Effects of Leadership Style on Organizational Performance in Small and Medium Scale Enterprises (SMEs) in Nigeria

The study examined effects of leadership styles on organizational performance in small and medium scale enterprises in Lagos state.  The main objective was to examine the effect leadership styles on the performance of SMEs in Nigeria. The study adopted the descriptive survey design using percentages and chi-square (X2) on hypothesis and questions formulated. The findings of the study revealed that good leadership style enhances employee morale and that there is what is known as participatory leadership style of management where both employers and employees take decisions that have positive impact on the growth of the organization and good welfare facilities for the employees. Keywords: Leadership Style, Organizational Performance, Small and Medium Enterprises and managemen

The effectiveness of the concrete / semi-concrete / abstract (CSA) appoach and drill- practice on grade 10 learners' ability to simplify addition and subtraction algebraic fractions

This study was conducted in one of the education districts in the Eastern Cape Province of South Africa. The purpose was to analyse the effectiveness of the concrete/semi-concrete/abstract (CSA) approach and drill-practice instructional strategies on Grade 10 learners’ ability to simplify addition and subtraction of algebraic fractions. The following two objectives were set. First, to identify the learners’ challenges in studying addition and subtraction of algebraic fractions in grade 10; and second to analyse the effectiveness of the CSA approach and drill-practice instructional strategies on Grade 10 learners’ ability to simplify addition and subtraction of algebraic fractions. Both threshold concepts and troublesome knowledge, Polya’s problem-solving techniques, CSA Approach theory and Drill-practice theory were all pertinent as a theoretical framework for the study. Positivism research paradigm was adopted for the study and it afforded the researcher opportunity to employ quantitative research approach. Based on the research question of this study, an experimental design was chosen as a suitable descriptive design. Purposive sampling method was used to select three schools which involved 135 grade 10 mathematics learners. Stratified random sampling method was thereafter employed to select 45 learners from each school for the study. The learners were grouped in each school as top, average and weak based on their performance in Algebra in term one. Pre-questionnaire and post-questionnaire were used to obtain data regarding challenges learners experience in simplifying addition and subtraction of algebraic fractions. Ethical clearance from the relevant school and university authorities were obtained. On the first two days, the researcher briefed the school authorities and learners and explained to them the purpose and details of the study. Day three was used to administer the pre-questionnaire test, thereafter, the next ten days were used to teach addition and subtraction of both numeric and algebraic fractions with same and different numerators and denominators. The next two days were used for revision and the last day was used to administer the postquestionnaire test out 25 marks. The respondent rate was 98.5%. The data collected were analysed by using SPSS version 16.10. Both descriptive and inferential statistics were used to analyse the data. The pre-questionnaire scores revealed that majority of the learners’ perceived fractions as two separate entities and as a result add or subtract numerator to numerator and denominator to denominator. It was also discovered that learners had a challenge in finding LCM of algebraic fractions. A t-Test for independent means was used to test the following hypotheses at = 0.05: : The CSA approach and drill-practice intervention has no significant effect on Grade 10 learners’ ability to simplify addition and subtraction of algebraic fractions; : The CSA approach and drill-practice will significantly enhance Grade 10 learners’ ability to simplify addition and subtraction of algebraic fractions. The t-Test revealed a p-value of 0.139 which was statistically significant at = 0.05. Therefore, the researcher rejected the null hypothesis and concluded that the CSA approach and drill-practice have significantly enhanced the Grade 10 learners’ ability to simplify algebraic fractions

2-But­oxy-N-[2-(diethyl­amino)­eth­yl]quinoline-4-carboxamide (dibucaine)

The mol­ecular conformation of the title compound, C20H29N3O2, is stabilized by an intra­molecular C—H⋯O hydrogen bond. The orientation of the amide group to the ring system is characterized by a C—C—C—O dihedral angle of 137.5 (3)°. In the crystal, inter­molecular N—H⋯O hydrogen bonds between the amide groups form C(4) chains running parallel to the a axis

Comparative Population Genetics and Evolutionary History of Two Commonly Misidentified Billfishes of Management and Conservation Concern

Background: Misidentifications between exploited species may lead to inaccuracies in population assessments, with potentially irreversible conservation ramifications if overexploitation of either species is occurring. A notable showcase is provided by the realization that the roundscale spearfish (Tetrapturus georgii), a recently validated species, has been historically misidentified as the morphologically very similar and severely overfished white marlin (Kajikia albida) (IUCN listing: Vulnerable). In effect, no information exists on the population status and evolutionary history of the enigmatic roundscale spearfish, a large, highly vagile and broadly distributed pelagic species. We provide the first population genetic evaluation of the roundscale spearfish, utilizing nuclear microsatellite and mitochondrial DNA sequence markers. Furthermore, we re-evaluated existing white marlin mitochondrial genetic data and present our findings in a comparative context to the roundscale spearfish. Results: Microsatellite and mitochondrial (control region) DNA markers provided mixed evidence for roundscale spearfish population differentiation between the western north and south Atlantic regions, depending on marker-statistical analysis combination used. Mitochondrial DNA analyses provided strong signals of historical population growth for both white marlin and roundscale spearfish, but higher genetic diversity and effective female population size (1.5-1.9X) for white marlin. Conclusions: The equivocal indications of roundscale spearfish population structure, combined with a smaller effective female population size compared to the white marlin, already a species of concern, suggests that a species-specific and precautionary management strategy recognizing two management units is prudent for this newly validated billfish

Cigarette smoking during breastfeeding in Papua New Guinea: Prevalence and demographic and socio-economic predictors

Background Cigarette smoking during breastfeeding is reported to contribute to significant changes in the composition of breast milk not only by reducing its protective features but also affecting infants' response to breastfeeding and breast milk. However, studies on the prevalence of cigarette smoking and associated factors during breastfeeding are limited in Papua New Guinea (PNG). This study estimates the prevalence of cigarette smoking and its association with demographic and economic factors among breastfeeding women in PNG. Methods We used weighted survey data from the 2016-2018 PNG Demographic and Health Survey (PNGDHS). A weighted sample of 3, 822 women who were breastfeeding during the survey were included in the study. The outcome variable in the present study is current cigarette smoking. A multiple logistic regression analysis was used to estimate the association between current cigarette smoking status and socio-demographic and economic variables of breastfeeding women. The regression analysis results were reported using adjusted odds ratios (aOR) with their respective 95% confidence intervals (CIs). Results From the weighted sample, the prevalence of cigarette smoking among breastfeeding women was 21.9%; of which 60.8% smoked daily. The mean number of cigarettes smoked in the last 24 hours preceding the survey was 6.05(SD = 5.99). Multiple logistic regression analysis revealed that breastfeeding women who were from the Momase (aOR: 2.337, CI: 1.786-3.058, p<0.001) and Highlands (AOR: 1.589, CI: 1.213-2.082, p = 0.001), had no religious affiliation (aOR: 3.665, CI: 1.235-10.877, p = 0.019), and households with daughters as household heads (aOR: 1.901, CI: 1.231-2.935, p = 0.004) and being in more than one union (aOR: 2.374, CI: 1.805-3.123, p<0.001) were significantly more likely to smoke cigarette compared to women from southern region, those affiliated to Anglican church, those with husband as household heads, and being in one union respectively. Conclusion Cigarette smoking among breastfeeding women in PNG is relatively high, and region of residence, religion, relationship to household head, and the number of unions remain independent predictors. Interventions should target the individual socio-economic and cultural contexts within which breastfeeding occurs

Molecular and phenotypic profiling of white Guinea yam (Dioscorea rotundata) breeding lines

Phenotypic and genotypic profiling helps identify genotypes with suitable and complementary traits for genetic improvement in crops. A total of 32 traits were assessed in 36 genotypes of white Guinea yam established in a 6 × 6 triple lattice design. The objective was to evaluate an array of plant traits that define the genetic merits of breeding lines for yam improvement. Different analytical tools were used to identify and prioritize relevant traits defining the genetic merits of breeding lines in the yam improvement program. Out of the 32 traits measured, the linear combination of 14 traits that minimize within-group variance and maximize between-group variance for discriminating the genetic values of yam breeding lines were identified. When best linear unbiased prediction with genomic relationship matrix (GBLUP) was used, the accuracies of genomic breeding values were higher (r=0.87 to 0.97) for the seven traits (dry matter content, intensity of flesh oxidization of shredded tuber, pasting temperature, pasting time, tuber flesh colour, yam mosaic virus and fresh tuber yield) with high broad-sense heritability values (H2m&gt;0.6). While, for the remaining seven traits with low (H2m&lt;0.3) to medium (H2m=0.3 to 0.54) broad-sense heritability values, the accuracies of genomic estimated breeding values (GEBV) were low (r&lt;0.4) to medium (r=0.4-0.8). The genotype–trait (GT) biplot display revealed superior clones with desirable genetic values for the key traits. These results are relevant for parental selection aimed at improving key agronomic traits in white Guinea yam

Broad Geographic Distribution of Roundscale Spearfish (Tetrapturus georgii) (Teleostei, Istiophoridae) in the Atlantic Revealed by DNA Analysis: Implications for White Marlin and Roundscale Spearfish Management

The recent validation of the roundscale spearfish (Tetrapturus georgii) within the western North Atlantic has introduced new complexities in the management of the overfished white marlin (Kajikia albida) in this region due to historical and contemporary misidentification between the two morphologically similar species. Compounding the management challenge for white marlin, which is currently assessed as a single Atlantic-wide stock, is an unclear picture of the extent of the roundscale spearfish\u27s overall Atlantic distribution. By using genetic tools (mitochondrial DNA ND4L-ND4 locus sequences) for species identification, we confirm that the roundscale spearfish has a much broader distribution than previously known, including the central North Atlantic and much of the western South Atlantic to at least 28°52′S. This much wider Atlantic distribution of the roundscale spearfish sympatric with its morphologically similar congeners, the white marlin and longbill spearfish (Tetrapturus pfluegeri), raises further management complexities: it increases the geographic scale for species misidentification in catch records that form the basis for stock assessments and uncertainty in currently accepted white marlin biological parameters. Additional vigilance in obtaining accurate species identification by improved fishery onboard observer training and incorporation of genetic tools is recommended for informing management of white marlin, longbill spearfish and roundscale spearfish throughout the Atlantic

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation

Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist. Of the 100 identified serotypes, ∼90% bind domain 1 of human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, making this an attractive target for development of therapies; however, ICAM-1 domain 1 is also required for host defence and regulation of cell trafficking, principally via its major ligand LFA-1. Using a mouse anti-human ICAM-1 antibody (14C11) that specifically binds domain 1 of human ICAM-1, we show that 14C11 administered topically or systemically prevented entry of two major groups of rhinoviruses, HRV16 and HRV14, and reduced cellular inflammation, pro-inflammatory cytokine induction and virus load in vivo. 14C11 also reduced cellular inflammation and Th2 cytokine/chemokine production in a model of major group HRV-induced asthma exacerbation. Interestingly, 14C11 did not prevent cell adhesion via human ICAM-1/LFA-1 interactions in vitro, suggesting the epitope targeted by 14C11 was specific for viral entry. Thus a human ICAM-1 domain-1-specific antibody can prevent major group HRV entry and induction of airway inflammation in vivo

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN