Confidentiality of 2D Code using Infrared with Cell-level Error Correction

Optical information media printed on paper use printing materials to absorb visible light. There is a 2D code, which may be encrypted but also can possibly be copied. Hence, we envisage an information medium that cannot possibly be copied and thereby offers high security. At the surface, the normal 2D code is printed. The inner layers consist of 2D codes printed using a variety of materials, which absorb certain distinct wavelengths, to form a multilayered 2D code. Information can be distributed among the 2D codes forming the inner layers of the multiplex. Additionally, error correction at cell level can be introduce

MEASUREMENT OF ANTIOXIDANT POWER OF MOUTHWASHES INDICATED IN STOMATITIS

ABSTRACTObjective: Hospital formulations containing allopurinol and rebamipide are used in the prophylactic and therapeutic management of stomatitis,owing to their antioxidant powers. The objective of this study was to measure the antioxidant powers of Zyloric® tablets (allopurinol), Mucosta®tablets (rebamipide), different hospital formulations indicated in the management of stomatitis (allopurinol and rebamipide mouthwashes), andAzulene® 0.4% for Gargle (sodium azulene sulfonate).Methods: We measured the antioxidant powers of Zyloric® and Mucosta® tablets, all hospital formulations indicated in the management of stomatitis(allopurinol and rebamipide mouthwashes), and the widely used Azulene® 0.4% for Gargle by employing the biological antioxidant potential test. Wecompared the efficacy of each of these drugs in the management of stomatitis.Results: Azulene® 0.4% for Gargle was found to have stronger antioxidant power than Zyloric® (100 mg) and Mucosta® (100 mg) tablets dissolved inwater. The antioxidant power of the solvent used in hospital formulations was similar to that of the prepared hospital formulation. Antioxidant powerof the drugs themselves was not observed in both the allopurinol and rebamipide mouthwashes.Conclusion: The antioxidant power of the drugs was not observed in both the allopurinol and rebamipide mouthwashes; therefore, hospitalformulations used as antioxidants were found to be less effective in the treatment of stomatitis. However, Azulene® 0.4% for Gargle was found to beuseful in the prophylactic and therapeutic management of stomatitis, owing to its antioxidant, and anti-inflammatory effects.Keywords: Stomatitis, Bone alkaline phosphatase-test, Allopurinol mouthwash, Rebamipide mouthwash, Azulene® 0.4% for Gargle, Antioxidant powe

Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing

Neuronal activity has an impact on β cleavage of amyloid precursor protein (APP) by BACE1 to generate amyloid-β peptide (Aβ). However, the molecular mechanisms underlying this effect remain to be elucidated. Cholesterol dependency of β cleavage prompted us to analyze immunoisolated APP-containing detergent-resistant membranes from rodent brains. We found syntaxin 1 as a key molecule for activity-dependent regulation of APP processing in cholesterol-dependent microdomains. In living cells, APP associates with syntaxin 1–containing microdomains through X11–Munc18, which inhibits the APP–BACE1 interaction and β cleavage via microdomain segregation. Phosphorylation of Munc18 by cdk5 causes a shift of APP to BACE1-containing microdomains. Neuronal hyperactivity, implicated in Aβ overproduction, promotes the switching of APP microdomain association as well as β cleavage in a partially cdk5-dependent manner. We propose that microdomain switching is a mechanism of cholesterol- and activity-dependent regulation of APP processing in neurons

Biased Bowl-Direction of Monofluorosumanene in the Solid State

Yakiyama Y., Li M., Zhou D., et al. Biased Bowl-Direction of Monofluorosumanene in the Solid State. Journal of the American Chemical Society 146, 5224 (2024); https://doi.org/10.1021/jacs.3c11311.A new curved π-conjugated molecule 1-fluorosumanene (1) was designed and synthesized that possesses one fluorine atom on the benzylic carbon of sumanene. This compound can exhibit bowl inversion in solution, leading to the formation of two diastereomers, 1endo and 1exo, with different dipole moments. Experimental and theoretical investigation revealed an energetical relationship among 1exo, 1endo, and solvent to realize the various endo:exo ratios in the single crystals of 1 depending on the crystallization solvent. Significantly, the molecular dynamics (MD) simulations revealed that 1exo positively worked for the elongation of the stacking structure and the final endo:exo ratio was affected by the relative stability difference between 1endo and 1exo derived by solvation. Such an arrangeable endo:exo ratio of 1 realized the preparation of unique materials showing a different dielectric response from the same molecule 1 just by changing the crystallization solvent

