Inter-Seasonal Range Relationships of Spanish Goats and Mule Deer in a Utah Oakbrush Community

Three experiments were conducted to assess the potential for using Spanish goats to manage Gambel oakbrush winter range, dominated by Gambel oak (Quercus gambelii), for mule deer (Odocoileus hemionus). Summer- time food selection of goats, effects on plant community composition, and consequent effects on mule deer nutrition and foraging behavior were examined. An apparent preference for juvenile oak browse, and low use of oak twigs was observed. Selection for juvenile browse may have been facilitated by the retarded phenology of oak as compared to that of associated flora. This differential was maintained by repeated browsing. Animal performance, reflected in mass-specific gain rates, varied markedly. However, poor performance when observed, was not correlated with high juvenile oak content in diets. Goat browsing did not affect density of any shrub species. Stem size distributions changed in browsed oak populations only; skewness of these increased over time because of sprouting. Sprout weights increased in browsed oak populations, but declined in comparably browsed serviceberry (Amelanchier alnifolia) populations. The only other significant sprout response was a numerical increase in browsed snowberry (Symphoricarpos oreophilus) populations. Relationships between stem size and stem productivity in heavily browsed oak and serviceberry were characterized by lower slopes than those for adjacent control populations. Conversely, relationships in rabbitbrush (Chrvsothamnus viscidiflorus) populations, which were little used, were characterized by higher slopes than those for adjacent control populations. Sagebrush (Artemisia tridentata wvominqensis) production also responded positively, but via increased intercept. Browsing reduced productivity of both serviceberry and oak, but enhanced that of sagebrush. A positive production response was suggested for herbaceous species. Forage-base changes induced by goats caused wintering deer to increase the proportion of sagebrush in their diets under snow-covered conditions but not under snow-free conditions. Under snow-covered conditions, deer using goat-browsed pastures consumed diets higher in dry matter digestibility, but not protein, than those consumed by deer in control pastures. Dietary quality was unaffected by prior goat browsing under snow- free conditions. Furthermore, quality of diets consumed under snow-free conditions was not better than that consumed under snow-covered conditions

Counter-intuitive moral judgement following traumatic brain injury

Several neurological patient populations, including Traumatic Brain Injury (TBI), appear to produce an abnormally ‘utilitarian’ pattern of judgements to moral dilemmas; they tend to make judgements that maximise the welfare of the majority, rather than deontological judgements based on the following of moral rules (e.g., do not harm others). However, this patient research has always used extreme dilemmas with highly valued moral rules (e.g., do not kill). Data from healthy participants, however, suggests that when a wider range of dilemmas are employed, involving less valued moral rules (e.g., do not lie), moral judgements demonstrate sensitivity to the psychological intuitiveness of the judgements, rather than their deontological or utilitarian content (Kahane et al., 2011). We sought the moral judgements of 30 TBI participants and 30 controls on moral dilemmas where content (utilitarian/deontological) and intuition (intuitive/counterintuitive) were measured concurrently. Overall TBI participants made utilitarian judgements in equal proportions to controls; disproportionately favouring utilitarian judgements only when they were counterintuitive, and deontological judgements only when they were counterintuitive. These results speak against the view that TBI causes a specific utilitarian bias, suggesting instead that moral intuition is broadly disrupted following TBI

Western Mercury (Sandwich)

Title Variations Western Mercury and Great South-western Railway Advocate Great South-western Railway Advocate Former Title British Canadian: the Western Mercury may be a continuation of the British Canadian. The two newspapers shared a business office. On page 2 of the Feb. 25, 1858 issue, the editor writes “All parties indebted to this office for the 1st vol., British Canadian or for printing, or advertising, are requested to make immediate payment.” The newspapers also share the same motto: Our country’s welfare first, and then, we stand by honest party men. Furthermore, the numbering of the Western Mercury seems to continue the numbering of the British Canadian. However, the two newspapers have different editors, different political perspectives (based on content in existing issues), and were published on different days. Publication Dates 1857: Nov.? (Vol. 2: no. 1) – 1859? This assumes a continuation in the numbering from the British Canadian. Frequency Weekly Online Holdings 1858: Feb. 18 (Vol. 2 : no. 14) 4p.1858: Feb. 25 (Vol. 2 : no. 15) 4p.1858: Mar. 25 (Vol. 2 : no. 19) 4p.1858: Apr. 15 (Vol. 2 : no. 22) 4p.https://scholar.uwindsor.ca/essexcountyontarionewspapers/1016/thumbnail.jp

