Multiwalength studies of star forming regions in the Magellanic Clouds

We present a multiwavelength study of several star forming regions in the LMC and SMC. Broad and narrowband IR imaging in conjunction with cold molecular emission of CO lines and mid IR imaging by ISO are providing us the data to define the massive star content and formation processes in low metallicity environments (1/3 to 1/10 solar) for comparison with Galactic star forming regions. Our multiwavelength studies show a clear correlation between the 2.12 μm H2, the 6.7 μm AIBs, and 230 GHz CO(2-1) emission as predicted by PDR models towards N66 in the SMC and 30 Doradus in the LMC. We have found IR embedded sources toward the peaks of the CO emission detected toward both HII regions. We find that the molecular gas that has not yet been photo dissociated by the UV radiation field of the O stars is in hot, dense clumps with very small filling factors. The distribution and morphology of the excited molecular gas in 30 Doradus as seen in the H2 line is clumpy with numerous knots while that of the ionized gas in the 2.16 μm Brγ emission shows a filamentary structure. The 6.7 μm images show a good correlation to the Br γ emission as expected for warm gas. Towards N11 and N159 in the LMC we have also found several IR embedded sources associated to the presence of cold molecular gas. These are seen in the interfaces between the molecular material and the HII regions. Thus, either induced or trigered star formation occurs in these interfaces producing a PDR region.Facultad de Ciencias Astronómicas y Geofísica

ISPI: the infared side port imager for the CITO 4-m telescope

The new operations model for the CTIO Blanco 4-m telescope will use a small suite of fixed facility instruments for imaging and spectroscopy. The Infrared Side Port Imager, ISPI, provides the infrared imaging capability. We describe the optical, mechanical, electronic, and software components of the instrument. The optical design is a refractive camera-collimator system. The cryo-mechanical packaging integrates two LN2-cooled dewars into a compact, straightline unit to fit within space constraints at the bent Cassegrain telescope focus. A HAWAII 2 2048 x 2048 HgCdTe array is operated by an SDSU II array controller. Instrument control is implemented with ArcVIEW, a proprietary LabVIEW-based software package. First light on the telescope is planned for September 2002

Clades of huge phages from across Earth's ecosystems.

Bacteriophages typically have small genomes1 and depend on their bacterial hosts for replication2. Here we sequenced DNA from diverse ecosystems and found hundreds of phage genomes with lengths of more than 200 kilobases (kb), including a genome of 735 kb, which is-to our knowledge-the largest phage genome to be described to date. Thirty-five genomes were manually curated to completion (circular and no gaps). Expanded genetic repertoires include diverse and previously undescribed CRISPR-Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribosomal proteins. The CRISPR-Cas systems of phages have the capacity to silence host transcription factors and translational genes, potentially as part of a larger interaction network that intercepts translation to redirect biosynthesis to phage-encoded functions. In addition, some phages may repurpose bacterial CRISPR-Cas systems to eliminate competing phages. We phylogenetically define the major clades of huge phages from human and other animal microbiomes, as well as from oceans, lakes, sediments, soils and the built environment. We conclude that the large gene inventories of huge phages reflect a conserved biological strategy, and that the phages are distributed across a broad bacterial host range and across Earth's ecosystems

ISPI: the infared side port imager for the CITO 4-m telescope

The new operations model for the CTIO Blanco 4-m telescope will use a small suite of fixed facility instruments for imaging and spectroscopy. The Infrared Side Port Imager, ISPI, provides the infrared imaging capability. We describe the optical, mechanical, electronic, and software components of the instrument. The optical design is a refractive camera-collimator system. The cryo-mechanical packaging integrates two LN2-cooled dewars into a compact, straightline unit to fit within space constraints at the bent Cassegrain telescope focus. A HAWAII 2 2048 x 2048 HgCdTe array is operated by an SDSU II array controller. Instrument control is implemented with ArcVIEW, a proprietary LabVIEW-based software package. First light on the telescope is planned for September 2002

A genomic storm in critically injured humans

Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes

De Novo Loss-of-Function Mutations in USP9X Cause a Female-Specific Recognizable Syndrome with Developmental Delay and Congenital Malformations

