Les prédicteurs dynamiques stables associés à la récidive des délinquants sexuels sous juridiction fédérale

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Premières expériences cliniques en formation médicale : entre éthique clinique et pédagogie médicale

La nature éthique intrinsèque de la pratique médicale procure à l’éthique clinique une place essentielle dans le cursus des étudiants au doctorat en médecine. La faculté de médecine de l’Université de Montréal a donc récemment introduit des ateliers de discussion et d’écriture sur des situations complexes vécues pendant les premiers stages d’externat. Ce projet de maîtrise consiste en une analyse thématique des textes rédigés par les étudiants. Nous avons ainsi répertorié les principaux enjeux éthiques rapportés, en avons fait un portrait quantitatif et nous avons analysé ce que provoquait le vécu de ces situations complexes chez les étudiants grâce à l’interrogation des passages narratifs de leurs récits. Les étudiants sont confrontés à des situations complexes liées à la communication, au consentement et à l’autonomie des patients, à la justice ou encore à la déontologie. Une proportion significative des enjeux décrits sont spécifiques à leur statut d’étudiant, c’est-à-dire ceux liés à l’apprentissage et à l’autorité. Nous avons également documenté que leur vécu des situations se traduit par des sentiments et de l’émotivité, par l’adoption d’une posture critique sur les événements, des descriptions du rôle qu’ils ont joué, des propositions et solutions ainsi que des réflexions sur l’impact qu’on eues sur eux ces situations. Nos résultats démontrent que le rôle de l’externe dans le milieu hospitalier demeure très hiérarchique, ce qui est à la source de plusieurs situations complexes et influence leur vécu et leur façon de réagir à celles-ci. Nos constats suggèrent que les thèmes répertoriés ainsi que la façon dont les étudiants en discutent sont en partie le reflet de la formation reçue, qui contribue notamment à l’omniprésence du souci pour le meilleur intérêt du patient retrouvé dans les vignettes. Finalement, l’introspection générée par la rédaction de tels travaux est d’une grande richesse pour la formation éthique, professionnelle et personnelle des étudiants. Il est essentiel de continuer à s’intéresser aux enjeux éthiques spécifiques aux étudiants, d’être sensibles à la détresse qu’ils peuvent engendrer et de provoquer davantage de situations de discussions de nature éthique pendant et après la formation.The intrinsic ethical nature of medical practice makes clinical ethics an essential part of the medical school curriculum. The Faculty of medicine of the University of Montréal has recently introduced discussion and writing workshops on complex situations experienced by students during their first clinical rotations. This project is a qualitative thematic analysis of the students’ writings. We have listed the main ethical issues retrieved, have reported them quantitatively and have analyzed what was experienced by students while going through these complex situations by focusing on narrative passages of their stories. Students face ethical dilemmas related to communication, consent and autonomy of patients, justice or deontology. A significant proportion of the issues are specific to their student status, namely issues related to learning and authority. We have also documented that their personal experiences with complex situations are conveyed by discussion about feelings and emotions, by adopting a critical stance on events, by naming the role they have played in the case, by putting forth solutions, and by reflecting on the impact that these situations have had on them. Our results show that the students’ status in hospitals remains very hierarchical, which entails several complex situations and influences their experience and how they react to them. Our findings suggest that the themes identified and the way in which the students discuss them partly reflect their medical education, which among others stands for the universal concern for patients’ best interest observed through their works. Finally, the introspection generated by such narratives is of great interest for students’ ethical, professional and personal growth. It is important that students’ specific ethical dilemmas and the distress they can engender remain an ongoing concern, and we need to make even more room for ethical discussions and writings during and after medical training

Evaluation of intensive versus standard blood pressure reduction and association with cognitive decline and dementia : a systematic review and metaAnalysis

Importance: Optimal blood pressure (BP) targets for the prevention of cognitive impairment remain uncertain. Objective: To explore the association of intensive (i.e. lower than usual) BP reduction compared to guidelines on the incidence of cognitive decline and dementia in adults with hypertension. Data Sources and Study Selection: We conducted a systematic review and meta-analysis of randomized controlled trials that evaluated the association of intensive systolic BP lowering on cognitive outcomes by searching MEDLINE, Embase, CENTRAL, Web of Science, CINAHL, PsycINFO, ICTRP and ClinicalTrials.gov for data up to October 27, 2020. Data Extraction and Synthesis: Data screening and extraction were performed independently by two reviewers based on PRISMA guidelines. The risk of bias was assessed using the Cochrane risk-of-bias 2 tool. We used random-effects models using the inverse variance method for our pooled analyses. We evaluated the presence of potential heterogeneity with the I2 index. Main Outcomes and Measures: Our primary outcome was cognitive decline. Secondary outcomes included the incidence of dementia, mild cognitive impairment (MCI), cerebrovascular events, serious adverse events, and all-cause mortality. Results: From 7,755 citations, we identified sixteen publications from five trials (17,396 participants, mean age 65.7 years, 60.5% males) and two additional ongoing trials. All five trials included in quantitative analyses were considered at unclear to high risk of bias. The mean followup duration was 3.3 years (range 2.0 to 4.7 years). Intensive BP reduction was not significantly associated with global cognitive performance (SMD 0.01, 95% CI -0.04 to 0.06, I2 = 0%, four trials, 5,246 patients), incidence of dementia (RR 1.09, 95% CI 0.32 to 3.67, I2 = 27%, two trials, 9,444 patients) or incidence of MCI (RR 0.91, 95% CI 0.73 to 1.14, I2 = 74%, two trials, 10,774 patients) when compared to standard treatment. However, we found a reduction of cerebrovascular events in the intensive arm (RR 0.79, 95% CI 0.67-0.93, I2 = 0%, five trials, 17,396 patients) without an increased risk of serious adverse events or mortality. Conclusions and Relevance: We did not detect a significant association between BP reduction and lower risk of cognitive decline, dementia or MCI. The certainty of this evidence is low due to the limited sample size, the risk of bias of included trials and the observed statistical heterogeneity. Hence, current available evidence does not justify the use of lower BP targets for the prevention of cognitive decline and dementi

Comparing the intestinal transcriptome of Meishan and Large White piglets during late fetal development reveals genes involved in glucose and lipid metabolism and immunity as valuable clues of intestinal maturity

Background: Maturity of intestinal functions is critical for neonatal health and survival, but comprehensive description of mechanisms underlying intestinal maturation that occur during late gestation still remain poorly characterized. The aim of this study was to investigate biological processes specifically involved in intestinal maturation by comparing fetal jejunal transcriptomes of two representative porcine breeds (Large White, LW; Meishan, MS) with contrasting neonatal vitality and maturity, at two key time points during late gestation (gestational days 90 and 110). MS and LW sows inseminated with mixed semen (from breed LW and MS) gave birth to both purebred and crossbred fetuses. We hypothesized that part of the differences in neonatal maturity between the two breeds results from distinct developmental profiles of the fetal intestine during late gestation. Reciprocal crossed fetuses were used to analyze the effect of parental genome. Transcriptomic data and 23 phenotypic variables known to be associated with maturity trait were integrated using multivariate analysis with expectation of identifying relevant genes-phenotypic variable relationships involved in intestinal maturation. Results: A moderate maternal genotype effect, but no paternal genotype effect, was observed on offspring intestinal maturation. Four hundred and four differentially expressed probes, corresponding to 274 differentially expressed genes (DEGs), more specifically involved in the maturation process were further studied. In day 110-MS fetuses, Ingenuity® functional enrichment analysis revealed that 46% of DEGs were involved in glucose and lipid metabolism, cell proliferation, vasculogenesis and hormone synthesis compared to day 90-MS fetuses. Expression of genes involved in immune pathways including phagocytosis, inflammation and defense processes was changed in day 110-LW compared to day 90-LW fetuses (corresponding to 13% of DEGs). The transcriptional regulator PPARGC1A was predicted to be an important regulator of differentially expressed genes in MS. Fetal blood fructose level, intestinal lactase activity and villous height were the best predicted phenotypic variables with probes mostly involved in lipid metabolism, carbohydrate metabolism and cellular movement biological pathways. [b]Conclusions[/b]: Collectively, our findings indicate that the neonatal maturity of pig intestine may rely on functional development of glucose and lipid metabolisms, immune phagocyte differentiation and inflammatory pathways. This process may partially be governed by PPARGC1A

Cómo evitar el déficit nutricional de las cerdas lactantes

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Importance of colostrum in relation to piglet survival

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Importance of colostrum production in relation to piglet performance

International audienc

Le colostrum porcin : rôles, quantité et qualité

International audienceColostrum provides the piglet with energy, passive immunity and growth factors essential for its survival, development and health. It also provides cells and numerous compounds for which the roles are currently unknown. There are many ways to improve the composition of colostrum. In particular, various ingredients with immunomodulatory properties (such as fish oils, pre- or probiotics) have been shown to increase the immunoglobulin content of colostrum and piglets. However, strategies to increase colostrum volume are still scarce, although it appears that the sow feeding system at the end of gestation could influence it.Le colostrum fournit au porcelet de l’énergie, une immunité passive et des facteurs de croissance indispensables à sa survie, son développement et sa santé. Il apporte aussi des cellules et de nombreux composés dont les rôles ne sont pas tous connus. De nombreuses pistes existent pour améliorer la composition du colostrum. Notamment, différents ingrédients qui auraient des propriétés immunomodulatrices (comme des huiles de poisson, des pré- ou probiotiques) ont augmenté les teneurs en immunoglobulines du colostrum et des porcelets. En revanche, les stratégies pour augmenter le volume de colostrum sont encore rares, même s’il semble que l’alimentation des truies en fin de gestation pourrait l’influencer