Auralization of Amplitude Modulated Helicopter Flyover Noise

Rotorcraft noise is an active field of study as the sound produced by these vehicles is often found to be annoying. A means to auralize rotorcraft flyover noise is sought to help understand the factors leading to annoyance. Previous work by the authors auralized a complete flyover event in which the source noise synthesis traversed a range of emission angles. The source noise definition process for the synthesis used helicopter flyover recordings. Although this process yielded both periodic and aperiodic (modulation) components at a set of discrete emission angles, only the periodic components were used in the previous work to synthesize the sound of the flyover event. In the current work, aperiodic amplitude modulation is incorporated into the source noise synthesis to improve its fidelity toward assessing rotorcraft noise annoyance. The method is demonstrated using ground recordings from a flight test of the AS350 helicopter for the source noise definition

Hubungan Luas Lahan USAhatani Padi Sawah dengan Ketersediaan Beras Rumah Tangga di Desa Cupak Kecamatan Danau Kerinci Kabupaten Kerinci

Penelitian ini bertujuan untuk mengetahui Hubungan Luas Lahan Usahatani Padi Sawah dengan Ketersediaan Beras Rumah Tangga di Desa Cupak Kecamatan Danau Kerinci Kabupaten Kerinci. Penelitian ini di laksanakan pada tanggal 06 Februari 2013 s/d 06 Maret 2013 di Desa Cupak Kecamatan Danau Kerinci Kabupaten Kerinci. Pengumpulan data dalam penelitian ini terdiri dari data primer dan data skunder. Populasi petani di Desa Cupak berjumlah 530 KK. Pengambilan sampel menggunakan metode acak sederhana (Simple Random Sampling). Sampel yang diambil adalah sebanyak 15% dari populasi sehingga diperoleh 80 KK petani padi sawah. Untuk mengetahui tentang gambaran ketersediaan beras dalam rumah tangga dan luas lahan USAhatani padi sawah didaerah penelitian, data diolah secara tabulasi dan dilanjutkan dengan analisis deskriptif menggunakan tabel distribusi frekuensi sementara untuk mengetahui hubungan luas lahan USAhatani padi sawah dengan ketersediaan beras dalam rumah tangga digunakan statistik nonparametrik melelui Uji Chi square ( ). Menurut Siagel (1992), uji chi square. Hasil penelitian ini menggungkapkan bahwa terdapat hubungan antara luas lahan USAhatani padi sawah dengan ketersediaan beras rumah tangga di Desa Cupak Kecamatan Danau Kerinci Kabupaten Kerinci. Hubungan luas lahan USAhatani padi sawah dengan ketersediaan beras rumah tangga petani ditunjukkan dengan petani yang memiliki lahan ≥ 0,15 – 0,80 ha beras cukup selama 1 tahun dengan jumlah anggota keluarga 4-5 orang/kk dengan jumlah 58 KK

Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens.

BACKGROUND:Breast cancer patients with early-stage disease are increasingly administered neoadjuvant chemotherapy (NAC) to downstage their tumors prior to surgery. In this setting, approximately 31% of patients fail to respond to therapy. This demonstrates the need for techniques capable of providing personalized feedback about treatment response at the earliest stages of therapy to identify patients likely to benefit from changing treatment. Diffuse optical spectroscopic imaging (DOSI) has emerged as a promising functional imaging technique for NAC monitoring. DOSI uses non-ionizing near-infrared light to provide non-invasive measures of absolute concentrations of tissue chromophores such as oxyhemoglobin. In 2011, we reported a new DOSI prognostic marker, oxyhemoglobin flare: a transient increase in oxyhemoglobin capable of discriminating NAC responders within the first day of treatment. In this follow-up study, DOSI was used to confirm the presence of the flare as well as to investigate whether DOSI markers of NAC response are regimen dependent. METHODS:This dual-center study examined 54 breast tumors receiving NAC measured with DOSI before therapy and the first week following chemotherapy administration. Patients were treated with either a standard of care maximum tolerated dose (MTD) regimen or an investigational metronomic (MET) regimen. Changes in tumor chromophores were tracked throughout the first week and compared to pathologic response and treatment regimen at specific days utilizing generalized estimating equations (GEE). RESULTS:Within patients receiving MTD therapy, the oxyhemoglobin flare was confirmed as a prognostic DOSI marker for response appearing as soon as day 1 with post hoc GEE analysis demonstrating a difference of 48.77% between responders and non-responders (p < 0.0001). Flare was not observed in patients receiving MET therapy. Within all responding patients, the specific treatment was a significant predictor of day 1 changes in oxyhemoglobin, showing a difference of 39.45% (p = 0.0010) between patients receiving MTD and MET regimens. CONCLUSIONS:DOSI optical biomarkers are differentially sensitive to MTD and MET regimens at early timepoints suggesting the specific treatment regimen should be considered in future DOSI studies. Additionally, DOSI may help to identify regimen-specific responses in a more personalized manner, potentially providing critical feedback necessary to implement adaptive changes to the treatment strategy

