Indices of the iterates of R3R^3-homeomorphisms at Lyapunov stable fixed points

Given any positive sequence (\{c_n\}_{n \in {\Bbb N}}), we construct orientation preserving homeomorphisms (f:{\Bbb R}^3 \to {\Bbb R}^3) such that (Fix(f)=Per(f)=\{0\}), (0) is Lyapunov stable and (\limsup \frac{|i(f^m, 0)|}{c_m}= \infty). We will use our results to discuss and to point out some strong differences with respect to the computation and behavior of the sequences of the indices of planar homeomorphisms.Comment: 19 pages, 8 figure

Novel brown adipose tissue candidate genes predicted by the human gene connectome

We would like to thank M. Thomas and R. de Casas for their helpful comments, and C. Osuna, F. Perfectti (CGL2013-47558-P), and the Scientific Supercomputing Center of the Universidad de Granada for sharing computational resources. We are also grateful to Ms. Carmen Sainz-Quinn for assistance with the English language. The study was supported by a Marie S. Curie Global Fellowship within the European Union research and innovation framework programme (2014-2020; ClimAHealth: 101030971). It was also supported by the Spanish Ministry of Economy and Competitiveness, Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III (PI13/01393), Fondos Estructurales de la Union Europea (FEDER), by the Fundacion Iberoamericana de Nutricion (FINUT), by the Redes tematicas de investigacion cooperativa RETIC (Red SAMID RD16/0022), by AstraZeneca HealthCare Foundation, by the University of Granada Plan Propio de Investigacion (Excellence actions: Unit of Excellence on Exercise and Health [UCEES]), and by the Junta de Andalucia, Consejeria de Economia, Conocimiento, Empresas y Universidad (ref. P18-624 RT-4455).Brown adipose tissue (BAT) is a promising therapeutic target against obesity. Therefore, research on the genetic architecture of BAT could be key for the development of successful therapies against this complex phenotype. Hypothesis-driven candidate gene association studies are useful for studying genetic determinants of complex traits, but they are dependent upon the previous knowledge to select candidate genes. Here, we predicted 107 novel-BAT candidate genes in silico using the uncoupling protein one (UCP1) as the hallmark of BAT activity. We first identified the top 1% of human genes predicted by the human gene connectome to be biologically closest to the UCP1, estimating 167 additional pathway genes (BAT connectome). We validated this prediction by showing that 60 genes already associated with BAT were included in the connectome and they were biologically closer to each other than expected by chance (p < 2.2 × 10− 16). The rest of genes (107) are potential candidates for BAT, being also closer to known BAT genes and more expressed in BAT biopsies than expected by chance (p < 2.2 × 10− 16; p = 4.39 × 10– 02). The resulting new list of predicted human BAT genes should be useful for the discovery of novel BAT genes and metabolic pathways.Marie S. Curie Global Fellowship within the European Union research and innovation framework programme ClimAHealth: 101030971Spanish Ministry of Economy and Competitiveness, Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III PI13/01393Fondos Estructurales de la Union Europea (FEDER)Fundacion Iberoamericana de Nutricion (FINUT)Redes tematicas de investigacion cooperativa RETIC Red SAMID RD16/0022AstraZenecaUniversity of Granada Plan Propio de InvestigacionJunta de Andalucia P18-624 RT-4455 CGL2013-47558-

Indices of the iterates of ({\Bbb R}^3)-homeomorphisms at fixed points which are isolated invariant sets

Let (U \subset {\mathbb R}^3) be an open set and (f:U \to f(U) \subset {\mathbb R}^3) be a homeomorphism. Let (p \in U) be a fixed point. It is known that, if (\{p\}) is not an isolated invariant set, the sequence of the fixed point indices of the iterates of (f) at (p), ((i(f^n,p))_{n\geq 1}), is, in general, unbounded. The main goal of this paper is to show that when (\{p\}) is an isolated invariant set, the sequence ((i(f^n,p))_{n\geq 1}) is periodic. Conversely, we show that for any periodic sequence of integers ((I_n)_{n \geq1}) satisfying Dold's necessary congruences, there exists an orientation preserving homeomorphism such that (i(f^n,p)=I_n) for every (n\geq 1). Finally we also present an application to the study of the local structure of the stable/unstable sets at (p)

Improving the structural reliability of steel frames using posttensioned connections

In this paper, various moment-resisting steel frames (MRSFs) are subjected to 30 narrow-band motions scaled at different ground motion intensity levels in terms of spectral acceleration at first mode of vibration in order to perform incremental dynamic analysis for peak and residual interstory drift demands. The results are used to compute the structural reliability of the steel frames by means of hazard curves for peak and residual drifts. It is observed that the structures exceed the threshold residual drift of 0.5%, which is perceptible to human occupants, and it could lead to human discomfort according to recent investigations. For this reason, posttensioned connections (PTCs) are incorporated into the steel frames in order to improve the structural reliability. The results suggest that the annual rate of exceedance of peak and residual interstory drift demands are reduced with the use of PTC. Thus, the structural reliability of the steel frames with PTC is superior to that of the MRSFs. In particular, the residual drift demands tend to be smaller when PTCs are incorporated in the steel structures.Peer ReviewedPostprint (published version

Ecological studies in Alto Guadalquivir wetlands : a first step towards the application of conservation plans

This paper reviews the most recent studies carried out in the Alto Guadalquivir wetlands. Data on wetland inventory and classification in typologies, faunal and floral community values are presented as well as the effects that agricultural pollutants have on some aquatic species. These results support the need for a correct wetland policy that allows for the conservation of these aquatic ecosystems.Este trabajo revisa los estudios más recientes llevados a cabo en los humedales de la comarca del Alto Guadalquivir. Se presentan datos sobre el inventario de humedales y su clasificación en tipologías, los valores más relevantes de sus comunidades de flora y fauna y los efectos que ejercen los contaminantes agrícolas sobre algunas especies. Estos resultados apoyan la necesidad de una correcta política de humedales que permita la conservación de estos ecosistemas acuáticos

Producción orgánica de hortalizas bajo atmósferas controladas utilizando tecnologías de bajo costo

Historically, agriculture has undergone a series of revolutions that have increased efficiency, yield and profitability to previously unattainable levels. Market forecasts for the next decade suggest that a “digital agricultural revolution” will be the most innovative change that could help make agriculture meet the needs of the world’s population in the future (La, Las, &amp; Rurales, 2019 , P 1). The adoption of agriculture 4.0 in the department of Quindío is low, which leads to the development of inefficient and profitable production models; The purpose of this project is the organic production of vegetables under controlled atmospheres, making use of low-cost measurement sensors (relative humidity, temperature, soil humidity), in order to validate their functionalityHistóricamente, la agricultura ha experimentado una serie de revoluciones que han incrementado la eficiencia, el rendimiento y la rentabilidad a niveles antes inalcanzables. Los pronósticos sobre los mercados para el próximo decenio sugieren que una “revolución agrícola digital” será el cambio más novedoso que podría ayudar a conseguir que la agricultura satisfaga las necesidades de la población mundial en el futuro. (La, Las, &amp; Rurales, 2019,P 1).La adopción de la agricultura 4.0 en el departamento del Quindío es baja, lo cual lleva a desarrollar modelos de producción poco eficientes y rentables; el propósito de este proyecto es la producción orgánica de hortalizas bajo atmosferas controladas, haciendo uso de sensores de medición a bajo costo (humedad relativa, temperatura, humedad del suelo), con el fin de validar su funcionalidad

Comparing hysteretic energy and ductility uniform annual failure rate spectra for traditional and a spectral shape-based intensity measure

In this study, with the objective to develop a reliability-based seismic design tool, ductility and dissipated hysteretic energy uniform annual failure rate (UAFR) spectra are obtained and compared using the spectral acceleration at first mode of vibration of the structure Sa(T1) and the well-known spectral shape-based intensity measure INp. Notice that this is the first time in the literature that UAFR spectra are obtained for the advanced spectral shape intensity measure INp. For this aim, 110 simulated ground motions recorded from the soft soil of Mexico City were selected due to their large energy amount demanded to the structures; moreover, four elastoplastic hysteretic behavior models are considered for the dynamic analyses with post-yielding stiffness of 0, 3, 5, and 10%. It is observed that the use of elasto-perfectly plastic models provided similar UAFR spectra in comparison with hysteretic models with different post-yielding stiffness. This conclusion is valid for the two selected intensity measures. In addition, the lateral resistance required to achieve similar structural reliability levels is larger when the INp intensity measure is used, especially for buildings with vibration periods equal or larger than the soil period, in such a way that the traditional use of Sa(T1) could provide structures with less structural reliability levels.Peer ReviewedPostprint (published version