Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Technique [Volume 89, Issue 2]

AA looks at academic changesAbout those athletes...Annual Heroes Awards brings music stars to AtlantaBeesball season ends with fall at regionalBreaking the BubbleCollege writers need fearlessnessGTRI names Cross as new directorHot or NotJoseph to head women's basketballLife and the Importance of Gummi BearsManagement prepares for Tech Square moveMelting Pot offers sizzling entreesNews BriefsOur Views: Consensus OpinionParking renews Stinger contract"Hook up" without ever leaving your roomSport ShortsStudents explore various summer activities on-campusWatson plans for futureWhat happens when ignorance stops being the issue

Technique [Volume 89, Issue 3]

ACC offers invitation to Miami, Va. TechAdvisory groups help students get involved academicallyA Few Reasons why I love (and hate) Georgia TechAguilera's concert proves to be emotional rollercoasterBoard of Regents makes exemptions in testing policyBreaking the BubbleDisappointed in GTPDFaces in the CrowdGTCN approves new cable channel line upHot or NotHow to prevent the summer doldrumsJackets place at U.S. Track & Field NationalsNews BriefsNew sorority helps Christian women bondOur Views: Consensus OpinionRamblin' Nights unveils fall 2004 scheduleReading encourages the imaginationShuffle at Athletic Association replaces MooreSport ShortsThe Hiss return to Atlanta after touring with Oasi

Technique [Volume 89, Issue 10]

ACC Round-UpA global trek with view from TechArr, matey! Students loot and pillage campus for Talk Like a Pirate DayBreaking the Bubbleby the numbersCoC may cut undergrad TAsCouncil Clippings Senate and HouseDad's Garage brings new playEntertainment BriefsFaces in the CrowdGeorgia Tech (1-3) vs. Vanderbilt (1-3)Gigantic custom car show invades Atlanta SpeedwayGrits, tea make the South sweetINTA class explores history of weaponryIntramural NotebookNews BriefsNo. 5 Tech dominates the fieldOUR VIEWS Consensus OpinionOUR VIEWS Hot or NotPositive changes abound this semesterPot, teachers, bikers and tattoos...is it love?'Rents come to town for Family WeekendRock, Scott fail to form coherent plot in RundownScream! It will make you feel betterSpeak Up survey, focus group report releasedSport ShortsStudent Life Fund extended indefinitelyStudents pursuing teaching certificate have limited optionsTigers give Jackets reality check...Two BitsYOUR VIEWS Letters to the EditorYummy in my tummy, plus some clas

Technique [Volume 89, Issue 25]

Alabama's Blue Epic packs Smith's Olde BarAtlanta Ballet gracefully lands at Fox with Romeo & JulietBreaking the Bubbleby the numbersCagers lose two in a row at homeClassic TV shows ending like losing a FriendClough names new vice presidentCouncil Clippings Senate and HouseDonation funds enterprise centerDuke SGA cuts fundsEntertainment BriefsFaces in the CrowdGet your INTA degree, no writing neededGolf team finishes eighth at classicGroup opposes network interference policyGTCN gets taste of own talk show with TylerInspector Gadget would be proudJackets look to upset perennial favorites at meetNews BriefsNo. 3 baseball sweeps VillanovaOUR VIEWS Consensus OpinionOUR VIEWS Hot or NotPerson hurdles his way into Tech's record booksPipe burst floods Center Street aptsSalar delivers top-notch, mouth-watering kabobsSlow sipping strongly encouragedSport ShortsStudent honors friend with Heads Up RaceTech begins accreditation processThink textbooks are too expensive? Recent report blames publishersThrough the looking glassTrack and field teams win titles at ACCsTrip to nuclear facility not exactly like Homer's jobTwisted turns out straightforward...Two BitsWomen's swim team breaks school recordsYOUR VIEWS Letters to the Edito

Technique [Volume 89, Issue 8]

