COMPARATIVE IN-VITRO ANTIBACTERIAL AND ANTIFUNGAL ATTRIBUTES OF DIFFERENT SOLVENT EXTRACTS FROM LEAF, BARK, ROOT AND INFLORESCENCE OF MEMECYLON UMBELLATUM BURM.

This paper describes the antibacterial and antifungal activities and Minimum Inhibitory Concentration (MIC) of different solvent (pet. ether, chloroform, ethyl acetate, acetone, methanol and water) extracts of leaves, bark, root and inflorescence of Memecylon umbellatum burm. The percent yields from leaves, bark, root and inflorescence was found to be 0.2062 to 2.836, 0.0601 to 0.5142, 0.050 to 1.425, 0.0210 to 0.717 respectively. Overall, acetone extract produced from the leaves exhibited significantly (P < 0.05) higher antibacterial activity along with superior antifungal activity. MIC for acetone and ethyl acetate extract of leaf was found to be 0.5 mg for the entire organisms compared to 3-15 mg for other extracts. Such study will explore pharmacological activity of the tested parts of Memecylon umbellatum burm especially, the leaves which might be valuable for therapeutic applications

Machine Learning Based Fluid-Transportation Monitoring and Controlling

The discipline of fluid mechanics is developing quickly, propelled by previously unheard-of data volumes from experiments, field measurements, and expansive simulations at various spatiotemporal scales. The field of machine learning (ML) provides a plethora of methods for gleaning insights from data that can be used to inform our understanding of the fluid dynamics at play. As an added bonus, ML algorithms can be used to automate duties associated with flow control and optimization, while also enhancing domain expertise. This article provides a review of the background, current state, and potential future applications of ML in fluid mechanics. We provide an introduction to the most fundamental ML approaches and describe their applications to the study, modelling, optimization, and management of fluid flows. From the standpoint of scientific inquiry, which treats data as an integral aspect of modelling, experiments, and simulations, the benefits and drawbacks of these approaches are discussed. Since ML provides a robust information-processing framework, it can supplement and potentially revolutionize conventional approaches to fluid mechanics study and industrial applications. &nbsp

Thia-Michael Addition in Diverse Organic Synthesis

Thia-Michael addition reactions are significant for organic syntheses of important class of compounds to form C-S bond and its derivatives. It shows the prominent feature in medicinal field and material science. This review is focused on various methods towards thia-Michael adducts using Michael addition of sulfur containing electron rich species (Michael donor) on electron poor olefins (Michael acceptor). The C-S bond is ideal of making bioactive molecules generalized for the synthesis of various drug molecules and applied in field as insect sprays and polymer substances which are common for daily life. Due to the importance of C-S bond in recent years, novel methods for C-S bond formation were developed, which are more convenient with environment

Phytochemical screening and In Vitro Antioxidant potential of Memecylon umbellatum Burm leaf extracts

Objective: Different dry extracts of Memecylon umbellatum Burm leaf obtained by various solvents such as petroleum ether, chloroform, ethyl acetate, acetone, methanol and chloroform water (IP) was screened to reap the benefits of its antioxidant and free radical scavenging properties using ascorbic acid as standard antioxidants. Methods: The in vitro free radical scavenging activity was evaluated using diphenyl picryl hydrazyl (DPPH) radical method using various concentrations of dry extract in distilled water (1, 2, 4, 8, 16, 20 μg/ml) against blank with ascorbic acid as a standard in same concentrations. Results: Among the all extracts, Methanol leaf extract has showed higher Antioxidant activity (84.65 ± 0.064 %) having IC50 Value 11.81 ± 0.033 μg/ml at 20 μg/ml. While, IC50 value for ascorbic acid was found to be 8.91 ± 0.084 μg/ml. Conclusion: The results clearly indicate that Methanol leaf extract of Memecylon umbellatum is effective in free radical scavenging. So in future, this may emerge as promising natural herbal source of powerful antioxidant. Keywords: Memecylon umbellatum, DPPH reagent, Antioxidant activity, Ascorbic acid, IC50

Colorimetric method for simultaneous estimation of amlodipine besylate from plasma

