La sérendipité sur Internet : égarement documentaire ou recherche créatrice?

Caractérisée par une rupture apparente dans la causalité et un fonctionnement aléatoire, la sérendipité, ou le don de faire une découverte inattendue, interroge les domaines de la logique, de la sémiotique et de la recherche documentaire. Favorisée par la recherche sur Internet et la lecture non linéaire hypertextuelle, la sérendipité tend peu à peu à trouver une place légitime au sein de la recherche d’information. Cette réflexion interdisciplinaire s’ancre dans les domaines de la sémiotique, la logique, la documentation et les cultures numériques. À partir d’une lecture peircienne de la sérendipité, assimilant ce phénomène au concept d’abduction, j’effectuerai une analyse des moteurs de recherche et plus généralement de l’hypertextualité sur le Web 2.0. Les exemples convoqués seront quatre outils de recherche documentaire sur Internet, soit l’encyclopédie en ligne Wikipédia, le site Amazon et les moteurs de recherche Google et Oamos. À partir de ces analyses, il s’agira d’observer les impacts et les limites de la sérendipité dans le champ de la recherche d’information sur Internet. Favorisée par la structure du réseau, la sérendipité apparaît alors comme une disponibilité de l’esprit à l’improbable et soulève également le risque de recherches documentaires malheureuses à travers le phénomène inverse de zemblanité

Analysis of the Influence of Socio-Demographic Variables and Some Nutrition and Lifestyle Habits on Beverage Consumption in the Spanish Population

Beverages and drinks play a significant role in maintaining the integral health of individuals. The aim of this study is to discover the pattern of beverage consumption in different groups of the Spanish population and to investigate its relationship with other nutritional variables and habits. To achieve the objectives, an observational, descriptive and cross-sectional study was conducted. For data collection, a questionnaire was designed and validated that explored different beverage and food consumption variables as well as socio-demographic and lifestyle variables. The instrument was disseminated, among the Spanish young adult population, through snowball sampling using social networks, collecting a sample of 17,541 valid surveys. Bivariate comparative analyses and correlation analyses were performed, and finally, the principal component analysis (PCA) method was used in order to study the relationships between variables related to drinking and health. The main results show significant differences in the pattern of beverage consumption between the socio-demographic variables of sex, age and educational level, as well as between different areas of Spain, while the PCA model shows the relationship between the consumption of sugar-sweetened beverages with the Healthy Nutrition Index of the population and sport practice. Based on the results of the study, the following conclusions were reached: the beverage consumption pattern of the Spanish population is affected by socio-demographic variables. Healthier drinking habits affect the nutrition and health of the population.Nutrición humana y dietétic

Diet and Lifestyle in the Spanish Population and Their Relationship with Sociodemographic Variables: A Descriptive Study

A healthy lifestyle and proper nutrition have a major impact on the well-being of a population. Therefore, the aim of this research is to describe the behavior of these habits in relation to sociodemographic variables to provide data on the development of effective training and awarenessraising actions. Methods: An observational, descriptive and cross-sectional study was carried out. To study the behavior of a series of variables related to eating habits and lifestyle, a questionnaire was designed and validated and subsequently disseminated online, by means of nonprobabilistic snowball sampling, relying on social networks. The sample collected consisted of 18,070 young adults of Spanish nationality. Bivariate comparative analyses were performed using t-test independent samples, and the effect size (ES) was calculated by determining Cohen’s D coefficient. A multivariate analysis were conducted using linear regression and principal component analysis. Results: Adults eat better but have a poorer quality of rest and are more sedentary than young people. No gender differences were found in nutritional habits; however, men engage in more sports and sleep better. People with a higher educational level have better nutritional and sleep habits, but are more sedentary, as are people of a higher socioeconomic level. Conclusions: Higher socioeconomic and educational levels seem to favor a healthier lifestyle. The Spanish population aged 18–45 years needs to make dietary changes but leads an active lifestyle.Medicin

