Low VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinoma

Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR55.78, 95% CI 3.17-10.53, P<0.0001), classical papillary morphology of the tumor (OR52.92, 95% CI 1.33-6.44, P=50.008) and multifocality (OR51.96, 95% CI 1.06-3.62, P=50.031). In disease-free survival analysis, low VHL expression had marginal significance (P=50.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated

Benefits of large broods by higher chick survival and better territories in a precocial shorebird

When reproductive success is constant in one breeding phase, different tactics that increase variation in reproductive success among individuals may evolve in other phases. For instance, in shorebirds, which usually have a limited clutch size of four eggs, variation in reproductive tactics among individuals is expected either before egg-laying (e.g. diverse mating systems) or after hatching of the young (e.g. diverse parental care). In this paper, I studied the pied avocet (Recurvirostra avosetta), a shorebird with a modal clutch size of four eggs, to test whether post-hatch chick adoption as an alternative tactic can be linked to increased variation in annual reproductive success. When predation was high, naturally adopting pairs produced more filial fledglings than did pairs not adopting chicks and not losing chicks to adoption. The number of filial fledglings increased with the number of adopted young, possibly through diluting the chances of predation on filial young. Experimental chick addition did not lead to more fledged young due to low brood integrity as shown by the frequent loss of chicks from some experimental broods. When predation was low, larger broods occupied feeding territories with higher prey abundance than smaller broods, possibly due to their dominance over smaller ones. Pairs that lost chicks to adoption (donors) fledged as many filial young in their broods as did non-adopters/non-donors, whereas the total number of donors' filial fledglings, including those raised in adopting broods, approached that of adopters. These findings show, for the first time, that post-hatch alternative reproductive tactics can lead to variation in annual reproductive success and to higher success for some pairs even in species where past adaptations limit variation in reproductive success in a certain phase of reproduction

Renaturing science : the role of childhoodnature in science for the anthropocene

This chapter proposes that there is a need to examine childhoodnature experiences and the way in which these might be influential in shaping an agenda for science and science education in the Anthropocene. A renaturing of science places a much greater emphasis on, and recognition of, the interdependency and relational nature of the natural world in which humans are inextricably embedded and suggests the need for the development of a strong ecological identity (Thomashow, Ecological identity: Becoming a reflective environmentalist. MIT Press, Cambridge, MA, 1996). This suggests that there is a need for increased availability of childhoodnature experiences and a focus on the quality of those experiences, as well as the need to explore further lifelong opportunities for developing innate biophilic (Wilson, Biophilia. Harvard University Press, Cambridge, MA, 1984) tendencies. The chapter examines the childhoodnature experiences of beginning undergraduate university students and how these influence their current relationship to the natural world. Literature suggests that the strength of a person’s nature relatedness can have an impact on the way they view the natural world and can, subsequently, influence the actions they take toward that natural world. This chapter describes a mixed-methods approach used to examine beginning university students’ childhoodnature experiences and how those experiences may have influenced their sense of nature connectedness. Data gathered indicates that there are statistically significant correlations between childhoodnature experiences and current sense of nature connectedness, although the qualitative data suggests that the form of those experiences may be of critical importance. Evidence from the study presented here suggests that exposure to childhoodnature, while necessary, is not sufficient in itself, and further research is required into the nature and quality of childhoodnature experiences. This concurs with previous studies, e.g., Vadala, Bixler, and James (J Environ Educ 39:3–18, 2007), which found that it was the particular qualities of the childhoodnature experience that appeared to play a significant part in shaping future interests, attitudes, and values