The problems of service realization to check WEB sites applying usability indicators

The article considers the concept of "site" and site functions, analyzes e-commerce sites and online stores in terms of usability, and provides a scheme for the development of an automated audit Web site usability service

Actionism in modern art and social space

The article interprets actionism in the light of the general specifics of modern art. Performativity, ?patage, temporality are reflected as generic features of modern art. The attention is drawn to acute relations between modern art and social lifeОсмысливается акционизм в свете общей специфики современного искусства. Отрефлексированы перформативность, эпатажность, темпоральность как родовые особенности современного искусства, рассмотрены модели автора и воспринимающего в акционизме. Обращается внимание на острые отношения между современным искусством и общественной жизнь

Неклассическая художественность: проблемы изучения и интерпретации

The Article is devoted to the topical problem of understanding non-classical arts, the relationship of classical and nonclassical artistic paradigms, the specifics of modern art and the principles of its interpretationСтатья посвещена актуальной проблеме понимания неклассического искусства, соотношению классической и неклассической художественных парадигм, специфике современного искусства и принципам его интерпретаци

Influence of Structural Features and Physico-chemical Properties of Metal-carbon Nanocomposites with Ferromagnetic Metal Inclusions on Microwave Radiation

Metal-carbon nanocomposites on the basis of polyacrylonitrile and compounds of metals (Fe, Ni, Co) synthesized at IR-heating and studied by SEM, X-ray phase analysis, Raman scattering, IR Fourier spec-troscopy are characterized by the carbon nanostructured amorphous graphite matrix with uniformly dis-tributed nanoparticles of metals (10-30 nm), their oxides and compounds – FeNi3 and FeCo, multilayered carbon nanotubes (~ 7-22 nm), and in the composition of Fe-Co / C fullerene-like formations – C60. All nanocomposites feature high absorption of electromagnetic waves in the frequency range 20-40 GHz. Two absorption mechanisms are proposed: dielectric loss in the amorphous carbon matrix and scattering of electric and magnetic components by ferromagnetic inclusions. Absorption was – 8.68 dB for Fe-Ni / C, – 12.93 dB for Fe / C, and – 7.07 dB for Ni / C and for Fe-Co / C was found to be maximum in the whole range studied (more than – 40 dB) with a peak of – 52.83 dB at 24.27 GHz, which is explained probably by both high nanocomposite electric conductivity 2 S / m and high specific magnetization of phase FeCo. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3625

The effect of the selective laser melting mode on second phases precipitation in 316L steel during subsequent heat treatment

The object of the study was 316L steel obtained by the method of selective laser melting (SLM). The structure of 316L steel was investigated after different SLM modes. The effect of different SLM modes on the second phases precipitation after heat treatment was studied. It is revealed that the fraction of precipitates of the χ-phase correlates with the energy density of the laser beam during SLM. © 2021 Institute of Physics Publishing. All rights reserved

Effect of exogenous human chorionic gonadotropin on ovulation in mice

The implementation of assisted reproductive technologies (ART), hormonal stimulation in particular, may change the quality of ovulated oocytes. The purpose of our work was to study ovulation in CD1 mice after their stimulation with human chorionic gonadotropin (hCG) and to investigate the effects of such hormonal stimulation on the pregnancy duration, fetal losses and the weight of the offspring. No significant differences were found in the total number of ovulated oocytes or in the number of immature (without a polar body) ovulated oocytes; nor were there differences between the groups in the number of oocytes with a developing polar body. However, the number of matured oocytes with a distinct polar body was significantly higher (p < 0.05) in mice stimulated with hCG (experimental group) as compared with the controls (6.2 ± 0.86 and 2.2 ± 0.97, respectively). No significant differences were observed between the experimental and control mice in the duration of pregnancy or in the numbers of term offspring, including the percentage of live and stillborn pups. However, the body weight of the offspring in the experimental group was significantly lower (p < 0.001) as compared with the controls on the fifth day after birth (3.16 ± 0.09 and 3.76 ± 0.07, respectively). Thus, exogenous hCG facilitates the development of mouse oocytes in vivo, which leads to the larger number of their mature forms at ovulation, however, the offspring born after hCG-stimulated pregnancy was characterized by a lower body weight on the fifth day after birth

Фискальные аспекты государственной политики по защите и поощрению капиталовложений

The subject. The institution of investing in the Russian Federation is determined by the set of economic and legal reformations. That is why discussions and debates about the necessity of creating of the investment code, unification of existing rules of investment activity regulation still exist. It is also necessary to form and systemise a kind of a common registry of state support measures and it is also necessary to control the provision of state support. Russian science studies legal regulation of state support of business subjects only in specific ways. Despite the plenty of works on the topic of legal regulation of activity of small and medium-sized businesses, this field of legislation is not developed enough to give an opportunity to conduct complex researches of theoretical and practical aspects relating to exclusively legal and financial framework of state support of the investment activity. In this article we detect and reveal general problems connected to introducing of tax frameworks of state support of promotion of investments in the conditions of existing Russian legislation. In the context of this article we show the analysis of novelties related to egal regulation of tax instrument of state support of investments. Theoretical importance of this article lies in suggestions on improving of this field of national legislation.This research is aimed at theoretical realising of legal regulations of current measures on performing of tax policy while implementing Act on investments.The methodology. The basic method of research of mentioned problems is a formal legal one. There are some problems in the process of investing based on the Agreement on protection and promotion of investment. With the help of this method these problems were examined taking into consideration the implementing tax policy in this field of entrepreneurship.The main results. Several legal problems are revealed and specified in this article. Authors prove their own point of view which consists of idea of detailed theoretical elaboration of the problematics in order to implement a framework of Agreement on protection and promotion of investment successfully, given that it is necessary to enact the list of bylaws by the Government of the Russian Federation and to create an impeccable software.Conclusions. Authors suggest measures for improving of legal regulations of current investment legislation and tax and fees legislations. It is crucial to point out that such issues as a procedure of entering into agreements (including the procedure of holding a tender within public project initiative) and common requirements to them; standard form of an agreement; the procedure of monitoring of realisation stages of an investment project (in relation to which the Agreement on protection and promotion of investment was signed); the procedure of keeping of a register of such Agreements; the procedure of the identifying of the level of the compensation of spendings needed for the project’s realisation and as well as spendings on payments of credits and loans’ interests, coupon payments from the bonded loan and etc. From the point of view of the legal regulation’s systematisation the complex law institution has been formed, and it contains principles and rules of both public and private law. The complexity of legal relationship, appearing in the process of investing, requires to take into account public and private interests, and moreover it conditions the necessity of intersectoral legal regulation. Combining diverse legal means provided for in the context of legal regulation of budgetary and tax relationships public legal entities in order to achieve a maximum effect can provide the stimulation of growth of investment which is able to become a booster for economic growth of the state.Представлены результаты комплексного исследования проблем, обусловленных вступлением в силу закона о защите и поощрении капиталовложений и реализуемой фискальной политикой в данной сфере. Исследованы теоретические и практические проблемы осуществления фискальной политики, связанной с реализацией заключения соглашений о защите и поощрении капиталовложений. На основе проведенного исследования выявлены перспективы развития правового регулирования правоотношений, связанных с проводимой фискальной политикой государства в сфере инвестиционной деятельности. Представлены предложения по совершенствованию законодательства в данной сфере

Beyond the marrow:insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors

Extramedullary multiple myeloma (EMM) is an aggressive form of multiple myeloma (MM). This study represents the most comprehensive next-generation sequencing analysis of EMM tumors (N = 14) to date, uncovering key molecular features and describing the tumor microenvironment. We observed the co-occurrence of 1q21 gain/amplification and MAPK pathway mutations in 79% of EMM samples, suggesting that these are crucial mutational events in EMM development. We also demonstrated that patients with mutated KRAS and 1q21 gain/amplification at the time of diagnosis have a significantly higher risk of EMM development (HR = 2.4, p = 0.011) using data from a large CoMMpass dataset. We identified downregulation of CXCR4 and enhanced cell proliferation, along with reduced expression of therapeutic targets (CD38, SLAMF7, GPRC5D, FCRH5), potentially explaining diminished efficacy of immunotherapy. Conversely, we identified significantly upregulated EZH2 and CD70 as potential future therapeutic options. For the first time, we report on the tumor microenvironment of EMM, revealing CD8+ T cells and NK cells as predominant immune effector cells using single-cell sequencing. Finally, this is the first longitudinal study in EMM revealing the molecular changes from the time of diagnosis to EMM relapse.</p

Сравнительная характеристика бета-герпес-вирусов человека 6А и 6В. Современный взгляд на проблему

This review is devoted to the comparative characteristics of human herpesvirus 6A (HHV6A) and human herpesvirus 6B (HHV6B), taking into account their exogenous and endogenous (inherited chromosomally integrated) forms. The analysis of the literature data on the main interspecies differences and intraspecies features of these viruses in molecular-genetic, biological, epidemiological and clinical aspects has been consistently carried out. Modern views about HHV6A and HHV6B, including their unique inherited chromosomal-integrated form, are the basis for organizing a system of epidemiological surveillance of infections caused by these viruses, as well as developing standardized methodological approaches to differential diagnosis, treatment and specific prevention of a wide range of virus-associated diseases. The development of this direction requires a greater evidence base and intensification of joint efforts of the scientific and medical communities.Представленный обзор посвящен сравнительной характеристике вируса герпеса человека 6А (ВГЧ6А) и вируса герпеса человека 6В (ВГЧ6В) с учетом их экзогенной и эндогенной (наследуемой хромосомно-интегрированной) форм. Последовательно проведен анализ литературных данных об основных межвидовых различиях и внутривидовых особенностях этих вирусов в молекулярно-генетическом, биологическом, эпидемиологическом и клиническом аспектах. Современные представления о ВГЧ6А и ВГЧ6В, в том числе их уникальной наследуемой хромосомно-интегрированной форме, являются основой для организации системы эпидемиологического надзора за инфекциями, вызываемыми данными вирусами, а также разработки стандартизованных методических подходов к дифференциальной диагностике, лечению и специфической профилактике широкого спектра вирус-ассоциированных заболеваний. Развитие данного направления требует большей доказательной базы и интенсификации совместных усилий научного и врачебного сообществ