O Antijudaísmo de Justino Mártir no Diálogo Com Trifão

Esta dissertação objetiva identificar as linhas mestras que se opõem ao judaísmo no corpo da obra Diálogo com Trifão, de Justino Mártir, a partir da metodologia engendrada por Norbert Elias, em Os Estabelecidos e os Outsiders. Em conseqüência, pretende retificar o estatuto da obra do filósofo cristão, pretendido por muitos estudiosos como proselitista, tomando-a documento formativo da identidade cristã e de sua dissociação do judaísmo. Para isso, o presente texto investiga e revista o aspecto sócio-cultural e político que deu origem ao cristianismo, o período do judaísmo do Segundo Templo, considerando as ponderações e dicotomias daí resultantes como propiciadoras, no seio da comunidade judaica, à ruptura manifesta na ascensão e disseminação do cristianismo na Roma do século II. Palavras chave: cristianismo; judaísmo; identidade; Justino Mártir; estigmatizaçã

An analysis of the most distant catalogued open clusters -- Re-assessing fundamental parameters with Gaia EDR3 and ASteCA\texttt{ASteCA}

Several studies have been presented in the last few years applying some kind of automatic processing of data to estimate the fundamental parameters of open clusters. These parameters are later on employed in larger scale analyses, for example the structure of the Galaxy's spiral arms. The distance is one of the more straightforward parameters to estimate, yet enormous differences can still be found among published data. This is particularly true for open clusters located more than a few kpc away. We cross-matched several published catalogues and selected the twenty-five most distant open clusters ($>$9000 pc). We then performed a detailed analysis of their fundamental parameters, with emphasis on their distances, to determine the agreement between catalogues and our estimates.} Photometric and astrometric data from the Gaia EDR3 survey was employed. The data was processed with our own membership analysis code (pyUPMASK), and our package for automatic fundamental cluster's parameters estimation ($\texttt{ASteCA}$). We find differences in the estimated distances of up to several kpc between our results and those catalogued, even for the catalogues that show the best matches with $\texttt{ASteCA}$ values. Large differences are also found for the age estimates. As a by-product of the analysis we find that vd Bergh-Hagen 176 could be the open cluster with the largest heliocentric distance catalogued to date. Caution is thus strongly recommended when using catalogued parameters of open clusters to infer large-scale properties of the Galaxy, particularly for those located more than a few kpc away.Comment: Accepted for publication in A&

Management of a Malpractice Dental Implant Case in a Patient with History of Oral Bisphosphonates Intake: A Case Report and Narrative Review of Recent Findings

The present article aims to describe the management of a malpractice dental implant case in a patient with a history of oral bisphosphonates (BF) intake (alendronic acid every 15 days for 20 years) and to perform a narrative review of recently published articles (2019–2023) on the topic. A female patient rehabilitated with 18 nails in the mandible 20 years ago underwent two surgeries; the first one included the explantation of the nails; the second one included the insertion of two implants in the anterior region. At the last follow-up (21 months from the first surgery and 15 months from the second one) no complications nor episodes of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were highlighted. Furthermore, 12 recent articles on the topic were reported and a narrative review was performed. Based on the narrative analysis, the topic related to dental implants in patients with BF intake seems to remain controversial. Most of the findings highlight how the evidence on both the safety of the treatment and the possibility to foresee the risk of onset based on preoperative factors seem to be scarce. The case described in the present article did not report any complications nor episodes of BRONJ. However, evidence from a single case report is scarce and more clinical trials are required to deepen the knowledge on the topic