Sweet Expectation

As we all know pregnancy is a long and sweet waiting to meet that beloved being. In the case of Patricia her wait has been distressing because the loss of two pregnancies and now she is expecting twins. In this picture, we can see her eyes towards the horizon, where she reflects the anguish that has passed but at the same time doubts of celebrating her double happiness

Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis.

Tumour cells are subjected to evolutionary selection pressures during progression from initiation to metastasis. We analysed the clonal evolution of squamous skin carcinomas induced by DMBA/TPA treatment using the K5CreER-Confetti mouse and stage-specific lineage tracing. We show that benign tumours are polyclonal, but only one population contains the Hras driver mutation. Thus, benign papillomas are monoclonal in origin but recruit neighbouring epithelial cells during growth. Papillomas that never progress to malignancy retain several distinct clones, whereas progression to carcinoma is associated with a clonal sweep. Newly generated clones within carcinomas demonstrate intratumoural invasion and clonal intermixing, often giving rise to metastases containing two or more distinct clones derived from the matched primary tumour. These data demonstrate that late-stage tumour progression and dissemination are governed by evolutionary selection pressures that operate at a multicellular level and, therefore, differ from the clonal events that drive initiation and the benign-malignant transition

Ephemeral Spaces, Undying Dreams: Social Justice Struggles In Contemporary Puerto Rico

The premise of this dissertation is that ephemeral spaces serve as practice ground for enacting fleeting moments of autonomy. My narrative centers the ephemeral nature of political possibility, doing so in a way that attempts to preserve the undecidable directionality of these moments. Focusing on occupation as a tactic of resistance, I discuss two contemporary manifestations I witnessed while in Puerto Rico from 2009-2011: the 62 day system wide student strike organized in 2010 at the University of Puerto Rico and El Campamento Playas Pa'l Pueblo, a squat founded in 2005 to prevent the privatization of a parcel of public coastal land. I call these spaces liberation experiments to underscore my interest in understanding them as part of the project to achieve self-determination for Puerto Ricans. Although there is some debate as to whether Puerto Rico is a colony in the strict sense of the word, since it was "decolonized" when it became a commonwealth of the United States, it still remains the case that such a relationship of over a century of partial integration to the United States has perverted the political terrain. By linking these queries into the micropolitics of resistance spaces to Puerto Rico's nonsovereign political terrain, I argue that these ephemeral space/times have political implications that go beyond efforts to shift modes of organizing to prefigurative action emergent across the globe. My project is to reclaim the term revolution in Puerto Rican Studies as a terrain that lies outside the traditional trajectory of nation-state formation and status debate and am keen to show how efforts to build ephemeral spaces of resistance assist participants in experimenting partial breaks, ruptures and gaps from what Nelson Maldonado Torres calls, "coloniality of being." This work builds upon the anthropology of social movements where scholars have done much to emphasize the mundane aspects of organizing, focusing on the affects and ambivalences produced by resistance work. In each chapter, I attend to the way political possibility is experienced and effaced in the intimate moments of struggle. However, my claim to the importance of the ephemeral in our theorizations of social movements is drawn from Caribbeanist, feminist and queer genealogies that posit alternative conceptualizations of temporality and aim to deconstruct transcendental models of History. By writing experimentally, prioritizing the storytelling and affective domain of living a moment of revolutionary possibility, I amplify the poetics of resistance space. I am not interested in making temporary encampments "more familiar" to the reader but rather in transferring some of that affect to readers through writing. In emphasizing the "poetics," I underscore that I am invested in producing a text that evokes memories, embodied realizations of my experience in the field-a place that is also my ancestral home(land). In attending to the poetics of ephemeral spaces of resistance, I aim to subvert what J.K. Gibson-Graham identify as "left melancholia" evidenced by our tendency to critique to the point of paralysis, instead stimulating our knowledge of the realm of the possible which emerge within the impossible conditions in which we live

Building Institutional Support for Undocumented and DACA-eligible College Students in Michigan

