XVI Congresso da Associação Portuguesa de Investigação Operacional: livro de resumos

Fundação para a Ciência e a Tecnologia - FC

Dioxinas: um problema de saúde pública

Dioxinas: um problema de saúde públic

Mannans and mannan oligosaccharides (MOS) from saccharomyces cerevisiae: a sustainable source of functional ingredients

Sustainable industry practices and circular economy concepts encourage the transformation of production waste into by-products. Saccharomyces cerevisiae is widely used in fermentation industry worldwide, generating large amounts of spent yeast which is mainly directed to animal feed or discarded as waste. Instead of becoming and environmental problem, spent yeast can be directed to the extraction of valuable compounds such as mannans and mannan oligosaccharides (MOS). This review presents a compilation of the studies up to date regarding the different chemical, enzymatic, mechanical or physical processes addressed for mannans extraction and MOS production. Additionally, the existing studies on the chemical modification of mannans aimed to improve specific characteristics are also discussed. Finally, the more relevant bioactivities and potential applications of mannans, MOS and mannose are presented, together with products on the market containing these compounds.info:eu-repo/semantics/acceptedVersio

Effects of drying technology on the physical and functional properties of mannans from S. cerevisiae

info:eu-repo/semantics/publishedVersio

Optimization of mannans extraction from spent yeast Saccharomyces cerevisiae

info:eu-repo/semantics/publishedVersio

Effect of mannan oligosaccharides extracts in uropathogenic escherichia coli adhesion in human bladder cells

info:eu-repo/semantics/publishedVersio

Detecção e Mapeamento da Descarga de Efluente Proveniente dum Emissário Submarino Utilizando um Veículo Submarino Autónomo

O Veículo Submarino Autónomo (VSA) Isurus constitui uma tecnologia de vanguarda ao nível damonitorização ambiental. A possibilidade de recolha de dados com elevada resolução e grande rapidezconstitui uma das muitas vantagens que apresenta em relação aos métodos de medição in-situtradicionais. A monitorização ambiental de efluentes provenientes de emissários submarinos constituiuma das aplicações em que pode trazer mais valias, quer ao nível do controlo do meio ambiente, querao nível da avaliação do desempenho do próprio emissário. Nesta publicação descreve-se uma missãode monitorização ambiental a um Emissário Submarino utilizando o VSA Isurus focando-se em especialos resultados obtidos e a estratégia de recolha de dados utilizada, que se baseia na utilização de ummodelo de previsão da dispersão

A step for the valorization of spent yeast through production of iron–peptide complexes — a process optimization study

Given the importance of iron in human nutrition and the significance of waste and by-product valorisation in a circular economy environment, we investigated the effects of protein and iron concentration on the production yield of iron–peptide complexes from spent Saccharomyces cerevisiae. For this purpose, different amounts of protein and iron were used in the complexation process. The results have shown that higher concentrations, although permitting a faster and larger scale process, provide a significantly lower complexation yield, which deems the process less feasible. This is corroborated by fluorescence analysis, which shows a lower degree of complexation with higher protein concentration. In addition, varying the concentration of iron does not change the quality of formed complexes, as evidenced by Fourier transform infrared spectroscopy (FT-IR) analysis. The morphology of all samples was also evaluated using scanning electron microscopy (SEM). Therefore, further studies are needed to optimize the process and to evaluate the best conditions for an economically sound valorization process for iron–peptide complexes. Nonetheless, current results in the development of a new process for the valorisation of spent yeast, in the form of iron-peptide complexes, look promising.info:eu-repo/semantics/publishedVersio

The role of endothelial cells in hematologic malignancies

A neoformação vascular constitui evento essencial para que ocorra o desenvolvimento humano. Nesta fase, o sistema vascular sofre expansão. Células endoteliais maduras (ECs) irão compor a parede dos vasos, enquanto células endoteliais oriundas da medula óssea (MO) migram para locais de neoformação vascular com subseqüente diferenciação em células endoteliais maduras. Processos fisiológicos e patológicos como câncer têm a angiogênese como importante componente. Estudos correlacionam a angiogênese com a agressividade tumoral em alguns tipos de tumores incluindo hematológicos, o que ressalta a importância da terapia antiangiogênica como alvo de pesquisas cada vez mais profundas. Neste artigo de revisão enfocamos o papel da angiogênese nas neoplasias hematológicas com ênfase em possíveis alvos terapêuticos.Vascular neoformation is an essential event in the development of the human body. In this phase vascular networks undergo expansion. Mature endothelial cells constitute the structure of vessel walls so endothelial cells from bone marrow migrate to sites of vascular neoformation with subsequent differentiation as mature endothelial cells (endothelial progenitor cells). Physiopathological and pathological processes such as cancer use angiogenesis as an important component for growth. Studies correlate angiogenesis with aggressive tumors for some types of tumors, including hematological malignancies, thereby highlighting the importance of anti-angiogenic therapy

Effect of drying technology in Saccharomyces cerevisiae mannans: structural, physicochemical, and functional properties

Mannans are polysaccharides whose physicochemical and biological properties render them commercialization in several products. Since these properties are strongly dependent on production conditions, the present study aims to assess the impact of different drying technologies – freeze (FDM) and spray drying (SDM) – on the structural, physicochemical, and biological properties of mannans from Saccharomyces cerevisiae. Structural analysis was assessed by FT-IR, PXRD and SEM, whereas physicochemical properties were evaluated based on sugars, protein, ash and water contents, solubility, and molecular weight distribution. Thermal behaviour was analysed by DSC, and antioxidant activity by DPPH and ABTS assays. The parameters which revealed major differences, in terms of structural and physicochemical properties regarded morphology (SEM), physical appearance (colour), moisture (3.6 ± 0.1 % and 11.9 ± 0.6% for FDM and SDM, respectively) and solubility (1 mg/mL for FDM and 25 mg/mL for SDM). Nevertheless, these differences were not translated into the antioxidant capacity.info:eu-repo/semantics/publishedVersio