73 research outputs found
Π€ΠΈΠ»ΠΎΡΠΎΡΡΠΊΠΎ-Π°Π½ΡΡΠΎΠΏΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ Π² ΡΠΈΡΠΎΡΠΈΠΊΠ΅. Π‘Π»ΡΡΠ°ΠΉ ΠΠ°ΡΡΠΈΡΠ΅ΡΠ°
Π ΡΡΠΎΠΉ ΡΡΠ°ΡΡΠ΅ ΠΌΡ ΡΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΠΌ, ΡΡΠΎ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΡ ΡΠΈΠΌΠ²ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ ΠΡΠ½ΡΡΠ° ΠΠ°ΡΡΠΈΡΠ΅ΡΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅Π·Π°ΠΌΠ΅Π½ΠΈΠΌΡΠΌ ΡΠΈΠ»ΠΎΡΠΎΡΡΠΊΠΎ-Π°Π½ΡΡΠΎΠΏΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠ°ΡΡΠ½Π΅ΡΠΎΠΌ ΡΠΈΡΠΎΡΠΈΠΊΠΈ. ΠΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌ, ΡΡΠΎ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΠ΅ ΡΠΈΡΠΎΡΠΈΠΊΠΎΠΉ ΡΠ΅ΠΎΡΠΈΠΈ ΡΠΈΠΌΠ²ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ ΠΠ°ΡΡΠΈΡΠ΅ΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π²ΡΠ²Π΅ΡΡΠΈ ΡΠΈΡΠΎΡΠΈΠΊΡ Π·Π° ΠΏΡΠ΅Π΄Π΅Π»Ρ Π΅Ρ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΡΡΠ΅ΠΉ ΡΡΠ°ΠΊΡΠΎΠ²ΠΊΠΈ ΠΊΠ°ΠΊ ΡΠ΅ΠΎΡΠΈΠΈ, ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΡΠ·ΡΠΊΠΎΠ²ΠΎΠ΅ Π²ΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅, ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π΅ΠΉ ΠΏΠΎΠ»Π½ΠΎΡΡΡΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠΈΡΠΎΠΊΠΎΠΌΡ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΡΠΈΡΠΎΡΠΈΠΊΠΈ ΠΊΠ°ΠΊ ΡΡΠ΅Π½ΠΈΡ ΠΎ ΡΠΎΠΌ, ΠΊΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ ΡΠΎΠ·Π΄Π°ΡΡΡΡ, ΡΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡ ΠΈ ΠΈΠ·ΠΌΠ΅Π½ΡΠ΅ΡΡΡ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅. Π§ΡΠΎΠ±Ρ ΡΠ΄Π΅Π»Π°ΡΡ Π½Π°ΡΠ΅ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΠΎΠ΅ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠΈΡΠΎΡΠΈΠΊΠΎ-ΡΠΈΠ»ΠΎΡΠΎΡΡΠΊΠΎ-Π°Π½ΡΡΠΎΠΏΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° Π±ΠΎΠ»Π΅Π΅ ΡΡΠ½ΡΠΌ, ΠΌΡ ΠΏΠΎΡΡΡΠΎΠΈΠ»ΠΈ Π½Π°ΡΠ΅ ΡΠ°ΡΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π½Π° ΠΊΡΠΈΡΠΈΠΊΠ΅ Π½Π΅Π΄Π°Π²Π½Π΅ΠΉ ΠΏΠΎΠΏΡΡΠΊΠΈ Π’ΠΎΠΌΠ°ΡΠ° Π. ΠΠΈΡΠ΅Π½Π½Ρ (Discenna, Rhetorica 32/3, 2014) Π²ΠΊΠ»ΡΡΠΈΡΡ ΠΠ°ΡΡΠΈΡΠ΅ΡΠ° Π² ΡΠΈΡΠΎΡΠΈΡΠ΅ΡΠΊΡΡ ΡΡΠ°Π΄ΠΈΡΠΈΡ Π² Ρ
ΠΎΠ΄Π΅ Π°Π½Π°Π»ΠΈΠ·Π° Π΄Π°Π²ΠΎΡΡΠΊΠΈΡ
Π΄Π΅Π±Π°ΡΠΎΠ² ΠΌΠ΅ΠΆΠ΄Ρ ΠΠ°ΡΡΠΈΡΠ΅ΡΠΎΠΌ ΠΈ Π. Π₯Π°ΠΉΠ΄Π΅Π³Π³Π΅ΡΠΎΠΌ 1929 Π³ΠΎΠ΄Π°; ΠΈ ΡΠ°ΡΡΠΈΡΠ½ΠΎ Π½Π° ΡΠ°Π·ΡΡΡΠ½Π΅Π½ΠΈΠΈ ΡΠ΅Ρ
Π°ΡΠΏΠ΅ΠΊΡΠΎΠ² ΠΌΡΡΠ»ΠΈ ΠΠ°ΡΡΠΈΡΠ΅ΡΠ°, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΡ ΡΡΠΈΡΠ°Π΅ΠΌ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π°ΠΆΠ½ΡΠΌΠΈ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠΈΡΠΎΡΠΈΠΊΠΎ-ΡΠΈΠ»ΠΎΡΠΎΡΡΠΊΠΎΠΉ Π°Π½ΡΡΠΎΠΏΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ Π²ΡΠ²ΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅Π·ΠΈΡ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΡ ΡΠΈΠΌΠ²ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ ΠΠ°ΡΡΠΈΡΠ΅ΡΠ° ΡΠΎΠ·Π΄Π°Π΅Ρ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΡΠΈΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΠ»ΠΎΡΠΎΡΡΠΊΠΎΠΉ Π°Π½ΡΡΠΎΠΏΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ°ΠΊ ΡΡΠ΅Π½ΠΈΡ ΠΎ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΡ
Π Π²ΠΎΠΏΡΠΎΡΡ ΠΎ doxa: ΡΠΏΠΈΡΡΠ΅ΠΌΠΎΠ»ΠΎΠ³ΠΈΡ βΠ½ΠΎΠ²ΠΎΠΉ ΡΠΈΡΠΎΡΠΈΠΊΠΈβ
M. Rosengren developed doxology as an 'other' take on epistemology, as teaching about how we actually do create the knowledge that we need. He has chosen to call his epistemic stance doxological in order to emphasise that all knowledge is doxic knowledge, thus turning the seminal Platonic distinction between doxa (beliefs, opinions) and episteme (objective, eternal knowledge) upside down
Π§Π΅Π»ΠΎΠ²Π΅ΠΊ ΠΊΠ°ΠΊ ΠΌΠ΅ΡΠ°. ΠΠ΅ΡΠ΅Π΄Π° Ρ ΠΠ°ΡΡΠΎΠΌ Π ΠΎΠ·Π΅Π½Π³ΡΠ΅Π½ΠΎΠΌ ΠΎ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠ΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΠΈ
A subject of a conversation is the social context for the emergence of a doxology as a project of the naturalised theory of knowledge. The Swedish philosopher Mats Rosengren developed the doxology. From his point of view, human knowledge has never been and will never be epistemic (in the Platonic sense). It is always cultural and historical determined, situational and changeable. During the conversation, Rosengren discusses the specifics of the doxological understanding of the constructive nature of scientific knowledge. He speaks about the importance of reception of the French philosophy of the 20th century for the emergence of a doxology. Mats Rosengren gave an interview on June 14, 2018, in Stockholm in the House of the Union of the Swedish writers. Mikael Nydahl did the simultaneous translation from Swedish. Further, Dmitry Vorobev made the transcript and editing of the conversation written text. The paper allows better to understand what the doxology is β as a modern version of the Protagorean theory of knowledge β and what is not. ΠΡΠ΅Π΄ΠΌΠ΅ΡΠΎΠΌ Π±Π΅ΡΠ΅Π΄Ρ ΡΡΠ°Π» ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΠΈ β Π½Π°ΡΡΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΡΠ΅ΠΎΡΠΈΠΈ ΠΏΠΎΠ·Π½Π°Π½ΠΈΡ, ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΠΎΠΉ ΡΠ²Π΅Π΄ΡΠΊΠΈΠΌ ΡΠΈΠ»ΠΎΡΠΎΡΠΎΠΌ ΠΠ°ΡΡΠΎΠΌ Π ΠΎΠ·Π΅Π½Π³ΡΠ΅Π½ΠΎΠΌ. Π‘ Π΅Π³ΠΎ ΡΠΎΡΠΊΠΈ Π·ΡΠ΅Π½ΠΈΡ ΡΠ΅Π»ΠΎΠ²Π΅ΡΠ΅ΡΠΊΠΎΠ΅ Π·Π½Π°Π½ΠΈΠ΅ Π½ΠΈΠΊΠΎΠ³Π΄Π° Π½Π΅ Π±ΡΠ»ΠΎ ΠΈ Π½Π΅ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΈΡΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ (Π² ΠΏΠ»Π°ΡΠΎΠ½ΠΎΠ²ΡΠΊΠΎΠΌ ΡΠΌΡΡΠ»Π΅). ΠΠ½ΠΎ Π²ΡΠ΅Π³Π΄Π° ΠΊΡΠ»ΡΡΡΡΠ½ΠΎ-ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΈΡΡΠ°ΡΠΈΠ²Π½ΠΎ, ΠΈΠ·ΠΌΠ΅Π½ΡΠΈΠ²ΠΎ. Π Ρ
ΠΎΠ΄Π΅ Π±Π΅ΡΠ΅Π΄Ρ Π ΠΎΠ·Π΅Π½Π³ΡΠ΅Π½ Π³ΠΎΠ²ΠΎΡΠΈΡ ΠΎ ΡΠΏΠ΅ΡΠΈΡΠΈΠΊΠ΅ Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ° Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ·Π½Π°Π½ΠΈΡ, ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΈΠΈ ΡΡΠ°Π½ΡΡΠ·ΡΠΊΠΎΠΉ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΠΈ XX Π²Π΅ΠΊΠ° Π΄Π»Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΡΠΎΡΠ΅ΡΡΠΎΡ Π ΠΎΠ·Π΅Π½Π³ΡΠ΅Π½ Π΄Π°Π» ΠΈΠ½ΡΠ΅ΡΠ²ΡΡ 14 ΠΈΡΠ½Ρ 2018 Π³ΠΎΠ΄Π° Π² Π‘ΡΠΎΠΊΠ³ΠΎΠ»ΡΠΌΠ΅ Π² Π΄ΠΎΠΌΠ΅ Π‘ΠΎΡΠ·Π° ΡΠ²Π΅Π΄ΡΠΊΠΈΡ
ΠΏΠΈΡΠ°ΡΠ΅Π»Π΅ΠΉ. Π‘ΠΈΠ½Ρ
ΡΠΎΠ½Π½ΡΠΉ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ΄ Ρ ΡΠ²Π΅Π΄ΡΠΊΠΎΠ³ΠΎ ΡΠ΄Π΅Π»Π°Π» ΠΠΈΠΊΠ°ΡΠ»Ρ ΠΡΠ΄Π°Π»Ρ. Π Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ Π½Π° Π±Π°Π·Π΅ Π°ΡΠ΄ΠΈΠΎΠ·Π°ΠΏΠΈΡΠΈ Π±Π΅ΡΠ΅Π΄Ρ ΠΠΌΠΈΡΡΠΈΠ΅ΠΌ ΠΠΎΡΠΎΠ±ΡΠ΅Π²ΡΠΌ Π±ΡΠ» ΡΠΎΠ·Π΄Π°Π½ ΠΈ ΠΎΡΡΠ΅Π΄Π°ΠΊΡΠΈΡΠΎΠ²Π°Π½ ΡΠ΅ΠΊΡΡ ΠΈΠ½ΡΠ΅ΡΠ²ΡΡ. ΠΠΎΠ²ΠΈΠ·Π½Π° Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ Π² ΡΠΎΠΌ, ΡΡΠΎ ΠΎΠ½Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π»ΡΡΡΠ΅ ΠΏΠΎΠ½ΡΡΡ, ΡΠ΅ΠΌ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈ ΡΠ΅ΠΌ Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΡ, Π·Π°ΡΠ²Π»Π΅Π½Π½Π°Ρ Π΅Π΅ Π°Π²ΡΠΎΡΠΎΠΌ ΠΊΠ°ΠΊ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ ΠΏΡΠΎΡΠ°Π³ΠΎΡΠ΅ΠΉΡΠΊΠΎΠΉ ΡΠ΅ΠΎΡΠΈΠΈ ΠΏΠΎΠ·Π½Π°Π½ΠΈΡ
Π’Π΅Π·ΠΈΡ ΠΡΠΎΡΠ°Π³ΠΎΡΠ°: Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π°
The paper presents doxological interpretation of homo-measure set. Traditionally this thesis is seen as an expression of the impermanent human doxa as the only possible truth. Using the approach of analytic philosophy to the interpretation of the famous speech, the author refuses treatment of man as an individual in favor of a generic understanding of the man. Generic feature of human in ancient world-view is the logos, which is coming to be seen as a measure of all things, including man himself
Π’Π΅Π·ΠΈΡ ΠΡΠΎΡΠ°Π³ΠΎΡΠ°: Π΄ΠΎΠΊΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π°
The paper presents doxological interpretation of homo-measure set. Traditionally this thesis is seen as an expression of the impermanent human doxa as the only possible truth. Using the approach of analytic philosophy to the interpretation of the famous speech, the author refuses treatment of man as an individual in favor of a generic understanding of the man. Generic feature of human in ancient world-view is the logos, which is coming to be seen as a measure of all things, including man himself
Overweight, obesity and the risk of LADA : results from a Swedish case-control study and the Norwegian HUNT Study
Aims/hypothesis Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. Methods Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. Results In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; Conclusions/interpretation Overweight/obesity is associated with increased risk of LADA, particularly when in combination with FHD. These findings support the hypothesis that, even in the presence of autoimmunity, factors linked to insulin resistance, such as excessive weight, could promote onset of diabetes.Peer reviewe
Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer.
Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes 3-9% of non-small cell lung cancer but is poorly characterized at the molecular level. Herein we analyzed 41 LC and 32 LCNEC (including 15 previously reported cases) tumors using massive parallel sequencing for mutations in 26 cancer-related genes and gene fusions in ALK, RET, and ROS1. LC patients were additionally subdivided into three immunohistochemistry groups based on positive expression of TTF-1/Napsin A (adenocarcinoma-like, n = 24; 59%), CK5/P40 (squamous-like, n = 5; 12%), or no marker expression (marker-negative, n = 12; 29%). Most common alterations were TP53 (83%), KRAS (22%), MET (12%) mutations in LCs, and TP53 (88%), STK11 (16%), and PTEN (13%) mutations in LCNECs. In general, LCs showed more oncogene mutations compared to LCNECs. Immunomarker stratification of LC revealed oncogene mutations in 63% of adenocarcinoma-like cases, but only in 17% of marker-negative cases. Moreover, marker-negative LCs were associated with inferior overall survival compared with adenocarcinoma-like tumors (p = 0.007). No ALK, RET or ROS1 fusions were detected in LCs or LCNECs. Together, our molecular analyses support that LC and LCNEC tumors follow different tumorigenic paths and that LC may be stratified into molecular subgroups with potential implications for diagnosis, prognostics, and therapy decisions
Novel subgroups of adult-onset diabetes and their association with outcomes : a data-driven cluster analysis of six variables
Background Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis. Methods We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Clusters were based on six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA(1c), and homoeostatic model assessment 2 estimates of beta-cell function and insulin resistance), and were related to prospective data from patient records on development of complications and prescription of medication. Replication was done in three independent cohorts: the Scania Diabetes Registry (n=1466), All New Diabetics in Uppsala (n=844), and Diabetes Registry Vaasa (n=3485). Cox regression and logistic regression were used to compare time to medication, time to reaching the treatment goal, and risk of diabetic complications and genetic associations. Findings We identified five replicable clusters of patients with diabetes, which had significantly different patient characteristics and risk of diabetic complications. In particular, individuals in cluster 3 (most resistant to insulin) had significantly higher risk of diabetic kidney disease than individuals in clusters 4 and 5, but had been prescribed similar diabetes treatment. Cluster 2 (insulin deficient) had the highest risk of retinopathy. In support of the clustering, genetic associations in the clusters differed from those seen in traditional type 2 diabetes. Interpretation We stratified patients into five subgroups with differing disease progression and risk of diabetic complications. This new substratification might eventually help to tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.Peer reviewe
Psychosocial factors during the first year after a coronary heart disease event in cases and referents. Secondary Prevention in Uppsala Primary Health Care Project (SUPRIM)
<p>Abstract</p> <p>Background</p> <p>A large number of studies have reported on the psychosocial risk factor pattern prior to coronary heart disease events, but few have investigated the situation during the first year after an event, and none has been controlled. We therefore performed a case-referent study in which the prevalence of a number of psychosocial factors was evaluated.</p> <p>Methods</p> <p>Three hundred and forty-six coronary heart disease male and female cases no more than 75 years of age, discharged from hospital within the past 12 months, and 1038 referents from the general population, matched to the cases by age, sex and place of living, received a postal questionnaire in which information on lifestyle, psychosocial and quality of life measures were sought.</p> <p>Results</p> <p>The cases were, as expected, on sick leave to a larger extent than the referents, reported poorer fitness, poorer perceived health, fewer leisure time activities, but unexpectedly reported better social support, and more optimistic views of the future than the referents. There were no significant case-referent differences in everyday life stress, stressful life events, vital exhaustion, depressive mood, coping or life orientation test. However, women reported less favourable situations than men regarding stressful life events affecting others, vital exhaustion, depressive mood, coping, self-esteem, sleep, and symptom reporting, and female cases reported the most unfavourable situation of all groups.</p> <p>Conclusion</p> <p>In this first controlled study of the situation during the first year after a CHD event disease and gender status both appeared to be determinants of psychological well-being, with gender status apparently the strongest. This may have implications for cardiac rehabilitation programmes.</p
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