Treponema denticola in Disseminating Endodontic Infections

Treponema denticola is a consensus periodontal pathogen that has recently been associated with endodontic pathology. In this study, the effect of mono-infection of the dental pulp with T. denticola and with polymicrobial “red-complex” organisms (RC) (Porphyromonas gingivalis, Tannerella forsythia, and T. denticola) in inducing disseminating infections in wild-type (WT) and severe-combined-immunodeficiency (SCID) mice was analyzed. After 21 days, a high incidence (5/10) of orofacial abscesses was observed in SCID mice mono-infected with T. denticola, whereas abscesses were rare in SCID mice infected with the red-complex organisms or in wildtype mice. Splenomegaly was present in all groups, but only mono-infected SCID mice had weight loss. T. denticola DNA was detected in the spleen, heart, and brain of mono-infected SCID mice and in the spleen from mono-infected wild-type mice, which also had more periapical bone resorption. The results indicate that T. denticola has high pathogenicity, including dissemination to distant organs, further substantiating its potential importance in oral and linked systemic conditions

Perceiving mixed valence emotions reduces intergroup dehumanisation

To deny others’ humanity is one of the most heinous forms of intergroup prejudice. Given evidence that perceiving various forms of complexity in outgroup members reduces intergroup prejudice, we investigated across three experiments whether the novel dimension of emotional complexity, or outgroup members’ joint experience of mixed-valence emotions, would also reduce their dehumanisation. Experiment 1 found that perceiving fictitious aliens’ experience of the same primary emotions (e.g. sadness) presented in mixed vs. non-mixed valence pairs led to reduced prejudice via attenuated dehumanisation, i.e. attribution of uniquely human emotions. Experiment 2 confirmed these results, using an unfamiliar real-world group as an outgroup target. Experiment 3 used a familiar outgroup and found generally similar effects, reducing social distance through reduced dehumanisation. These processes suggest that an alternate route to reduced dehumanising of outgroups might involve presenting mixed valence emotions

Neighbor cache prefetching for multimedia image and video processing

Cache performance is strongly influenced by the type of locality embodied in programs. In particular, multimedia programs handling images and videos are characterized by a bidimensional spatial locality, which is not adequately exploited by standard caches. In this paper we propose novel cache prefetching techniques for image data, called neighbor prefetching, able to improve exploitation of bidimensional spatial locality. A performance comparison is provided against other assessed prefetching techniques on a multimedia workload (with MPEG-2 and MPEG-4 decoding, image processing, and visual object segmentation), including a detailed evaluation of both the miss rate and the memory access time. Results prove that neighbor prefetching achieves a significant reduction in the time due to delayed memory cycles (more than 97% on MPEG-4 with respect to 75% of the second performing technique). This reduction leads to a substantial speedup on the overall memory access time (up to 140% for MPEG-4). Performance has been measured with the PRIMA trace-driven simulator, specifically devised to support cache prefetching

Improving data prefetching efficacy in multimedia applications

The workload of multimedia applications has a strong impact on cache memory performance, since the locality of memory references embedded in multimedia programs differs from that of traditional programs. In many cases, standard cache memory organization achieves poorer performance when used for multimedia. A widely-explored approach to improve cache performance is hardware prefetching, which allows the pre-loading of data in the cache before they are referenced. However, existing hardware prefetching approaches are unable to exploit the potential improvement in performance, since they are not tailored to multimedia locality. In this paper we propose novel effective approaches to hardware prefetching to be used in image processing programs for multimedia. Experimental results are reported for a suite of multimedia image processing programs including MPEG-2 decoding and encoding, convolution, thresholding, and edge chain coding

PIXE and ToF-SIMS analysis of streaker samplers filters

This paper presents methodological innovations introduced in the characterisation of urban aerosol collected in Italy in a recent campaign. Two complementary ion beam analysis (IBA) techniques were used to analyse Nuclepore filters used in continuous streaker samplers to collect airborne particles in four Italian towns. Na to Pb elemental concentrations were obtained by particle induced X-ray emission (PIXE), while time of flight secondary ion mass spectrometry (ToF-SIMS) produced, on the same samples, time trends for several elements and molecular fragments. In addition, light attenuation measurements were used as a tracer for black carbon. The data produced by these three techniques was merged into a unique data set to address the characterisation of particulate matter sources. Correlations between elemental concentration trends (PIXE) and relative trends for molecular fragments (ToF-SIMS) and black carbon (light attenuation) have been studied by cluster and principal component analysis

Performance analysis of MPEG-4 decoder and encoder

© 2002 Croatian Soc. Electronics in Marine-ELMAR. A performance analysis of MPEG-4 encoder and decoder programs on a standard personal computer is presented. The paper first describes the MPEG-4 computational load and discusses related works, then outlines the performance analysis. Experimental results show that while the decoder program can be easily executed in real time, the encoder requires execution times in the order of seconds per frame which call for substantial optimisation to satisfy real-time constraints

Protection of health information in Italy: a step too far?

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Development of innovative embedding procedures for the analyses of paint cross sections in ATR FITR microscopy

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Deep eutectic solvents: green solvents for the removal of degraded gelatin on cellulose nitrate cinematographic films

Cellulose nitrate (CN) has been used in the past as support for photographic negatives and cinematographic films. This material is particularly unstable and can undergoes severe degradation due to thermal, photocatalytic and hydrolytic loss of nitro groups from the lateral chain. Thus, to prevent the disappearance of the movies, their scanning and digitalization become a priority. However, CN bases degradation may prevent the scanning of the films. The decrease in pH, for instance, lowers the viscosity of gelatin, which becomes softer. This causes the formation of gelatin residues which stick on the back of the superimposed frames inside the reels creating a deposit. Traditional approaches to clean gelatin residues from the surface of CN bases include the mechanical removal with scalpels and the use of organic solvents (such as isopropyl alcohol). However, these methods are either slow and ineffective or could potentially damage the degraded CN supports. To overcome these drawbacks, we have evaluated the performance of three choline chloride and betaine-based Deep Eutectic Solvent (DES) formulations as alternative for the removal of gelatine residues from CN supports. These solvents are inexpensive (when compared to traditional solvents), easy to prepare, green (non volatile, safe towards the operators and the environment, and potentially recyclable), non flammable and have been previously proposed for the extraction of proteinaceous materials, but their use for the restoration of photographic negatives or cinematographic films has not been reported yet. Selected areas over the frames of a real deteriorated CN cinematographic film were cleaned comparing the DES performances with the ones obtained using isopropyl alcohol as an example of a traditional method. In particular, the tested DES formulations showed superior cleaning power compared to isopropyl alcohol and, at the selected application times, resulted capable to remove the gelatin residues without affecting the CN film supports. Graphical abstract: [Figure not available: see fulltext.]