The Role of Nephritis-Associated Plasmin Receptor (NAPlr) in Glomerulonephritis Associated with Streptococcal Infection

It is well known that glomerulonephritis can occur after streptococcal infection, which is classically referred to as acute poststreptococcal glomerulonephritis (APSGN). The pathogenic mechanism of APSGN has been described by so-called immune complex theory, which involves glomerular deposition of nephritogenic streptococcal antigen and subsequent formation of immune complexes in situ and/or the deposition of circulating antigen-antibody complexes. However, the exact entity of the causative antigen has remained a matter of debate. We isolated a nephritogenic antigen for APSGN from the cytoplasmic fractions of group A streptococcus (GAS) depending on the affinity for IgG of APSGN patients. The amino acid and the nucleotide sequences of the isolated protein revealed to be highly identical to those of reported plasmin(ogen) receptor of GAS. Thus, we termed this antigen nephritis-associated plasmin receptor (NAPlr). Immunofluorescence staining of the renal biopsy tissues with anti-NAPlr antibody revealed glomerular NAPlr deposition in essentially all patients with early-phase APSGN. Furthermore, glomerular plasmin activity was detected by in situ zymography in the distribution almost identical to NAPlr deposition in renal biopsy tissues of APSGN patients. These data suggest that NAPlr has a direct, nonimmunologic function as a plasmin receptor and may contribute to the pathogenesis of APSGN by maintaining plasmin activity

Calibration of Photomultiplier Tubes for the Fluorescence Detector of Telescope Array Experiment using a Rayleigh Scattered Laser Beam

We performed photometric calibration of the PhotoMultiplier Tube (PMT) and readout electronics used for the new fluorescence detectors of the Telescope Array (TA) experiment using Rayleigh scattered photons from a pulsed nitrogen laser beam. The experimental setup, measurement procedure, and results of calibration are described. The total systematic uncertainty of the calibration is estimated to be 7.2%. An additional uncertainty of 3.7% is introduced by the transport of the calibrated PMTs from the laboratory to the TA experimental site.Comment: 43 pages, 15 figure

Overexpression of RORγt Enhances Pulmonary Inflammation after Infection with Mycobacterium Avium

Mycobacterium avium complex (MAC) is the most common cause of nontuberculous mycobacterial disease in humans. The role of Th17 immunity in the pathogenesis of intracellular bacteria, such as MAC, is not currently understood. Transcription factor RAR-related orphan receptor gamma t (RORγt) is known as the master regulator for Th17 cell development. Here, we investigated the role of RORγt in host responses against MAC infection. Wild-type (WT) mice and RORγt-overexpressing mice were infected with MAC via intratracheal inoculation. Systemic MAC growth was not different between WT mice and RORγt-overexpressing mice. However, neutrophilic pulmonary inflammation following MAC infection was enhanced in RORγt-overexpressing mice compared with that in WT mice. The cytokine expression shifted toward a Th17 phenotype in the lungs of RORγt-overexpressing mice following MAC infection; the levels of IL-6 and IL-17 were significantly higher in the lung of these mice than in WT mice. In addition to the increase in IL-17 single-positive T cells, T cells producing both IL-17 and interferon-γ were elevated in the lung of RORγt-overexpressing mice following MAC infection. These findings suggest that RORγt overexpression-mediated Th17 bias contributes to local inflammation rather than systemic responses, by regulating neutrophil recruitment into the sites of infection during MAC infection

Exciton entanglement in two coupled semiconductor microcrystallites

Entanglement of the excitonic states in the system of two coupled semiconductor microcrystallites, whose sizes are much larger than the Bohr radius of exciton in bulk semiconductor but smaller than the relevant optical wavelength, is quantified in terms of the entropy of entanglement. It is observed that the nonlinear interaction between excitons increases the maximum values of the entropy of the entanglement more than that of the linear coupling model. Therefore, a system of two coupled microcrystallites can be used as a good source of entanglement with fixed exciton number. The relationship between the entropy of the entanglement and the population imbalance of two microcrystallites is numerically shown and the uppermost envelope function for them is estimated by applying the Jaynes principle.Comment: 16 pages, 6 figure

Absence of in vivo selection for K13 mutations after artemether–lumefantrine treatment in Uganda

Additional file 1. Eligibility criteria for recruitment into the therapeutic efficacy study and the molecular study