315 research outputs found
Catching up with Method and Process Practice: An Industry-Informed Baseline for Researchers
Software development methods are usually not applied by the book.companies are under pressure to continuously deploy software products that meet market needs and stakeholders\u27 requests. To implement efficient and effective development processes, companies utilize multiple frameworks, methods and practices, and combine these into hybrid methods. A common combination contains a rich management framework to organize and steer projects complemented with a number of smaller practices providing the development teams with tools to complete their tasks. In this paper, based on 732 data points collected through an international survey, we study the software development process use in practice. Our results show that 76.8% of the companies implement hybrid methods.company size as well as the strategy in devising and evolving hybrid methods affect the suitability of the chosen process to reach company or project goals. Our findings show that companies that combine planned improvement programs with process evolution can increase their process\u27 suitability by up to 5%
Computer-Assisted Proofs of Some Identities for Bessel Functions of Fractional Order
We employ computer algebra algorithms to prove a collection of identities
involving Bessel functions with half-integer orders and other special
functions. These identities appear in the famous Handbook of Mathematical
Functions, as well as in its successor, the DLMF, but their proofs were lost.
We use generating functions and symbolic summation techniques to produce new
proofs for them.Comment: Final version, some typos were corrected. 21 pages, uses svmult.cl
Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking
Podocytes are insulin-sensitive and take up glucose in response to insulin. This requires nephrin, which interacts with vesicle-associated membrane protein 2 (VAMP2) on GLUT4 storage vesicles (GSVs) and facilitates their fusion with the plasma membrane. In this paper, we show that the filament-forming GTPase septin 7 is expressed in podocytes and associates with CD2-associated protein (CD2AP) and nephrin, both essential for glomerular ultrafiltration. In addition, septin 7 coimmunoprecipitates with VAMP2. Subcellular fractionation of cultured podocytes revealed that septin 7 is found in both cytoplasmic and membrane fractions, and immunofluorescence microscopy showed that septin 7 is expressed in a filamentous pattern and is also found on vesicles and the plasma membrane. The filamentous localization of septin 7 depends on CD2AP and intact actin organization. A 2-deoxy-d-glucose uptake assay indicates that depletion of septin 7 by small interfering RNA or alteration of septin assembly by forchlorfenuron facilitates glucose uptake into cells and further, knockdown of septin 7 increased the interaction of VAMP2 with nephrin and syntaxin 4. The data indicate that septin 7 hinders GSV trafficking and further, the interaction of septin 7 with nephrin in glomeruli suggests that septin 7 may participate in the regulation of glucose transport in podocytes
First-Digit Law in Nonextensive Statistics
Nonextensive statistics, characterized by a nonextensive parameter , is a
promising and practically useful generalization of the Boltzmann statistics to
describe power-law behaviors from physical and social observations. We here
explore the unevenness of the first digit distribution of nonextensive
statistics analytically and numerically. We find that the first-digit
distribution follows Benford's law and fluctuates slightly in a periodical
manner with respect to the logarithm of the temperature. The fluctuation
decreases when increases, and the result converges to Benford's law exactly
as approaches 2. The relevant regularities between nonextensive statistics
and Benford's law are also presented and discussed.Comment: 11 pages, 3 figures, published in Phys. Rev.
Subretinal Implantation of Electrospun, Short Nanowire, and Smooth Poly(ε-caprolactone) Scaffolds to the Subretinal Space of Porcine Eyes
Biodegradable scaffolds play an important adjunct role in transplantation of retinal progenitor cells (RPCs) to the subretinal space. Poly(ε-Caprolactone) (PCL) scaffolds with different modifications were subretinally implanted in 28 porcine eyes and evaluated by multifocal electroretinography (mfERG) and histology after 6 weeks of observation. PCL Short Nanowire, PCL Electrospun, and PCL Smooth scaffolds were well tolerated in the subretinal space in pigs and caused no inflammation and limited tissue disruption. PCL Short Nanowire had an average rate of preserved overlying outer retina 17% higher than PCL Electrospun and 25% higher than PCL Smooth. Furthermore, PCL Short Nanowire was found to have the most suitable degree of stiffness for surgical delivery to the subretinal space. The membrane-induced photoreceptor damage could be shown on mfERG, but the reductions in P1 amplitude were only significant for the PCL Smooth. We conclude that of the tested scaffolds, PCL Short Nanowire is the best candidate for subretinal implantation
Distress, depression and coping in HLA-B27-associated anterior uveitis with focus on gender differences
Background/aims To evaluate depression, coping with
disease and stress, and the subjective impression of
distress and/or life events as triggers for recurrences in
HLA-B27-associated anterior uveitis (B27-AU), with
attention to gender-specific characteristics.
Methods 171 patients with a history of B27-AU
responded to a postal survey performed between
January 2006 and April 2008 using standardised
psychological questionnaires: Beck Depression Inventory,
Freiburg Questionnaire on Coping with Illness, and Stress
Coping Inventory.
Results Patients with B27-AU differed from healthy
controls showing more depressive symptoms (Beck
Depression Inventory, 31.6%), applying characteristic
disease coping as well as negative stress coping
strategies. Female B27-AU patients tended to react with
depression and male patients to use negative stress
coping strategies. 57.9% of patients believed that
psychological distress was a trigger for relapses, and
34.5% stated specific life events. Together, this group of
patients achieved higher depression scores and used
more negative disease and stress coping styles than
patients without perception of distress.
Conclusion Patients with B27-AU patients exhibited
significant psychopathology concerning depression and
disease coping. Distress and life events were
subjectively suspected to be a trigger. By imparting
knowledge to the patients on probable development of
depressive moods and the role of stress/life events as
trigger for relapses, as well as offering behaviour therapy
to optimise coping, may help patients to cope better
with B27-AU
Quasisymmetric graphs and Zygmund functions
A quasisymmetric graph is a curve whose projection onto a line is a
quasisymmetric map. We show that this class of curves is related to solutions
of the reduced Beltrami equation and to a generalization of the Zygmund class
. This relation makes it possible to use the tools of harmonic
analysis to construct nontrivial examples of quasisymmetric graphs and of
quasiconformal maps.Comment: 21 pages, no figure
Asexuality: Classification and characterization
This is a post-print version of the article. The official published version can be obtaineed at the link below.The term “asexual” has been defined in many different ways and asexuality has received very little research attention. In a small qualitative study (N = 4), individuals who self-identified as asexual were interviewed to help formulate hypotheses for a larger study. The second larger study was an online survey drawn from a convenience sample designed to better characterize asexuality and to test predictors of asexual identity. A convenience sample of 1,146 individuals (N = 41 self-identified asexual) completed online questionnaires assessing sexual history, sexual inhibition and excitation, sexual desire, and an open-response questionnaire concerning asexual identity. Asexuals reported significantly less desire for sex with a partner, lower sexual arousability, and lower sexual excitation but did not differ consistently from non-asexuals in their sexual inhibition scores or their desire to masturbate. Content analyses supported the idea that low sexual desire is the primary feature predicting asexual identity
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