A fourth-order compact finite volume scheme for fully nonlinear and weakly dispersive Boussinesq-type equations. Part I: Model development and analysis

International audienceA high‐order finite volume scheme is developed to numerically integrate a fully nonlinear and weakly dispersive set of Boussinesq‐type equations (the so‐called Serre equations) (J. Fluid Mech. 1987; 176:117–134; Surveys Geophys. 2004; 25(3–4):315–337). The choice of this discretization strategy is motivated by the fact that this particular set of equations is recasted in a convenient quasi‐conservative form. Cell face values are reconstructed using implicit compact schemes (J. Comput. Phys. 1999; 156:137–180; J. Comput. Phys. 2004; 198:535–566) and time integration is performed with the help of a four‐stage Runge–Kutta method. Numerical properties of the proposed scheme are investigated both, analytically using linear spectral analysis, and numerically for highly nonlinear cases. The numerical analysis indicates that the newly developed scheme has wider stability regions and better spectral resolution than most of the previously published numerical methods used to handle equivalent set of equations. Moreover, it was also noticed that the use of mixed‐order strategies to discretize convective and dispersive terms may result in an important overall reduction of the spectral resolution of the scheme. Additionally, there is some numerical evidence, which seems to indicate that the incorporation of a high‐order dispersion correction term as given by Madsen et al. (Coastal Eng. 1991; 15:371–388) may introduce instability in the syste

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer\u27s disease and PET amyloid-positive patient identification

BACKGROUND: Cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine 181 (pT181) are currently used to discriminate between Alzheimer\u27s disease and other neurodegenerative diseases. However, these changes are not entirely specific to Alzheimer\u27s disease, and it is noteworthy that other phosphorylated isoforms of tau, possibly more specific for the disease process, have been described in the brain parenchyma of patients. The precise detection of these isoforms in biological fluids remains however a challenge. METHODS: In the present study, we used the latest quantitative mass spectrometry approach, which achieves a sensitive detection in cerebrospinal fluid biomarker of two phosphorylated tau isoforms, pT181 and pT217, and first analyzed a cohort of probable Alzheimer\u27s disease patients and patients with other neurological disorders, including tauopathies, and a set of cognitively normal controls. We then checked the validity of our results on a second cohort comprising cognitively normal individuals and patients with mild cognitive impairments and AD stratified in terms of their amyloid status based on PiB-PET imaging methods. RESULTS: In the first cohort, pT217 but not pT181 differentiated between Alzheimer\u27s disease patients and those with other neurodegenerative diseases and control subjects much more specificity and sensitivity than pT181. T217 phosphorylation was increased by 6.0-fold in patients with Alzheimer\u27s disease whereas T181 phosphorylation was only increased by 1.3-fold, when compared with control subjects. These results were confirmed in the case of a second cohort, in which the pT217 cerebrospinal fluid levels marked out amyloid-positive patients with a sensitivity and a specificity of more than 90% (AUC 0.961; CI 0.874 to 0.995). The pT217 concentrations were also highly correlated with the PiB-PET values (correlation coefficient 0.72; P \u3c 0.001). CONCLUSIONS: Increased cerebrospinal fluid pT217 levels, more than those of pT181, are highly specific biomarkers for detecting both the preclinical and advanced forms of Alzheimer\u27s disease. This finding should greatly improve the diagnosis of Alzheimer\u27s disease, along with the correlations found to exist between pT217 levels and PiB-PET data. It also suggests that pT217 is a promising potential target for therapeutic applications and that a link exists between amyloid and tau pathology

Investigation of caliciviruses and astroviruses in Gabonese rodents: A possible influence of national and international trade on the spread of enteric viruses.

Caliciviruses (Caliciviridae) and astroviruses (Astroviridae) are among the leading cause of non-bacterial foodborne disease and gastroenteritis in human. These non-enveloped RNA viruses infect a wide range of vertebrate species including rodents. Rodents are among the most important hosts of infectious diseases globally and are responsible for over 80 zoonotic pathogens that affect humans. Therefore, screening pathogens in rodents will be is necessary to prevent cross-species transmission to prevent zoonotic outbreaks. In the present study, we screened caliciviruses and astroviruses in order to describe their diversity and whether they harbor strains that can infect humans. RNA was then extracted from intestine samples of 245 rodents and retrotranscribed in cDNA to screen caliciviruses and astroviruses by PCRs. All the samples tested negative for caliciviruses and while astroviruses were detected in 18 (7.3%) samples of Rattus rattus species. Phylogenetic analyses based on the RdRp gene showed that all the sequences belonged to Mamastrovirus genus in which they were genetically related to R. rattus related AstVs previously detected in Gabon or in Rattus spp. AstV from Kenya and Asia. These findings suggested that transportation such as land and railway, as well national and international trade, are likely to facilitate spread of AstVs by the dissemination of rodents

Le rococo et la musique française ? Deux points de vue

International audienceConsiders whether the term “rococo” may be accurately applied to French music of the early 18th c. and the aesthetic implications of the word

Contribution à la commande en efforts pour la robotique chirurgicale

PARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

A mathematical approach for human centered decision aid

International audienceA mathematical approach for human centered decision ai