Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients

What information could the main actors of liquid biopsy provide? A representative case of non-small cell lung cancer (NSCLC)

In non-small cell lung cancer (NSCLC), there is a consensus regarding the use of liquid biopsy, generally, to detect "druggable" mutations and, in particular, to monitor tyrosine kinase inhibitor (TKI) treatments. However, whether circulating tumor cells (CTCs) are better tools than cell-free DNA (cfDNA), is still a matter of debate, mainly concerning which antigen(s) we should use to investigating simultaneously both epithelial and epithelial-to-mesenchymal transient (EMT) phenotype in the same sample of CTCs. To address this item, we exploited here a single-tube liquid biopsy, to detect both epithelial cell adhesion molecule (EpCAM)-positive CTCs and EpCAM-low/negative CTCs, because down-modulation of EpCAM is considered the first step in EMT. Furthermore, we analyzed the DNA from CTCs of four different phenotypes (ctcDNA), according to their EpCAM expression and cytokeratin pattern, and circulating tumor DNA (ctDNA) by droplet digital PCR (ddPCR), in order to disclose activating and resistancedriving mutations. Liquid biopsy reflected spatial and temporal heterogeneity of the tumor under treatment pressure. We provide the proof-of-concept that the complementary use of ctDNA and ctcDNA represents a reliable, minimally invasive and dynamic tool for a more comprehensive view of tumor evolution

adhesion of functional layer on polymeric substrates for optoelectronic applications

The use of plastic film substrates for organic electronic devices promises to enable new applications, such as flexible displays. Plastic substrates have several distinct advantages, such as ruggedness, robustness, ultra lightness, conformability and impact resistance over glass substrates, which are primarily used in flat panel displays (FPDs) today. However, high transparency, proper surface roughness, low gas permeability and high transparent electrode conductivity of the plastic substrate are required for commercial applications. Polyesters, both amorphous and semicrystalline, are a promising class of commercial polymer for optoelectronic applications. Surface modification of polyester films was performed via chemical solution determining hydrolysis or oxidation. Hydrolysis was carried out by means of sodium hydroxide solution and oxidation by using standard clean 1 (SC-1) of RCA procedure [1]. For this work we have used commercial polymer films of 100µm in thickness: AryLite™ [2], supplied by Ferrania Imaging Technologies S.p.A. and characterised by very high glass transition temperature, Mylar™ (Polyethylene Terephthalate PET) and Teonex™ (Polyethylene Naphthalate PEN) both supplied by Dupont. More over, a bioriented and semicrystalline PET have been used. The aim of this study is modifying the polymer surface to improve the adhesion between organic-inorganic layer. It was found that the NaOH and SC-1 treatment cause a decrease of contact angles. In the present study we have deposited a thin films of amorphous hydrogenated silicon (a-Si:H) and its oxide (SiO2) on a new high temperature polymer substrate, AryLite™, by plasma enhanced chemical vapour deposition (PECVD) [3], with a radio frequency plasma system

EChO Payload electronics architecture and SW design

EChO is a three-modules (VNIR, SWIR, MWIR), highly integrated spectrometer, covering the wavelength range from 0.55 $\mu$m, to 11.0 $\mu$m. The baseline design includes the goal wavelength extension to 0.4 $\mu$m while an optional LWIR module extends the range to the goal wavelength of 16.0 $\mu$m. An Instrument Control Unit (ICU) is foreseen as the main electronic subsystem interfacing the spacecraft and collecting data from all the payload spectrometers modules. ICU is in charge of two main tasks: the overall payload control (Instrument Control Function) and the housekeepings and scientific data digital processing (Data Processing Function), including the lossless compression prior to store the science data to the Solid State Mass Memory of the Spacecraft. These two main tasks are accomplished thanks to the Payload On Board Software (P-OBSW) running on the ICU CPUs.Comment: Experimental Astronomy - EChO Special Issue 201

Assessing the performance of a scroll expander with a selection of fluids suitable for low-temperature applications

This paper presents calculations of micro organic Rankine cycles equipped with a scroll expander whose performance is simulated by a model reported in literature. In particular, the original working fluid (R245fa) is replaced with selected hydrofluorocarbons and hydrocarbons for assessing the performance of the power cycle as a function of the specific working fluid. After setting the power output from the expander at 2 kW, the relationship between cycle efficiency and maximum cycle temperature is presented for each fluid. Thus, the possibility of matching the operation of the organic Rankine cycle to heat sources at lower temperature is investigated

Preliminary analysis of the genetic variability of two natural beds of the Scallop Euvola ziczac (Linnaeus, 1758) in Brazil

Euvola ziczac (formerly Pecten ziczac), a simultaneous hermaphroditic scallop was heavily fished in Brazil between 1972 and 1980. The production peaked in 1980 with 8,800 tons and was followed by the total collapse of the resource. In order to investigate the possible loss of genetic variability of the stock associated to overfishing and self-fertilization, the polymorphism of phosphoglucomutase (PGM) and glucose phosphate isomerase (GPI) was analyzed by electrophoresis of the adductor muscle of scallops from São Francisco (26° 20.583S; 48° 16.507W) and Bom Abrigo (25° 28.735S; 47° 37.621W) beds; the southern and northern extremes of the scallop fishing ground, respectively. Animals from São Francisco showed a strong deficiency of heterozygosity for GPI and PGM. In addition, PGM showed *exclusive alleles for each bed. Such results coupled with other information about the species suggested the following hypothesis: a) the stock was a metapopulation with at least two populations; b) some reproductive isolation might be occurring which might be influenced by conditions of larval transport and by the extremely low densities of scallops; c) presently, the stock seemed to be mostly maintained through self-fertilization; d) São Francisco could constitute a source-area, contributing with larvae and recruits to Bom Abrigo and other areas; e) both beds were suffering a genetic homogenization more evident in São Francisco. Such hypothesis needed to be investigated in order to furnish guidelines for future programs of recovery and management of the resource.info:eu-repo/semantics/publishedVersio

