard Maria
- Barnhill Peggy
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Beatrice Zanata Petry Tarissa
- Beatriz Schiavi Lilia
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berenice Saavedra Sanchez Sandra
- Bermudez Lidia
- Bernardo Marializa
- Bhajan Manocha Anita
- Bhushan Raju Sree
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bordonava Anselmo
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brusco Osvaldo
- Buganova Ingrid
- Burgos Soto Mario
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calella Pedro
- Canaan Yamil
- Caringal Clodoaido
- Cariou Bertrand
- Carlo Sasso Ferdinando
- Carlo Tibes Hachmann Jean
- Carlos Santos Juan
- Castellino Pietro
- Cecilia Cantero Maria
- Cecilia Coloma Gabriela
- Cercos Esteban
- Cereto Castro Fernando
- Ceriello Antonio
- Chandra Vyasam Ramesh
- Chen Qinkai
- Cherney David
- Chevaile Ramos Jose
- Chew Wong Alfredo
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Chwen-Tzuei Chang Taiwan:
- Cif Adriana
- Cigarran Guldris Secundino
- Cohen Kenneth
- Cohen Robert
- Cohen- Stein Debbie
- Colombo Hugo
- Commendatore Victor
- Conway James
- Cook Charles
- Cosma Dana
- Cournoyer Serge
- Coyne Daniel
- Crawford Allison Dale
- Crisan Carmen
- Cristian Greloni Gustavo
- Cristina Camelo Sanches Fernanda
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- d'Avila Domingos
- Daboul Nizar
- Danos Peter
- Dario Dran Ricardo
- Dario Vargas Alonso Ruben
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- Daud Che Yusof Mohd
- David Gomez Rangel Jose
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- De Cosmo Salvatore
- De Nicola Luca
- De Serres Sacha
- de Souza Portes Evandro
- de Souza Pedro
- Deak Laszlo
- Deck Kenneth
- del Carmen Gonzalez Colaso Patricia
- Delos Santos Lalaine
- Derosa Giuseppe
- Desouza Cyrus
- Despina Demian Luiza
- Dev Devasmita
- Dewan Deepak
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Diaz Escalante Tonatiu
- Diego Higuera Juan
- Dimitrov Stefan
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Dominguez Lopez Marta
- Dovie Lallaine Ygpuara Ma.
- Drasnar Tomas
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dub\ue9 Fran\ue7ois
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- Eder Frank
- Edmundo Enriquez Sosa Favio
- Edwin Fernando M.
- Egido de los Rios Jesus
- Egle Gaupsiene Lithuania:
- El Kossi Mohsen
- El-Shahawy Mohamed
- Emilia Ferariu Ioana
- English Patrick
- Enrique Herrera Jimenez Luis
- Eric Alamartine France:
- Erika Rucker Joerg Isabel
- Ernesto Andres Diaz Ruiz Jorge
- Ervin John
- Esquenazi Alberto
- Esteban Jodar Gimeno Jose
- Esther Visco Virginia
- Ethel Yap Yvette
- Evans John
- Faghih Markus
- Farias Eduardo
- Faulmann Grit
- Fauvel Jean-Pierre
- Ferkl Richard
- Fernandez Fresnedo Gema
- Fernando Flota Cervera Luis
- Finkelstein Hernan
- Fishbane Steven
- Florencia Fernandez Maria
- Flores Lozano Fernando
- Fragale Guillermo
- Fraige Filho Fadlo
- Francisco Kerr Saraiva Jose
- Frasc\ue0 Giovanni
- Fraser Donald
- Fraser Ian
- Frenk Baron Paul
- Frias Juan
- Fuiano Giorgio
- Fulop Peter
- Fushtey Ivan
- Gabriela Onaca Adriana
- Galan Serrano Antonio
- Galindo-Ramos Eugenia
- Galphin Claude
- Gambaro Giovanni
- Gan Shenglian
- Garcia Ballesteros Cecilia
- Garcia Isabel
- Garibotto Giacomo
- Gastaldi Anibal
- Gelersztein Elizabeth
- Geloneze Neto Bruno
- Genadieva Veselka
- Genova-Hristova Gabriela
- Ghazi Adline
- Giorda Carlo
- Glinkina Irina
- Gnudi Luigi
- Godlevska Olga
- Goldenberg Ronald
- Golovchenko Oleksandr
- Gomes Marcus
- Gomez Olivert
- Gon Kim Sin
- Gonzalez Alexander
- Gonzalez Enrique
- Gonzalo Godoy Jorquera Juan
- Gopalakrishnan Natarajan
- Gorson David
- Gourdy Pierre
- Govender Ravendran
- Govender Vimladhevi
- Gowda Anupama
- Goycoa Claudia
- Gracious Noble
- Greco Barbara
- Grineva Elena
- Grubb Stephen
- Guillermo Douthat Walter
- Guinsburg Adrian
- Gulati Rakesh
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gyongyi Csecsei Hungary:
- Gyrina Olga
- H-H Sheu Wayne
- Halciakova Katarina
- Hall Timothy
- Haller Hermann
- Halmagyi Ildiko
- Hammoud Jamal
- Hancu Nicolae
- Handelsman Stuart
- Hanif Wasim
- Harcsa Eleonora
- Hartman Israel
- Hector Resk Jorge
- Hector Sanchez Mijangos Jose
- Henein Sam
- Henrique Canani Luis
- Hermida Sonia
- Hernandez Triana Eric
- Hernando Garcia Ortiz Luis
- Hershon Kenneth
- Hiser Daniel
- Hitoshi Akiyama Japan:
- Ho Yoon Kun
- Hon George
- Hoon Kim Yeong
- Horacio Garcia Nestor
- Hotlos Lucyna
- Hristozov Kiril
- Hsia Te-Lin
- Hsieh Chang-Hsun
- Hwang ShangJyh
- Iitsuka Tadashi
- Ilavska Adriana
- In\ue9s Molina de Salazar Dora
- Ines Orio Silvia
- Isabel Klyver Maria
- Isaias Juncos Luis
- Isela Luna Ceballos Rosa
- Ismail Mastura
- Jackson Alan
- Jacob Radu
- Jaime Maria
- Jain Dinesh
- Jamal Aamir
- Jana Babikova Slovakia:
- Januszewicz Andrzej
- Javier Gonzalez Martinez Francisco
- Javier Zaidman Cesar
- Jeong Kwon Min
- Jeong In-Kyung
- Jerwan-Keim Reinhold
- Jimenez Flores Fernando
- Jimeno Cecilia
- Johnson Andrew
- Johnson David
- Jorge da Silva Franco Roberto
- Jose Luis Accini Mendoza Colombia:
- Jose Tinahones Madueno Francisco
- Joseph Franklin
- Joshi Mukesh
- Jurgens Jaco
- Kaczmarek Barbara
- Kajiyama Shizuo
- Kaldun Nossuli A.
- Kamenov Zdravko
- Kaminska Anna
- Kashine Susumu
- Kaupke Charles
- Kawada Toshio
- Kazmirchuk Anatoliy
- Keightley Gerald
- Keiko Kohara Suely
- Keitel Elizete
- Keltai Katalin
- Kendereski Aleksandra
- Keresztesi Sandor
- Kern Elizabeth
- Keshavamurthy C. B.
- Khandwala Hasnain
- Khanna Rakhi
- Khirmanov Vladimir
- Khitan Zeid
- Khullar Dinesh
- Kim Sun
- Kingdom: Kamal Abouglila United
- Kiss Krisztian
- Klein Alexandre
- Klokocnikova Vera
- Kodera Takamoto
- Kolesnyk Mykola
- Kolmakova Elena
- Komisarenko Iuliia
- Kong Yaozhong
- Kono Hiroshi
- Konyves Laszlo
- Kopyt Nelson
- Korea: Dong-Wan Chae South
- Koroleva Tatiana
- Korzh Oleksii
- Koundurdjiev Atanas
- Kovar Richard
- Kovesdy Csaba
- Koyama Kazunori
- Kozloviene Dalia
- Kraft Florencia
- Kravchun Nonna
- Krishna Gopal
- Krishnan Singhan
- Krynski Fernando
- Kumar Amrendra
- Kumar Jayant
- Kumar Neil
- Kumeda Yasuro
- Kumwenda Mick
- Kun Lim Soo
- Kusnir Jorge
- Kvitkova Liudmila
- Kwon Hyuk-Sang
- Lalic Katarina
- Lalic Nebojsa
- Lane Wendy
- Lastuvka Jiri
- Latiff Gulam
- Laviada Molina Hugo
- Lawrence Mary
- Lazuka Lech
- Le Meur Yannick
- Lee Gan Chye
- Lee Byung-Wan
- Lee JungEun
- Lee Moon-Kyu
- Legun Oleg
- Lehrner Lawrence
- Leiter Lawrence
- Lentz John
- Levin Adeera
- Levinson Dennis
- Lewis Derek
- Li Detian
- Li Wenge
- Li Xuemei
- Liliana Monica Angelescu Romania:
- Lin Chih-Ching
- Lin Hongli
- Lindolfo Cunha Borges Jo\ue3o
- Liss Kenneth
- Liu Jian
- Lombard Landman
- Loong Loh Chek
- Lopez Mendoza Manuel
- Loss de Carvalho Contieri Fabiana
- Lozanov Lachezar
- Lu Weiping
- Lu Yung-Chuan
- Luis David Abraira Munoz Mexico:
- Lukac Martin
- M\uf4nica Deboni Luciane
- Ma Portoles Perez Jose
- MacDougall Iain
- Maddux Andreas
- Madej Andrzej
- Madore Fran\ue7ois
- Maheshwari Hiralal
- Major Lajos
- Malaver Natalia
- Malberti Fabio
- Malek Marin Tamara
- Mandayam Sreedhar
- Mandreoli Marcora
- Mankovskyy Borys
- Mann Mah Peak
- Mannucci Edoardo
- Mao Hong
- Mar\ueda Alicia Fern\ue1ndez Montenegro Chile:
- Marar Isam
- Marasaev Viacheslav
- Marchetta Nora
- Margaritov Viktor
- Maria Cusumano Ana
- Maria Elosegui Ana
- Maria Veronelli Anna
- Martin del Campo Blanco Belia
- Martinka Emil
- Martynyuk Liliya
- Maxeiner Stephan
- Mazur Stanislaw
- Mc- Mahon Alan
- Medina Fari\uf1a Marcelo
- Mehta Bhasker
- Mele Pablo
- Melemadathil Sreelatha
- Middleton John
- Milagres Ros\ue2ngela
- Mileder Margit
- Min Cho Young
- Miyauchi Shozo
- Mizuyama Kazuyuki
- Mkrtumyan Ashot
- Mlodawska-Choluj Dorota
- Mohamed Railey United Arab Emirates: Salah Abusnana
- Molnar Marta
- Montenegro Junior Renan
- Mookadam Mohamed
- Morales Franco Guadalupe
- Morales Portillo Cristobal
- Mordujovich Jorge
- Moreda Ramon
- Moreira de Brito Claudia
- Morugova Tatiana
- Mostovoy Yuriy
- Moustafa Moustafa
- Mu\uf1oz Torres Manuel
- Mucsi Janos
- Muirhead Norman
- Mujica Trenche Samuel
- Munteanu Mircea
- Mustieles Rocha Cynthia
- Nagibovich Galina
- Nagibovich Oleg
- Nam Moon-Suk
- Nan Chen China:
- Narayanan Mohanram
- Naresh Aggarwal Canada:
- Narvarte Javier
- Nassar Tareq
- Nasser Hissa Miguel
- Navickas Antanas
- Nedogoda Sergei
- Negru Doru
- Newman George
- Ngai Wah Cheung Australia:
- Ngcakani Nomangesi
- Nichol Brian
- Nicholls Kathy
- Nicol Philip
- Nicolai Silvia
- Nieto Iglesias Javier
- Niiya Tetsuji
- Nisnisan Josier
- Nixon Paul
- Nonchev Boyan
- Noonan Paul
- Noronha Irene
- Nortje Hendrik
- Nowicki Michal
- Nur Fatnoon Nik Ahmad Nik
- O'Hare Joseph
- O'Shaughnessy Andrew
- Obialo Chamberlain
- Obrador Vera Gregorio
- Ochodnicka Zuzana
- Oh Kook-Hwan
- Oishi Hiroko
- Olelewe Sarah
- Olga Barna Ukraine:
- Oliver Michael
- Oosthuizen Helena
- Orlowska-Kowalik Grazyna
- Oroszlan Tamas
- Orozco Castellanos Ricardo
- Orsi Emanuela
- Ory Ivan
- Osipova Irina
- Osvaldo Fretes Jose
- Ota Satoshi
- Otreras Fabian
- Oviedo Alejandra
- Pablo Albisu Juan
- Pablo Gonzalez Joaquin
- Pablo Moreira Diaz Juan
- Packham David
- Padron John
- Panarotto Daniel
- Pankhaniya Rohit
- Pantoja Perez Jonay
- Paragh Gyorgy
- Park Cheol-Young
- Park Sun-Hee
- Parker Reginald
- Paschen Bj\uf6rn
- Pashkovska Nataliia
- Patel Devesh
- Patel Gnyandev
- Patel Nina
- Paul Haase Franklin
- Pavon Humberto
- Pecoits Filho Roberto
- Pella Daniel
- Penfornis Alfred
- Peralta Calcaneo Juan
- Pere Alvarez Garcia Spain:
- Pererva Larysa
- Perez Vera Merce
- Perez Armando
- Perez Carlos
- Peringat Jayameena
- Perlman Alan
- Pertseva Tetyana
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- Peterfai Eva
- Peterka Karel
- Petrica Ligia
- Petro Gizella
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- Pharr Walter
- Philip Sam
- Phillips Andrea
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- Pichette Vincent
- Pillay-Ramaya Larisha
- Plassmann Georg
- Popenda Grazyna
- Popovic-Radinovic Vesna
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- Proietto Joseph
- Prozesky Hans
- Pumprla Jiri
- Purighalla Raman
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- Rabasa-Lhoret Remi
- Raffaele Pablo
- Ramtoola Shenaz
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- Rangelov Rangel
- Ranjan Rajiv
- Raskina Tatiana
- Rastogi Sanjeev
- Ratnasingam Vanassa
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- Reddy Jeevren
- Reddy Sreedhar
- Regina Nazario Sabbag \uc2ngela
- Remus Popa Amorin
- Ren Yan
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- Rendell Marc
- Republic: Dagmar Bartaskova Czech
- Revesz Katalin
- Rewerska Barbara
- Rheeder Paul
- Ricardo Correa Rotter Jose
- Riccardo Bonadonna Italy:
- Rich Lisa
- Rista Lucas
- Roberto Abr\ue3o Raduan Brazil:
- Roberto Chacra Ant\uf4nio
- Roberto Kurtz Lisboa Hugo
- Roberts Anthony
- Robinson Michael
- Rodolfo Cartasegna Luis
- Rodriguez Papini Nelson
- Rodriguez Pattzi Hiromi
- Rodriguez Hector
- Roger Simon
- Rohana Abdul Ghani Malaysia:
- Ronaldo Arturo Gonzalez Orellana Guatemala:
- Rosa Ulla Maria
- Rosas Guzman Juan
- Rosas Sylvia
- Rose Ludger
- Rosero Ricardo
- Roussel Ronan
- Rychlik Ivan
- Saavedra Gajardo Victor
- Saba Fadi
- Sahay Manisha
- Sakakibara Terue
- Sala Jorgelina
- Samoylov Oleksandr
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- Sankaram Rallabhandi
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- Santos Florence
- Saporito Wladmir
- Sarin Ravi
- Satyanarayana Rao K.
