Housing, home ownership and the governance of ageing

'Active ageing' has become core to ageing policy internationally. This paper argues that housing, and specifically home purchase, is fundamental to the governance of active ageing in liberal welfare states such as Australia, the UK, the US and Canada. Specifically, the paper expands understanding of how neoliberally inflected active ageing agendas are advanced in conjunction with housing consumption, and builds new knowledge of the governance of asset-based welfare, the investor subject, and housing marginality, showing how these practices and identities are governed temporally through ideas about what it means to age well. Arguments are advanced through analysis of Australian government ageing and age-connected housing strategies in the 20 years to 2015. These strategies construct three key connections between housing and ageing. First, housing is framed as a base (or location) for active ageing, with secure, appropriate and affordable housing depicted as enabling participation. Second, home ownership is positioned as an individual responsibility. In this framing home ownership becomes a 'choice' and means through which individuals can demonstrate responsibility by self-insuring against the fiscal risks of older age. Third, home ownership is connected to the activation of ideal ageing identities by enabling home owners as productive agers (the home as a form of income) and active consumers (home as a resource to fund prudential and age-defying consumption in older age). Significantly, in framing home ownership as an individual responsibility and choice the importance of structural factors shaping housing access are downplayed. This is a question of key geographical significance, foregrounding an interlinked agenda of not just how, but where, ageing should take place

Co-living, gentlemen's clubs, and residential hotels : a long view of shared housing infrastructures for single young professionals

Shared housing is an important infrastructure for young single professionals living and working in the city. Co-living is a contemporary shared housing infrastructure. But it certainly is not the first. We advocate for what Flanagan and Jacobs (2019) call taking a “long view” by drawing connections between early 19th-century gentlemen’s clubs, mid-19th-century residential hotels and contemporary co-living. We argue each have been dynamic infrastructures of mobility, work, and sociality that make certain practices more or less possible and reflect on how the socio-material form of these infrastructures connects with the infrastructural work it does. We draw on our own research study into co-living, connecting our findings with research on the historical housing types. Our findings show that shrinking private spaces, maximizing productive spaces, and integrating services are strategies that animate the infrastructural work of these housing types. By linking co-living with historical housing types, we demonstrate the importance of taking a “long view” when thinking infrastructurally about novel housing practices

'The early exposure is really helpful' : students' views of participating in communication skills screening

Students commence university with many hopes and dreams for their future and for most, these are realised. Health professional students must succeed in both their academic and clinical experiences. Excellent communication with their patients and colleagues on placement is necessary and particularly so for speech pathology students. This qualitative, descriptive study investigates how first- and final-year students view the screening of their communication skills in which they participate. The focus groups took place within the speech pathology department of a major Australian metropolitan university. Data were transcribed and analysed thematically. Three main themes arose: professional development, students’ cognitive and emotional responses, and the organisation of the screener. Both groups of students felt the screener was both an important part of their professional development and a way of identifying and supporting speech pathology students with communication difficulties. They valued the student-led nature of the process. Implications for the value of using a student-led communication screener to identify students with weaker communication skills early in their program and for the support of such students are discussed

Articulating Value in Cooperative Housing: International and Methodological Review

Housing cooperatives are a growing presence in Australia’s housing system, providing a diversity of housing forms to a variety of household types across the income spectrum, typically serving low- and moderate-income households. International evidence shows that housing cooperatives can provide a range of housing from very low price points through to market rate in both non-urban and urban contexts. The research presented in this report reviewed a selection of international cooperative housing sectors in addition to the Australian context, with two aims: 1. Compile the current evidence for the social and financial benefits of housing cooperatives, to develop a framework to assess this in Australia; and, 2. Identify preliminary issues regarding the growth and diversification of housing cooperatives in Australia

Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?

Psychosis has been hypothesised to be a continuously distributed quantitative phenotype and disorders such as schizophrenia and bipolar disorder represent its extreme manifestations. Evidence suggests that common genetic variants play an important role in liability to both schizophrenia and bipolar disorder. Here we tested the hypothesis that these common variants would also influence psychotic experiences measured dimensionally in adolescents in the general population. Our aim was to test whether schizophrenia and bipolar disorder polygenic risk scores (PRS), as well as specific single nucleotide polymorphisms (SNPs) previously identified as risk variants for schizophrenia, were associated with adolescent dimension-specific psychotic experiences. Self-reported Paranoia, Hallucinations, Cognitive Disorganisation, Grandiosity, Anhedonia, and Parent-rated Negative Symptoms, as measured by the Specific Psychotic Experiences Questionnaire (SPEQ), were assessed in a community sample of 2,152 16-year-olds. Polygenic risk scores were calculated using estimates of the log of odds ratios from the Psychiatric Genomics Consortium GWAS stage-1 mega-analysis of schizophrenia and bipolar disorder. The polygenic risk analyses yielded no significant associations between schizophrenia and bipolar disorder PRS and the SPEQ measures. The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value=2.57x10-4) and rs9960767 (p-value=6.23x10-4). Replication in an independent sample of 16-year-olds (N=3,427) assessed using the Psychotic-Like Symptoms Questionnaire (PLIKS-Q), a composite measure of multiple positive psychotic experiences, failed to yield significant results. Future research with PRS derived from larger samples, as well as larger adolescent validation samples, would improve the predictive power to test these hypotheses further. The challenges of relating adult clinical diagnostic constructs such as schizophrenia to adolescent psychotic experiences at a genetic level are discussed

Rental Insights A COVID-19 Collection

This Collection offers insights from twenty of Australia’s leader academics and thinkers into the survey results of 15,000 Australian rental households. The Collection draws on data from The Australian Rental Housing Conditions Dataset funded by the Australian Research Council in partnership with six Australian universities as well an additional AHURI funded COVID-19 module

The Human Connectome Project's neuroimaging approach

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease

An empirical model for probabilistic decadal prediction: global attribution and regional hindcasts

Empirical models, designed to predict surface variables over seasons to decades ahead, provide useful benchmarks for comparison against the performance of dynamical forecast systems; they may also be employable as predictive tools for use by climate services in their own right. A new global empirical decadal prediction system is presented, based on a multiple linear regression approach designed to produce probabilistic output for comparison against dynamical models. A global attribution is performed initially to identify the important forcing and predictor components of the model . Ensemble hindcasts of surface air temperature anomaly fields are then generated, based on the forcings and predictors identified as important, under a series of different prediction ‘modes’ and their performance is evaluated. The modes include a real-time setting, a scenario in which future volcanic forcings are prescribed during the hindcasts, and an approach which exploits knowledge of the forced trend. A two-tier prediction system, which uses knowledge of future sea surface temperatures in the Pacific and Atlantic Oceans, is also tested, but within a perfect knowledge framework. Each mode is designed to identify sources of predictability and uncertainty, as well as investigate different approaches to the design of decadal prediction systems for operational use. It is found that the empirical model shows skill above that of persistence hindcasts for annual means at lead times of up to 10 years ahead in all of the prediction modes investigated. It is suggested that hindcasts which exploit full knowledge of the forced trend due to increasing greenhouse gases throughout the hindcast period can provide more robust estimates of model bias for the calibration of the empirical model in an operational setting. The two-tier system shows potential for improved real-time prediction, given the assumption that skilful predictions of large-scale modes of variability are available. The empirical model framework has been designed with enough flexibility to facilitate further developments, including the prediction of other surface variables and the ability to incorporate additional predictors within the model that are shown to contribute significantly to variability at the local scale. It is also semi-operational in the sense that forecasts have been produced for the coming decade and can be updated when additional data becomes available

Generation of neutralizing antibodies and divergence of SIVmac239 in cynomolgus macaques following short-term early antiretroviral therapy.

Neutralizing antibodies (NAb) able to react to heterologous viruses are generated during natural HIV-1 infection in some individuals. Further knowledge is required in order to understand the factors contributing to induction of cross-reactive NAb responses. Here a well-established model of experimental pathogenic infection in cynomolgus macaques, which reproduces long-lasting HIV-1 infection, was used to study the NAb response as well as the viral evolution of the highly neutralization-resistant SIVmac239. Twelve animals were infected intravenously with SIVmac239. Antiretroviral therapy (ART) was initiated ten days post-inoculation and administered daily for four months. Viral load, CD4(+) T-cell counts, total IgG levels, and breadth as well as strength of NAb in plasma were compared simultaneously over 14 months. In addition, envs from plasma samples were sequenced at three time points in all animals in order to assess viral evolution. We report here that seven of the 12 animals controlled viremia to below 10(4) copies/ml of plasma after discontinuation of ART and that this control was associated with a low level of evolutionary divergence. Macaques that controlled viral load developed broader NAb responses early on. Furthermore, escape mutations, such as V67M and R751G, were identified in virus sequenced from all animals with uncontrolled viremia. Bayesian estimation of ancestral population genetic diversity (PGD) showed an increase in this value in non-controlling or transient-controlling animals during the first 5.5 months of infection, in contrast to virus-controlling animals. Similarly, non- or transient controllers displayed more positively-selected amino-acid substitutions. An early increase in PGD, resulting in the generation of positively-selected amino-acid substitutions, greater divergence and relative high viral load after ART withdrawal, may have contributed to the generation of potent NAb in several animals after SIVmac239 infection. However, early broad NAb responses correlated with relatively preserved CD4(+) T-cell numbers, low viral load and limited viral divergence

Pooled sequencing of 531 genes in inflammatory bowel disease identifies an associated rare variant in BTNL2 and implicates other immune related genes.

The contribution of rare coding sequence variants to genetic susceptibility in complex disorders is an important but unresolved question. Most studies thus far have investigated a limited number of genes from regions which contain common disease associated variants. Here we investigate this in inflammatory bowel disease by sequencing the exons and proximal promoters of 531 genes selected from both genome-wide association studies and pathway analysis in pooled DNA panels from 474 cases of Crohn's disease and 480 controls. 80 variants with evidence of association in the sequencing experiment or with potential functional significance were selected for follow up genotyping in 6,507 IBD cases and 3,064 population controls. The top 5 disease associated variants were genotyped in an extension panel of 3,662 IBD cases and 3,639 controls, and tested for association in a combined analysis of 10,147 IBD cases and 7,008 controls. A rare coding variant p.G454C in the BTNL2 gene within the major histocompatibility complex was significantly associated with increased risk for IBD (p = 9.65x10-10, OR = 2.3[95% CI = 1.75-3.04]), but was independent of the known common associated CD and UC variants at this locus. Rare (T) or decreased risk (IL12B p.V298F, and NICN p.H191R) of IBD. These results provide additional insights into the involvement of the inhibition of T cell activation in the development of both sub-phenotypes of inflammatory bowel disease. We suggest that although rare coding variants may make a modest overall contribution to complex disease susceptibility, they can inform our understanding of the molecular pathways that contribute to pathogenesis