RELATÓRIO TÉCNICO DOS CRUZEIROS DO PROJETO VIEIRA. I. CRUZEIRO 1(4 A 9 DE DEZEMBRO DE 1995)

Main technical results and original data of Cruise I of the Scallop Project (December 4 to 9, 1995) are presented in this Report. Sampling sites were distributed along seven transects, between the 30 and 50 meters isobaths, according to information of previous surveys carried out in 1975. Salinity and temperature of the water column, and sediment samples were obtained at each sampling site for a physical characterisation of the scallop grounds. Two types of beam-trawl and one dredge were tested to catch scallops and benthic samples. Salinity and temperature showed an important gradient, with high temperatures and low salinities at surface waters, and low temperature and high salinities at bottom waters. Sediments were constituted by pure fine to very fine sands. Organic matter and calcium carbonate content, together with other statistical sediment parameters, showed a bathymetrical variation. Along the study area, two beds were found, at SSE of Bom Abrigo Island (São Paulo State) and E of São Francisco do Sul Island (Santa Catarina State), both between 36 and 40 m depth. Very low scallop catches were probably related to a total depletion of the original stock. Future cruises will try to determine the efficiencies of the beam-trawl for a real estimation of scallops densities.Neste relatório são apresentados os dados originais e principais resultados técnicos do Cruzeiro I do Projeto Vieira, realizado entre 4 e 9 de dezembro de 1995. As estações de amostragem foram distribuídas ao longo de 7 transversais entre as isóbatas de 30 e 50 m, em áreas de reconhecida ocorrência de vieiras no passado. Foram obtidos perfis verticais de temperatura e salinidade da água em todas as estações, bem como amostras de sedimento, visando uma caracterização física da região. Dois tipos de beam trawl e uma draga foram empregados na captura de vieira e amostras da macrofauna bentõnica. A temperatura e a salinidade mostraram um gradiente acentuado, com altas temperaturas e baixas salinidades em superfície, e baixas temperaturas e altas salinidades junto ao fundo. Os sedimentos são constituídos de areia fina a muito fina. Tanto os parâmetros granulométricos como o conteúdo de matéria orgânica e carbonato de cálcio mostraram um gradiente batimétrico em seus valores. Ao longo da área de estudo, foram encontrados dois bancos de vieira, um a SSE da Ilha do Bom Abrigo, no litoral sul de São Paulo, e outro a E da Ilha de São Francisco do Sul, no norte de Santa Catarina, ambos entre 36 e 40 metros de profundidade. Entretanto, as capturas em ambos os bancos foram reduzidas, indicando, provavelmente, a ocorrência de uma depleção total no estoque original. Em cruzeiros futuros, a eficiência de captura do beam trawl será determinada com o objetivo de realizar uma estimação real da densidade de vieiras nas áreas

An unexpected guest: Pulmonary echinococcosis diagnosed by intraoperative frozen section examination. A case report and literature review

Echinococcosis is caused by tapeworms belonging to the Echinococcus genus. The most common site of infection is the liver although it may involve almost any organ. Symptoms of pulmonary echinococcosis vary depending on the location and structure of the cyst. While uncomplicated cysts usually appear at imaging as well-defined homogeneous lesions with fluid content and smooth walls of variable thickness, complicated lesions may have a more heterogeneous content with higher density making more difficult the distinction from malignancies or other infections. Hereby we describe the case of a 61-year-old Northern African male admitted to our tertiary center for left upper chest pain who then underwent a chest computed tomography (CT) scan which demonstrated a large hypodense lesion, with smooth and thick walls, in the upper left lobe. The following magnetic resonance confirmed the homogeneous fluid content, and the 18 F- fluorodeoxyglucose-positron emission tomography/CT demonstrated a mild uptake of the walls. According to these findings, the main differential diagnoses at imaging included bronchogenic cyst, synovial sarcoma, and pulmonary hematoma although the patient denied any recent trauma. Given the large size and clinical symptoms he underwent surgery. Intra-operative frozen section, supported by imprint cytology, excluded the presence of malignancy while suggested an echinococcal laminar exocyst. The final pathological examination confirmed the diagnosis of echinococcosis (i.e., Echinococcus Granulosus protoscolex). After surgery he was treated with albendazole and at the six-month follow-up he was in good clinical conditions. Our case highlights the importance of considering rare infections, particularly in individuals from endemic areas. Frozen tissue analyses can be a diagnostic challenge and often require ancillary tools such as imprint cytology and serial sections for more sensitive and accurate diagnosis

Transverse orange nail lesions following SARS-CoV-2 infection

We report the case of an 89-year-old woman in a nursing home who amid an outbreak of coronavirus disease 2019 (COVID-19) presented cough and asthenia