Dietary α‐Linolenic Acid, Marine ω‐3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvención con DIeta MEDiterránea (PREDIMED) Study

Background: Epidemiological evidence suggests a cardioprotective role of α‐linolenic acid (ALA), a plant‐derived ω‐3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω‐3 fatty acids (long‐chain n‐3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all‐cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long‐chain n‐3 polyunsaturated fatty acids (≥500 mg/day). Methods and Results: We longitudinally evaluated 7202 participants in the PREvención con DIeta MEDiterránea (PREDIMED) trial. Multivariable‐adjusted Cox regression models were fitted to estimate hazard ratios. ALA intake correlated to walnut consumption (r=0.94). During a 5.9‐y follow‐up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios for meeting ALA recommendation (n=1615, 22.4%) were 0.72 (95% CI 0.56–0.92) for all‐cause mortality and 0.95 (95% CI 0.58–1.57) for fatal cardiovascular disease. The hazard ratios for meeting the recommendation for long‐chain n‐3 polyunsaturated fatty acids (n=5452, 75.7%) were 0.84 (95% CI 0.67–1.05) for all‐cause mortality, 0.61 (95% CI 0.39–0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29–0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22–1.01) for sudden cardiac death. The highest reduction in all‐cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [95% CI 0.45–0.87]). Conclusions: In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all‐cause mortality, whereas protection from cardiac mortality is limited to fish‐derived long‐chain n‐3 polyunsaturated fatty acids. Clinical Trial Registration URL: http://www.Controlled-trials.com/. Unique identifier: ISRCTN35739639

Síntesis de RNA que contiene Polia en los núcleos de las glándulas salivares de drosophila hydei hibridación "in situ" del HNRNA Y MRNA

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid. Facultad de Ciencias. Departamento de Bioquímica y Biología Molecular. Fecha de lectura: 16-06-197

The experience of giving birth in a hospital in Spain: humanization versus technification

Aim: to explore and describe the experiences of women giving birth in a tertiary public hospital, with special focus on experiences related to humanized care and women's participation in decision making. Method: this is a qualitative phenomenological study through semi-structured interviews to postpartum women giving birth in a tertiary hospital between January and May 2017. Data were analysed through content analysis. Results: the two overarching themes emerged were the professional-information dyad and privacy. Subthemes of the first main theme were the therapeutic relationship, decision-making, feeding the baby, procedures, and the time factor. Subthemes of the second topic were the feelings generated by the hospital environment, the delivery room, and the maternity ward. Conclusions: if the therapeutic relationship is good, technology is not seen as dehumanising but rather as necessary to ensure continuing safety. "Humanising" material resources are not a priority for women in the birth process and are little used. Privacy was experienced as being a particularly intense need, which women called for throughout the healthcare process

A novel higher plant protein tyrosine phosphatase interacts with SNF1-related protein kinases via a KIS (kinase interaction sequence) domain

A novel protein phosphatase in Arabidopsis thaliana was identified by database searching. This protein, designated AtPTPKIS1, contains a protein tyrosine phosphatase (PTP) catalytic domain and a kinase interaction sequence (KIS) domain. It is predicted to interact with plant SNF1-related kinases (SnRKs), representing central regulators of metabolic and stress responses. AtPTPKIS1 has close homologues in other plant species, both dicots and monocots, but is not found in other kingdoms. The tomato homologue of AtPTPKIS1 was expressed as a recombinant protein and shown to hydrolyse a generic phosphatase substrate, and phosphotyrosine residues in synthetic peptides. The KIS domain of AtPTPKIS1 was shown to interact with the plant SnRK AKIN11 both in vivo in the yeast two-hybrid system, and in vitro in a GST-fusion 'pull down' assay. The genomes of Arabidopsis and other plants contain further predicted proteins related to AtPTPKIS1, which could also interact with SnRKs and act in novel regulatory and signalling pathways

Phospholipid transfer protein: full-length cDNA and amino acid sequence in maize

International audienc

L’école et la nation

Une vieille question, si nationale. « Et d’abord, l’école n’est pour rien dans la création de la nation française », affirme d’emblée Antoine Prost. Pourtant, en France, dès lors que la société et le pouvoir politique s’interrogent sur la nation et ses troubles, c’est à l’école qu’ils posent la question de l’identité collective et de sa construction, c’est vers elle qu’ils se tournent pour rechercher les responsabilités, imaginer les solutions. Ainsi, ce livre interroge, en s’en détachant, le débat français sur l’identité nationale, classique, ambivalent et propice aux instrumentalisations. Une réponse internationale, neuve. Dès lors, pour dépasser ces singulières ambiguïtés franco-françaises, et parce que l’école et la nation est un champ scientifique commun par-delà les frontières, cet ouvrage choisit de répondre à la (dé-)raison nationale par la comparaison internationale. Grâce à la mobilisation exceptionnelle du réseau de chercheurs de l’Institut national de recherche pédagogique (devenu Institut français de l’Éducation), de nombreux auteurs s’attachent à dépayser le cas d’école français en le confrontant à bien d’autres situations nationales, et s’efforcent de déconstruire, loin des idées reçues, ce rapport de l’école à la nation.An old question, of national importance. “And firstly, education has nothing to do with the creation of the French nation”, declares Antoine Prost. However, in France, since society and the public authorities are concerned about the nation and the disorder therein, it is to education that they direct the question of collective identity and its construction and it is to education that they turn to seek accountability and to devise solutions. This book, therefore, stands back from the issue to examine the French debate on national identity - a debate which is conventional, contradictory and lends itself to manipulation. A new, international response.Therefore, to overcome this unique and purely French ambiguity, and because education and the nation is a scientific discipline which extends beyond borders, this volume opts to respond to national (in)sanity by means of comparison with other countries. Thanks to the exceptional mobilisation by the network of researchers at the National Institute for Pedagogical Research (now the French Institute of Education), a large number of stakeholders are taking the case of French education beyond national boundaries by comparing it to many other national situations, and, shunning generally accepted ideas, are striving to deconstruct this relationship between education and the nation