Dynamic S0 Galaxies: a Case Study of NGC 5866

S0 galaxies are often thought to be passively evolved from spirals after star formation is quenched. To explore what is occurring in S0s, we present a multi-wavelength study of NGC5866--an isolated nearby edge-on S0. This study shows strong evidence for dynamic activities in the interstellar medium, which are most likely driven by supernova explosions in the galactic disk and bulge. We utilize Chandra, HST, and Spitzer data as well as ground-based observations to characterize the content, structure, and physical state of the medium and its interplay with stars in NGC5866. A cold gas disk is detected with an exponential scale height of 100pc. Numerous off-disk dusty spurs are clearly present: prominent ones can extend as far as 300pc from the galactic plane and are probably produced by individual SNe, whereas faint filaments can have ~ kpc scale and are likely produced by SNe collectively in disk/bulge. We also detect substantial amounts of diffuse Ha- and Pa-emitting gas with a comparable scale height as the cold gas. We find that the heating of the dust and warm ionized gas cannot be explained by the radiation from evolved stars alone, strongly indicating the presence of young stars in the disk at a low formation rate of ~ 0.05Msun/yr. We reveal the presence of diffuse X-ray-emitting hot gas, which extends as far as 3.5kpc from the disk and can be heated easily by Type Ia SNe in the bulge. However, the temperature of this gas is ~ 0.2keV, substantially lower than what might be expected from the mass-loss of evolved stars and Type Ia SNe heating alone, indicating mass loading from cool gas is important. The total masses of the cold, warm and hot gases are ~ 5*10^8, 10^4 and 3*10^7Msun. The relative richness of the gases, undergoing circulations between disk/halo, is perhaps a result of its relative isolation.Comment: 27 pages, 6 figures, 3 tables, ApJ in press, comments are welcom

Suppression of power-broadening in strong-coupling photoassociation in the presence of a Feshbach resonance

Photoassociation (PA) spectrum in the presence of a magnetic Feshbach resonance is analyzed. Nonperturbative solution of the problem yields analytical expressions for PA linewidth and shift which are applicable for arbitrary PA laser intensity and magnetic field tuning of Feshbach Resonance. We show that by tuning magnetic field close to Fano minimum, it is possible to suppress power broadening at increased laser intensities. This occurs due to quantum interference of PA transitions from unperturbed and perturbed continuum. Line narrowing at high laser intensities is accompanied by large spectral shifts. We briefly discuss important consequences of line narrowing in cold collisions.Comment: 12 pages, 5 figure

Doubly Enhanced Skyrmions in ν=2\nu =2 Bilayer Quantum Hall States

By tilting the samples in the magnetic field, we measured and compared the Skyrmion excitations in the bilayer quantum Hall (QH) state at the Landau-level filling factor $\nu =2$ and in the monolayer QH state at $\nu =1$. The observed number of flipped spins is $N_s=14$ in the bilayer system with a large tunneling gap, and $N_s=7$ in the bilayer system with a small tunneling gap, while it is $N_s=7$ in the monolayer system. The difference is interpreted due to the interlayer exchange interaction. Moreover, we have observed seemingly preferred numbers $N_s=14,7,1$ for the flipped spins by tilting bilayer samples.Comment: 4 pages, 4 figure

Interlayer Coherence in the ν=1\nu=1 and ν=2\nu=2 Bilayer Quantum Hall States

We have measured the Hall-plateau width and the activation energy of the bilayer quantum Hall (BLQH) states at the Landau-level filling factor $\nu=1$ and 2 by tilting the sample and simultaneously changing the electron density in each quantum well. The phase transition between the commensurate and incommensurate states are confirmed at $\nu =1$ and discovered at $\nu =2$. In particular, three different $\nu =2$ BLQH states are identified; the compound state, the coherent commensurate state, and the coherent incommensurate state.Comment: 4 pages including 5 figure

Tick tock, tick tock: Mouse culture and tissue aging captured by an epigenetic clock

Aging is associated with dramatic changes to DNA methylation (DNAm), although the causes and consequences of such alterations are unknown. Our ability to experimentally uncover mechanisms of epigenetic aging will be greatly enhanced by our ability to study and manipulate these changes using in vitro models. However, it remains unclear whether the changes elicited by cells in culture can serve as a model of what is observed in aging tissues in vivo. To test this, we serially passaged mouse embryonic fibroblasts (MEFs) and assessed changes in DNAm at each time point via reduced representation bisulfite sequencing. By developing a measure that tracked cellular aging in vitro, we tested whether it tracked physiological aging in various mouse tissues and whether anti-aging interventions modulate this measure. Our measure, termed CultureAGE, was shown to strongly increase with age when examined in multiple tissues (liver, lung, kidney, blood, and adipose). As a control, we confirmed that the measure was not a marker of cellular senescence, suggesting that it reflects a distinct yet progressive cellular aging phenomena that can be induced in vitro. Furthermore, we demonstrated slower epigenetic aging in animals undergoing caloric restriction and a resetting of our measure in lung and kidney fibroblasts when re-programmed to iPSCs. Enrichment and clustering analysis implicated EED and Polycomb group (PcG) factors as potentially important chromatin regulators in translational culture aging phenotypes. Overall, this study supports the concept that physiologically relevant aging changes can be induced in vitro and used to uncover mechanistic insights into epigenetic aging