Analysis of the influence of educational level on the nutritional status and lifestyle habits of the young Spanish population

AimThis study aims to analyze some nutrition and health habits of young people and the impact of educational attainment on health.MethodsAn observational, descriptive, and cross-sectional study was carried out using surveys. Using non-probabilistic snowball sampling, a previously validated questionnaire was disseminated through networks, collecting a sample of 9,681 people between 18 and 30  years old. Comparative analyses between groups were obtained by clustering and the corresponding statistical tests.ResultsThe results showed how young people with higher education generally have a lower BMI, a higher healthy nutrition index, less frequent consumption of sugary drinks, and less smoking than their peers with basic education. These healthier habits are reflected in the higher self-perceived health status of the higher-educated group. While for all the educational levels analyzed, the minutes of physical activity practice are above the 150 min recommended by the WHO.ConclusionOur findings suggest that young people’s education level is of fundamental importance for health, particularly for nutritional habits. In general, the lifestyle habits of the young Spanish population are healthy, but there is a need for improvement in those aspects related to nutrition and food

Inducible Activation of Akt Increases Skeletal Muscle Mass and Force Without Satellite Cell Activation

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JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy

Decreasing JunB expression causes muscle atrophy, whereas overexpression induces hypertrophy and blocks atrophy via myostatin inhibition and regulation of atrogin-1 and MuRF expression via FoxO3

Promoción y prevención relacionadas con salud mental en hombres y mujeres entre 15 a 35 Años en San Andrés, Providencia y Santa Catalina

El departamento de San Andrés, Providencia y Santa Catalina (Colombia), al igual que muchas poblaciones “olvidadas” por el Estado, sufre a diario y desde hace muchos años las consecuencias de un “sistema con enormes limitaciones para atender a la población como es debido” (González, 2018). La limitación geográfica del archipiélago (aislado del resto del país), y todo ello atravesado por la corrupción, entre otros aspectos, genera graves problema para la salud pública de la población del archipiélago. Dentro de los problemas que se pueden evidenciar dentro del territorio isleño, pueden encontrarse problemas relacionados con las catástrofes naturales que se han ido presentando a lo largo de los últimos años, pero, fue el paso del huracán Iota en el 2020, el que dejó en evidencia un problema dentro del archipiélago, la falta de atención a los problemas de salud mental que presentan algunos de los pobladores. Dicha alerta fue realizada en su momento por la fundación Médicos Sin Fronteras, quienes estuvieron en la isla en una misión médica y se dieron cuenta que las personas están expuestas a sufrir depresión y ansiedad. Y que, dentro del sistema de salud, este tipo de enfermedades no son tenidas en cuenta bajo ninguno de los regímenes de inclusión para la prestación de este tipo de servicios, lo que genera una preocupación significativa dentro de la población, pero a la vez, para las autoridades que trabajan en el archipiélago. Alejandrina Camargo líder de equipo de Médicos Sin Fronteras en Providencia, quien estuvo un mes atendiendo algunas necesidades médicas de los isleños con un equipo conformado por tres médicos, una enfermera y tres psicólogos, narra su llegada a la isla de Providencia, pocos días después de la tragedia. Identificaron todas las necesidades médicas de los isleños, entre