86 research outputs found
Book Reviews
Reviews of the following books: Chansonetta: The Life and Photographs of Chansonetta Stanley Emmons, 1859-1937 by Marius B. Peladeau; Raymond Then and Now by Ernest H. Knight; The Jesuit Heritage of New England by Vincent A. Lapomarda; The Landing: A Remembrance of Her People and Shipyards by Thomas W. Murphy; A History of the Town of Hancock, 1828-1979 prepared by the Sesquicentennial Committee of the Town of Hancoc
Transforming Marketing Education of the Future: The Role of Intelligent Agent Technologies (IATs) in Enhancing Student Learning
This conceptual paper introduces IATs and discusses how such intelligent and interactive applications can translate into better education environment for marketing curriculum, particularly marketing research. We present a conceptual model based on extant literature. We present some initial test of our conceptual model of IAT usage in marketing education in a marketing research class
BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy
We report on the temporal behavior of the high-energy power law continuum
component of gamma-ray burst spectra with data obtained by the Burst and
Transient Source Experiment. We have selected 126 high fluence and high flux
bursts from the beginning of the mission up until the present. Much of the data
were obtained with the Large Area Detectors, which have nearly all-sky
coverage, excellent sensitivity over two decades of energy and moderate energy
resolution, ideal for continuum spectra studies of a large sample of bursts at
high time resolution. At least 8 spectra from each burst were fitted with a
spectral form that consisted of a low-energy power law, a spectral break at
middle energies and a high-energy continuum. In most bursts (122), the
high-energy continuum was consistent with a power law. The evolution of the
fitted high-energy power-law index over the selected spectra for each burst is
inconsistent with a constant for 34% of the total sample. The sample
distribution of the average value for the index from each burst is fairly
narrow, centered on -2.12. A linear trend in time is ruled out for only 20% of
the bursts, with hard-to-soft evolution dominating the sample (100 events). The
distribution for the total change in the power-law index over the duration of a
burst peaks at the value -0.37, and is characterized by a median absolute
deviation of 0.39, arguing that a single physical process is involved. We
present analyses of the correlation of the power-law index with time, burst
intensity and low-energy time evolution. In general, we confirm the general
hard-to-soft spectral evolution observed in the low-energy component of the
continuum, while presenting evidence that this evolution is different in nature
from that of the rest of the continuum.Comment: 30 pages, with 2 tables and 9 figures To appear in The Astrophysical
Journal, April 1, 199
Investigation of a mesospheric gravity wave ducting event using coordinated sodium lidar and Mesospheric Temperature Mapper measurements at ALOMAR, Norway (69°N)
New measurements at the ALOMAR observatory in northern Norway (69°N, 16°E) using the Weber sodium lidar and the Advanced Mesospheric Temperature Mapper (AMTM) allow for a comprehensive investigation of a gravity wave (GW) event on 22 and 23 January 2012 and the complex and varying propagation environment in which the GW was observed. These observational techniques provide insight into the altitude ranges over which a GW may be evanescent or propagating and enable a clear distinction in specific cases. Weber sodium lidar measurements provide estimates of background temperature, wind, and stability profiles at altitudes from ~78 to 105âkm. Detailed AMTM temperature maps of GWs in the OH emission layer together with lidar measurements quantify estimates of the observed and intrinsic GW parameters centered near 87âkm. Lidar measurements of sodium densities also allow more precise identification of GW phase structures extending over a broad altitude range. We find for this particular event that the extent of evanescent regions versus regions allowing GW propagation can vary largely over a period of hours and significantly change the range of altitudes over which a GW can propagate
The EX-FRAIL CKD Trial: a study protocol for a pilot randomised controlled trial of a home-based EXercise programme for pre-FRAIL and FRAIL, older adults with Chronic Kidney Disease
Introduction Frailty is highly prevalent in adults with chronic kidney disease (CKD) and is associated with adverse health outcomes including falls, poorer health-related quality of life (HRQOL), hospitalisation and mortality. Low physical activity and muscle wasting are important contributors to physical frailty in adults with CKD. Exercise training may improve physical function and frailty status leading to associated improvements in health outcomes, including HRQOL. The EX-FRAIL CKD trial aims to inform the design of a definitive randomised controlled trial (RCT) that investigates the effectiveness of a progressive, multi-component home-based exercise programme in pre-frail and frail older adults with CKD. Methods and Analysis The EX-FRAIL CKD trial is a two-arm parallel group pilot RCT. Participants categorised as pre-frail or frail, following Frailty Phenotype assessment, will be randomised to receive exercise or usual care. Participants randomised to the intervention arm will receive a tailored 12-week exercise programme, which includes weekly telephone calls to advise on exercise progression. Primary feasibility outcome measures include rate of recruitment, intervention adherence, outcome measure completion and participant attrition. Semi-structured interviews with a purposively selected group of participants will inform the feasibility of the randomisation procedures, outcome measures and intervention. Secondary outcome measures include physical function (walking speed and Short Physical Performance Battery), frailty status (Frailty Phenotype), fall concern (Falls Efficacy Scale-International tool), activities of daily living (Barthel Index), symptom-burden (Palliative Care Outcome Scale-Symptoms RENAL) and HRQOL (Short Form-12v2). Ethics and Dissemination Ethical approval was granted by a National Health Service (NHS) Regional Ethics Committee and the NHS Health Research Authority. The study team aim to publish findings in a peer-reviewed journal and present the results at relevant national and international conferences. A summary of findings will be provided to participants, a local kidney patient charity and the funding body
Functional gene group analysis indicates no role for heterotrimeric G proteins in cognitive ability
Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences
LargeâAmplitude Mountain Waves in the Mesosphere Observed on 21 June 2014 During DEEPWAVE: 1.Wave Development, Scales, Momentum Fluxes, and Environmental Sensitivity
A remarkable, largeâamplitude, mountain wave (MW) breaking event was observed on the night of 21 June 2014 by groundâbased optical instruments operated on the New Zealand South Island during the Deep Propagating Gravity Wave Experiment (DEEPWAVE). Concurrent measurements of the MW structures, amplitudes, and background environment were made using an Advanced Mesospheric Temperature Mapper, a Rayleigh Lidar, an AllâSky Imager, and a FabryâPerot Interferometer. The MW event was observed primarily in the OH airglow emission layer at an altitude of ~82 km, over an ~2âhr interval (~10:30â12:30 UT), during strong eastward winds at the OH altitude and above, which weakened with time. The MWs displayed dominant horizontal wavelengths ranging from ~40 to 70 km and temperature perturbation amplitudes as large as ~35 K. The waves were characterized by an unusual, âsawâtoothâ pattern in the largerâscale temperature field exhibiting narrow cold phases separating much broader warm phases with increasing temperatures toward the east, indicative of strong overturning and instability development. Estimates of the momentum fluxes during this event revealed a distinct periodicity (~25 min) with three wellâdefined peaks ranging from ~600 to 800 m2/s2, among the largest ever inferred at these altitudes. These results suggest that MW forcing at small horizontal scales (km) can play large roles in the momentum budget of the mesopause region when forcing and propagation conditions allow them to reach mesospheric altitudes with large amplitudes. A detailed analysis of the instability dynamics accompanying this breaking MW event is presented in a companion paper, Fritts et al. (2019, https://doi.org/10.1029/2019jd030899)
The non-synonymous SNP, R1150W, in SCN9A is not associated with chronic widespread pain susceptibility
Acknowledgements The authors wish to thank all of the primary care practices and participants in the EPIFUND study, the EPIFUND study team and Arthritis Research UK lab staff for carrying out the genotyping. The authors thank the men who participated in the seven countries and the research/nursing staff in the seven centres of the EMAS study used in the current analysis: C Pott (Manchester), E Wouters (Leuven), M del Mar Fernandez (Santiago de Compostela), M Jedrzejowska (Lodz), H-M Tabo (Tartu) and A Heredi (Szeged) for their data collection, and C Moseley (Manchester) for data entry and project coordination. DV and SB are senior clinical investigators of the Fund for Scientific Research-Flanders, Belgium (F W O-Vlaanderen). SB is holder of the Leuven University Chair in Gerontology and Geriatrics. The researchers thank the Framingham study participants and personnel. This work was supported by Arthritis Research UK, Chesterfield, UK. The European Male Ageing Study (EMAS) is funded by the Commission of the European Communities Fifth Framework Programme âQuality of life and management of living resourcesâ grant QLK6-CT-2001-00258. Genotyping of the Dyne Steel DNA Bank for Ageing and Cognition cohort was supported by the BBSRC and the study was supported by AgeUK. The Framingham study was supported by grants from the National Heart, Lung, and Blood Institute (NHLBI contract N01-HC-25195) and NIH AR47785 and AG18393.Peer reviewedPublisher PD
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