- Saudek Frantisek
- Saul Irizar Santana Sergio
- Saulnier Pierre-Jean
- Saxena Manish
- Sazonova Olga
- Scafuto Scotton Antonio
- Schreiman Robert
- Schuch Tiago
- Scott David
- Scott Russell
- Seeber Mary
- Sekkarie Mohamed
- Sennik Davesh
- Sensenbrenner John
- Serafinceanu Cristian
- Serrano Sanson Pablo
- Serviddio Gaetano
- Sessa Horacio
- Severina Comia Rhea
- Shahrizal Bin Shudim Saiful
- Shakeel Muhammad
- Shamkhalova Minara
- Shanik Michael
- Shaw Sylvia
- Shinkov Alexander
- Shutemova Elena
- Shwartz Yuriy
- Sim\uf5es de Almeida Roberto
- Simo Canonge Rafael
- Simon Godwin
- Sing Ng Kee
- Singh Baldev
- Slobodan Antic Serbia:
- Slompo Ramos C\ue1ssio
- Smatanova Iveta
- Smirnov Ivan
- Smith Casabella Tomas
- Smith Stephen
- Soares Fel\uedcio Jo\ue3o
- Solomon Richard
- Song Weihong
- Soto Gonzalez Alfonso
- Sowinski Dariusz
- Sprague Amy
- Spry Leslie
- States: Joseph Abdallah United
- Steele Andrew
- Stella Andrea
- Stephens Jeffrey
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- Suchinda Pusadee
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- Sun Jiao
- Sun Lin
- Surampudi Prasanth
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- Takacs Robert
- Takai Masahiko
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- Teresa Zanella Maria
- Terns Riera Manel
- Terrelonge Antonio
- Tesar Vladimir
- Thervet Eric
- Thom\ue9 Fernando
- Thompson Michael
- Toarba Cristina
- Tolentino Marsha
- Tomashkevych Halyna
- Tomonaga Osamu
- Topchii Ivan
- Torshizi Ali
- Trespalacios Fernando
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- Velichkova Ekaterina
- Velo Plaza Mercedes
- Venegas Carrillo Luis
- Vengadasalam Paranthaman
- Ventrapragada Sailaja
- Vicente Sanchez Polo Jos\ue9
- Viktoria Andreeva Bulgaria:
- Villagordoa Mesa Juan
- Villarino Adriana
- Villegas Ivan
- Virginia Lanchiotti Paulina
- Vizir Vadym
- Vlasenko Maryna
- Volker Burst Germany:
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler David
- Williams Michael
- Williams Shelley
- Win Lam Swee
- Winocour Peter
- Woo Vincent
- y Orozco Juan Alfredo Tamayo
- Yakov Andrian
- Yamada Masayo
- Yamada S\ue9rgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yen Kong Wei
- Yin Aiping
- Yoiti Hayashida Cesar
- Young Simon
- Yu Xueqing
- Yuan Lee Li
- Yumita Wataru
- Yupanqui Hernan
- Zalunardo Nadia
- Zamarripa Escobedo Rolando
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zaynab Abejuela Philippines:
- Zealand: John Baker New
- Zemek Stanislav
- Zhao Minghui
- Zheng Hongguang
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus.METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-analysis.RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (<45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]).CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02065791
International Impact of COVID-19 on the Diagnosis of Heart Disease
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afonso Shiozaki
- Afroza Akhter
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T Ahmed Tawakol
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
- Alejandro Becerril González-Montecinos
- Alejandro Canderoli
- Alejandro De La Vega
- Alejandro Deviggiano
- Alejandro Horacio Meretta
- Alejandro Maldonado
- Alejandro Radzinschi
- Alejandro Zuluaga
- Alessia Gimelli
- Alex Frenkel
- Alexander Kokov
- Alexander Pitman
- Alexander Sasse
- Alexandra Smith
- Alexey Ansheles
- Alexia Farrugia
- Alfonso Waller
- Alfredo Astesiano
- Alfredo Perez
- Alfredo Rodrigues
- Ali Sellem
- Alia Hassan
- Alicia Camarero
- Alistair Gummow
- Alix Juillet de Saint Lager Lucas
- Allam A. H.
- Allan Johansen
- Alvin Quinon
- Amalia Peix
- Amanda Marn
- Ambedhkar Shantaram Naojee
- Amelia Jimenez-Heffernan
- Ami Iskandrian
- Amit Patel
- Amit Pursnani
- Amjed Albadr
- Ana Alfaro
- Ana Baric
- Ana Camila Flores
- Ana Sevilla
- Anand Gaikwad
- Anastasia Oikonomou
- Anatoly Karalkin
- Anda Bularga
- Anders Thomassen
- Anders Tjellaug Bråten
- Andor Glaudemans
- Andrea Astesiano
- Andrea Bruno
- Andrea De Lorenzo
- Andrej Vondrak
- Andres Vasquez
- Andressa Borges
- Andrew Choi
- Andrew Kelion
- Andrew Taylor
- Andrew To
- Andrés Preciado-Anaya
- Angela Burandt
- Angela Byrne
- Angela Gaudiano
- Anggoro Praja Mukti
- Anibal Mele
- Anjori Dunbar
- Anne Poksi
- Anri Inaki
- Ante Punda
- Anthony Murray
- Anthony Samuel
- Anthony Upton
- Antonella Stefanelli
- Antonio Cabrera
- Antonio Calderón Moncayo
- Antonio Ferreira
- Anupama Kottam
- Anxo Martinez de Alegria
- Aparna Deshpande
- Aparna Irodi
- Armando Ugo Cavallo
- Artan Goda
- Artem Kalinin
- Arthur Scholte
- Arturo Romero Acuña
- Arve Jørgensen
- Aryeh Shalev
- Asbjørn Scholtens
- Asela Barroso
- Ashok Gangasandra Basavaraj
- Ashwani Sood
- Atsutaka Okizaki
- Atul Verma
- Augusto Almeida
- Aulia Huda
- Austin Robinson
- Axel Rominger
- Ayreen Cordero
- Azhar Khokhar
- Balint Szilveszter
- Barbara Gužic Salobir
- Barbara Nardi
- Barry Elison
- Bart De Boeck
- Basuki Hidayat
- Batool Albalooshi
- Benjamin Chow
- Benjamin Hudson
- Benjapa Khiewvan
- Bernardo Spiro
- Better N.
- Bettina Tecson
- Bhagwant Rai Mittal
- Bhanupriya Singh
- Bhatia M.
- Bijoy Rajbanshi
- Bo Zerahn
- Brian Abbott
- Brian Ghoshhajra
- Brian Goldner
- Brian Pomerantz
- Bruce Decter
- Bruce Goodwin
- Bruno Castro
- Bruno Ghini
- Bruno Strada
- Caiying Li
- Calum Young
- Cameron Foster
- Campisi R.
- Candace Candela
- Carla Gonzalez
- Carlo Liguori
- Carlos Anselmi
- Carlos Caicedo
- Carlos Collaud
- Carlos Eduardo Soares
- Carlos Novoa
- Carlos Rodrigues
- Carmen Concha
- Carolina Bas Norton
- Caroline M Van De Heyning
- Carolyn Hawkins
- Cerci R.
- Cesar Lovera
- Cesar Nomura
- Cesar Rodríguez
- Chae Moon Hong
- Chanan Moffitt
- Chandraguptha Udugama
- Chang Kyeong Namgung
- Charles Chao
- Charles Peebles
- Chen Low
- Chetan Patel
- Chibuzo Madu
- Chimura Misato Chimura
- Choi A. D.
- Chris Ellis
- Chris Johnson
- Christel H Kamani
- Christian Hamilton-Craig
- Christian Michael Pawhay
- Christian Picard
- Christina Fragkaki
- Christine Jellis
- Christoforos Panagidis
- Christoph Gräni
- Christopher Occleshaw
- Christopher Rofe
- Claudia Cortes
- Claudia Jaimes
- Claudia T Gutierrez Villamil
- Claudio Marcassa
- Claudio Pereyra Sueldo
- Claudiu Adrian Stan
- Cláudio Tinoco Mesquita
- Cohen Y.
- Connor Saunders
- Conor Meehan
- Corrado Cittanti
- Cristiano Siqueira
- Cristina Rodríguez Rey
- Cristina Sebastião Matushita
- D'Arne Downie
- Dainia Baugh
- Daisuke Sato
- Damayanthi Nanayakkara
- Damiana Vergel
- Dan Han
- Daniel Calderon Rodriguez
- Daniel Cragnolino
- Daniel Fisher
- Daniel Fitzpatrick
- Danilo Naves
- Daria Ryzhkova
- Daultai Batyrkhanov
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- David Cusack
- David Kerins
- David Min
- David Murphy
- David Prior
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- David Winchester
- David Wolinsky
- David Wong
- Davidson Pastrana
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- Deepa Gopalan
- Deepa Shetty
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- Deepanjan Mitra
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- Desiree Trinidad
- Diana Litmanovich
- Dianbo Cao
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- Diego Ruiz
- Diego Sadler
- Dilip Patel
- Dinesh Kalra
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- Djoko Prawiro
- Domenico Albano
- Dominique Dabreo
- Donald Chang
- Donatas Vajauskas
- Dondi M.
- Dong Li
- Dora Lenturut-Katal
- Dorbala S.
- Dragana Sobic Saranovic
- Duane Chambers
- Duncan Coles
- Dustin Thomas
- Edgar Monroy
- Edgardo Mastrovito
- Edison Edison
- Edit Várady
- Eduardo Noguera
- Eduardo Paixao
- Edward Nicol
- Edward O'Rourke
- Edward Passen
- Eed Abu Zaid
- Einstein A. J.
- Ekaterina Migunova
- Elen Efros-Monsen
- Elena Busnardo
- Elena Califaretti
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- Fadi Hage
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- Filip Homans
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- Samir Shah
- Samuel Burg
- Samuel Unzek
- Sandra Abramson
- Sandra Ayala
- Sandra Gracia-López
- Sandra Graciela Rosales Uvera
- Sandra Yost
- Sang-Geon Cho
- Santiago Aguadé-Bruix
- Santosh Singh
- Sara Pacella
- Sara Ranser
- Sara Santana
- Sara Taleb
- Satoshi Isobe
- Satoshi Okayama
- Saurav Chatterjee
- Scott Beuzeville
- Scott Jerome
- Sean Blue
- Sebastian Perez Ascani
- Sergienko V.
- Sergio Baldari
- Seth Uretsky
- Seyed Rasoul Zakavi
- Shady Abohashem
- Shamil Morayati
- Shankar Vamadevan
- Shantanu Sengupta
- Sharon Gomez
- Shashank Jain
- Shaw Hua Anthony Kueh
- Shaw L. J.
- Shawn Ullery
- Shazia Fatima
- Shereen Bejai
- Sherif Nabil
- Shigeki Nagamachi
- Shinichiro Fujimoto
- Shinichiro Kumita
- Shinichiro Yamada
- Shinya Shiraishi
- Shinya Yamazaki
- Shivani Patel
- Sigelinda Sandoval
- Signe Helene Forsdahl
- Sijin Li
- Silvia Carames
- Silvia Siu
- Silvia Teresa De Maria
- Simone Brandão
- Sinisa Stankovic
- Sinitsyn V.
- Siroos Mirzaei
- Sofia Chatziioannou
- Sofia Haider
- Son Hong Mai
- Sonexay Rajvong
- Sonia Simona Traverzo
- Sonia Traverso
- Sophia Koukouraki
- Sorin Danciu
- Srdja Ilic
- Srikanth Vallurupalli
- Stefan Pool
- Stefania Zoboli
- Stephan Probst
- Stephen Bloom
- Stephen Cheung
- Stephen E Matis
- Stephen Horgan
- Steve Leung
- Steven H Lee
- Steven Shayani
- Steven Sigman
- Steven Unger
- Stuart More
- Su Jin Jang
- Subhani Okarvi
- Subodh Joshi
- Sudhir Saxena
- Suhny Abbara
- Sujata Shanbhag
- Sujith Seneviratne
- Sukriti Kumar
- Summanther Kaviratne
- Suresh Ramamurti
- Susana Molteni
- Susana Zeffiro
- Svetlana Agranovich
- Svetlana Sazonova
- Sze Mun Mak
- Søren Hess
- Tadhg Gleeson
- Taghreed Ahmed
- Taimur Abbasi
- Tairkhan Dautov
- Takao Kato
- Takashi Norikane
- Tanyaluck Thientunyakit
- Tao Li
- Tapan Patel
- Tara Torbet
- Tarek Al-Abboud
- Tatjana Trifonova
- Tatsuya Yoneyama
- Tchoyoson Lim Coie
- Teerapon Premprabha
- Teresa Cuadra
- Teresa Massardo
- Theodora Benedek
- Thiago Ferreira De Souza
- Thomas Biggans
- Thomas Hartley
- Thomas Porter
- Thomas Semple
- Tiago Magalhães
- Tiago Senra
- Tien Chang
- Tiffany Chen
- Timothy Fairbairn
- Tolulope Ayodele
- Tomoaki Nakata
- Tomohisa Fukunaga
- Tonci Batinic
- Tong Zhang
- Tony Fuisz
- Tony Mcrae
- Tony Stanton
- Toshiaki Kadokami
- U Joseph Schoepf
- Ulises González
- Umberto Conti
- Vaclav Engelmann
- Valentina Soldat-Stankovic
- Valtteri Uusitalo
- Vania Naue
- Vania Tacher
- Velipekka Kokkonen
- Venjamin Majstorov
- Venkatesh Murthy
- Venkateshwar Polsani
- Veronica Della Tommasina
- Veronique Roelants
- Victar Hsieh
- Victor Hasbani
- Victor Jäger
- Victor Wayne
- Vijay Sai Chowdekar
- Vijay Solanki
- Vikas Tandon
- Vikas Verma
- Viktor Persic
- Viktor Pospelov
- Villines T. C.
- Vincent Habouzit
- Vincent Peter Magboo
- Vincenzo Russo
- Vinícius Kameoka
- Violeta Cortés
- Virgil Chan
- Virginia Peiro
- Virginia Pubul-Nuñez
- Vitola J. V.
- Vivek Bhat
- Viviana Frantellizzi
- Vladimír Kincl
- Volodymyr Pliatsek
- Vsevolod Milyevich Gulyaev
- Warren Moore
- William Duvall
- William Topping
- William Van Gaal
- Williams M. C.
- Wilson Furlan Alves
- Wladimir Yurievich Ussov
- Won Jun Kang
- Woon Chong
- Wu Yin
- Xiaoli Zhang
- Ximing Wang
- Xu Dai
- Xuan Canh Nguyen
- Yamile Marcos Gutierrez
- Yamile Marcos Gutierrez
- Yang Hou
- Yao Lu
- Yariela Herrera
- Yaroslav Kmetyuk
- Yasmin Hamirani
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yetunde Onimode
- Yiannis Chatzizisis
- Yifan Wang
- Yining Wang
- Yiyan Liu
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yong-Gao Zhang
- Yoshimitsu Fukushima
- Yoshinobu Suwa
- Youdaline Theng
- Young So
- Youyou Yang
- Zabah Jawa
- Zerida Muyinda
- Zhao-Qian Wang
- Zhifang Wu
- Zhuoran Xu
- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery of diagnostic care for cardiovascular disease, which remains the leading cause of death worldwide, have not been quantified. Objectives: The study sought to assess COVID-19's impact on global cardiovascular diagnostic procedural volumes and safety practices. Methods: The International Atomic Energy Agency conducted a worldwide survey assessing alterations in cardiovascular procedure volumes and safety practices resulting from COVID-19. Noninvasive and invasive cardiac testing volumes were obtained from participating sites for March and April 2020 and compared with those from March 2019. Availability of personal protective equipment and pandemic-related testing practice changes were ascertained. Results: Surveys were submitted from 909 inpatient and outpatient centers performing cardiac diagnostic procedures, in 108 countries. Procedure volumes decreased 42% from March 2019 to March 2020, and 64% from March 2019 to April 2020. Transthoracic echocardiography decreased by 59%, transesophageal echocardiography 76%, and stress tests 78%, which varied between stress modalities. Coronary angiography (invasive or computed tomography) decreased 55% (p < 0.001 for each procedure). In multivariable regression, significantly greater reduction in procedures occurred for centers in countries with lower gross domestic product. Location in a low-income and lower–middle-income country was associated with an additional 22% reduction in cardiac procedures and less availability of personal protective equipment and telehealth. Conclusions: COVID-19 was associated with a significant and abrupt reduction in cardiovascular diagnostic testing across the globe, especially affecting the world's economically challenged. Further study of cardiovascular outcomes and COVID-19–related changes in care delivery is warranted
Impact of COVID-19 on Diagnostic Cardiac Procedural Volume in Oceania: The IAEA Non-Invasive Cardiology Protocol Survey on COVID-19 (INCAPS COVID)
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afghanistan: Mohammad Nawaz Nasery Albania: Artan Goda
- Afonso Shiozaki
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Tawakol
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
- Alejandro Becerril González-Montecinos
- Alejandro Canderoli
- Alejandro De La Vega
- Alejandro Deviggiano
- Alejandro Horacio Meretta
- Alejandro Radzinschi
- Alejandro Zuluaga Costa Rica: Isabel Berrocal Gamboa
- Alessia Gimelli
- Alex Frenkel
- Alexander Kokov
- Alexander Pitman
- Alexander Sasse
- Alexandra Smith
- Alexia Farrugia
- Alfonso Waller
- Alfredo Astesiano
- Alfredo Rodrigues
- Alia Hassan
- Alicia Camarero
- Alistair Gummow
- Alix Juillet de Saint Lager Lucas
- Allan Johansen
- Alvin Quinon
- Amalia Peix
- Amanda Marn
- Ambedhkar Shantaram Naojee Mexico: Erick Alexanderson-Rosas
- Amelia Jimenez-Heffernan
- Ami Iskandrian
- Amit Patel
- Amit Pursnani
- Ana Sevilla
- Anand Gaikwad
- Anastasia Oikonomou
- Anatoly Karalkin
- Anda Bularga
- Anders Thomassen
- Anders Tjellaug Bråten Oman: Humoud Al Dhuhli
- Andor Glaudemans
- Andrea Astesiano
- Andrea Bruno
- Andrea De Lorenzo
- Andres Vasquez
- Andressa Borges
- Andrew Choi
- Andrew Kelion
- Andrew Taylor
- Andrew To
- Andrés Preciado-Anaya
- Angela Burandt
- Angela Byrne
- Angela Gaudiano
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- Arturo Romero Acuña
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- Asbjørn Scholtens
- Asela Barroso
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- Ashwani Sood
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- Atul Verma Indonesia: Erwin Affandi
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- Diana Litmanovich
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- Dilip Patel
- Dinesh Kalra
- Djibrillou Moussa Issoufou Nigeria: Tolulope Ayodele
- Djoko Prawiro
- Dominique Dabreo
- Donald Chang
- Donatas Vajauskas Luxembourg: Christian Picard Malaysia: Noor Khairiah A. Karim Malta: Luise Reichmuth
- Dondi M.