ellas los problemas psiquiátricos, pues “estos empiezan con un estrés agudo posterior al huracán en medio de todo este dolor, toda esa incertidumbre” (El Tiempo, 2020). En el departamento, las instituciones prestadoras de salud son el Hospital Departamental Clarence Lynd Newball (nivel de atención II), con el 60% de su infraestructura inhabilitada y un reducido volumen de personal asistencial para suplir las necesidades de la población raizal; la Clínica Villareal, la cual brinda atención a pacientes de manera particular; el Hospital Local de Providencia (nivel de atención I), al cual deben acudir todos los habitantes de Providencia y Santa Catalina para recibir atención médica. En este sentido, es claro que la atención medica de los habitantes de las islas de Providencia y Santa Catalina, solo se da de manera generalizada, y no se cuenta con atención médica especializada. La atención médica a pacientes, se encuentra a cargo de única y exclusivamente de médicos generales y aquellos médicos que prestan su servicio social obligatorio (Forbes-Acevedo, Porras, & Rico, 2022).  The department of San Andrés, Providencia and Santa Catalina (Colombia), like many populations "forgotten" by the State, has suffered daily and for many years the consequences of a "system with enormous limitations to care for the population as it should" . (González, 2018). The geographical limitation of the archipelago (isolated from the rest of the country), and all this crossed by corruption, among other aspects, creates serious public health problems for the population of the archipelago. Among the problems that can be found within the island territory, problems related to natural disasters that have been occurring in recent years can be found, but it was the passage of Hurricane Iota in 2020, which revealed a problem within the archipelago. , the lack of attention to the mental health problems that some of the inhabitants present. This alert was made at the time by the Doctors Without Borders Foundation, who were on the island on a medical mission and realized that people are exposed to depression and anxiety. And that, within the health system, these types of diseases are not taken into account under any of the inclusion regimes for the provision of this type of services, which generates great concern in the population, but at the same time, for authorities working in the archipelago Alejandrina Camargo, leader of the Doctors Without Borders team in Providencia, who spent a month attending to some of the medical needs of the islanders with a team made up of three doctors, a nurse and three psychologists, narrates her arrival on the island of Providencia, a few days after the tragedy. She identified all the medical needs of the islanders, including psychiatric problems, since "they begin with acute post-hurricane stress in the midst of all this pain, all this uncertainty" (El Tiempo, 2020). In the department, the health-providing institutions are the Clarence Lynd Newball Departmental Hospital (care level II), with 60% of its infrastructure disabled and a reduced volume of health personnel to meet the needs of the Raizal population; the Villareal Clinic, which provides care to patients in a particular way; the Providencia Regional Hospital (care level I), where all the residents of Providencia and Santa Catalina must go to receive medical attention. In this sense, it is clear that the medical attention of the inhabitants of the islands of Providencia and Santa Catalina is only given in a general way, and there is no specialized medical attention. Medical care for patients is solely and exclusively the responsibility of general practitioners and those doctors who provide their mandatory social service (Forbes-Acevedo, Porras, & Rico, 2022)

