Finite Element Modelling of Strengthened Simple Beams using FRP Techniques: A parametric Study

The main objective of this paper is to study analytically the strengthening of a simplereinforced concrete beams due to excessive uniform loads in flexure, shear and acombination of flexure and shear, using externally bonded FRP sheets technique. Acommercial finite element computer program ANSYS has been used to perform a structurallinear and non-linear analysis for several models using several schemes of FRP sheets. Aparametric study has been performed for a lot of strengthened beams. FE models studies amain parameter of different schemes of FRP sheets in flexure, shear and combinationflexure/shear. Comparing the results with a control beam model – simple reinforcedconcrete beam without strengthening – it is obvious that all strengthened beams have agreater ultimate capacity than the control beam and noticeable enhancement in memberductility. The increasing level differs as a result of the strengthening scheme. Thestrengthened beam in both flexure and shear gives a higher ultimate load capacity, delay thefailure and prevent debonding failure up to a level at which debonding occurs in bothlongitudinal and wrapped jackets CFRP sheets

A NEW METHOD FOR SOLVING LINEAR PROGRAMMING PROBLEMS

ABSTRACT Anew method which does not depend on the simplex method for solving the linear programming (LP) problems is given. The proposed method is based mainly upon solving this problem algebraically using the concept of duality .The important of this method is that we are not based our work on vertex information which may have difficulties as the problem size increases. A simple example is given to clarify the developed theory of this proposed method

An O((m+n) Max {m+n, n³}) Procedure for Solving the Linear Programming Problem

An iterative method based on conjugate gradient projection method (and not on any variant of Karmarkars algorithm) for solving linear programming problems is given. Our method consists of a sequence of moves: Starting with an initial interior point x our procedure finds a second feasible point 0 x then a third point and so on until the optimal point is reached in at most m+n steps . A simple example is given to illustrate our method

Transfer hydrogenation as a redox process in nucleotides

© 2014 American Chemical Society. Using a combined theoretical and experimental strategy, the heats of hydrogenation of the nucleotide bases uracil, thymine, cytosine, adenine, and guanine have been determined. The most easily hydrogenated base is uracil, followed by thymine and cytosine. Comparison of these hydrogenation enthalpies with those of ketones and aldehydes derived from sugar models indicates the possibility of near-thermoneutral hydrogen transfer between uracil and the sugar phosphate backbone in oligonucleotides. (Figure Presented

Compact Size Triple Notched-bands UWB Antenna with Sharp Band-Rejection Characteristics at WiMAX and WLAN Bands

In this paper, a compact triple band-notched Ultra Wideband (UWB) antenna with sharp band-elimination features and controlled notched bandwidths is proposed and discussed. The design is made up of a rectangular-shaped   patch UWB planar monopole antenna with double collections of band-notched configurations. The band-notched configurations are involved to produce the desired lower and upper stop bands with good frequency selectivity and suitable stop bandwidths. The first notch is realized by using a C-shaped slot etched in the radiating patch in order to eliminate the interference at the WiMAX (3.4 - 3.8 GHz) applications. The second and the third notches are realized together by using a pair of U-shaped resonators that are located beside the feed line in both sides to eliminate the interference with the lower WLAN (5.15–5.35 GHz) and the higher WLAN (5.725–5.825GHz) bands.  Additionally, the bandwidths of the lower and upper stop bands can be control separately by changing the parameters of the band-notched configurations. Furthermore, the suggested triple notched bands UWB antenna is optimized, fabricated, and measured for verification purposes. The measured results are close to the simulated ones

Controlling of crystal size and optical band gap of CdO nanopowder semiconductors by low and high Fe contents

The CdO:Fe nanopowder semiconductors were synthesized by the sol–gel calcination for the first time. The structural properties of Fe doped CdO samples were analyzed by AFM and XRD measurements. XRD patterns of the pure and Fe-doped CdO samples reveal that the pure and Fe doped CdO nanopowders are polycrystalline of cubic CdO structure. The crystallite size of undoped and Fe-doped CdO samples is changed unsystematically with a regular increase of Fe content. The optical band gaps of Fe doped CdO samples were determined for the first time by diffused reflectance measurements. The optical band gap of the samples is increased with the increase of Fe dopant inside the host matrix (CdO) up to 15 % followed by a decrease in its value. It is evaluated that Fe doped CdO nanopowder semiconductors can be producted by sol–gel calcination for advanced technological application

Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma

BackgroundProteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed multiple myeloma (MM) but has been associated with cardiovascular adverse events (CVAE) such as hypertension, cardiomyopathy, and heart failure. This study aimed to investigate the contribution of germline genetic variants in protein-coding genes in CFZ-CVAE among MM patients using whole-exome sequencing (WES) analysis.MethodsExome-wide single-variant association analysis, gene-based analysis, and rare variant analyses were performed on 603,920 variants in 247 patients with MM who have been treated with CFZ and enrolled in the Oncology Research Information Exchange Network (ORIEN) at the Moffitt Cancer Center. Separate analyses were performed in European Americans and African Americans followed by a trans-ethnic meta-analysis.ResultsThe most significant variant in the exome-wide single variant analysis was a missense variant rs7148 in the thymosin beta-10/TraB Domain Containing 2A (TMSB10/TRABD2A) locus. The effect allele of rs7148 was associated with a higher risk of CVAE [odds ratio (OR) = 9.3 with a 95% confidence interval of 3.9—22.3, p = 5.42*10−7]. MM patients with rs7148 AG or AA genotype had a higher risk of CVAE (50%) than those with GG genotype (10%). rs7148 is an expression quantitative trait locus (eQTL) for TRABD2A and TMSB10. The gene-based analysis also showed TRABD2A as the most significant gene associated with CFZ-CVAE (p = 1.06*10−6).ConclusionsWe identified a missense SNP rs7148 in the TMSB10/TRABD2A as associated with CFZ-CVAE in MM patients. More investigation is needed to understand the underlying mechanisms of these associations

Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak. Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March – May 2020, “period 1”), and then again between May and June (“period 2”) and June and July 2020 (“period 3”). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume. Results: The impact of the pandemic continued to be felt well after countries’ first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence. Conclusion: Centres reported a broad return of services approaching pre-pandemic “normal” by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries