¿Convivencia o bullying? Análisis, prevención y afrontamiento del acoso entre iguales

Observatorio Andaluz de la InfanciaPostprin

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Ecos de la academia: Revista de la Facultad de Educación, Ciencia y Tecnología - FECYT Nro 5

Ecos de la academia, Revista de la Facultad de Educación Ciencia y Tecnología es una publicación científica de la Universidad Técnica del Norte, con revisión por pares a doble ciego que publica artículos en idioma español, quichua, portugués e inglés. Se edita con una frecuencia semestral con dos números por año.En ella se divulgan trabajos originales e inéditos generados por los investigadores, docentes y estudiantes de la FECYT, y contribuciones de profesionales de instituciones docentes e investigativas dentro y fuera del país, con calidad, originalidad y relevancia en las áreas de ciencias sociales y tecnología aplicada.Realidad socioinclusiva del adulto mayor del grupo etario mayor a los 70 años en las parroquias urbanas de Ibarra. Orientación vocacional y personalidad en el Sistema Nacional de Nivelación y Admisión en la Universidad Técnica de Ambato. Las primeras tarjetas postales de Ibarra, Ecuador: 1906-1914. Aprendizaje móvil en el aula. Aproximación a la Concepción Etnomatemática. La ética en la investigación educativa: ¿condición indispensable?. Inteligencia sociocultural para la inclusión. Atención al alumnado inmigrante: la visión de una profesora francesa en Galicia. Análisis crítico de la dimensión ambiental del ecosistema montañoso Guamuhaya, Cuba (1995-2014). La adaptación curricular inclusiva en la educación regular. El arte en la provincia de Imbabura de mediados del siglo XIX en torno a las escuelas de arte. Formación integral: un estudio de algunos logros y carencias. Experiencias en la publicidad online en la ciudad de Ibarra, Ecuador. Estudio exploratorio de la incidencia de los hogares disfuncionales en la iniciación sexual temprana de los adolescentes. Etnografía Virtual como aplicación metodológica: Caso Chevron en Ecuador. Alfabetización y calidad de vida: percepción de los alfabetizados. Elaboración de un manual mediante el método Delphi para la enseñanza de patronaje. Pertinencia de la Carrera de Turismo de la UTN, en el contexto de la Región 1 del Ecuador, 2016-2020. Preferencias por doble titulación de bachilleres de la Zona 1 de Ecuador y Nariño de Colombia. “Mucha Publicidad”, II Simposio de Diseño, Publicidad y Sociedad, de la UTN. Normas de presentación de artículos en la revista Ecos de la Academia

Use of Fourier transform infrared spectroscopy to create models forecasting the tartaric stability of wines

Tartaric instability of wines still represents a serious problem in terms of the commercial value of bottled wines, particularly whites, leading consumers to be suspicious as regards the effective healthiness or wholesomeness of products. The study, carried out on 536 Italian wines, investigated the potential of using Fourier Transform Infrared Spectroscopy, distinguishing between white and red/rosé wines, to create models predicting the instability of wines, assessed in comparison to two of the most widespread methods of reference: the “mini-contact test” (10 min, 0 °C, KHT) and the “cooling test” (5 days, −4 °C). The models proposed, constructed using 80% of the samples and based on Partial Least Squares-Regression and Artificial Neural Networks, were shown to work well in terms of correct classification (from 89% to 97%) of the external validation subset (20%). As regards the more problematical question of technical management of wines before bottling, in the worst cases only 4–6% of unstable samples were erroneously classified as stabl

Venous thromboembolism in pediatric patients with acute lymphoblastic leukemia under chemotherapy treatment. Risk factors and usefulness of thromboprophylaxis. Results of LAL-SEHOP-PETHEMA-2013.

Symptomatic venous thromboembolism (VTE) is diagnosed in 3%-14% of patients during pediatric acute lymphoblastic leukemia (ALL) therapy. There are well-known risk factors, but the role of others as inherited thrombophilia is still controversial. Prophylaxis with low molecular weight heparin (LMWH) has been described, but its use is not globally accepted. A retrospective multicentric study in ALL patients 1-18 years old following SEHOP-PETHEMA-2013 treatment guideline was performed to evaluate VTE rate, anticoagulant treatment, outcome, risk factors, and safety and usefulness of LMWH administration as primary thromboprophylaxis in children with inherited thrombophilia. A total of 652 patients were included in the study. VTE incidence was 8.7%. Most of the cases occurred during induction therapy associated with central venous catheter. Univariant analysis showed that family history of thrombosis, presence of mediastinal mass, high-risk treatment group, and inherited thrombophilia were statistically significant risk factors. LMWH administration seemed to decrease VTE rate in patients with inherited thrombophilia and those with T-cell ALL phenotype. Most of the VTE cases occurred in patients without inherited thrombophilia, but when it is present, the VTE risk is higher. LMWH administration was useful to decrease VTE in these patients