NEUROPHYSIOLOGICAL AND BEHAVIOURAL PERTURBATIONS IN Caenorhabditis elegans EXPOSED TO ORGANOPHOSPHATE PESTICIDES

The ubiquitous use of pesticides all over the world leads to adverse effects on both targets as well as non-target species. The extensive and uncontrolled use of organophosphates (OPs), a large group of pesticidal compounds in agricultural and household products are resulting in high exposure to humans.  This research has been carried out to study the adverse effect of OPs i.e., chlorpyrifos, trichlorfon, and disulfoton on model organism Caenorhabditis elegans to evaluate their behavioural as well as developmental toxicity at different time intervals i.e., 4, 24, 48, and 72 hours (hrs) of exposure. A significant difference was observed in all the behavioural endpoints like locomotion, egg-laying, offspring count, and learning along with developmental parameters like mortality, paralysis, and growth rendering from moderate to high toxic effects. Based on the above screening, trichlorfon resulted in glutamatergic and cholinergic neurodegeneration along with elevated autofluorescence. Loss in Yellow fluorescent Protein (YFP) and Green Fluorescent Protein (GFP) was recorded by 57.96% and 30.52% using transgenic strains OH11124 (otIs388 [eat-4(fosmid)::SL2::YFP::H2B + (pBX)pha-1(+)] III) and OH13083 (otIs576 [unc-17(fosmid)::GFP + lin-44::YFP]). These results have shown the biological potency of toxicants in C. elegans and pave the way forward to provide insight into various neurogenerative diseases in humans

Cultivating Relationship With Tourists: Role of Public Relations in Constructing and Promoting Authentic Experiences

This study examined the role of public relations in communicating authentic experiences to cultivate long-term relationships with tourists. Focus group and interviews were conducted with 11 public relations practitioners of a cultural and eco-archaeological theme park in Mexico to understand their role and responsibilities in developing and promoting the park’s image that fosters perceptions of an authentic tourism experience. Additionally, the study analyzed survey data collected from 545 tourists to evaluate their attitudes and opinions about the park’s image and authenticity. Variations in perceived authenticity with demographics, visit characteristics, and information sources were also examined. Findings revealed that a destination’s image is a significant predictor of its perceived authenticity, which in turn positively influences visitors’ trust, satisfaction, and commitment with the destination

Personality and Education Mining based Job Advisory System

Every job demands an employee with some specific qualities in addition to the basic educational qualification. For example, an introvert person cannot be a good leader despite of a very good academic qualification. Thinking and logical ability is required for a person to be a successful software engineer. So, the aim of this paper is to present a novel approach for advising an ideal job to the job seeker while considering his personality trait and educational qualification both. Very well-known theories of personality like MBTI indicator and OCEAN theory, are used for personality mining. For education mining, score based system is used. The score based system captures the information from attributes like most scoring subject, dream job etc. After personality mining, the resultant values are coalesced with the information extracted from education mining. And finally, the most suited jobs, in terms of personality and educational qualification are recommended to the job seekers. The experiment is conducted on the students who have earned an engineering degree in the field of computer science, information technology and electronics. Nevertheless, the same architecture can easily be extended to other educational degrees also. To the best of the author’s knowledge, this is a first e-job advisory system that recommends the job best suited as per one’s personality using MBTI and OCEAN theory both

Delivering Higher Value Through Higher Performance: Insights On Performance Evaluation And Talent Management In Corporate Communication

This study explored the current state of performance evaluation and talent management in corporate communication from the perspective of senior communication leaders including the members of the Arthur W. Page society. The findings of a national survey underscore several opportunities for communication leaders to elevate performance and importance of their function. In addition to actionable insights, key trends and best practices in measuring communication effectiveness, the study also concludes with recommendations on developing high performing teams that also deliver higher value

Evaluation of the incidence, risk factors, severity, and outcome of hydrocephalic fetuses in a tertiary healthcare center located in Northern India: a prospective observational study

