NASA/ESA CT-990 Spacelab simulation. Appendix A: The experiment operator

A joint NASA/ESA endeavor was established to conduct an extensive spacelab simulation using the NASA CV-990 airborne laboratory. The scientific payload was selected to perform studies in upper atmospheric physics and infrared astronomy with principal investigators from France, the Netherlands, England, and several groups from the United States. Two experiment operators from Europe and two from the U.S. were selected to live aboard the aircraft along with a mission manager for a six-day period and operate the experiments in behalf of the principal scientists. This appendix discusses the experiment operators and their relationship to the joint mission under the following general headings: selection criteria, training programs, and performance. The performance of the proxy operators was assessed in terms of adequacy of training, amount of scientific data obtained, quality of data obtained, and reactions to problems that arose in experiment operation

NASA/ESACV-990 spacelab simulation. Appendix B: Experiment development and performance

Eight experiments flown on the CV-990 airborne laboratory during the NASA/ESA joint Spacelab simulation mission are described in terms of their physical arrangement in the aircraft, their scientific objectives, developmental considerations dictated by mission requirements, checkout, integration into the aircraft, and the inflight operation and performance of the experiments

Spacelab simulation using a Lear Jet aircraft: Mission no. 4 (ASSESS program)

The fourth ASSESS Spacelab simulation mission utilizing a Lear Jet aircraft featured trained experiment operators (EOs) in place of the participating scientists, to simulate the role and functions of payload specialists in Spacelab who may conduct experiments developed by other scientists. The experiment was a broadband infrared photometer coupled to a 30-cm, open port, IR telescope. No compromises in equipment design or target selection were made to simplify operator tasks; the science goals of the mission were selected to advance the mainline research program of the principle investigator (PI). Training of the EOs was the responsibility of the PI team and consisted of laboratory sessions, on-site training during experiment integration, and integrated mission training using the aircraft as a high-fidelity simulator. The EO permission experience in these several disciplines proved adequate for normal experiment operations, but marginal for the identification and remedy of equipment malfunctions. During the mission, the PI utilized a TV communication system to assist the EOs to overcome equipment difficulties; both science and operations were successfully implemented

Study of airborne science experiment management concepts for application to space shuttle. Volume 1: Executive summary

The management concepts and operating procedures are documented as they apply to the planning of shuttle spacelab operations. Areas discussed include: airborne missions; formulation of missions; management procedures; experimenter involvement; experiment development and performance; data handling; safety procedures; and applications to shuttle spacelab planning. Characteristics of the airborne science experience are listed, and references and figures are included

Shuttle spacelab simulation using a Lear jet aircraft: Mission no. 3 (ASSESS program)

The third ASSESS mission using a Lear Jet aircraft conducted to continue the study of scientific experiment operations in a simulated Spacelab environment. Prior to the mission, research planning and equipment preparation were observed and documented. A flight readiness review for the experiment was conducted. Nine of the ten scheduled flights were completed during simulation mission and all major science objectives were accomplished. The equipment was well qualified for flight and gave little trouble; telescope malfunctions occurred early in the mission and were corrected. Both real-time and post-observation data evaluation were used to assess research progress and to plan subsequent flight observations for maximum effectiveness

Study of airborne science experiment management concepts for application to space shuttle. Volume 3: Appendixes

Detailed information is presented concerning specific airborne missions in support of the ASSESS program. These missions are the AIDJEX expeditions, meteor shower expeditions, CAT and atmospheric sampling missions, ocean color expeditions, and the Lear Jet missions. For Vol. 2, see N73-31729

Modelling and filtering almost periodic signals by time-varying fourier series with application to near-infrared spectroscopy

We propose a new approach to modelling almost periodic signals and to model-based estimation of such signals from noisy observations. The signal model is based on Fourier series where both the coefficients and the fundamental frequency can continuously change over time. This signal model can be represented by a factor graph which we use to derive message passing algorithms to estimate the time-dependent model parameters from the observed samples

Chikungunya as a cause of acute febrile illness in southern Sri Lanka

10.1371/journal.pone.0082259PLoS ONE812-POLN

The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes

Background: The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10–15%, and neurological sequelae in 30– 50% of cases. Infections can be attributable to nosocomial sources, however the pre-colonisation of enteral feeding tubes has not been considered as a specific risk factor. Methods: Thirty E. coli strains, which had been isolated in an earlier study, from the residual lumen liquid and biofilms of neonatal nasogastric feeding tubes were genotyped using pulsed-field gel electrophoresis, and 7-loci multilocus sequence typing. Potential pathogenicity and biofilm associated traits were determined using specific PCR probes, genome analysis, and in vitro tissue culture assays. Results: The E. coli strains clustered into five pulsotypes, which were genotyped as sequence types (ST) 95, 73, 127, 394 and 2076 (Achman scheme). The extra-intestinal pathogenic E. coli (ExPEC) phylogenetic group B2 ST95 serotype O1:K1:NM strains had been isolated over a 2 week period from 11 neonates who were on different feeding regimes. The E. coli K1 ST95 strains encoded for various virulence traits associated with neonatal meningitis and extracellular matrix formation. These strains attached and invaded intestinal, and both human and rat brain cell lines, and persisted for 48 h in U937 macrophages. E. coli STs 73, 394 and 2076 also persisted in macrophages and invaded Caco-2 and human brain cells, but only ST394 invaded rat brain cells. E. coli ST127 was notable as it did not invade any cell lines. Conclusions: Routes by which E. coli K1 can be disseminated within a neonatal intensive care unit are uncertain, however the colonisation of neonatal enteral feeding tubes may be one reservoir source which could constitute a serious health risk to neonates following ingestion