Scaling behavior of drug transport and absorption in in silico cerebral capillary networks

Drug delivery to the brain is challenging due to the presence of the blood-brain barrier. Mathematical modeling and simulation are essential tools for the deeper understanding of transport processes in the blood, across the blood-brain barrier and within the tissue. Here we present a mathematical model for drug delivery through capillary networks with increasingly complex topologies with the goal to understand the scaling behavior of model predictions on a coarse-to-fine sequence of grids. We apply our model to the delivery of L-Dopa, the primary drug used in the therapy of Parkinson\u27s Disease. Our model replicates observed blood flow rates and ratios between plasma and tissue concentrations. We propose an optimal network grain size for the simulation of tissue volumes of 1 cm3 that allows to make reliable predictions with reasonable computational costs

Accurate interlaminar stress recovery from finite element analysis

The accuracy and robustness of a two-dimensional smoothing methodology is examined for the problem of recovering accurate interlaminar shear stress distributions in laminated composite and sandwich plates. The smoothing methodology is based on a variational formulation which combines discrete least-squares and penalty-constraint functionals in a single variational form. The smoothing analysis utilizes optimal strains computed at discrete locations in a finite element analysis. These discrete strain data are smoothed with a smoothing element discretization, producing superior accuracy strains and their first gradients. The approach enables the resulting smooth strain field to be practically C1-continuous throughout the domain of smoothing, exhibiting superconvergent properties of the smoothed quantity. The continuous strain gradients are also obtained directly from the solution. The recovered strain gradients are subsequently employed in the integration o equilibrium equations to obtain accurate interlaminar shear stresses. The problem is a simply-supported rectangular plate under a doubly sinusoidal load. The problem has an exact analytic solution which serves as a measure of goodness of the recovered interlaminar shear stresses. The method has the versatility of being applicable to the analysis of rather general and complex structures built of distinct components and materials, such as found in aircraft design. For these types of structures, the smoothing is achieved with 'patches', each patch covering the domain in which the smoothed quantity is physically continuous

Cognitive correlates of pragmatic language comprehension in adult traumatic brain injury: A systematic review and meta-analyses

Effective pragmatic comprehension of language is critical for successful communication and interaction, but this ability is routinely impaired following Traumatic Brain Injury (TBI) [1,2]. Individual studies have investigated the cognitive domains associated with impaired pragmatic comprehension, but there remains little understanding of the relative importance of these domains in contributing to pragmatic comprehension impairment following TBI. This paper presents a systematic meta-analytic review of the observed correlations between pragmatic comprehension and cognitive processes following TBI. Five meta-analyses were computed, which quantified the relationship between pragmatic comprehension and five key cognitive constructs (declarative memory; working memory; attention; executive functions; social cognition). Significant moderate-to-strong correlations were found between all cognitive measures and pragmatic comprehension, where declarative memory was the strongest correlate. Thus, our findings indicate that pragmatic comprehension in TBI is associated with an array of domain general cognitive processes, and as such deficits in these cognitive domains may underlie pragmatic comprehension difficulties following TBI. The clinical implications of these findings are discussed

Free-Range Pre-Programmed RC Car

There is a growing interest in the capabilities and utilization of autonomous vehicles. The objective of this project is to design a small scale illustration of an autonomous vehicle driven by user input. An application will be designed that will allow a user to create a track that an RC car will accurately follow. As the car follows the track, a microcontroller on the vehicle will send movement information back to the application. This information is used by the application to process where the vehicle is currently at and where it needs to go. While in motion, on-board sensors will actively detect obstacles in the path and adjust the vehicle’s direction to avoid collision

Thermodynamic restrictions on evolutionary optimization of transcription factor proteins

Conformational fluctuations are believed to play an important role in the process by which transcription factor proteins locate and bind their target site on the genome of a bacterium. Using a simple model, we show that the binding time can be minimized, under selective pressure, by adjusting the spectrum of conformational states so that the fraction of time spent in more mobile conformations is matched with the target recognition rate. The associated optimal binding time is then within an order of magnitude of the limiting binding time imposed by thermodynamics, corresponding to an idealized protein with instant target recognition. Numerical estimates suggest that typical bacteria operate in this regime of optimized conformational fluctuations

Three-Dimensional Geometric Analysis of Felid Limb Bone Allometry

Studies of bone allometry typically use simple measurements taken in a small number of locations per bone; often the midshaft diameter or joint surface area is compared to body mass or bone length. However, bones must fulfil multiple roles simultaneously with minimum cost to the animal while meeting the structural requirements imposed by behaviour and locomotion, and not exceeding its capacity for adaptation and repair. We use entire bone volumes from the forelimbs and hindlimbs of Felidae (cats) to investigate regional complexities in bone allometry.Computed tomographic (CT) images (16435 slices in 116 stacks) were made of 9 limb bones from each of 13 individuals of 9 feline species ranging in size from domestic cat (Felis catus) to tiger (Panthera tigris). Eleven geometric parameters were calculated for every CT slice and scaling exponents calculated at 5% increments along the entire length of each bone. Three-dimensional moments of inertia were calculated for each bone volume, and spherical radii were measured in the glenoid cavity, humeral head and femoral head. Allometry of the midshaft, moments of inertia and joint radii were determined. Allometry was highly variable and related to local bone function, with joint surfaces and muscle attachment sites generally showing stronger positive allometry than the midshaft.Examining whole bones revealed that bone allometry is strongly affected by regional variations in bone function, presumably through mechanical effects on bone modelling. Bone's phenotypic plasticity may be an advantage during rapid evolutionary divergence by allowing exploitation of the full size range that a morphotype can occupy. Felids show bone allometry rather than postural change across their size range, unlike similar-sized animals

Adult-onset Alexander disease with typical "tadpole" brainstem atrophy and unusual bilateral basal ganglia involvement: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Alexander disease (ALX) is a rare neurological disorder characterized by white matter degeneration and cytoplasmic inclusions in astrocytes called Rosenthal fibers, labeled by antibodies against glial fibrillary acidic protein (GFAP). Three subtypes are distinguished according to age at onset: infantile (under age 2), juvenile (age 2 to 12) and adult (over age 12). Following the identification of heterozygous mutations in <it>GFAP </it>that cause this disease, cases of adult-onset ALX have been increasingly reported.</p> <p>Case Presentation</p> <p>We present a 60-year-old Japanese man with an unremarkable past and no family history of ALX. After head trauma in a traffic accident at the age of 46, his character changed, and dementia and dysarthria developed, but he remained independent. Spastic paresis and dysphagia were observed at age 57 and 59, respectively, and worsened progressively. Neurological examination at the age of 60 revealed dementia, pseudobulbar palsy, left-side predominant spastic tetraparesis, axial rigidity, bradykinesia and gaze-evoked nystagmus. Brain MRI showed tadpole-like atrophy of the brainstem, caused by marked atrophy of the medulla oblongata, cervical spinal cord and midbrain tegmentum, with an intact pontine base. Analysis of the <it>GFAP </it>gene revealed a heterozygous missense mutation, c.827G>T, p.R276L, which was already shown to be pathogenic in a case of pathologically proven hereditary adult-onset ALX.</p> <p>Conclusion</p> <p>The typical tadpole-like appearance of the brainstem is strongly suggestive of adult-onset ALX, and should lead to a genetic investigation of the <it>GFAP </it>gene. The unusual feature of this patient is the symmetrical involvement of the basal ganglia, which is rarely observed in the adult form of the disease. More patients must be examined to confirm, clinically and neuroradiologically, extrapyramidal involvement of the basal ganglia in adult-onset ALX.</p