126 research outputs found

    Towards greater transparency and coherence in funding for sustainable marine fisheries and healthy oceans

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    This final manuscript in the special issue on “Funding for ocean conservation and sustainable fisheries” is the result of a dialogue aimed at connecting lead authors of the special issue manuscripts with relevant policymakers and practitioners. The dialogue took place over the course of a two-day workshop in December 2018, and this “coda” manuscript seeks to distil thinking around a series of key recurring topics raised throughout the workshop. These topics are collected into three broad categories, or “needs”: 1) a need for transparency, 2) a need for coherence, and 3) a need for improved monitoring of project impacts. While the special issue sought to collect new research into the latest trends and developments in the rapidly evolving world of funding for ocean conservation and sustainable fisheries, the insights collected during the workshop have helped to highlight remaining knowledge gaps. Therefore, each of the three “needs” identified within this manuscript is followed by a series of questions that the workshop participants identified as warranting further attention as part of a future research agenda. The crosscutting nature of many of the issues raised as well as the rapid pace of change that characterizes this funding landscape both pointed to a broader need for continued dialogue and study that reaches across the communities of research, policy and practice.S

    Methotrexate and relative risk of dementia amongst patients with rheumatoid arthritis:A multi-national multi-database case-control study

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    Background: Inflammatory processes have been shown to play a role in dementia. To understand this role, we selected two anti-inflammatory drugs (methotrexate and sulfasalazine) to study their association with dementia risk. Methods: A retrospective matched case-control study of patients over 50 with rheumatoid arthritis (486 dementia cases and 641 controls) who were identified from ele

    TOI-199 b: A well-characterized 100-day transiting warm giant planet with TTVs seen from Antarctica

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    We present the spectroscopic confirmation and precise mass measurement of the warm giant planet TOI-199 b. This planet was first identified in TESS photometry and confirmed using ground-based photometry from ASTEP in Antarctica including a full 6.5 \,h long transit, PEST, Hazelwood, and LCO; space photometry from NEOSSat; and radial velocities (RVs) from FEROS, HARPS, CORALIE, and CHIRON. Orbiting a late G-type star, TOI-199\,b has a 104.854−0.002+0.001 d\mathrm{104.854_{-0.002}^{+0.001} \, d} period, a mass of 0.17±0.02 MJ\mathrm{0.17\pm0.02 \, M_J}, and a radius of 0.810±0.005 RJ\mathrm{0.810\pm0.005 \, R_J}. It is the first warm exo-Saturn with a precisely determined mass and radius. The TESS and ASTEP transits show strong transit timing variations, pointing to the existence of a second planet in the system. The joint analysis of the RVs and TTVs provides a unique solution for the non-transiting companion TOI-199 c, which has a period of 273.69−0.22+0.26 d\mathrm{273.69_{-0.22}^{+0.26} \, d} and an estimated mass of 0.28−0.01+0.02 MJ\mathrm{0.28_{-0.01}^{+0.02} \, M_J}. This period places it within the conservative Habitable Zone.Comment: 33 pages, 23 figures. Accepted for publication in A

    Three Saturn-mass planets transiting F-type stars revealed with TESS and HARPS

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    While the sample of confirmed exoplanets continues to increase, the population of transiting exoplanets around early-type stars is still limited. These planets allow us to investigate the planet properties and formation pathways over a wide range of stellar masses and study the impact of high irradiation on hot Jupiters orbiting such stars. We report the discovery of TOI-615b, TOI-622b, and TOI-2641b, three Saturn-mass planets transiting main sequence, F-type stars. The planets were identified by the Transiting Exoplanet Survey Satellite (TESS) and confirmed with complementary ground-based and radial velocity observations. TOI-615b is a highly irradiated (∌\sim1277 F⊕F_{\oplus}) and bloated Saturn-mass planet (1.69−0.06+0.05^{+0.05}_{-0.06}RJupR_{Jup} and 0.43−0.08+0.09^{+0.09}_{-0.08}MJupM_{Jup}) in a 4.66 day orbit transiting a 6850 K star. TOI-622b has a radius of 0.82−0.03+0.03^{+0.03}_{-0.03}RJupR_{Jup} and a mass of 0.30−0.08+0.07^{+0.07}_{-0.08}~MJupM_{Jup} in a 6.40 day orbit. Despite its high insolation flux (∌\sim600 F⊕F_{\oplus}), TOI-622b does not show any evidence of radius inflation. TOI-2641b is a 0.37−0.04+0.05^{+0.05}_{-0.04}MJupM_{Jup} planet in a 4.88 day orbit with a grazing transit (b = 1.04−0.06+0.05^{+0.05}_{-0.06 }) that results in a poorly constrained radius of 1.61−0.64+0.46^{+0.46}_{-0.64}RJupR_{Jup}. Additionally, TOI-615b is considered attractive for atmospheric studies via transmission spectroscopy with ground-based spectrographs and JWST\textit{JWST}. Future atmospheric and spin-orbit alignment observations are essential since they can provide information on the atmospheric composition, formation and migration of exoplanets across various stellar types.Comment: 16 pages, 17 figures, submitted to A&

    Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management

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    Atrioventricular block is classified as congeni- tal if diagnosed in utero, at birth, or within the first month of life. The pathophysiological process is believed to be due to immune-mediated injury of the conduction system, which occurs as a result of transplacental pas- sage of maternal anti-SSA/Ro-SSB/La antibodies. Childhood atrioventricular block is therefore diagnosed between the first month and the 18th year of life. Genetic variants in multiple genes have been described to date in the pathogenesis of inherited progressive car- diac conduction disorders. Indications and techniques of cardiac pacing have also evolved to allow safe perma- nent cardiac pacing in almost all patients, including those with structural heart abnormalities
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