Mutations in more than a hundred genes have been reported to cause X-linked recessive intellectual disability (ID) mainly in males. In contrast, the number of identified X-linked genes in which de novo mutations specifically cause ID in females is limited. Here, we report 17 females with de novo loss-of-function mutations in USP9X, encoding a highly conserved deubiquitinating enzyme. The females in our study have a specific phenotype that includes ID/developmental delay (DD), characteristic facial features, short stature, and distinct congenital malformations comprising choanal atresia, anal abnormalities, post-axial polydactyly, heart defects, hypomastia, cleft palate/bifid uvula, progressive scoliosis, and structural brain abnormalities. Four females from our cohort were identified by targeted genetic testing because their phenotype was suggestive for USP9X mutations. In several females, pigment changes along Blaschko lines and body asymmetry were observed, which is probably related to differential (escape from) X-inactivation between tissues. Expression studies on both mRNA and protein level in affected-female-derived fibroblasts showed significant reduction of USP9X level, confirming the loss-of-function effect of the identified mutations. Given that some features of affected females are also reported in known ciliopathy syndromes, we examined the role of USP9X in the primary cilium and found that endogenous USP9X localizes along the length of the ciliary axoneme, indicating that its loss of function could indeed disrupt cilium-regulated processes. Absence of dysregulated ciliary parameters in affected female-derived fibroblasts, however, points toward spatiotemporal specificity of ciliary USP9X (dys-)function

Коррекция двигательных и поведенческих функций в лечении и реабилитации больных шизотипическим расстройством

На основании особенностей невербального поведения больных шизотипическим расстройством разработаны поведенческие методы, применение которых в их комплексной терапии позволяет добиться более полной редукции психопатологической симптоматики.Behavioral methods were worked out basing of the peculiarities of non−verbal behavior of the patients with schizotypical disorders. The use of the methods in complex therapy allows to achieve more complete reduction in psychopathological signs

A comprehensive study of Hα\alpha emitters at z∼z \sim 0.62 in the DAWN survey: the need for deep and wide regions

We present new estimates of the luminosity function (LF) and star formation rate density (SFRD) for an H$\alpha$ selected sample at $z\sim0.62$ from the Deep And Wide Narrow-band (DAWN) survey. Our results are based on a new H$\alpha$ sample in the extended COSMOS region (compared to Coughlin et al. 2018) with the inclusion of flanking fields, resulting in a total area coverage of $\sim$1.5 deg$^2$. A total of 241 H$\alpha$ emitters were selected based on robust selection criteria using spectro-photometric redshifts and broadband color-color classification. We explore the effect of different dust correction prescriptions by calculating the LF and SFRD using a constant dust extinction correction, A{$_{\textrm{H}\alpha}=1$} mag, a luminosity-dependent correction, and a stellar-mass dependent correction. The resulting H$\alpha$ LFs are well fitted using Schechter functions with best-fit parameters: L$^*=10^{42.24}$ erg s$^{-1}$, $\phi^*=10^{-2.85}$ Mpc$^{-3}$, $\alpha = -1.62$ for constant dust correction, L$^*=10^{42.31}$ erg s$^{-1}$, $\phi^*=10^{-2.8}$ Mpc$^{-3}$, $\alpha=-1.39$ for luminosity-dependent dust correction, and L$^*=10^{42.36}$ erg s$^{-1}$, $\phi^*=10^{-2.91}$ Mpc$^{-3}$, $\alpha = -1.48$, for stellar mass-dependent dust correction. The deep and wide nature of the DAWN survey effectively samples H$\alpha$ emitters over a wide range of luminosities, thereby providing better constraints on both the faint and bright end of the LF. Also, the SFRD estimates $\rho_{\textrm{SFR}}=10^{-1.39}$ M$_{\odot}$yr$^{-1}$Mpc$^{-3}$ (constant dust correction), $\rho_{\textrm{SFR}}=10^{-1.47}$ M$_{\odot}$yr$^{-1}$Mpc$^{-3}$ (luminosity-dependent dust correction), and $\rho_{\textrm{SFR}}=10^{-1.49}$ M$_{\odot}$yr$^{-1}$Mpc$^{-3}$ (stellar mass-dependent dust correction) are in good agreement with the evolution of SFRD across redshifts ($0 < z < 2$) seen from previous H$\alpha$ surveys.Comment: 16 pages, 8 figures, Accepted for publication in Ap

New Frontiers-class Uranus Orbiter: Exploring the feasibility of achieving multidisciplinary science with a mid-scale mission

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