Observation of the rare decay B+ -> K+π0π0 and measurement of the quasi-two-body contributions B+ -> K*(892)+π0, B+ -> f0(980)K+, and B+ -> χc0K+

We report an analysis of charmless hadronic decays of charged B mesons to the final state K(+) pi(0)pi(0), using a data sample of (470.9 +/- 2.8) x 10(6) B (B) over bar events collected with the BABAR detector at the Y(4S) resonance. We observe an excess of signal events, with a significance above 10 standard deviations including systematic uncertainties, and measure the branching fraction and CP asymmetry to be B(B(+) -> K(+) pi(0)pi(0)) = (16.2 +/- 1.2 +/- 1.5) x 10(-6) and A(CP)(B(+) -> K(+) pi(0)pi(0)) = -0.06 +/- 0.06 +/- 0.04, where the uncertainties are statistical and systematic, respectively. Additionally, we study the contributions of the B(+) -> K*(892)(+) pi(0), B(+) -> f(0)(980)K(+), and B(+) -> chi(c0)K(+) quasi-two-body decays. We report the world's best measurements of the branching fraction and CP asymmetry of the B(+) -> K(+) pi(0)pi(0) and B(+) -> K(+)(892)(+) pi(0) channels

Fibre Monitoring System for the Beam Permit Loops at the LHC and Future Evolution of the Beam Interlock System

The optical fibres that transmit the beam permit loop signals at the CERN accelerator complex are deployed along radiation areas. This may result in increased attenuation of the fibres, which reduces the power margin of the links. In addition, other events may cause the links to not function properly and result in false dumps, reducing the availability of the accelerator chain and affecting physics data taking. In order to evaluate the state of the fibres, an out-of-band fibre monitoring system is proposed, working in parallel to the actual beam permit loops. The future beam interlock system to be deployed during LHC long shutdown 2 will implement online, real-time monitoring of the fibres, a feature the current system lacks. Commercial off-the-shelf components to implement the optical transceivers are proposed whenever possible instead of ad-hoc designs.Comment: Presented in IPAC 201

Examination of coalescence as the origin of nuclei in hadronic collisions

The origin of weakly bound nuclear clusters in hadronic collisions is a key question to be addressed by heavy-ion collision (HIC) experiments. The measured yields of clusters are approximately consistent with expectations from phenomenological statistical hadronization models (SHMs), but a theoretical understanding of the dynamics of cluster formation prior to kinetic freeze-out is lacking. The competing model is nuclear coalescence, which attributes cluster formation to the effect of final state interactions (FSI) during the propagation of the nuclei from kinetic freeze-out to the observer. This phenomenon is closely related to the effect of FSI in imprinting femtoscopic correlations between continuum pairs of particles at small relative momentum difference. We give a concise theoretical derivation of the coalescence-correlation relation, predicting nuclear cluster spectra from femtoscopic measurements. We review the fact that coalescence derives from a relativistic Bethe-Salpeter equation, and recall how effective quantum mechanics controls the dynamics of cluster particles that are nonrelativistic in the cluster center-of-mass frame. We demonstrate that the coalescence-correlation relation is roughly consistent with the observed cluster spectra in systems ranging from PbPb to pPb and pp collisions. Paying special attention to nuclear wave functions, we derive the coalescence prediction for the hypertriton and show that it, too, is roughly consistent with the data. Our work motivates a combined experimental programme addressing femtoscopy and cluster production under a unified framework. Upcoming pp, pPb, and peripheral PbPb data analyzed within such a program could stringently test coalescence as the origin of clusters

A techno-economic approach for decision-making in metal additive manufacturing: metal extrusion versus single and multiple laser powder bed fusion

This work presents a decision-making methodology that allows the merging of quantitative and qualitative decision variables for selecting the optimal metal Additive Manufacturing (AM) technology. The approach is applied on two competing technologies in the field of metal AM industry, i.e., the metal extrusion AM process (metal FFF) and the Laser Powder Bed Fusion process (LPBF) with single and multiple lasers, which represent the benchmark solution currently on the market. A comprehensive techno-economical comparison is presented where the two processes are analysed in terms of process capabilities (quality, easiness of use, setup time, range of possible materials, etc.) and costs, considering two different production scenarios and different parts’ geometries. In the first scenario, the AM system is assumed to be dedicated to one single part production while in this second scenario, the AM system is assumed to be saturated, as devoted to producing a wide mix of part types. For each scenario, two different part types made of 17–4 PH stainless steel are considered as a reference to investigate the effect of shape complexity, part size and production times to select the best technology when metal FFF and LPBF must be considered. The first part type refers to an extrusion die, to represent typical shapes of interest in the tooling industry, while the second part type is an impeller which can be used in many different industrial sectors, ranging from oil and gas to aerospace. In order to include quantitative and qualitative criteria, a decision-making model based on Analytic Hierarchy Process (AHP) is proposed as the enabler tool for decision making. The proposed approach allows to determine the most effective solution depending on the different production configurations and part types and can be used as a guideline and extended to include other technologies in the field of metal AM. On the other side, the critical discussion of the criteria selected, and the results achieved allow to highlight the pros and cons of the competing technologies, thus defining the existing limits to define directions for future research