Aim: The present work was to develop the method of analysis which can estimate drug in combined form without prior separation. Materials and method: By using UV spectroscopy colorimetric method was used for determination of Amlodipine besylate (AML) from plasma. Result and conclusion: This method is based on the formation of green colour in reaction between AML and 0.4 % Ferric chloride (FC) and 0.2 % Potassium ferricyanide (PF).The absorbance was measured at 775 nm. Result of tablet analysis showed % S.D. values in the range of 098.22 to 100,63%. Standard deviation value for tablet analysis by using methanol ranging from 98.01 to 101,13 % which proves the ability of the method to remain unaffected by small but deliberate change in reaction conditions and this method is used for estimation of AML from biological samples.Objetivo. El objetivo del presente estudio era desarrollar un método de análisis que permitiera estimar la cantidad de fármaco en forma combinada sin separación previa. Material y Método. Se utilizó espectroscopía colorimétrica UV para la determinación de Amlodipino Besilato (AML) plasmático Resultados. El presente método está basado en la formación de color verde en la reacción entre Amlodipino Besilato (AML) y cloruro férrico 0,4% y ferrocianuro potásico 0,2%. La medida de la absorbancia se realizó a 775nm. El resultado del análisis de los comprimidos mostró unos valores de DE comprendidos entre 098,22 y 100,63%. El valor de la DE utilizando metanol oscilan entre 98,01 y 101,13% lo que demuestra la capacidad del método de permanecer inalterado por pequeños pero intencionados cambios en las condiciones de la reacción, este método es usado para la estimación de Amlodipino Besilato (AML) en muestras biológicas

A overview: non-steroidal anti-inflammatory drugs and mechanisms

The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabolized primarily in the liver. They vary in their half-lives and bioavailability. Given the multitude of available NSAIDs, the variability of their half-lives allows for different dosing regimens. The fluid in the inflamed area is known as inflammatory exudates, commonly called as pus. These exudates contain dead cells and debris in addition to body fluids. The inflammatory response is characterized by the following symptoms: Reddening of the localized area, swelling, pain and elevated temperature. Reddening results from capillary dialation that allows more blood to flow to the damaged tissue. Elevated temperature results from capillary dialation which permits increased blood flow through these vessels, with associated high metabolic activities of neutrophils and macrophages. The release of histamine from mast cells during antigen antibody reactions is well known, as is its involvement in the inflammatory response to skin injury. The present review focused on list and precautions of NSAID with its typed and classification, Analgesic activity study, histamine

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations

The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved the way for commercialization. Thin film freezing (TFF) is a new emerging freeze-drying technique available for various treatment modalities in drug delivery. TFF has now been used for the commercialization of pharmaceuticals, food, and biopharmaceutical products. The present review highlights the fundamentals of TFF along with modulated techniques used for drying pharmaceuticals and biopharmaceuticals. Furthermore, we have covered various therapeutic applications of TFF technology in the development of nanoformulations, dry powder for inhalations and vaccines. TFF holds promise in delivering therapeutics for lung diseases such as fungal infection, bacterial infection, lung dysfunction, and pneumonia

NEW PARADIGM FOR SHADE NET

Shade net is a framed structure made of material such pipes, angle iron, wood or bamboo. Due to natural weather disturbances such as wind, rain, birds and insects can come inside the shade net affect crops. Each plant has it's individual requirements for sunlight and shade under which it flourishes at its best. To create optimum climatic conditions, selection of the correct percentage of shade factor plays an important role to enhance plants productivity to its optimum

The An Event Driven Campus Navigation System On Android Platform

This paper presents the event based campus navigation system that we are build an android application which helps to candidates/persons to navigate to an event which is being organised in a campus.This application is developed for all the colleges to enter their event details or college workshops or gatherings dates,timings and fees so that it can be viewable to all the students of different colleges and becomes an easy way to participate through this application.There is no such system to inform all existing as well as outside students,teachers and staff to inform about any event very quickly with its proper place,which may start few minutes or few hours later and the structure of fees.As a result there is a high opportunity to miss any valuable event.To reduce this pain inside a university campus,a very user friendly Google map based Event-driven campus navigation system on android platform has been designed,implemented and tested successfully in this work.This application provides route guide forusers from his/her own location to desired location and event updates with its proper place

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Not AvailableFruits and vegetablesare currently marketed through the "open market transactionssystem" under the conventional APMC regulations.Market yardsset up under the APMC Acts are playing a vital role in terms ofpricediscovery. as well as product aggregationand disaggregation along the chain. However, the present marketing system ofhorticultural produce in the state, lacks system approach. Producershave often failed to realize expenses incurred on transportation to markets, let alone the cost of productionand capital investment, during the period of glut Fruit and vegetable growers are receiving only a small part of pricepaid by the consumers as Lion's share is being taken by chain of middlemen. The high profi.tmargin ofintermediaries is quite disproportionate to their services. In order to increase the income offarmers and promote the role of private sector in the agriculture marketing there is need to improve existing APMC's for better realization ofproducers share in consumer's rupee. Thus, it is imperativeto make our APMC more vibrant and strong in terms of infrastructure,management and transparency. It is also important to understand implicationsof FD/ in retail forwholesale marketsand traders/CAsand therein there is need for more efficient and lowercost APMC markets in the state. It is essential to facilitatedevelopment ofmarketing infrastructure through private sector investments and create avenues for alternate marketing channels for farmers forsales transactions of their produce where prices areremunerative to them.Not Availabl