Estrategias de neuromarketing para el servicio al cliente en las agencias de viaje

El presente estudio tiene como principal objetivo identificar estrategias de Neuromarketing para mejorar el servicio al cliente de las agencias de viaje. Para ello, se analizaron las estrategias de Neuromarketing aplicadas en el sector servicios, se establecieron las estrategias de Neuromarketing que fortalezcan el servicio al cliente en las agencias de viaje en la ciudad de Santa Marta y se aplicaron los principios de Neuromarketing en las estrategias de servicio al cliente.The main objective of this study is to identify Neuromarketing strategies to improve the customer service of travel agencies. To do this, Neuromarketing strategies applied in the service sector were analyzed, Neuromarketing strategies that strengthen customer service in travel agencies in the city of Santa Marta were established, and Neuromarketing principles were applied in service strategies. to the client.Neuromarketing -- Neuromarketing en Colombia -- Metodología -- Desarrollo Técnico - - Resultadosna33 página

Prevalência de dislipidemia e sua relação com condições sociodemográficas, de saúde e de comportamento entre usuários da atenção primária à saúde/ Prevalence of dyslipidemia and its relationship with sociodemographic, health and behavioral conditions among users of primary health care

Introdução: a dislipidemia é definida pela elevação anormal dos níveis de lipídeos no sangue, sendo um importante fator de risco cardiovascular por estar associado ao desenvolvimento de doenças ateroscleróticas. Objetivo: estimar a prevalência de dislipidemia e sua relação com características sociodemográficas, de saúde e de comportamento em usuários da Atenção Primária à Saúde (APS). Metodologia: trata-se de um estudo transversal realizado em 34 unidades urbanas de APS de Passo Fundo, RS, no qual a dislipidemia foi avaliada por meio de diagnóstico médico autorreferido de hipercolesterolemia e/ou hipertrigliceridemia. A coleta de dados ocorreu de maio a agosto de 2019, por aplicação de questionário a adultos e idosos que aguardavam atendimento nesses locais. A análise estatística incluiu a descrição da amostra, o cálculo da prevalência do desfecho com intervalo de confiança de 95% (IC95) e a verificação da sua distribuição de acordo com sexo, idade, cor da pele, escolaridade, exercício de atividade remunerada, renda, estado nutricional, hábitos alimentares, autopercepção de saúde, diagnóstico médico autorreferido de doenças crônicas prévias (hipertensão arterial sistêmica, diabetes mellitus e problema cardíaco), tabagismo, consumo de bebida alcoólica e prática de atividade física (teste do qui-quadrado, admitindo-se erro α de 5%). Resultados: na amostra composta por 1.365 participantes, observou-se uma prevalência de dislipidemia de 31% (IC95 28-33), maior conforme aumento da idade (50,6% em pessoas com ≥65 anos; p<0,001), em participantes com excesso de peso (33,7%; p=0,002), hábitos alimentares adequados (43,9%, p<0,001), autopercepção de saúde negativa (41,2%; p<0,001), hipertensão arterial sistêmica (51,1%; p<0,001), diabetes mellitus (64,6%, p<0,001), problema cardíaco (55,1%; p<0,001), não fumantes (32,6%; p<0,001), não etilistas (32,4%; p<0,040) e que praticavam atividade física (36,4%; p<0,001). Conclusão: a dislipidemia apresenta prevalência importante entre os usuários da APS, com diferença de acordo com variáveis específicas, necessitando, assim, da criação e da intensificação de ações estratégicas que visem ao diagnóstico e ao tratamento precoce dessa patologia nessa população

A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study

Currently there are no reliable biomarkers to predict outcome of exemestane treatment. We designed a prospective study to investigate whether constitutive genetic background might affect response to therapy. In a population of 302 advanced breast cancer patients treated with exemestane we showed that a 5-polymorphism-based genetic score could be used to identify patients with different risks of progression and death.Introduction: Approximately 50% of locally advanced or metastatic breast cancer (MBC) patients treated with first-line exemestane do not show objective response and currently there are no reliable biomarkers to predict the outcome of patients using this therapy. The constitutive genetic background might be responsible for differences in the outcome of exemestane-treated patients. We designed a prospective study to investigate the role of germ line polymorphisms as biomarkers of survival. Patients and Methods: Three hundred two locally advanced or MBC patients treated with first-line exemestane were genotyped for 74 germ line polymorphisms in 39 candidate genes involved in drug activity, hormone balance, DNA replication and repair, and cell signaling pathways. Associations with progression-free survival (PFS) and overall survival (OS) were tested with multivariate Cox regression. Bootstrap resampling was used as an internal assessment of results reproducibility. Results: Cytochrome P450 19A1-rs10046TC/CC, solute carrier organic anion transporter 1B1-rs4149056TT, adenosine triphosphate binding cassette subfamily G member 2-rs2046134GG, fibroblast growth factor receptor-4-rs351855TT, and X-ray repair cross complementing 3-rs861539TT were significantly associated with PFS and then combined into a risk score (0-1, 2, 3, or 4-6 risk points). Patients with the highest risk score (4-6 risk points) compared with ones with the lowest score (0-1 risk points) had a median PFS of 10 months versus 26.3 months (adjusted hazard ratio [AdjHR], 3.12 [95% confidence interval (CI), 2.18-4.48]; P < .001) and a median OS of 38.9 months versus 63.0 months (AdjHR, 2.41 [95% CI, 1.22-4.79], P = .012), respectively. Conclusion: In this study we defined a score including 5 polymorphisms to stratify patients for PFS and OS. This score, if validated, might be translated to personalize locally advanced or MBC patient treatment and management