Diseño y prueba experimental de bloques ecológicos a base de materiales orgánicos e inorgánicos

This article describes the experimental design and testing of ecological blocks based on organic and inorganic materials. For the development of this project we formulated two experimental designs for the manufacture of blocks specifying the dimensions of the blocks, proportions, materials, and also the weight of those materials, then we brought those designs to the reality manufacturing 8 blocks for each experimental design. Later the testing of compressive strength of the blocks was made following the requirements of the Panamanian Technical Standard DGNTI-COPANIT 163-2001 for sampling and testing of blocks to determine if the ecological blocks satisfy the requirements of compressive resistance for non-structural blocks because they fall in this category for their dimensions as well as it is established in the Panamanian Technical Standard DGNTI-COPANIT 161-2001. Finally the results showed that the dimensions of the blocks for both experimental designs comply with the dimensions that must comply blocks of trade name 4 “x 18” for non-structural use, and also the blocks exceed the requirements of compressive strength with only 20 days of curing, having a resistance higher than expected and propose.Este artículo describe el diseño y prueba experimental de bloques ecológicos a base de materiales orgánicos e inorgánicos. Para el desarrollo de este proyecto, se formularon dos diseños experimentales para la fabricación de bloques especificando las dimensiones de los bloques, proporciones, materiales, y peso de los mismos, para luego llevar esos diseños a la realidad y fabricar 8 bloques para cada diseño experimental. Posteriormente se realizaron las pruebas de resistencia a la compresión de los bloques ecológicos basándonos en la Norma Técnica Panameña DGNTICOPANIT 163-2001 de muestreo y ensayo para bloques de hueco de concreto, y así poder determinar si los bloques ecológicos cumplían con los requisitos de resistencia a la compresión para bloques no estructurales, ya que por sus dimensiones entran en esta categoría, así como lo establece la Norma Técnica Panameña DGNTI-COPANIT 161-2001. Finalmente, los resultados demostraron que las dimensiones de los bloques cumplen en gran parte con requisitos en cuanto a dimensiones que deben cumplir los bloques de 4” x 18” para uso no estructural, y según los resultados de resistencia a la compresión, los bloques sobrepasan los requisitos de resistencia a la compresión con tan solo 20 días de curado, teniendo una resistencia mucho más superior a lo esperado y propuesto

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

Diseño y prueba experimental de bloques ecológicos a base de materiales orgánicos e inorgánicos

This article describes the experimental design and testing of ecological blocks based on organic and inorganic materials. For the development of this project we formulated two experimental designs for the manufacture of blocks specifying the dimensions of the blocks, proportions, materials, and also the weight of those materials, then we brought those designs to the reality manufacturing 8 blocks for each experimental design. Later the testing of compressive strength of the blocks was made following the requirements of the Panamanian Technical Standard DGNTI-COPANIT 163-2001 for sampling and testing of blocks to determine if the ecological blocks satisfy the requirements of compressive resistance for non-structural blocks because they fall in this category for their dimensions as well as it is established in the Panamanian Technical Standard DGNTI-COPANIT 161-2001. Finally the results showed that the dimensions of the blocks for both experimental designs comply with the dimensions that must comply blocks of trade name 4 “x 18” for non-structural use, and also the blocks exceed the requirements of compressive strength with only 20 days of curing, having a resistance higher than expected and propose.Este artículo describe el diseño y prueba experimental de bloques ecológicos a base de materiales orgánicos e inorgánicos. Para el desarrollo de este proyecto, se formularon dos diseños experimentales para la fabricación de bloques especificando las dimensiones de los bloques, proporciones, materiales, y peso de los mismos, para luego llevar esos diseños a la realidad y fabricar 8 bloques para cada diseño experimental. Posteriormente se realizaron las pruebas de resistencia a la compresión de los bloques ecológicos basándonos en la Norma Técnica Panameña DGNTICOPANIT 163-2001 de muestreo y ensayo para bloques de hueco de concreto, y así poder determinar si los bloques ecológicos cumplían con los requisitos de resistencia a la compresión para bloques no estructurales, ya que por sus dimensiones entran en esta categoría, así como lo establece la Norma Técnica Panameña DGNTI-COPANIT 161-2001. Finalmente, los resultados demostraron que las dimensiones de los bloques cumplen en gran parte con requisitos en cuanto a dimensiones que deben cumplir los bloques de 4” x 18” para uso no estructural, y según los resultados de resistencia a la compresión, los bloques sobrepasan los requisitos de resistencia a la compresión con tan solo 20 días de curado, teniendo una resistencia mucho más superior a lo esperado y propuesto

A vascular image registration method based on network structure and circuit simulation

Abstract Background Image registration is an important research topic in the field of image processing. Applying image registration to vascular image allows multiple images to be strengthened and fused, which has practical value in disease detection, clinical assisted therapy, etc. However, it is hard to register vascular structures with high noise and large difference in an efficient and effective method. Results Different from common image registration methods based on area or features, which were sensitive to distortion and uncertainty in vascular structure, we proposed a novel registration method based on network structure and circuit simulation. Vessel images were transformed to graph networks and segmented to branches to reduce the calculation complexity. Weighted graph networks were then converted to circuits, in which node voltages of the circuit reflecting the vessel structures were used for node registration. The experiments in the two-dimensional and three-dimensional simulation and clinical image sets showed the success of our proposed method in registration. Conclusions The proposed vascular image registration method based on network structure and circuit simulation is stable, fault tolerant and efficient, which is a useful complement to the current mainstream image registration methods