In 2017, the state of Michigan operated, and continues to operate, in an unstipulated policy environment related to undocumented students. There is no higher education commission or policy coordinating body in Michigan nor has the state legislature passed any legislation related to undocumented students or students who are DACA-eligible. Under this unstipulated policy environment, postsecondary institutions have the discretion to establish their own admissions policies and practices, including tuition and financial aid guidelines for undocumented students. Some institutions have stated their public support of these students through what they identify as inclusive and supportive institutional practices via their websites. However, these polices have created a nebulous environment which has created additional barriers for undocumented and DACA-eligible students trying to access postsecondary education. The lack of clear and consistent financial aid and admission policies across the state has resulted in a convoluted environment for undocumented and DACA-eligible students in applying to institutions. In this paper, we highlight how a group of undergraduate and graduate University of Michigan student researchers, both documented and undocumented, developed an instrument to analyze institutional policies related to in-state resident tuition, admission, financial aid, as well as the availability of dedicated student support services for undocumented and DACA-eligible students in the state of Michigan during the Fall of 2017. The data for this project has been turned into a website with updated (as of 2020) and available at https://uleadnet.org/mi-undocu-map

Frecuencia de tratamientos pulpares en niños de 18 a 48 meses de edad atendidos en hospital nacional de Lima

El objetivo de la presente investigación fue determinar la frecuencia de tratamientos pulpares en niños de 18 a 48 meses atendidos en el Instituto Nacional de Salud del Niño en el segundo semestre del año 2017, el diseño metodológico fue de tipo descriptivo, el tipo de investigación fue transversal, retrospectivo y observacional, tuvo un enfoque cuantitativo. Se empleó una muestra no aleatoria, por conveniencia, constituida por 100 Historias Clínicas de pacientes atendidos en el Servicio de Estomatología del Instituto de Salud del Niño en el segundo semestre del año 2017.The objective of this research was to determine the frequency of pulp treatments in children aged 18 to 48 months treated at the National Institute of Child Health in the second semester of 2017, the methodological design was descriptive, the type of research was cross-sectional, retrospective and observational, had a quantitative approach. A non-random sample was used, for convenience, consisting of 100 clinical histories of patients treated at the Stomatology Service of the Children's Health Institute in the second semester of 201

Centro Comunitario de Formación de Artes y Oficios en el distrito Mi Perú - Callao

El objetivo central es la búsqueda, selección, análisis y creación de herramientas que sirvan de base para el desarrollo del diseño arquitectónico de un centro comunitario de formación en artes y oficios, donde se ofrezca educación técnico-productiva para jóvenes y adultos, especialmente enfocado al grupo “nini” en el distrito Mi Perú y sus alrededores

Oregano essential oil-pectin edible films as anti-quorum sensing and food antimicrobial agents

Edible films can be used as carriers for antimicrobial compounds to assure food safety andquality; in addition, pathogenesis of food bacteria is related to a cell to cell communicationmechanism calledquorum sensing(QS). Oregano essential oil (OEO) has proved to beuseful as food antimicrobial; however, its foodapplications can be compromised by thevolatile character of its active constituents.Therefore, formulation of edible films containingOEO can be an alternative to improve its food usages. QS inhibitory activity of OEO andpectin-OEO films was evaluated usingChromobacterium violaceumas bacterial model.Additionally, antibacterial activity was tested againstEscherichia coliO157:H7,SalmonellaCholeraesuis,Staphylococcus aureus,andListeria monocytogenes. OEO was effective toinhibit bacterial growth at MIC of 0.24 mg/mL for all tested bacteria and MBC of 0.24,0.24, 0.48, and 0.24 mg/mL againstE. coliO157:H7,S.Choleraesuis,S. aureus, andL.monocytogenes, respectively. Pectin-films incorporated with 36.1 and 25.9 mg/mL of OEOshowed inhibition diameters of 16.3 and 15.2 mm forE. coliO157:H7; 18.1 and 24.2 mm forS.Choleraesuis; 20.8 and 20.3 mm forS. aureus; 21.3 and 19.3 mm forL. monocytogenes,respectively. Pectin-OEO film (15.7 mg/mL) was effective againstE. coliO157:H7 (9.3 mm),S. aureus(9.7 mm), andL. monocytogenes(9.2 mm), but not forS.Choleraesuis. Allconcentrations of OEO (0.0156, 0.0312, 0.0625 and 0.125 mg/mL) and pectin-OEO films(15.7, 25.9 and 36.1 mg/mL) showed a significant anti-QS activity expressed as inhibition ofviolacein production byC. violaceum. Additionally, the application of pectin-OEO films waseffective reducing total coliforms, yeast, and molds of shrimp and cucumber slices storedat 4◦C during 15 d.These results demonstrated the potential of pectin films enriched withOEO as food related microorganisms and QS inhibitorsFil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Ortega Ramirez, Luis Alberto. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Gutierrez Pacheco, Maria Melissa. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Bernal Mercado, Thalia. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Rodriguez Garcia, Isela. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; MéxicoFil: Ponce, Alejandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Moreira, Maria del Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Roura, Sara Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Departamento de Ingeniería Química. Grupo de Investigación en Ingeniería En Alimentos; ArgentinaFil: Ayala Zavala, Jesús Fernando. Centro de Investigación en Alimentación y Desarrollo. Hermosillo; Méxic