Adams, Hopper invade High MuseumAnd the goalposts came tumbling downBall fever takes over campus as quarterback deliversBlood, vomit, flesh-eating viruses make for wild weekend at CabinBreaking the Bubbleby the numbersCake, Cheap Trick ignite three-week concert tour with stop at TabernacleCareer fair brings back familiar anxieties for many studentsCelebrity laden Rooney rocks Cotton ClubCouncil Clippings Senate and HouseFaces at Georgia TechFaces in the CrowdFree stuff provides great reason to go to FairFunny name, no nonsense music launch a fir-ju wellGeorgia Tech vs. Florida StateGTAA auctions tickets on eBayIntramural NotebookJackets sting no. 17 Tigers in upsetLibrary users jump to 830,000 per yearNeurotic con man, daughter form perfect team, enjoyable filmNews BriefsNew Stinger fleet replaces older modelsOUR VIEWS Consensus OpinionOUR VIEWS Hot or NotProject aims to improve family housingReaders Respond Tech vs Auburn gameSexy On_Line open for one weekSport ShortsTech rugby stomps Auburn 30-10The who, what, when and where of Tech's goalpost-tearing traditionsThieves deserve RIAA legal action...Two BitsYOUR VIEWS Letters to the Edito

Technique [Volume 89, Issue 5]

NOTE: These PDF files were created from the HTML issue on the Technique's website, since no original PDF version exists.2003 Georgia Tech Football: New year, new challengesAA changes ticket pick-up procedureA Global Trek with View from TechAll about the TechniqueAtlanta offers many options for movie lovers of all kindsBeyond the White and GoldBob Furniss takes over as new Parking directorBored yet? Find out what Tech and Atlanta have to offerBreaking the Bubbleby the numbersCar thefts jump sharplyDying to see the BYU Game? Check this outFaces in the CrowdFrom the archives...GTCN revamps cable line-up, adds forty new channelsGT numbers: why I'm gtg and you're gteIneligibilities cause shake-upIt's not just the freshman fifteen anymore: America is fatIt's Official: Miami and Virginia Tech are inNew director brings New York experience to choral programNews BriefsOld-fashioned trolley bridges Technology Square gapOUR VIEWS Consensus OpinionOUR VIEWS Hot or NotPolicy change allows some students to exempt Regents'Recycling isn't just for aluminum cans and newspapersSafe Space program provides haven for GLBT and alliesSeabiscuit proves to be champion by too many lengthsSmith leads by example, on and off the fieldSport ShortsStudents face tuition increaseStudents return from summer vacation to a completed Technology SquareSweeping out my digital dust bunniesTech leads in black engineering degreesTechnique CredoThe Hiss return to Atlanta after touring with OasisThink you know Rock? Get to know MoRisen RecordsThis "old" man dishes out adviceWoodruff re-opening delayedYOUR VIEWS Letters to the Edito

Technique [Volume 89, Issue 14]

Bake sale cooks up controversyBreaking the Bubbleby the numbersCouncil Clippings Senate and HouseEntertainment BriefsEnthusiasm for Halloween events cover whole spectrumFaces in the CrowdGeorgia Tech 7, Maryland 3Get on over to Mama's for top-notch Asian cuisineGovernor unveils nanotech centerGT SMART copes with misconceptions, publicityHewitt's boys ready to take on critics, ACCHOPE proposal cuts fees, booksHuman Stain leaves indelible markJackets sweep N.C. StateMidterm grade reports releasedNews BriefsNo. 4 volleyball scores wins over ACC foesOld bookstore space set for February openingOUR VIEWS Consensus OpinionOUR VIEWS Hot or NotPlaying with LEGOs not just for kidsPriority registration offers perks, incentives for various groupsProposed Caucasian Club riles emotions in CARamblin" with Wes DurhamSpooky delights abound in ATLSports ShortsTake a second to get to know music of 7 Sharp 9Tech Hockey survives tough tourneyTech ready to challenge conference rivals with Joseph...Two BitsVertical Horizon releases Go, levels Variety PlayhouseWriting not a chore for budding novelistsYour high school was like this...right?YOUR VIEWS Letters to the Edito