- Dong Li
- Dorbala S.
- Duane Chambers
- Duncan Coles
- Dustin Thomas
- Edgar Monroy
- Edgardo Mastrovito
- Edison Edison
- Edit Várady India: Nilesh Banthia
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- Einstein A. J.
- Ekaterina Migunova
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- Elizabeth Capasso
- Elizabeth Joseph
- Ellen Wang
- Emilio Fentanes
- Enrique Vallejo
- Erasmo De La Peña
- Eric Cruz
- Erik Bieging
- Erik-Jan Van Asperen
- Erika Barragan
- Ernest Madu
- Ervina Shirka Algeria: Rabie Benlabgaa
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- Erzsébet Schmidt
- Estevan Vieira Cabeda
- Eugene Leung
- Evangelos Repasos
- Evelina Faragasso
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- Fadi Hage
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- Federico Rovaletti
- Felipe Villela Pedras
- Felix Nunura Japan: Hiroshi Asano
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- Fernando de Amorim Fernandes
- Fernando Dettori
- Fernando Faccio
- Fernando Kay
- Fernando Mendoza
- Fernando Mut Uzbekistan: Omoa Djuraev
- Filiberto Cortés
- Filip Homans
- Filipe Penna De Carvalho
- Fiona Murton
- Florence Rich
- Floyd W. Burke
- Franca Chierichetti
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- Ganesh Shrestha
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- Gary Small
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- Girish Dwivedi
- Giuseppe De Vincentis
- Giuseppe Rubini
- Goebel B.
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- Guilherme Azevedo
- Guilherme Urpia Monte
- Guilhermina Cantinho
- Guillermo Arroñada
- Gulnora Rozikhodjaeva Vietnam: Ha Le Ngoc
- Gustavo Raimondi
- Guzaliya Saifullina
- Habusari Hapkido
- Haluk Sayman Uganda: Mugisha Julius Sebikali
- Hamid Salehi
- Hamza Regaieg
- Hany Maurice
- Harlem Gongxeka
- Harold Arturo
- Hayato Ishimura
- Hector Bladimir Roque Vanegas Niger: Idrissa Adamou Soli
- Henry Bom
- Hideki Otsuka
- Hilman Syawaluddin Iraq: Amjed Albadr Islamic Republic of Iran: Majid Assadi
- Hiram Rivera Luna
- Hiroki Teragawa
- Hirotaka Maruno
- Hiroyuki Mataki
- Hirschfeld C. B.
- Hoosen Lakhi
- Horacio Del Riego
- Howard Lewin
- Hug Cuellar-Calabria
- Hui Liu
- Husam Farah
- Ian Swainson
- Ibraim Pinto
- Idan Roifman
- Ilan Gottlieb
- Ildiko Garai
- Imre Benedek
- Ioannis Datseris
- Ioannis Petrou Czech Republic: Vaclav Engelmann
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- Irene Casáns-Tormo
- Irina Itskovich
- Irina Shurupova
- Isabel Blanco
- Isabel Carvajal-Juarez
- Isabel Krohn
- Isabella Bruno
- Israel Shlomo Maor Moalem
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- Jaetae Lee
- Jagat Narula
- James Clarcq
- James Streeter
- James White
- Jamie Kitt
- Jamshid Shirani
- Javier Courtis
- Javier Lopez Diaz
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- Jean Engela
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- Jennifer Calcott
- Jennifer Chen
- Jeremy Markowitz
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- Jerry Obaldo
- Jesse Habets
- Jessica Brothers
- Ji-Young Kim
- Jia Hao Jason See
- Jian Wang
- Jiang Wu
- Jiangxi Xiao
- Jianqun Yu
- Jinendra Kumar Bhagat
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- John Dougan
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- John Michael Medina
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- John O. Prior
- John Rumberger
- John Younger Austria: Gudrun Feuchtner
- John-Paul Carpenter
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- Jon Martin
- Jonathan Carl Luis Rodrigues
- Jonathan Shulman
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- Jonathon Leipsic
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- José Soares Junior
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- Murch Stuart
- Musab Riaz
- Myron Gerson
- Nadia Ismaili Alaoui
- Nadine Kawel-Boehm
- Naeema Al-Bulushi
- Nagara Tamaki
- Nahla Zeidán Sri Lanka: Damayanthi Nanayakkara
- Nailya Valiullina
- Naima Tag Pakistan: Muhammad Shehzad Afzal
- Natale Quartuccio
- Natalia Gonza
- Natalie Rutherford
- Naveen Sharma
- Neil Doherty
- Nelsy Gonzalez Ramírez
- Nghi Mai
- Nicholas Heath
- Nico Malan
- Niels Peter Rønnow Sand
- Niels Van Pelt
- Niels Veltman
- Nikant Sabharwal
- Nikhil Joshi
- Nils Wagenaar New Zealand: John Edmond
- Nimish Dhruva
- Nina Gagarina
- Nishant Shah
- Noam Muskal
- Nobuo Iguchi
- Nobuo Tomizawa
- Ntouskou Marousa
- O'Malley S.
- O'Sullivan P.
- Olena Mykhalchenko
- Olga Dariy
- Olga Drozdova
- Olivier Lairez
- Omar Almousalli
- Omar Khalique
- Osayande Evbuomwan
- Oscar Cendoya
- Osvaldo Horacio Masoli
- Osvaldo Masoli
- Otto Lang
- Otávia Veríssimo
- Pablo Benteo
- Pablo Hidalgo
- Pablo Pollono
- Paco Bravo
- Padma Savenadia Alam
- Paez D.
- Panagiotis Georgoulias
- Paola Anna Erba
- Paola Ferro
- Paola Smanio
- Paolo Bertelli
- Parker Ward
- Partha Choudhury
- Pascual T. N. B.
- Patricia O'Sullivan
- Patrick Butler
- Patrícia Carrascosa
- Paul Thimister
- Paul Thomas
- Paulo Henrique Alves Togni
- Paulo Schvartzman
- Pavlo Korol
- Paw Holdgaard
- Petar Medakovic
- Peter Burger
- Peter Strouhal
- Peter Wilson
- Petros Stavrou
- Philip Hasbak
- Philip Sabra
- Phillip Hernandez
- Phyo Si Thu Nepal: Ram Kumar Ghimire
- Pierluigi Rossini
- Pierpaolo Alongi
- Pipitsa Valsamaki Guatemala: Carla Gonzalez
- Prabhjot Nijjar
- Prasad Guntur Ramkumar
- Prashant Nagpal
- Pravin Patil
- Prem Soman
- Priscila Possetti
- Prof Dr Girijanandan Mahapatra
- Punit Bedi
- Purbhoo Khushica
- Purvi Parwani
- Pushpa Shivaram
- Pynda Y.
- Pál Maurovich-Horvat
- Pål Løvhaugen
- Qais Nailli Argentina: Mariela Agolti
- Rachael Edwards
- Rachael Kirkbride
- Rachel Bar-Shalom
- Rachel Lugassi
- Rachele Bonfiglioli
- Raef Boktor
- Rafael Torres
- Rafael Willain Lopes
- Raffaele Giubbini
- Raggi P.
- Rajaram Poludasu
- Rajesh Burgul
- Rajesh Janardhanan
- Raluca Mititelu
- Rami Doukky
- Ramkumar Sekar
- Randall Thompson
- Randazzo M.
- Raul Cabrejas
- Ravi Patel
- Raymond Russell
- Rayner Menéndez
- Rebecca Schofield
- Rene Barette
- Renée Bullock-Palmer
- Rexhep Durmo
- Ria Bester
- Ria Garg
- Ricardo Castro
- Ricardo Geronazzo
- Ricardo Machado e Silva
- Ricardo Rocha
- Ricardo Ruano Perez
- Riccardo Faletti
- Riccardo Laudicella
- Riccardo Liga
- Richard R. Bayer
- Riemer Slart
- Rishi Bhargava
- Robert Greenough
- Robert Hendel
- Robert Manka
- Robert Miller
- Roberta Araújo
- Roberta Casoni
- Roberto Boni
- Roberto Cury
- Roberto Dantas
- Roberto Nicolas Aguero
- Roberto Nolasco
- Roberto Sciagrà
- Roberto Waltrick
- Robson De Macedo Filho
- Rodolfo Ferrando
- Rodrigo Biancardi
- Rodrigo Moreno-Reyes
- Rodrigo Rizzo Nogueira Ramos
- Rohan Poulter
- Rolf Steffensen
- Romina Lorena Romero
- Ron Blankstein
- Ronaldo Lima
- Ronny Ralf Buechel
- Rosco Gore
- Roslyn Francis
- Ross Keenan
- Roxana Campisi
- Ruben Emilio Enriquez
- Rubén Leta
- Russell Bull
- Ryan Paul
- Ryan Prentice
- Ryo Nakazato
- Ryota Morimoto
- Sabbrina Bezerra
- Sabha Bhatti
- Sabina Pulizzi
- Said Atyani
- Sakata Yasushi Sakata
- Salah Bouyoucef
- Salvatore Ialuna
- Sameh Kaffas
- Samir Shah
- Samuel Burg
- Samuel Unzek
- Sandra Abramson
- Sandra Ayala
- Sandra Gracia-López
- Sandra Graciela Rosales Uvera
- Sandra Yost
- Sang-Geon Cho
- Santosh Singh
- Sara Pacella
- Sara Ranser
- Sara Santana
- Sara Taleb Myanmar: Khin Pa Pa Myo
- Satoshi Isobe
- Satoshi Okayama
- Saurav Chatterjee
- Scott Jerome
- Sean Blue
- Sebastian Perez Ascani
- Sergio Baldari
- Seth Uretsky
- Seyed Rasoul Zakavi Israel: Eed Abu Zaid
- Shady Abohashem
- Shamil Morayati
- Shankar Vamadevan
- Shantanu Sengupta
- Sharon Gomez
- Shashank Jain
- Shaw Hua (Anthony) Kueh
- Shaw L. J.
- Shawn Ullery
- Shazia Fatima
- Sherif Nabil
- Shigeki Nagamachi
- Shinichiro Fujimoto
- Shinichiro Kumita
- Shinichiro Yamada
- Shinya Shiraishi
- Shinya Yamazaki
- Shivani Patel
- Sigelinda Sandoval
- Signe Helene Forsdahl
- Sijin Li
- Silvia Carames
- Silvia Siu
- Silvia Teresa De Maria
- Simone Brandão
- Sinisa Stankovic Brazil: Maria Helena Albernaz Siqueira
- Siroos Mirzaei
- Sofia Chatziioannou
- Sofia Haider
- Son Hong Mai
- Sonexay Rajvong Latvia: Artem Kalinin
- Sonia Simona Traverzo
- Sonia Traverso
- Sophia Koukouraki
- Sorin Danciu
- Srikanth Vallurupalli
- Stefan Pool
- Stefania Zoboli Jamaica: Dainia Baugh
- Stephan Probst
- Stephen Bloom
- Stephen Cheung
- Stephen E Matis
- Stephen Horgan
- Steve Leung
- Steven H Lee
- Steven Shayani
- Steven Sigman
- Steven Unger
- Stuart More
- Su Jin Jang
- Subhani Okarvi Serbia: Dragana Sobic Saranovic Singapore: Felix Keng
- Subodh Joshi
- Sudhir Saxena
- Sujata Shanbhag
- Sujith Seneviratne
- Sukriti Kumar
- Summanther Kaviratne
- Suresh Ramamurti
- Susana Molteni
- Susana Zeffiro Armenia: Mari Sakanyan Australia: Scott Beuzeville
- Svetlana Agranovich
- Svetlana Sazonova
- Sze Mun Mak
- Søren Hess
- Tadhg Gleeson
- Taghreed Ahmed
- Taimur Abbasi
- Tairkhan Dautov Kenya: Khalid Makhdomi
- Takao Kato
- Takashi Kudo
- Takashi Norikane
- Tanyaluck Thientunyakit Tunisia: Ali Sellem Turkey: Kemal Metin Kir
- Tao Li
- Tapan Patel
- Tara Torbet
- Tarek Al-Abboud
- Tatjana Trifonova
- Tatsuya Yoneyama Jordan: Mohammad Rawashdeh Kazakhstan: Daultai Batyrkhanov
- Teerapon Premprabha
- Teresa Massardo
- Thiago Ferreira De Souza
- Thomas Biggans
- Thomas Hartley
- Thomas Porter
- Thomas Semple
- Tiago Magalhães
- Tiago Senra
- Tien Chang
- Tiffany Chen
- Timothy Fairbairn
- Tomoaki Nakata
- Tomohisa Fukunaga
- Tonci Batinic
- Tong Zhang
- Tony Fuisz
- Tony Mcrae
- Tony Stanton
- Toshiaki Kadokami
- U. Joseph Schoepf
- Ulises González
- Umberto Conti
- Valtteri Uusitalo France: Matthieu Bailly
- Van Pelt N.
- Vania Naue
- Vania Tacher Germany: Roman P. Schneider Ghana: Harold Ayetey Greece: George Angelidis
- Velipekka Kokkonen
- Venkatesh Murthy
- Venkateshwar Polsani
- Veronica Della Tommasina
- Veronique Roelants
- Victar Hsieh
- Victor Hasbani
- Victor Jäger
- Victor Wayne
- Vijay Sai Chowdekar
- Vijay Solanki
- Vikas Tandon
- Vikas Verma
- Viktor Persic
- Viktor Pospelov
- Villines T. C.
- Vincent Habouzit
- Vincent Peter Magboo
- Vincenzo Russo
- Vinícius Kameoka
- Violeta Cortés
- Virgil Chan
- Virginia Peiro
- Virginia Pubul-Nuñez
- Vitola J. V.
- Vivek Bhat
- Viviana Frantellizzi
- Vladimir Sergienko
- Vladimír Kincl
- Volodymyr Pliatsek
- Vsevolod Milyevich Gulyaev
- Warren Moore
- William Duvall
- William Topping
- William Van Gaal
- Williams M. C.
- Wilson Furlan Alves
- Wladimir Yurievich Ussov
- Won Jun Kang
- Woon Chong
- Wu Yin
- Xiaoli Zhang
- Ximing Wang
- Xu Dai
- Xuan Canh Nguyen
- Yamile Marcos Gutierrez
- Yamile Marcos Gutierrez
- Yang Hou
- Yasmin Hamirani
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yetunde Onimode Norway: Elen Efros-Monsen
- Yiannis Chatzizisis
- Yifan Wang
- Yining Wang
- Yiyan Liu
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yong-Gao Zhang
- Yoshimitsu Fukushima
- Yoshinobu Suwa
- Young So
- Younger J.
- Youyou Yang
- Zabah Jawa
- Zerida Muyinda Ukraine: Yaroslav Kmetyuk
- Zhao-Qian Wang
- Zhifang Wu
- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: The INCAPS COVID Oceania study aimed to assess the impact caused by the COVID-19 pandemic on cardiac procedure volume provided in the Oceania region. Methods: A retrospective survey was performed comparing procedure volumes within March 2019 (pre-COVID-19) with April 2020 (during first wave of COVID-19 pandemic). Sixty-three (63) health care facilities within Oceania that perform cardiac diagnostic procedures were surveyed, including a mixture of metropolitan and regional, hospital and outpatient, public and private sites, and 846 facilities outside of Oceania. The percentage change in procedure volume was measured between March 2019 and April 2020, compared by test type and by facility. Results: In Oceania, the total cardiac diagnostic procedure volume was reduced by 52.2% from March 2019 to April 2020, compared to a reduction of 75.9% seen in the rest of the world (p<0.001). Within Oceania sites, this reduction varied significantly between procedure types, but not between types of health care facility. All procedure types (other than stress cardiac magnetic resonance [CMR] and positron emission tomography [PET]) saw significant reductions in volume over this time period (p<0.001). In Oceania, transthoracic echocardiography (TTE) decreased by 51.6%, transoesophageal echocardiography (TOE) by 74.0%, and stress tests by 65% overall, which was more pronounced for stress electrocardiograph (ECG) (81.8%) and stress echocardiography (76.7%) compared to stress single-photon emission computerised tomography (SPECT) (44.3%). Invasive coronary angiography decreased by 36.7% in Oceania. Conclusion: A significant reduction in cardiac diagnostic procedure volume was seen across all facility types in Oceania and was likely a function of recommendations from cardiac societies and directives from government to minimise spread of COVID-19 amongst patients and staff. Longer term evaluation is important to assess for negative patient outcomes which may relate to deferral of usual models of care within cardiology
Reduction of cardiac imaging tests during the COVID-19 pandemic: The case of Italy. Findings from the IAEA Non-invasive Cardiology Protocol Survey on COVID-19 (INCAPS COVID)
- Author
- Abdelkader Medjahedi
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Aditya Sood
- Adna Lima
- Adolfo Facello
- Adriana Puente Barragan
- Adwait Trivedi
- Afonso Shiozaki
- Agha Haider
- Agnès Pasquet
- Ahmad Mansy
- Ahmad Ozair
- Ahmad Slim
- Ahmed Asfour
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Tawakol
- Aikaterini Archontaki
- Alan Goldberg
- Alastair Moss
- Alberico Del Torto
- Albert Flotats
- Albert T
- Alberto Cadena
- Alberto Cossu
- Alberto Cuocolo
- Aldo Carnevale
- Alejandra Marquez
- Alejandro Becerril González-Montecinos
- Alejandro Canderoli
- Alejandro De La Vega
- Alejandro Deviggiano
- Alejandro Horacio Meretta
- Alejandro Radzinschi
- Alejandro Zuluaga Costa Rica: Isabel Berrocal Gamboa
- Alessia Gimelli
- Alex Frenkel
- Alexander Kokov
- Alexander Pitman
- Alexander Sasse
- Alexandra Smith
- Alexia Farrugia
- Alfonso Waller
- Alfredo Astesiano
- Alfredo Rodrigues
- Alia Hassan
- Alicia Camarero
- Alistair Gummow
- Alix Juillet de Saint Lager Lucas
- Allan Johansen
- Alvin Quinon
- Amalia Peix
- Amanda Marn
- Ambedhkar Shantaram Naojee Mexico: Erick Alexanderson-Rosas
- Amelia Jimenez-Heffernan
- Ami Iskandrian
- Amit Patel
- Amit Pursnani
- Ana Sevilla
- Anand Gaikwad
- Anastasia Oikonomou
- Anatoly Karalkin
- Anda Bularga
- Anders Thomassen
- Anders Tjellaug Bråten Oman: Humoud Al Dhuhli
- Andor Glaudemans
- Andrea Astesiano
- Andrea Bruno
- Andrea De Lorenzo
- Andres Vasquez
- Andressa Borges
- Andrew Choi
- Andrew Kelion
- Andrew Taylor
- Andrew To
- Andrés Preciado-Anaya
- Angela Burandt
- Angela Byrne
- Angela Gaudiano
- Anggoro Praja Mukti
- Anibal Mele
- Anjori Dunbar
- Anri Inaki
- Ante Punda Cuba: Juan Felipe Batista
- Anthony Murray
- Anthony Samuel Mauritius: Mohammad Aaftaab Allarakha
- Anthony Upton
- Antonella Stefanelli
- Antonio Cabrera
- Antonio Calderón Moncayo
- Antonio Calderón Moncayo
- Antonio Ferreira Qatar: Ghulam Syed Republic of Ireland: Samer Arnous
- Anupama Kottam
- Anxo Martinez de Alegria
- Aparna Deshpande
- Aparna Irodi
- Armando Ugo Cavallo
- Arthur Scholte
- Arturo Romero Acuña
- Arve Jørgensen
- Aryeh Shalev Jamaica: Dainia Baugh
- Asbjørn Scholtens
- Asela Barroso
- Ashok Gangasandra Basavaraj
- Ashwani Sood
- Atsutaka Okizaki
- Atul Verma Indonesia: Erwin Affandi
- Augusto Almeida
- Aulia Huda
- Austin Robinson
- Axel Rominger
- Ayreen Cordero
- Azhar Khokhar
- Balint Szilveszter
- Barbara Nardi
- Barry Elison
- Bart De Boeck
- Basuki Hidayat
- Benjamin Chow
- Benjamin Hudson
- Bernardo Spiro
- Better N.
- Bettina Tecson
- Bhagwant Rai Mittal
- Bhanupriya Singh
- Bijoy Rajbanshi Netherlands: Peter Barneveld
- Bin Lu
- Bjarne Linde Norgaard
- Bo Zerahn Dominican Republic: Alfredo Perez Ecuador: Giovanni Alejandro Escorza Velez
- Brian Abbott
- Brian Ghoshhajra
- Brian Goldner
- Brian Pomerantz
- Bruce Decter
- Bruce Goodwin
- Bruno Castro
- Bruno Ghini
- Bruno Strada
- Caiying Li
- Calum Young Nicaragua: Teresa Cuadra
- Cameron Foster
- Candace Candela
- Carlo Liguori
- Carlos Anselmi
- Carlos Caicedo
- Carlos Collaud
- Carlos Collaud
- Carlos Eduardo Soares
- Carlos Novoa
- Carlos Rodrigues
- Carmen Concha
- Carolina Bas Norton
- Caroline M. Van De Heyning Bolivia: Raúl Araujo Ríos Bosnia - Herzegovina: Valentina Soldat-Stankovic
- Carolyn Hawkins
- Cerci R.
- Cesar Lovera
- Cesar Nomura
- Cesar Rodríguez
- Chae Moon Hong
- Chanan Moffitt
- Chandraguptha Udugama Sweden: Magnus Simonsson Switzerland: Hatem Alkadhi
- Chang Kyeong Namgung
- Charles Chao
- Charles Peebles
- Chen Low
- Chetan Patel
- Chibuzo Madu
- Chimura Misato Chimura
- Chris Ellis
- Chris Johnson
- Christel H. Kamani
- Christian Hamilton-Craig
- Christian Michael Pawhay
- Christina Fragkaki
- Christine Jellis
- Christoph Gräni
- Christopher Occleshaw
- Christopher Rofe
- Claudia Cortes
- Claudia Jaimes
- Claudia T. Gutierrez Villamil
- Claudio Marcassa
- Claudio Pereyra Sueldo
- Claudiu Adrian Stan Russian Federation: Alexey Ansheles
- Cláudio Tinoco Mesquita
- Connor Saunders
- Conor Meehan
- Corrado Cittanti
- Cristiano Siqueira
- Cristina Rodríguez Rey
- Cristina Sebastião Matushita
- Croatia: Ana Baric
- D'Arne Downie
- Daisuke Sato
- Damiana Vergel
- Dan Han
- Daniel Calderon Rodriguez
- Daniel Cragnolino
- Daniel Fisher
- Daniel Fitzpatrick
- Danilo Naves
- Daria Ryzhkova
- David Bluemke
- David Cusack
- David Kerins
- David Min
- David Murphy
- David Prior
- David Smith
- David Winchester
- David Wolinsky
- David Wong
- Davidson Pastrana
- Dee Nandurkar
- Deepa Gopalan
- Deepa Shetty
- Deepak Subedi
- Deepanjan Mitra
- Demetrius Voutnis
- Derk Verschure
- Desiree Trinidad
- Diana Litmanovich
- Diego Bromfman Pianta
- Diego Garofalo
- Diego Ruiz
- Diego Sadler
- Dilip Patel
- Dinesh Kalra
- Djibrillou Moussa Issoufou Nigeria: Tolulope Ayodele
- Djoko Prawiro
- Dominique Dabreo
- Donald Chang
- Donatas Vajauskas Luxembourg: Christian Picard Malaysia: Noor Khairiah A. Karim Malta: Luise Reichmuth
- Dondi M.
- Dong Li
- Dorbala S.
- Duane Chambers
- Duncan Coles
- Dustin Thomas
- Edgar Monroy
- Edgardo Mastrovito
- Edison Edison
- Edit Várady India: Nilesh Banthia
- Eduardo Noguera
- Eduardo Paixao
- Edward Nicol
- Edward O'Rourke
- Edward Passen
- Einstein A. J.
- Ekaterina Migunova
- Elena Busnardo
- Elena Califaretti
- Eleni Kyrozi
- Eleonora Del Giudice
- Elisa Bagatin
- Elisa Mcalindon
- Elisa Milan
- Elizabeth Capasso
- Elizabeth Joseph
- Ellen Wang
- Emilio Fentanes
- Enrique Vallejo
- Erasmo De La Peña
- Eric Cruz
- Erik Bieging
- Erik-Jan Van Asperen
- Erika Barragan
- Ernest Madu
- Ervina Shirka Algeria: Rabie Benlabgaa
- Erwin Affandi Soeriadi
- Erzsébet Schmidt
- Estevan Vieira Cabeda
- Eugene Leung
- Evangelos Repasos
- Evelina Faragasso
- Fabien Hyafil
- Fabio Fernandes
- Fabio Fernandes
- Fabio Massimo Fringuelli
- Fabrizio Ricci
- Fadi Hage
- Faith Kelly
- Faiza Al Kindi
- Farshad Emami
- Federico Rovaletti
- Felipe Villela Pedras
- Felix Nunura Japan: Hiroshi Asano
- Fernanda Erthal
- Fernando Cunali Jr.
