Exclusive surgical treatment for vestibular schwannoma regrowth or recurrence: A meta-analysis of the literature

Vestibular schwannomas can be treated in different ways, but for symptomatic or growing tumors, the gold standard is surgical removal of the lesion. In order to preserve neurovascular structures, partial removal is often performed, leaving a residual that may grow in subsequent years. To date, there is no consensus with regard to surgical treatment of vestibular schwannoma residuals, and so this review focuses on this topic. A structured search was performed on PubMed searching for all articles discussing vestibular schwannoma residuals and recurrences. Only articles discussing surgical treatment were included, focusing on studies which also examined facial nerve outcomes. A total of 51 articles were eligible for review and these included 375 patients. Statistical analysis was performed by correlating the following parameters: patients' gender and age at first surgery, surgical approach adopted at first and subsequent surgeries, tumor and residual size, and extent of resection (gross total, near total, subtotal or others) at first and subsequent surgical procedures. Facial nerve function was also analyzed focusing on its performance when correlated with the different surgical approaches. The data were analyzed by linear regression but there were no correlations between any of the parameters chosen. There was a statistically significant difference between the first approach used (mainly the retrosigmoid route) compared with subsequent approaches (mainly the translabyrinthine route). In total, 8.5 % of patients needed further treatment due to residual regrowth. Facial nerve outcome was independent of the parameters chosen. Exclusive surgical treatment for vestibular schwannoma residuals had a very low failure rate in terms of requiring further treatment. The approach usually chosen for second surgery was the translabyrinthine technique, and this may be explained by the location of the residual, rather than its size. The choice of a particular surgical approach rather than another had no influence on facial nerve function. Complications rates are comparable to Gamma Knife Radiosurgery's as reported in the literature

Assessment of susceptibility to European stone fruit yellows phytoplasma of new plum variety and five rootstock/plum variety combinations

Two separate experiments were carried out to assess the plum susceptibility to infection by European stone fruit yellows phytoplasmas during a five years period. Commercial varieties/cultivars and new selections grafted on Myrabolan 29C were evaluated in at least two plots of four plants each. Visual inspection and PCR/RFLP identification of phytoplasmas detected an increasing phytoplasma presence in both symptomatic and asymptomatic plants. Eight Japanese plum selections showed ESFY symptoms or pathogen presence in the 50% of the plants and nine selections showed ESFY infection in 20% of the plants. Only nine selections showed absence of both symptoms and pathogen. Although the European selections/cultivars were not symptomatic, plants belonging to six of these cultivars were positive for phytoplasma infection. The evaluation of cultivar/rootstock combinations indicate phytoplasma presence from the first year after plantation on. Two of the rootstocks seem to induce a delay in symptoms appearance and cultivar T.C. Sun resulted to be the most susceptible to the disease independently from the rootstock employed. Keywords: Japanese plum, European plum, European stone fruit yellows phytoplasmas, resistance, disease

Comparison of protein carbonyl (Pco), paraoxonase-1 (pon1) and c-reactive protein (crp) as diagnostic and prognostic markers of septic inflammation in dogs

Reliable diagnostic and prognostic markers of sepsis are lacking, but essential in veterinary medicine. We aimed to assess the accuracy of C-Reactive Protein (CRP), protein carbonyls (PCO) and paraoxonase-1 (PON1) in differentiating dogs with sepsis from those with sterile inflammation and healthy ones, and predict the outcome in septic dogs. These analytes were retrospectively evaluated at admission in 92 dogs classified into healthy, septic and polytraumatized. Groups were compared using the Kruskal–Wallis test, followed by a Mann–Whitney U test to assess differences between survivors and non-survivors. Correlation between analytes was assessed using the Spearman’s test, and their discriminating power was assessed through a Receiver Operating Characteristic (ROC) curve. PON1 and CRP were, respectively, significantly lower and higher in dogs with sepsis compared with polytraumatized and clinically healthy dogs (p < 0.001 for both the analytes), and also in dogs with trauma compared with healthy dogs (p = 0.011 and p = 0.017, respectively). PCO were significantly increased in septic (p < 0.001) and polytraumatized (p < 0.005) as compared with healthy dogs. PON1 and CRP were, respectively, significantly lower and higher in dogs that died compared with survivors (p < 0.001 for both analytes). Ultimately, evaluation of CRP and PON1 at admission seems a reliable support to diagnose sepsis and predict outcomes

