705 research outputs found
Fano versus Kondo Resonances in a Multilevel "Semi-Open" Quantum Dot
Linear conductance across a large quantum dot via a single level e_0 with
large hybridization to the contacts is strongly sensitive to quasi-bound states
localized in the dot and weakly coupled to e_0. It oscillates with the gate
voltage due to interference of the Fano type. At low temperature and Coulomb
blockade, Kondo correlations damp the oscillations on an extended range of gate
voltage values, by freezing the occupancy of the e_0 level itself. As a
consequence, antiresonances of Fano origin are washed out. The results are in
good correspondence with experimental data for a large quantum dot in the
semi-open regime.Comment: 4 eps figures, RevTex format, revised version, to appear in Phys.
Rev. Letter
On Type IIA geometries dual to N = 2 SCFTs
We provide explicit solutions of Type IIA supergravity which are believed to
be dual to N = 2 superconformal four dimensional gauge theories. These explicit
solutions are based on the general ansatz for such a type of backgrounds
introduced by Gaiotto and Maldacena.Comment: 23 pages, 10 figures; minor corrections, references correcte
Open Semiclassical Strings and Long Defect Operators in AdS/dCFT Correspondence
We consider defect composite operators in a defect superconformal field
theory obtained by inserting an AdS_4 x S^2-brane in the AdS_5 x S^5
background. The one-loop dilatation operator for the scalar sector is
represented by an integrable open spin chain. We give a description to
construct coherent states for the open spin chain. Then, by evaluating the
expectation value of the Hamiltonian with the coherent states in a long
operator limit, a Landau-Lifshitz type of sigma model action is obtained. This
action is also derived from the string action and hence we find a complete
agreement in both SYM and string sides. We see that an SO(3)_H pulsating string
solution is included in the action and its energy completely agrees with the
result calculated in a different method. In addition, we argue that our
procedure would be applicable to other AdS-brane cases.Comment: 22 pages, 1 figure, LaTeX, minor corrections and references added.
v3) some new results added. shortened and accepted version in PR
A new, universal Series Hybrid Cascaded H-Bridge Converter for Power-Hardware in the Loop Emulation
A standardized and modular power electronics platform for academic research on advanced grid-connected converter control and microgrids
This paper introduces a multifunctional converter platform rated at 30kW. Individual units allow research on advanced grid-connected converter control, while their interconnection enables isolated microgrid investigations. The standardized and modular design allows simple reconfiguration of the system for different setups, for which multiple measurements are presented
Causal effects of PetroCaribe on sustainable development: a synthetic control analysis
We examine the causal effects of the energy subsidy programme PetroCaribe in the three dimensions of sustainable development: economic, social and environmental. We use the synthetic control method to construct a counterfactual and compare it to the outcomes of the beneficiary countries and thus estimate the magnitude and direction of the PetroCaribe effect. PetroCaribe had a positive effect on economic growth in most of the beneficiary countries; however, this economic boost was not followed by an improvement in social development. Environmentally, PetroCaribe did not negatively or positively impact the environmental quality of the member countries, in the sense that we do not find a significant effect on the trend of urn:x-wiley:14636786:media:manc12275:manc12275-math-0001 emissions per capita
APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells
Chemoresistance is one of the leading causes of cancer-related deaths in the United States. Triple negative breast cancer (TNBC), a subtype lacking the known breast cancer receptors used for targeted therapy, is reliant on chemotherapy as the standard of care. The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in 70% of sporadic breast cancers with APC-deficient tumors resembling the TNBC subtype. Using mammary tumor cells from the ApcMin/+ mouse model crossed to the Polyoma middle T antigen (PyMT) transgenic model, we previously showed that APC loss decreased sensitivity to doxorubicin (DOX). Understanding the molecular basis for chemoresistance is essential for the advancement of novel therapeutic approaches to ultimately improve patient outcomes. Resistance can be caused via different methods, but here we focus on the DNA repair response with DOX treatment. We show that MMTV-PyMT;ApcMin/+ cells have decreased DNA damage following 24 hour DOX treatment compared to MMTV-PyMT;Apc+/+ cells. This decreased damage is first observed 24 hours post-treatment and continues throughout 24 hours of drug recovery. Activation of DNA damage response pathways (ATM, Chk1, and Chk2) are decreased at 24 hours DOX-treatment in MMTV-PyMT;ApcMin/+ cells compared to control cells, but show activation at earlier time points. Using inhibitors that target DNA damage repair kinases (ATM, ATR, and DNA-PK), we showed that ATM and DNA-PK inhibition increased DOX-induced apoptosis in the MMTV-PyMT;ApcMin/+ cells. In the current work, we demonstrated that APC loss imparts resistance through decreased DNA damage response, which can be attenuated through DNA repair inhibition, suggesting the potential clinical use of DNA repair inhibitions as combination therapy
- …