ELVIS - ELectromagnetic Vector Information Sensor

The ELVIS instrument was recently proposed by the authors for the Indian Chandrayaan-1 mission to the Moon and is presently under consideration by the Indian Space Research Organisation (ISRO). The scientific objective of ELVIS is to explore the electromagnetic environment of the moon. ELVIS samples the full three-dimensional (3D) electric field vector, E(x,t), up to 18 MHz, with selective Nyqvist frequency bandwidths down to 5 kHz, and one component of the magnetic field vector, B(x,t), from a few Hz up to 100 kHz.As a transient detector, ELVIS is capable of detecting pulses with a minimum pulse width of 5 ns. The instrument comprises three orthogonal electric dipole antennas, one magnetic search coil antenna and a four-channel digital sampling system, utilising flexible digital down conversion and filtering together with state-of-the-art onboard digital signal processing.Comment: 8 pages, 3 figures. Submitted to the DGLR Int. Symposium "To Moon and Beyond", Bremen, Germany, 2005. Companion paper to arXiv:astro-ph/050921

Surface activated chemical ionization - Electrospray mass spectrometry in the analysis of urinary thiodiglycolic acid

RATIONALE Thiodiglycolic acid (TDGA) is a urinary metabolite of the oxazaphosphorine class of chemotherapeutics, in particular of ifosfamide. Ifosfamide metabolism generates chloroacetaldehyde (CAA), a toxic compound associated with neurotoxicity, nephrotoxicity, urotoxicity and cardiotoxicity. CAA, in turn, interacts with cellular thiol groups leading to GSH depletion, cell death and generation of thiodiglycolic acid (TDGA), as a final product. TDGA is mainly excreted in the urine. The ability to accurately measure TDGA in urine, therefore, will be a useful way of monitoring the ifosfamide exposure during chemotherapy. METHODS TDGA in urine samples was measured with liquid chromatograpy coupled to mass spectrometry (LC-MS) by means of a novel Surface Activated Chemical Ionization - Electrospray (SACI-ESI) or a classical ESI ion source alone. RESULTS The SACI - ESI and ESI alone based methods for analysis of urinary TDGA were optimized and compared. A strong reduction in matrix effect together with enhanced quantification performances was obtained with the SACI \u2013 ESI when compared with the ESI. In particular, an increase in quantification precision (from 85 to 95%) and accuracy (from 59 to 90%) were observed, which allowed for optimal detection of TDGA. CONCLUSIONS The LC-SACI-ESI-MS approach provides a very sensitive and quantitative method for the analysis of TDGA. Thanks to sensitivity enhancement and matrix effect reduction, the SACI \u2013 ESI enables the use of a relatively low cost ion-trap mass spectrometer in the analysis of this toxicity biomarker in urine. Due to these characteristics, this approach would constitutes an invaluable tool in the clinical laboratory, for measuring TDGA and other toxicity related biomarkers of chemotherapy with proper sensitivity and accuracy

Genomic and transcriptomic comparison between Staphylococcus aureus strains associated with high and low within herd prevalence of intra-mammary infection

Background: Staphylococcus aureus (Staph. aureus) is one of the major pathogens causing mastitis in dairy ruminants worldwide. The chronic nature of Staph. aureus infection enhances the contagiousness risk and diffusion in herds. In order to identify the factors involved in intra-mammary infection (IMI) and diffusion in dairy cows, we investigated the molecular characteristics of two groups of Staph. aureus strains belonging to ST8 and ST398, differing in clinical properties, through comparison of whole genome and whole transcriptome sequencing. Results: The two groups of strains, one originated from high IMI prevalence herds and the other from low IMI prevalence herds, present a peculiar set of genes and polymorphisms related to phenotypic features, such as bacterial invasion of mammary epithelial cells and host adaptation. Transcriptomic analysis supports the high propensity of ST8 strain to chronicity of infection and to a higher potential cytotoxicity. Conclusions: Our data are consistent with the invasiveness and host adaptation feature for the strains GTB/ST8 associated to high within-herd prevalence of mastitis. Variation in genes coding for surface exposed proteins and those associated to virulence and defence could constitute good targets for further research

Implicit theories of a desire for fame

The aim of the present studies was to generate implicit theories of a desire for fame among the general population. In Study 1, we were able to develop a nine-factor analytic model of conceptions of the desire to be famous that initially comprised nine separate factors; ambition, meaning derived through comparison with others, psychologically vulnerable, attention seeking, conceitedness, social access, altruistic, positive affect, and glamour. Analysis that sought to examine replicability among these factors suggested that three factors (altruistic, positive affect, and glamour) neither display factor congruence nor display adequate internal reliability. A second study examined the validity of these factors in predicting profiles of individuals who may desire fame. The findings from this study suggested that two of the nine factors (positive affect and altruism) could not be considered strong factors within the model. Overall, the findings suggest that implicit theories of a desire for fame comprise six factors. The discussion focuses on how an implicit model of a desire for fame might progress into formal theories of a desire for fame

Development of a biosensor for copper detection in aqueous solutions using an Anemonia sulcata recombinant GFP

Fluorescent proteins from marine organisms represent potential candidates for biosensor development. In this paper, we described the isolation of a native green fluorescent protein from Anemonia sulcata and the cloning and purification of its equivalent as a recombinant protein in Escherichia coli. Furthermore, the spectroscopic behaviours of the native and recombinant GFPs were investigated as a function of Cu2+, Cd2+, Pb 2+ and Ni2+ concentration. Our results suggest the high selectivity of both proteins at copper than the other metals and, for the recombinant protein, a great sensitivity at a very low concentration (0.1-1 μM). Moreover, starting from these data, using the combination of molecular biology techniques and optical setup, we developed a device for the detection of Cu2+ in water solutions. The quenching effect detected with the device showed that the relative attenuation of the signal (0.46±0.02 AU) was slightly larger than the data measured by fluorescence spectra (0.65±0.03 AU). The good sensitivity in the span of two orders of the magnitude of Cu2+ concentration, the fact that the instrument is made up of low-cost and sturdy parts and the selective quenching of rAsGFP to copper ions make this setup suited as a low cost, on-the-field, copper ion-specific biosensor. © 2013 Springer Science+Business Media