Las órdenes militares en la cruzada granadina de Alfonso el Benigno (1329-1334)

A la memoria de la Dra. Regina Sainz de la MazaEn este estudio se recupera la investigación las Órdenes militares catalanoaragonesas durante el siglo XIV. El interés del trabajo radica en el hecho de que en él se considera, de manera conjunta, la actuación en la cruzada de las cuatro Órdenes militares enclavadas en territorio catalanoaragonés, lo cual permite observar tanto su distinto grado de participación como la diferente actitud del monarca hacia cada una de ellas.Peer reviewe

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments. They inherit key biological characteristics of the guiding natural product, such as chemical and physiological properties, yet define small molecule chemotypes with unprecedented or unexpected bioactivity. We iterate the design principles underpinning PNP scaffolds and highlight their syntheses and biological investigations. We provide a cheminformatic analysis of PNP collections assessing their molecular properties and shape diversity. We propose and discuss how the iterative analysis of NP structure, design, synthesis, and biological evaluation of PNPs can be regarded as a human‐driven branch of the evolution of natural products, that is, a chemical evolution of natural product structure

A Man-Made ATP-Binding Protein Evolved Independent of Nature Causes Abnormal Growth in Bacterial Cells

Recent advances in de novo protein evolution have made it possible to create synthetic proteins from unbiased libraries that fold into stable tertiary structures with predefined functions. However, it is not known whether such proteins will be functional when expressed inside living cells or how a host organism would respond to an encounter with a non-biological protein. Here, we examine the physiology and morphology of Escherichia coli cells engineered to express a synthetic ATP-binding protein evolved entirely from non-biological origins. We show that this man-made protein disrupts the normal energetic balance of the cell by altering the levels of intracellular ATP. This disruption cascades into a series of events that ultimately limit reproductive competency by inhibiting cell division. We now describe a detailed investigation into the synthetic biology of this man-made protein in a living bacterial organism, and the effect that this protein has on normal cell physiology

Synthese und stereoselektive Biotransformation silicium- und germaniumorganischer Verbindungen Versuche zur Herstellung optisch aktiver Silane und Germane mittels Biokatalyse

Available from TIB Hannover: DW 8243 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman