Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Lifestyle Behaviours Profile of Spanish Adolescents Who Actively Commute to School

The aim of this study was to study different ‘healthy profiles’ through the impact of multiple lifestyle behaviours (sleep patterns, screen time and quality diet) on active commuting to school (ACS) in adolescents. Sixteen secondary schools from four Spanish cities were randomly selected. All participants filled in an “Ad-Hoc” questionnaire to measure their mode of commuting and distance from home to school and their lifestyle behaviours. A multivariate logistic regression model was performed to analyse the main predictor variables of ACS. The final sample was 301 adolescents (50.2% girls; mean age ± SD: 14.9 ± 0.48 years). The percentage of ACS was 64.5%. Multiple logistic regressions showed: boys were more active commuters than girls [OR = 2.28 (CI 95%: 1.12–4.64); p = 0.02]; adolescents who lived farther had lower probability to ACS [OR = 0.74 (CI 95%: 0.69–0.80); p p = 0.04], while with each hour of sleep, the odds of ACS was reduced [OR = 0.51 (CI 95%: 0.30–0.89); p = 0.02]; higher odds were shown to ACS in adolescents who have more adherence to MD [OR = 1.16(CI 95%: 1.00–1.33); p = 0.05]; and habitual breakfast consumption was inversely associated with ACS [OR = 0.41 (CI: 95%: 0.18–0.96); p = 0.04]. ACS was associated with being a boy, living at a shorter distance to school, a daily sleep time ≥ 8 h and presented a higher adherence to MD

Protocolo del Proyecto PACOyPACA CLM : (Pedalea y Anda al Cole y Pedalea y Anda a Casa en Castilla-La Mancha)

The PACOyPACA Project aims to explore the relationships of active commuting to school (ACS) in different settings (urban, semi-urban and rural) with physical environment characteristics, psychosocial factors and lifestyle (sleep patterns, screen time and nutritional aspects) within the adolescent population of Castilla-La Mancha. The PACOyPACA Project is a cross-sectional study with a sample of students in their 3rd year of Compulsory Secondary Education (ESO) (14-15 years old) from the five provinces of Castilla-La Mancha (Toledo, Ciudad Real, Albacete, Cuenca and Guadalajara), and their parents. To guarantee the representativeness of the sample, a stratified sampling was carried out according to the size of the population in the schools’ localities, classifying them as urban, semi-urban and rural settings. Questionnaires have been created ad hoc for both adolescents and their parents/legal guardians to gather information on the physical environment, psychosocial factors and lifestyle based on previously validated surveys. The PACOyPACA Project in Castilla-La Mancha will be useful to raise awareness on the current state of ACS in adolescence and the factors possibly associated with ACS. This knowledge will provide a better understanding of the current situation and will be useful for the design and creation of ACS promotion strategies in different environments of Castilla-La Mancha. Likewise, the evidence collected may justify the implementation of ACS promotion strategies within the Community in urban, semi-urban and rural settings.&nbsp;El Proyecto PACOyPACA tiene como objetivo explorar las relaciones de los desplazamientos activos al centro educativo (DACE) en distintos entornos (urbano, semi-urbano y rural) con características del entorno físico, factores psicosociales y estilos de vida (patrones de sueño, actividad física, tiempo de pantalla y aspectos nutricionales) en la población adolescente de Castilla-La Mancha en España. El Proyecto PACOyPACA es un estudio transversal. Su muestra se compone de estudiantes en 3º curso de Educación Secundaria Obligatoria (ESO) (14-15 años) de las cinco provincias de Castilla-La Mancha (Toledo, Ciudad Real, Albacete, Cuenca y Guadalajara), y sus padres. Para garantizar su representatividad, se realizó un muestreo estratificado de acuerdo con el tamaño poblacional de las localidades de los centros, clasificándolos como urbanos, semi-urbanos y rurales. Se crearon cuestionarios ad hoc para ambos, adolescentes y padres/madres/tutores legales, para recoger información sobre DACE, entorno físico, factores psicosociales y estilos de vida. Estos se basan en cuestionarios previamente validados. El Proyecto PACOyPACA en Castilla-La Mancha será útil para concienciar sobre el estado de DACE actual en la adolescencia y los factores asociados a los DACE. Este conocimiento será de ayuda para el diseño y creación de estrategias de fomento de los DACE en distintos entornos de Castilla-La Mancha. Asimismo, la evidencia recogida podrá servir para desarrollar la implementación de estrategias de promoción de los desplazamientos activos en el ámbito comunitario atendiendo a la zona urbana, semi-urbana y rural de manera más eficaz.&nbsp

Cátedra Manuel Ancizar. Derecho, conflicto armado y paz: memorias

Capítulo 1. Información general; Presentación; Homenaje a Ciro Angarita Barón; Programa; Producción derivada de la cátedra; Medios de difusión; Sistema de evaluación. Capítulo 2. Listado de estudiantes. Capítulo 3. Listado de particulares. Capítulo 4. Memorias – primera sesión. El derecho a la paz; segunda sesión: derecho y conflicto; tercera sesión: derecho y conflicto armado cuarta sesión: derecho y resolución de conflictos; quinta sesión: guerra y delito político; sexta sesión: derecho internacional humanitario y Derechos humanos séptima sesión: derecho y desplazamiento interno; octava sesión: guerra, paz y economía; novena sesión: conflictos sociales, derecho y paz; décima sesión: paz y reformas sociales; décimo primera sesión: derecho y negociación política del conflicto armad

Role of age and comorbidities in mortality of patients with infective endocarditis.

The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327  There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th