Background: Hydrocephalus is a heterogeneous disease marked by abnormal dilatation of the cerebral ventricles secondary to varying etiologies. This study was aimed to determine the incidence, risk factors, severity, and outcome of hydrocephalic fetuses presenting to a tertiary healthcare hospital located in northern India.Methods: In this prospective observational study, pregnant women visiting the obstetrics outpatient department of our hospital from 01 July 2017 to 31 June 2018 were screened for hydrocephalic fetuses via ultrasonography along with a detailed history, and a comprehensive battery of diagnostic investigations. They were followed up for a minimum period of two months after delivery/termination of pregnancy.Results: A total of 3627 pregnant women were screened, of which 10 had hydrocephalic fetuses in the observed time period. The incidence of hydrocephalus was determined to be 2.75 per 1000 live births. Low socio-economic status was identified as a major risk factor. 50% of the hydrocephalic fetuses were severely afflicted and were discontinued. The remaining 50% were successfully delivered and were managed via a ventriculo-peritoneal shunt or are under close observation in the postnatal period without any adverse outcome.Conclusions: The burden of hydrocephalus is considerably high in India, as compared to western countries. In rural settings, low socioeconomic status and lack of folic acid supplementation have a major influence in the etiopathogenesis of hydrocephalus. Management of hydrocephalus requires a multidisciplinary approach and is tailored according to the severity of the presentation. Severe cases of hydrocephalus and cases with associated anomalies have a poor prognosis

The Revival of an Old Assailant with Oral Implications

Syphilis is among the primogenital documented sexually transmitted diseases (STD). In the past decade, its incidence has levitated significantly in the urbanized world. Oral syphilitic lesions, the most common extragenital insignia of infection, pose a diagnostic challenge to dentists, who are frequently the first to observe them. Oral lesions in secondary stage syphilis are particularly common in association with general symptoms and cutaneous eruptions. However, an exclusive oral localization, not associated with general manifestations, is uncommon. We report a case of a 19-year-old male patient with isolated oral ulceration as the sole presentation of secondary syphilis

The SunPy Project: Open Source Development and Status of the Version 1.0 Core Package

The goal of the SunPy project is to facilitate and promote the use and development of community-led, free, and open source data analysis software for solar physics based on the scientific Python environment. The project achieves this goal by developing and maintaining the sunpy core package and supporting an ecosystem of affiliated packages. This paper describes the first official stable release (version 1.0) of the core package, as well as the project organization and infrastructure. This paper concludes with a discussion of the future of the SunPy project

Imaging in Diabetes Mellitus

Diabetes mellitus [DM] is the commonest endocrine disorder encountered in the clinical practice. It in fact, comprises of multiple disorders that manifest in the form of hyperglycemia. It is a multisystem disorder with pathophysiologic changes occurring in almost all the major systems and organs of the human body resulting in serious physical and mental disturbances and also posing tremendous burden on the health care resources of the country. The common sites of involvement include cardiovascular system, nervous system (central and peripheral), eyes, gastrointestinal system, genitourinary system, nasal and paranasal sinus region, hepatopancreatobiliary system, etc. Radiological manifestations are directly proportional to the duration and severity of involvement of the various systems. Various imaging (diagnostic and invasive) techniques can be used to detect the various manifestations as well as subsequent complications occurring during the course of disease. The following imaging techniques can be utilized for the purpose of evaluating the patients of DM: • Radiography&nbsp; • Special investigations • Ultrasonography (USG) and color doppler study (including echocardiography – ECHO]• Computed tomography (CT)• Magnetic resonance imaging (MRI)• Radionuclide scintigraphy (including single photon emission computed tomography – SPECT)</p

Personality and Education Mining based Job Advisory System

Every job demands an employee with some specific qualities in addition to the basic educational qualification. For example, an introvert person cannot be a good leader despite of a very good academic qualification. Thinking and logical ability is required for a person to be a successful software engineer. So, the aim of this paper is to present a novel approach for advising an ideal job to the job seeker while considering his personality trait and educational qualification both. Very well-known theories of personality like MBTI indicator and OCEAN theory, are used for personality mining. For education mining, score based system is used. The score based system captures the information from attributes like most scoring subject, dream job etc. After personality mining, the resultant values are coalesced with the information extracted from education mining. And finally, the most suited jobs, in terms of personality and educational qualification are recommended to the job seekers. The experiment is conducted on the students who have earned an engineering degree in the field of computer science, information technology and electronics. Nevertheless, the same architecture can easily be extended to other educational degrees also. To the best of the author�s knowledge, this is a first e-job advisory system that recommends the job best suited as per one�s personality using MBTI and OCEAN theory both