Hidden and uninterested populations : methodological insights and unresolved issues from the study of Cannabis Social Clubs

Cannabis Social Clubs are typically non-profit associations established by adult users of cannabis, which produce and distribute cannabis among their members. Such associations can be found in several European countries and beyond, but with exception of Uruguay, they are illegal or otherwise operate at the margins of domestic drug control legislation, at risk for law enforcement detection. We have conducted several individual and collaborative studies on Cannabis Social Clubs and their key actors (e.g. Cannabis Social Clubs leaders, users affiliated as members, cannabis growers, other stakeholders), primarily drawing on qualitative methods (e.g. ethnographic fieldwork, interviews, qualitative media analyses) but also employing a quantitative approach (e.g. online surveys). In this article, we reflect on the research experiences of the authors in studying Cannabis Social Clubs, providing insights for future research in this area and within criminology and socio-legal studies. In particular, we aim to examine our approaches with regard to the recruitment of participants and research design, identifying good practices, but also discussing what the less successful strategies were. We draw on research conducted since 2014 in different countries, with different legal frameworks, which provides an opportunity for a comparative and more in-depth critical consideration of what might be helpful ways of reaching and researching hard-to-reach populations

Viabilidad tecnológica de la instalación de una planta productora de fideo a base de harina de camote (Ipomoea batatas) y linaza (Linum usitatissimum) en el Perú

Este artículo pretende mostrar la viabilidad técnica de la instalación de una fábrica de fideos con harina de patata y linaza, describiendo el producto, el proceso de producción y la capacidad de la planta. Este fideo es un producto que satisface la necesidad de una alimentación saludable que ayude a una mejor digestión y aporte mayores nutrientes. Además, su aporte nutricional es básicamente una gran cantidad de minerales como el potasio, hierro, magnesio, manganeso y fosforo, y vitaminas como la B y E, sin olvidar que brinda un nivel alto en fibra, ácidos grasos como Omega 3, 6 y 9, y antioxidantes esenciales para el organismoThis article aims to show the technical viability of installing a noodle factory using potato and linseed flour by describing the product, production process, and plant capacity. This noodle is a product that satisfies the need for a healthy diet that helps better digestion and provides more nutrients. In addition, its contribution the nutritional contribution is basically a large amount of minerals such as potassium, iron, magnesium, manganese and phosphorus, and vitamins such as B and E, without forgetting that it provides a high level of fiber, fatty acids such as Omega 3, 6 and 9, and essential antioxidants for the body

Percepción de la calidad del usuario externo del servicio de tópico del centro de salud el Progreso 2016

El objetivo general de la investigación fue Identificar el nivel de percepción de la calidad del usuario externo del servicio de tópico del centro de salud el Progreso, 2016. La población objeto de estudio, estuvo conformada por 850 usuarios externos del centro de salud el Progreso, 2016, la muestra fue de 110 usuario El método empleado en la investigación fue básica, descriptiva y según su propósito el diseño no experimental, de corte transversal, para la recolección de datos se utilizó como técnica la encuesta y el instrumento fue un cuestionario el cual abarco las dimensiones de fiabilidad, capacidad de respuesta, seguridad, empatía, aspectos tangibles; conformado por 2 ítems medidos en una escala Likert. La investigación evidencio que el 52,7% de los encuestados manifiestan que está en un nivel regular la percepción de la calidad del usuario externo del servicio de tópico del centro de salud el Progreso, 2016. En lo referente a las dimensiones a excepción de empatía que tiene su mayor porcentaje (54,5%)en el nivel bueno mientras capacidad de respuesta en un nivel regular con un 66,4%; elementos tangibles con un 59,1% , a fiabilidad con un 65,5% y por último la empatía (58,2%