A MACHINE LEARNING APPROACH TO MULTISPECTRAL SATELLITE DERIVED BATHYMETRY

Abstract. Bathymetry in coastal environment plays a key role in understanding erosion dynamics and evolution along coasts. In the presented investigation depth along the shore-line was estimated using different multispectral satellite data. Training and validation data derived from a traditional bathymetric survey developed along transects in Cesenatico; measured data were collected with a single-beam sonar returning centimetric precision. To limit spatial auto-correlation training and validation dataset were built choosing alternatively one transect as training and another as validation. Each set was composed by a total of ~6000 points. To estimate water depth two methods were tested, Support Vector Machine (SVM) and Random Forest (RF). The RF method provided the higher accuracy with a root mean square error value of 0.228 m and mean absolute error of 0.158 m, against values of 0.409 and 0.226 respectively for SVM. Results show that application of machine learning methods to predict depth near shore can provide interesting results that can have practical applications

ROSAT HRI X-ray Observations of the Open Globular Cluster NGC 288

A ROSAT HRI X-ray image was obtained of the open globular cluster NGC 288, which is located near the South Galactic Pole. This is the first deep X-ray image of this system. We detect a Low Luminosity Globular Cluster X-ray source (LLGCX) RXJ005245.0-263449 with an X-ray luminosity of (5.5+-1.4)x10^32 ergs/s (0.1-2.0 keV), which is located very close to the cluster center. There is evidence for X-ray variability on a time scale of <~ 1 day. The presence of this LLGCX in such an open cluster suggests that dense stellar systems with high interaction rates are not needed to form LLGCXs. We also searched for diffuse X-ray emission from NGC 288. Upper limits on the X-ray luminosities are L_X^h < 9.5x10^32 ergs/s (0.52-2.02 keV) and L_X^s < 9.3x10^32 ergs/s (0.11-0.41 keV). These imply upper limits to the diffuse X-ray to optical light ratios in NGC 288 which are lower than the values observed for X-ray faint early-type galaxies. This indicates that the soft X-ray emission in these galaxies is due either to a component which is not present in globular clusters (e.g., interstellar gas, or a stellar component which is not found in low metallicity Population II systems), or to a relatively small number of bright Low Mass X-ray Binaries (LMXBs).Comment: The Astrophysical Journal in press. Minor revisions to improve presentation. 6 pages with 3 embedded Postscript figures in emulateapj.st

Risk Assessment at the Cosmetic Product Manufacturer by Expert Judgment Method

A case study was performed in a cosmetic product manufacturer. We have identified the main risk factors of occupational accidents and their causes. Risk of accidents is assessed by the expert judgment method. Event tree for the most probable accident is built and recommendations on improvement of occupational health and safety protection system at the cosmetic product manufacturer are developed. The results of this paper can be used to develop actions to improve the occupational safety and health system in the chemical industry

Do dogs and cats passively carry sars-cov-2 on hair and pads?

The epidemiological role of domestic animals in the spread and transmission of SARS-CoV-2 to humans has been investigated in recent reports, but some aspects need to be further clarified. To date, only in rare cases have dogs and cats living with COVID-19 patients been found to harbour SARS-CoV-2, with no evidence of pet-to-human transmission. The aim of the present study was to verify whether dogs and cats act as passive mechanical carriers of SARS-CoV-2 when they live in close contact with COVID-19 patients. Cutaneous and interdigital swabs collected from 48 dogs and 15 cats owned by COVID-19 patients were tested for SARS-CoV-2 by qRT-PCR. The time elapsed between owner swab positivity and sample collection from pets ranged from 1 to 72 days, with a median time of 23 days for dogs and 39 days for cats. All samples tested negative, suggesting that pets do not passively carry SARS-CoV-2 on their hair and pads, and thus they likely do not play an important role in the virus transmission to humans. This data may contribute to confirming that the direct contact with the hair and pads of pets does not represent a route for the transmission of SARS-CoV-2

Another Faint UV Object Associated with a Globular Cluster X-Ray Source: The Case of M92

The core of the metal poor Galactic Globular Cluster M92 (NGC 6341) has been observed with WFPC2 on the Hubble Space Telescope through visual, blue and mid-UV filters in a program devoted to study the evolved stellar population in a selected sample of Galactic Globular Clusters. In the UV $(m_{255}, m_{255}-U)$ color magnitude diagram we have discovered a faint `UV-dominant' object. This star lies within the error box of a Low Luminosity Globular Cluster X-ray source (LLGCX) recently found in the core of M92. The properties of the UV star discovered in M92 are very similar to those of other UV stars found in the core of some clusters (M13, 47 Tuc, M80, etc)---all of them are brighter in the UV than in the visible and are located in the vicinity of a LLGCX. We suggest that these stars are a new sub-class of cataclysmic variables.Comment: 21 pages, 4 figures. Astrophysical journal in pres