Halogenated indole-3-acetic acids as oxidatively activated prodrugs with potential for targeted cancer therapy

Peer reviewe

L-band briefcase terminal network operation

During 1989, SkyWave Electronics Ltd. developed a lightweight battery powered, L Band Briefcase Satellite Terminal (LBT) which is capable of providing truly portable voice and data communications on a global scale. The LBT is designed to operate through Inmarsat's Atlantic Region Satellite MARECSB-2, and Teleglobe Canada's 18 meter Laurentides Earth Station. A small operating network, consisting of up to 20 mobile terminals and homing on the Laurentides Earth Station, was set up in the spring of 1990 to provide commercial service to LBT users, both domestic and international. This paper describes the LBT and the operation of the network

Refreshing the D2N2 Strategic Economic Plan: the case for inclusive growth

The D2N2 Local Enterprise Partnership is in the process of revising its Strategic Economic Plan, which will run to 2030. The most recent D2N2 state of the economy report highlighted the persistent productivity gap and the inclusive growth challenge for the D2N2 area. Two detailed pieces of research have been commissioned on the challenges of productivity, and on inclusive growth in order to provide an evidence base to support the revision of the SEP. This report forms one of those pieces of research and as such will act as an integral piece of work to the SEP. With significant funding streams soon to expire, this SEP refresh has the opportunity to make its own case for a local economic strategy. The starting point for this report is that unless inclusive growth is the guiding principle of an economic strategy, rather than a strand of work, it is doomed to fail. Inclusive growth is an approach which has the potential to be transformative precisely because different policy and programme concerns are explored in terms of their impact across both the economic and the social. This is about what is done, but also about how it is done

Public health service options for affordable and accessible noncommunicable disease and related chronic disease prevention and management

Globally, nations are confronted with the challenge of providing affordable health services to populations with increasing levels of noncommunicable and chronic disease. Paradoxically, many nations can both celebrate increases in life expectancy and bemoan parallel increases in chronic disease prevalence. Simply put, despite living longer, not all of that time is spent in good health. Combined with factors such as rising levels of obesity and related noncommunicable disease, the demand for health services is requiring nations to consider new models of affordable health care. Given the level of disease burden, all staff, not just doctors, need to be part of the solution and encouraged to innovate and deliver better and more affordable health care, particularly preventative primary health care services. This paper draws attention to a range of exemplars to encourage and stimulate readers to think beyond traditional models of primary health service delivery. Examples include nurse-led, allied health-led, and student-led clinics; student-assisted services; and community empowerment models. These are reported for the interest of policy makers and health service managers involved in preventative and primary health service redesign initiatives

Fatigue detection using computer vision

Long duration driving is a significant cause of fatigue related accidents of cars, airplanes, trains and other means of transport. This paper presents a design of a detection system which can be used to detect fatigue in drivers. The system is based on computer vision with main focus on eye blink rate. We propose an algorithm for eye detection that is conducted through a process of extracting the face image from the video image followed by evaluating the eye region and then eventually detecting the iris of the eye using the binary image. The advantage of this system is that the algorithm works without any constraint of the background as the face is detected using a skin segmentation technique. The detection performance of this system was tested using video images which were recorded under laboratory conditions. The applicability of the system is discussed in light of fatigue detection for drivers

Surface electrical properties experiment, part 1

The work is reported which was performed on the Surface Electrical Properties Experiment Data Acquisition System. Areas discussed include: data handling and processing, installation and external signal application, operation of the equipment, and digital output. Detailed circuit descriptions are included