- Fernando de Amorim Fernandes
- Fernando Dettori
- Fernando Faccio
- Fernando Kay
- Fernando Mendoza
- Fernando Mut Uzbekistan: Omoa Djuraev
- Filiberto Cortés
- Filip Homans
- Filipe Penna De Carvalho
- Fiona Murton
- Florence Rich
- Floyd W. Burke
- Franca Chierichetti
- Francesca Giuffrida
- Francesca Pugliese
- Francesco Bianco
- Francisco Martin
- Francisco Medina
- Franck Proffit
- Fábio Martins Silva
- Fábio Medeiros
- Gabriel Blacher Grossman
- Gabriel Castro
- Gabriel Castro Muñoz
- Gaby Weissman
- Galit Knafo
- Ganesh Shrestha
- Gani Gunawan
- Gareth Morgan-Hughes
- Gary Small
- Gaspare Arnone
- Gaurav Sharma
- George Bennie
- George Kinzfogl Iii
- George Pandos
- George Wesbey
- Gerrit Engelbrecht
- Gertrudis Sabatel Hernández
- Giampiero Longo
- Gian Mauro Sacchetti
- Gianluca Pontone
- Gianmario Sambuceti
- Giedre Kviecinskiene
- Giorgio Cavenaghi
- Giovanna Pepe
- Girish Dwivedi
- Giubbini R.
- Giuseppe De Vincentis
- Giuseppe Rubini
- Goleat Gutierrez Honduras: Alejandro Maldonado Hungary: Klara Buga
- Golnaz Houshmand
- Gongshun Tang
- Gordon Mander
- Graciela Eva Melado
- Gregory Hill
- Guido Ventroni
- Guilherme Azevedo
- Guilherme Urpia Monte
- Guilhermina Cantinho
- Guillermo Arroñada
- Gulnora Rozikhodjaeva Vietnam: Ha Le Ngoc
- Gustavo Raimondi
- Guzaliya Saifullina
- Habusari Hapkido
- Haluk Sayman Uganda: Mugisha Julius Sebikali
- Hamid Salehi
- Hamza Regaieg
- Hany Maurice
- Harlem Gongxeka
- Harold Arturo
- Hayato Ishimura
- Hector Bladimir Roque Vanegas Niger: Idrissa Adamou Soli
- Henry Bom
- Hideki Otsuka
- Hilman Syawaluddin Iraq: Amjed Albadr Islamic Republic of Iran: Majid Assadi
- Hiram Rivera Luna
- Hiroki Teragawa
- Hirotaka Maruno
- Hiroyuki Mataki
- Hirschfeld C. B.
- Hoosen Lakhi
- Horacio Del Riego
- Howard Lewin
- Hug Cuellar-Calabria
- Hui Liu
- Husam Farah
- Ian Swainson
- Ibraim Pinto
- Idan Roifman
- Ilan Gottlieb
- Ildiko Garai
- Imre Benedek
- Ioannis Datseris
- Ioannis Petrou Czech Republic: Vaclav Engelmann
- Irena Kostadinova Cambodia: Youdaline Theng Canada: Gad Abikhzer
- Irene Casáns-Tormo
- Irina Itskovich
- Irina Shurupova
- Isabel Blanco
- Isabel Carvajal-Juarez
- Isabel Krohn
- Isabella Bruno
- Israel Shlomo Maor Moalem
- Italy: Domenico Albano
- Jacqueline Kircher
- Jaetae Lee
- Jagat Narula
- James Clarcq
- James Streeter
- James White
- Jamie Kitt
- Jamshid Shirani
- Javier Courtis
- Javier Lopez Diaz
- Jay Layer
- Jean Engela
- Jean-François Deux
- Jean-Paul Vallée Thailand: Benjapa Khiewvan
- Jeanelle Margareth Tang
- Jeff Huffman
- Jeffrey Askew
- Jeffrey Leppo
- Jenni-Mari Hildre Dimmen
- Jennifer Calcott
- Jennifer Chen
- Jeremy Markowitz
- Jeroen Manders
- Jerry Obaldo
- Jesse Habets
- Jessica Brothers
- Ji-Young Kim
- Jia Hao Jason See
- Jian Wang
- Jiang Wu
- Jiangxi Xiao
- Jianqun Yu
- Jinendra Kumar Bhagat
- Jinkang Liu
- Joao Bruno Oliveira
- Joao Cavalcante
- Joaquín Ruiz
- Johan Verjans
- Johanne Neill
- John Dougan
- John Lesser
- John Magnussen
- John Michael Medina
- John Murray
- John O. Prior
- John Rumberger
- John Younger Austria: Gudrun Feuchtner
- John-Paul Carpenter
- Jolanta Kunikowska Portugal: Nuno Bettencourt
- Jon Martin
- Jonathan Carl Luis Rodrigues
- Jonathan Shulman
- Jonathan Weir-Mccall United States of America: Suhny Abbara
- Jonathon Leipsic
- Jorge Cachero
- Jorge Ensinas
- Jorge Gonzalez
- Jorge Torreao
- Jose Alberto Ortga Ramirez
- Jose Henrique Andrade
- Jose Javier Bustos
- Jose Maria Lotti
- Joseph Krepp
- Joseph Lee
- José Claudio Meneghetti
- José Ortellado People's Republic of Bangladesh: Afroza Akhter People's Republic of China: Dianbo Cao
- José Soares Junior
- Juan Blanco
- Juan Carlos Rojas
- Juan Ignacio Rayo Madrid
- Juan Javier Marquez-Cabeza
- Juan Londoño
- Juan Lopez-Mattei
- Juan Luis Londoño Blair
- Juan Manuel Bonelli
- Juan Manuel Gómez Lauchy
- Juan Sebastian Weihmuller
- Juan Wolcan
- Juliano Fernandes
- Julie O'Brien Republic of Korea: Ji-In Bang
- Julio Manuel Lewkowicz
- Jun Hashimoto
- Junichi Taki
- Kae Fukuyama
- Kai Sun
- Karen Hassen
- Karen Moncher
- Karin Lederer
- Karthikeyan Ananthasubramaniam
- Kasper Kyhl
- Katarina Milos
- Katarina Nelson
- Katharine Tweed
- Katherine Zukotynski Chile: Jose Canessa
- Kathleen Magurany
- Katie Hawthorne
- Kazuya Takehana
- Kelley Branch
- Kelly White
- Kelvin Bush
- Ken Lee
- Kenichi Nakajima
- Kenichi Tsujita
- Kenneth Lee
- Kentaro Takanami
- Kerry Esquitin
- Kerryanne Johnson
- Kevin Ombati Kuwait: Faridah Alkandari
- Kim Robles
- Kim Taubman
- Kirby Wong
- Kirill Zhuravlev Saudi Arabia: Mirvat Alasnag
- Klaas Pieter Koopmans
- Koichiro Fujisue
- Konrad Weiss Belarus: Natallia Maroz-Vadalazhskaya Belgium: Olivier Gheysens
- Konstantin Zavadovsky
- Kristian Altern Øvrehus
- Kristine Joy Uson
- Kunthi Pathmaraj
- Kyle Napier
- Kyoko Umeji
- Kyoung Sook Won Republic of North Macedonia: Venjamin Majstorov
- Lara Carreira
- Lars Christian Gormsen
- Laura Dragonetti
- Laura Evangelista
- Laure Sarda-Mantel
- Lawrence Phillips
- Lea Attanasio
- Lei Xu
- Leila Romantini
- Leon Menezes
- Leonardo Sara da Silva
- Leonie Scholtz
- Li Yuan
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- Yang Hou
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- Yiannis Chatzizisis
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- Zhao-Qian Wang
- Zhifang Wu
- Zorana Mrsic
- Óscar Ulises Preciado-Gutiérrez
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: In early 2020, COVID-19 massively hit Italy, earlier and harder than any other European country. This caused a series of strict containment measures, aimed at blocking the spread of the pandemic. Healthcare delivery was also affected when resources were diverted towards care of COVID-19 patients, including intensive care wards. Aim of the study: The aim is assessing the impact of COVID-19 on cardiac imaging in Italy, compare to the Rest of Europe (RoE) and the World (RoW). Methods: A global survey was conducted in May–June 2020 worldwide, through a questionnaire distributed online. The survey covered three periods: March and April 2020, and March 2019. Data from 52 Italian centres, a subset of the 909 participating centres from 108 countries, were analyzed. Results: In Italy, volumes decreased by 67% in March 2020, compared to March 2019, as opposed to a significantly lower decrease (p < 0.001) in RoE and RoW (41% and 40%, respectively). A further decrease from March 2020 to April 2020 summed up to 76% for the North, 77% for the Centre and 86% for the South. When compared to the RoE and RoW, this further decrease from March 2020 to April 2020 in Italy was significantly less (p = 0.005), most likely reflecting the earlier effects of the containment measures in Italy, taken earlier than anywhere else in the West. Conclusions: The COVID-19 pandemic massively hit Italy and caused a disruption of healthcare services, including cardiac imaging studies. This raises concern about the medium- and long-term consequences for the high number of patients who were denied timely diagnoses and the subsequent lifesaving therapies and procedures