Experimental simulation: using generative modeling and palaeoecological data to understand human-environment interactions

The amount of palaeoecological information available continues to grow rapidly, supporting improved descriptions of the dynamics of past ecosystems and enabling them to be seen from new perspectives. At the same time, there has been concern over whether palaeoecological enquiry needs to move beyond descriptive inference to a more hypothesis-focussed, or experimental approach. However, the extent to which conventional hypothesis-driven scientific frameworks can be applied to historical contexts (i.e., the past) is the subject of ongoing debate. In other disciplines concerned with human-environment interactions, including physical geography and archaeology, there has been growing use of generative simulation models, typified by agent-based approaches. Generative modeling encourages counter-factual questioning (“what if…?,”) a mode of argument that is particularly important in systems and time-periods, such as the Holocene, and now the Anthropocene, where the effects of humans and other biophysical processes are deeply intertwined. However, palaeoecologically focused simulation of the dynamics of the ecosystems of the past either seems to be conducted to assess the applicability of some model to the future or treats humans simplistically as external forcing factors. In this review we consider how generative simulation-modeling approaches could contribute to our understanding of past human-environment interactions. We consider two key issues: the need for null models for understanding past dynamics and the need to be able learn more from pattern-based analysis. In this light, we argue that there is considerable scope for palaeoecology to benefit from developments in generative models and their evaluation. We discuss the view that simulation is a form of experiment and by using case studies, consider how the many patterns available to palaeoecologists can support model evaluation in a way that moves beyond simplistic pattern-matching and how such models might also inform us about the data themselves and the processes generating them. Our emphasis is on how generative simulation might complement traditional palaeoecological methods and proxies rather than on a detailed overview of the modeling methods themselves

Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking

Background & Aims Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane compartments for viral replication. Several RNA viruses, including poliovirus and hepatitis C virus (HCV), require phosphatidylinositol (PI) 4-kinases for their replication. However, it is not known how PI 4-kinases and their product, PI(4)P, facilitate host membrane reorganization and viral replication. In addition, although the HCV replication compartment, known as the membranous web, is believed to be cholesterol enriched, the mechanisms by which this occurs have not been elucidated. We aimed to identify and characterize a PI 4-kinase effector in HCV replication. Methods We used a combination of microscopic and biochemical methods to study HCV replication, web morphology, the distribution of intracellular protein and PI(4)P, along with cholesterol trafficking in HCV-infected cells. PI 4-kinase and oxysterol-binding protein (OSBP) were inhibited using RNA interference or small molecules in cells expressing a full-length genotype 1b replicon or infected with the JFH-1 strain of HCV. Results OSBP was required for HCV replication and membranous web integrity. OSBP was recruited to membranous webs in a PI 4-kinase-dependent manner, and both these factors were found to regulate cholesterol trafficking to the web. We also found OSBP to be required for poliovirus infection but dispensable for dengue virus. Conclusions OSBP is a PI 4-kinase effector in HCV infection, and contributes to the integrity and cholesterol enrichment of the membranous web. OSBP might also be a PI 4-kinase effector in poliovirus infection and could be involved in replication of other viruses that require PI 4-kinases

Letter from Matthew C. Perry, in Norfolk, Virginia aboard the U.S. Steam Frigate Mississippi, to William J.W. Clancy, commanding U.S. Steam Frigate Powhattan, directing him on the route by which he shall sail to Macau (China). November 23, 1852.

Intructions from Mathew C. Perry to William J.W. Clancy regarding his voyage on the Powhattan to China. Perry directs Clancy to stop in Madeira to refuel and then again at the Cape of Good Hope, and again at Mauritius or Isle of France. Perry also discusses other details of the voyage. November 23, 1852. Norfolk, Virginia, abourd the U.S Mississippi.https://digitalcommons.wofford.edu/littlejohnmss/1208/thumbnail.jp

Dairy Cattle Feeding Experiments.

14 p

Noncommutative Topological Half-flat Gravity

We formulate a noncommutative description of topological half-flat gravity in four dimensions. BRST symmetry of this topological gravity is deformed through a twisting of the usual BRST quantization of noncommutative gauge theories. Finally it is argued that resulting moduli space of instantons is characterized by the solutions of a noncommutative version of the Plebanski's heavenly equation.Comment: 12+1 pages, revtex4, no figure

Effects of hydrostatic pressure on the magnetic susceptibility of ruthenium oxide Sr3Ru2O7: Evidence for pressure-enhanced antiferromagnetic instability

Hydrostatic pressure effects on the temperature- and magnetic field dependencies of the in-plane and out-of-plane magnetization of the bi-layered perovskite Sr3Ru2O7 have been studied by SQUID magnetometer measurements under a hydrostatic helium-gas pressure. The anomalously enhanced low-temperature value of the paramagnetic susceptibility has been found to systematically decrease with increasing pressure. The effect is accompanied by an increase of the temperature Tmax of a pronounced peak of susceptibility. Thus, magnetization measurements under hydrostatic pressure reveal that the lattice contraction in the structure of Sr3Ru2O7 promotes antiferromagnetism and not ferromagnetism, contrary to the previous beliefs. The effects can be explained by the enhancement of the inter-bi-layer antiferromagnetic spin coupling, driven by the shortening of the superexchange path, and suppression, due to the band-broadening effect, of competing itinerant ferromagnetic correlations.Comment: 11 pages, 4 figure

Thinking about growth : a cognitive mapping approach to understanding small business development

School of Managemen

Investigation of the ferromagnetic transition in the correlated 4d perovskites SrRu1−x_{1-x}Rhx_xO3_3

The solid-solution SrRu$_{1-x}$Rh$_x$O$_3$ ($0\le x \le1$) is a variable-electron-configuration system forming in the nearly-cubic-perovskite basis, ranging from the ferromagnetic 4$d^4$ to the enhanced paramagnetic 4$d^5$. Polycrystalline single-phase samples were obtained over the whole composition range by a high-pressure-heating technique, followed by measurements of magnetic susceptibility, magnetization, specific heat, thermopower, and electrical resistivity. The ferromagnetic order in long range is gradually suppressed by the Rh substitution and vanishes at $x \sim 0.6$. The electronic term of specific-heat shows unusual behavior near the critical Rh concentration; the feature does not match even qualitatively with what was reported for the related perovskites (Sr,Ca)RuO$_3$. Furthermore, another anomaly in the specific heat was observed at $x \sim 0.9$.Comment: Accepted for publication in PR

Two-dimensional Quantum-Corrected Eternal Black Hole

The one-loop quantum corrections to geometry and thermodynamics of black hole are studied for the two-dimensional RST model. We chose boundary conditions corresponding to the eternal black hole being in the thermal equilibrium with the Hawking radiation. The equations of motion are exactly integrated. The one of the solutions obtained is the constant curvature space-time with dilaton being a constant function. Such a solution is absent in the classical theory. On the other hand, we derive the quantum-corrected metric (\ref{solution}) written in the Schwarzschild like form which is a deformation of the classical black hole solution \cite{5d}. The space-time singularity occurs to be milder than in classics and the solution admits two asymptotically flat black hole space-times lying at "different sides" of the singularity. The thermodynamics of the classical black hole and its quantum counterpart is formulated. The thermodynamical quantities (energy, temperature, entropy) are calculated and occur to be the same for both the classical and quantum-corrected black holes. So, no quantum corrections to thermodynamics are observed. The possible relevance of the results obtained to the four-dimensional case is discussed.Comment: Latex, 28 pges; minor corrections in text and abstract made and new references adde