Unidad didáctica: El Marketing Mix

Este trabajo desarrolla la unidad didáctica sobre el Marketing mix que se encuadra dentro de los contenidos de la asignatura de Economía de la Empresa de segundo de Bachillerato. Antes de centrarse en la citada unidad didáctica se hace un recorrido por los distintos apartados que componen la programación anual de la asignatura, para posteriormente desarrollar la unidad didáctica en sí. Se incluyen actividades, métodos y recursos concretos para llevar a cabo en el aula, de una forma variada y atractiva para los alumnos, intentando despertar en ellos su interés por la Economía de la Empresa en general y el Marketing en particular.Organización de Empresa y Comercialización e Investigación de MercadosMáster en Profesor de Educación Secundaria Obligatoria y Bachillerato, Formación Profesional y Enseñanzas de Idiomas (Especialidad: Economía

Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome : clinical and genetic study in a series of Spanish patients

Altres ajuts: European Regional Development Fund; Federación Española de Enfermedades Raras (FEDER); European Social Fund (ESF).Background: The limited knowledge about the PTEN hamartoma tumor syndrome (PHTS) makes its diagnosis a challenging task. We aimed to define the clinical and genetic characteristics of this syndrome in the Spanish population and to identify new genes potentially associated with the disease. Results: We reviewed the clinical data collected through a specific questionnaire in a series of 145 Spanish patients with a phenotypic features compatible with PHTS and performed molecular characterization through several approaches including next generation sequencing and whole exome sequencing (WES). Macrocephaly, mucocutaneous lesions, gastrointestinal polyposis and obesity are prevalent phenotypic features in PHTS and help predict the presence of a PTEN germline variant in our population. We also find that PHTS patients are at risk to develop cancer in childhood or adolescence. Furthermore, we observe a high frequency of variants in exon 1 of PTEN, which are associated with renal cancer and overexpression of KLLN and PTEN. Moreover, WES revealed variants in genes like NEDD4 that merit further research. Conclusions: This study expands previously reported findings in other PHTS population studies and makes new contributions regarding clinical and molecular aspects of PHTS, which are useful for translation to the clinic and for new research lines