Origin of the X-ray Emission in the Nuclei of FR Is

We investigate the X-ray origin in FRIs using the multi-waveband high resolution data of eight FR I sources, which have very low Eddington ratios. We fit their multi-waveband spectrum using a coupled accretion-jet model. We find that X-ray emission in the source with the highest L_X (~1.8*10^-4 L_Edd) is from the advection-dominated accretion flow (ADAF). Four sources with moderate L_X(~several*10^-6 L_Edd) are complicated. The X-ray emission of one FR I is from the jet, and the other three is from the sum of the jet and ADAF. The X-ray emission in the three least luminous sources (L_X<1.0*10^-6L_Edd) is dominated by the jet. These results roughly support the predictions of Yuan and Cui(2005) where they predict that when the X-ray luminosity of the system is below a critical value, the X-radiation will not be dominated by the emission from the ADAF any longer, but by the jet. We also find that the accretion rates in four sources must be higher than the Bondi rates, which implies that other fuel supply (e.g., stellar winds) inside the Bondi radius should be important.Comment: 6 pages. To published in Journal of Physics, in proceedings of "The Universe under the Microscope - Astrophysics at High Angular Resolution" (Bad Honnef, Germany, April 2008), eds. R. Schoedel, A. Eckart, S. Pfalzner, and E. Ro

Synthesis of layered silicon-graphene hetero-structures by wet jet milling for high capacity anodes in Li-ion batteries

While silicon-based negative electrode materials have been extensively studied, to develop high capacity lithium-ion batteries (LIBs), implementing a large-scale production method that can be easily transferred to industry, has been a crucial challenge. Here, a scalable wet-jet milling method was developed to prepare a silicon-graphene hybrid material to be used as negative electrode in LIBs. This synthesized composite, when used as an anode in lithium cells, demonstrated high Li ion storage capacity, long cycling stability and high-rate capability. In particular, the electrode exhibited a reversible discharge capacity exceeding 1763 mAh g−1 after 450 cycles with a capacity retention of 98% and a coulombic efficiency of 99.85% (with a current density of 358 mA g−1). This significantly supersedes the performance of a Si-dominant electrode structures. The capacity fade rate after 450 cycles was only 0.005% per cycle in the 0.05–1 V range. This superior electrochemical performance is ascribed to the highly layered, silicon-graphene porous structure, as investigated via focused ion beam in conjunction with scanning electron microscopy tomography. The hybrid electrode could retain 89% of its porosity (under a current density of 358 mA g−1) after 200 cycles compared with only 35% in a Si-dominant electrode. Moreover, this morphology can not only accommodate the large volume strains from active silicon particles, but also maintains robust electrical connectivity. This confers faster transportation of electrons and ions with significant permeation of electrolyte within the electrode. Physicochemical characterisations were performed to further correlate the electrochemical performance with the microstructural dynamics. The excellent performance of the hybrid material along with the scalability of the synthesizing process is a step forward to realize high capacity/energy density LIBs for multiple device applications

DIMA 3.0: Domain Interaction Map

Domain Interaction MAp (DIMA, available at http://webclu.bio.wzw.tum.de/dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46 900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software

Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations

Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important survival and growth signals. To circumvent this problem, we utilized a lentivirus-based delivery system to express physiologically relevant levels of human interleukin-7 (hIL-7) in Rag2-/-γc-/- mice following a single intravenous injection. hIL-7 promoted homeostatic proliferation of both adoptively transferred and endogenously generated T-cells in Rag2-/-γc-/- Human Immune System (HIS) mice. Interestingly, we found that hIL-7 increased T lymphocyte numbers in the spleens of HIV infected HIS mice without affecting viral load. Taken together, our study unveils a versatile approach to deliver human cytokines to HIS mice, to both improve engraftment and determine the impact of cytokines on human diseases

Phase Transition in \nu=2 Bilayer Quantum Hall State

The Hall-plateau width and the activation energy were measured in the bilayer quantum Hall state at filling factor \nu=2, 1 and 2/3, by changing the total electron density and the density ratio in the two quantum wells. Their behavior are remarkably different from one to another. The \nu=1 state is found stable over all measured range of the density difference, while the \nu=2/3$ state is stable only around the balanced point. The \nu=2 state, on the other hand, shows a phase transition between these two types of the states as the electron density is changed.Comment: 5 pages including figures, RevTe