Prevalence of hyperemesis gravidarum using the 24-hour pregnancy unique quantification of emesis scale scoring-a descriptive study

Background: Nausea and vomiting occur in 80% of all pregnancies that do not require treatment however; hyperemesis gravidarum (HG), a potentially life-threatening condition affecting 0.3% to 2% of pregnancies, which is characterized by protracted vomiting, retching, severe dehydration, and weight loss (>5% of pre-pregnancy weight) require hospitalization. Methods: This was a hospital based cross-sectional descriptive study done at Kathmandu medical college over duration of 18 months from 1st January 2018 to 30th June 2019. Pregnant women ≤22nd weeks of gestation admitted with nausea and vomiting were taken as study group. Data collection was done with the questionnaire (modified 24 hours pregnancy unique quantification of emesis (PUQE) scoring system) on a structured proforma covering the relevant subjects of the study. Data were analyzed comparing difference in percentages of categorical variables chi-square test. Results: Hundred and forty-nine women were enrolled in this study with nausea vomiting in pregnancy (NVP) among 692 patients of all obstetric admission within 22 weeks of pregnancy. The prevalence of NVP during the study period was 21.67%. Most of the women in the study group belonged to age group of 20-30 years. Only 12% of cases admitted with severe NVP. Mean duration of hospital stay was found to be 2.95±1.86 days. The incidence of the disease was maximum between 7-9 weeks of gestation. Conclusions: There was no significant relation seen in severity of NVP and age, gravidity, education, occupation and BMI of women. Treatment with regular hydration and antiemetic had favourable outcome with early recovery

Depression Detection Using Stacked Autoencoder from Facial Features and NLP

Depression has become one of the most common mental illnesses in the past decade, affecting millions of patients and their families. However, the methods of diagnosing depression almost exclusively rely on questionnaire-based interviews and clinical judgments of symptom severity, which are highly dependent on doctors’ experience and makes it a labor-intensive work. This research work aims to develop an objective and convenient method to assist depression detection using facial features as well as textual features. Most of the people conceal their depression from everyone. So, an automated system is required that will pick out them who are dealing with depression. In this research, different research work focused for detecting depression are discussed and a hybrid approach is developed for detecting depression using facial as well as textual features. The main purpose of this research work is to design and propose a hybrid system of combining the effect of three effective models: Natural Language Processing, Stacked Deep Auto Encoder with Random forest (RF) classifier and fuzzy logic based on multi-feature depression detection system. According to literature several fingerprint as well as fingervein recognition system are designed that uses various techniques in order to reduce false detection rate and to enhance the performance of the system. A comparative study of different recognition technique along with their limitations is also summarized and optimum approach is proposed which may enhance the performance of the system. The result analysis shows that the developed technique significantly advantages over existing methods

Evaluation of iron overload and adequacy of packed red blood cells transfusion in children with thalassemia major

Background: Transfusion therapy in patients with thalassemia major needs to address the common questions such as what should be the optimal hemoglobin (Hb) level for effective transfusion and how do transfusion requirements affect the success of iron chelation therapy. Objective: The objective of the study was to evaluate iron overload and adequacy of packed red blood cells (PRBCs) transfusion in children with thalassemia major along with the correlation of serum ferritin level with transfusional iron load and pre‑transfusion Hb level. Materials and Methods: This single‑center retroprospective observational study was carried out in thalassemia day care center of tertiary care hospital for 1 year over 32 transfusion‑dependent β‑thalassemic patients up to 18 years of age. Data including pre‑transfusion hemoglobin level, number and volume of PRBC transfused, and serum ferritin level for 1 year were analyzed, and annual transfusion iron load was calculated. Correlation of serum ferritin level with transfusional iron load and pre‑transfusion Hb level was determined using Pearson coefficient (r) and p-value. Results: The mean pre‑transfusion hemoglobin level was 6.4±0.23 g%. The average number and volume of PRBCs transfused in a year were 12.5±3.02 and 112 ml/kg, respectively, with the average annual transfusional iron load of 121.3 mg/kg ±28.9 or 0.3 mg/kg/day. A significant positive (r=0.4184, p=0.017) correlation was observed between serum ferritin level and transfusional iron load with the mean serum ferritin level of 1744±604.6 ng/ml. Negative correlation was observed between serum ferritin and pre‑transfusion Hb level (r=−0.2624 and p=0.1537). Conclusion: All patients were undertransfused and this undertransfusion further leads to more accumulation of iron in the body through increased absorption of dietary iron as a result of anemia and ineffective erythropoiesis

Efficacy of Oil Pulling in the Management of Oral Submucous Fibrosis: A Preliminary Study

Objective: To evaluate the effectiveness of oil pulling in the management of oral submucous fibrosis (OSMF). Material and Methods: A total of 62 patients clinically and histopathologically diagnosed as OSMF were incorporated in the present study. The subjects are randomly divided equally into two groups, Group A (oil pulling group) and Group B (placebo group). Subjects in Group A were asked to perform OP with sesame oil on an empty stomach in the morning for 3 months and Group B was given placebo capsules for 3 months. Assessment of various clinical parameters was done regularly, and data were analyzed using the Chi-square test. Results: Eighty-two percent had a habit of betel nut chewing, while 18% of the patients had tobacco chewing habits, which were among the main causative factors for OSMF. Clinical improvements in mouth opening, tongue protrusion, difficulty in speech and deglutition, and burning sensation were significant in the Group A. None of the patients reported any discomfort or side effects. The symptoms were not severe in nature and resolved in few days without stopping the therapy. Conclusion: Oil pulling can bring about significant clinical improvements in the symptoms like a mouth opening and tongue protrusion

Genetic divergence of Chikungunya viruses in India (1963-2006) with special reference to the 2005-2006 explosive epidemic

Re-emergence of Chikungunya (CHIK), caused by CHIK virus, was recorded in India during 2005-2006 after a gap of 32 years, causing 1.3 million cases in 13 states. Several islands of the Indian Ocean reported similar outbreaks in the same period. These outbreaks were attributed to the African genotype of CHIK virus. To examine relatedness of the Indian isolates (IND-06) with Reunion Island isolates (RU), full-genome sequences of five CHIK virus isolates representative of different Indian states were determined. In addition, an isolate obtained from mosquitoes in the year 2000 (Yawat-2000), identified as being of the African genotype, and two older strains isolated in 1963 and 1973 (of the Asian genotype), were sequenced. The IND-06 isolates shared 99.9 % nucleotide identity with RU isolates, confirming involvement of the same strain in these outbreaks. The IND-06 isolates shared 98.2 % identity with the Yawat-2000 isolate. Of two crucial substitutions reported for RU isolates in the E1 region, M269V was noted in the Yawat-2000 and IND-06 isolates, whereas D284E was seen only in the IND-06 isolates. The A226V shift observed with the progression of the epidemic in Reunion Island, probably associated with adaptation to the mosquito vector, was absent in all of the Indian isolates. Three unique substitutions were noted in the IND-06 isolates: two (T128K and T376M) in the Nsp1 region and one (P23S) in the capsid protein. The two Asian strains showed 99.4 % nucleotide identity to each other, indicating relative stability of the virus. No evidence of recombination of the Asian and African genotypes, or of positive selection was observed. The results may help in understanding the association, if any, of the unique mutations with the explosive nature of the CHIK outbreak

Valsartan (Profiles of Drugs Substances, Excipients and Related Methodology)

Valsartan is an antihypertensive drug which selectively inhibits angiotensin receptor type II. This tetrazole derivative was first developed by Novartis and marketed under brand name Diovan® . This compound is orally active and is rapidly absorbed after oral doses, having a bioavailability of approximately 23% . Valsartan appears as a white or almost white hygroscopic powder. This compound must be kept in an air-tight container and should be protected from light and heat. It is available in film-coated tablets containing valsartan 40, 80, 160, or 320 mg, and capsules with dosage of 80 or 160 mg. Tablet combinations of valsartan with hydrochlorothiazide or amlodipine are also availabl

An Overview of the TAPAS Architecture

This report has been produced in response to the First Year Review requirement that "D5 should be extended by an attachment which describes the overall architecture of the TAPAS platform including the actual software tools and runtime support envisaged to exist at the end of the project&quot