4,615 research outputs found
A re-evaluation of the Earth’s surface temperature response to radiative forcing
This is the final version. Available on open access from IOP Publishing via the DOI in this recordData availability statement:
All the time-series data used in this analysis is freely available for research: http://cdiac.ornl.gov/trends/temp/jonescru/jones.html; www.pik-potsdam.de/~mmalte/rcps/; www.cgd.ucar.edu/cas/catalog/climind/AMO.html. The models in this paper have been inferred statistically from the data record available when the present study was initiated and they can change over time. The data that support the findings of this study are available upon reasonable request from the authorsThere is much current debate about the way in which the earth's climate and temperature are responding to anthropogenic and natural forcing. In this paper we re-assess the current evidence at the globally averaged level by adopting a generic 'data-based mechanistic' modelling strategy that incorporates statistically efficient parameter estimation. This identifies a low order, differential equation model that explains how the global average surface temperature variation responds to the influences of total radiative forcing (TRF). The model response includes a novel, stochastic oscillatory component with a period of about 55 years (range 51.6–60 years) that appears to be associated with heat energy interchange between the atmosphere and the ocean. These 'quasi-cycle' oscillations, which account for the observed pauses in global temperature increase around 1880, 1940 and 2001, appear to be related to ocean dynamic responses, particularly the Atlantic multidecadal oscillation. The model explains 90% of the variance in the global average surface temperature anomaly and yields estimates of the equilibrium climate sensitivity (ECS) (2.29 compfnC with 5%–95% range 2.11 compfnC to 2.49 compfnC) and the transient climate response (TCR) (1.56 compfnC with 5%–95% range 1.43 compfnC to 1.68 compfnC), both of which are smaller than most previous estimates. When a high level of uncertainty in the TRF is taken into account, the ECS and TCR estimates are unchanged but the ranges are increased to 1.43 compfnC to 3.14 compfnC and 0.99 compfnC to 2.16 compfnC, respectively.Engineering and Physical Sciences Research Council (EPSRC)Natural Environment Research Council (NERC)Newton Funded China Services Partnership (CSSP
Interleukin-1ß mRNA expression in ischemic rat cortex
Background and Pur pose: Interleukin-1ß is a proinftammatory cytokine produced by blood-borne and resident brain inftammatory cells. The present study was conducted to determine if interleukin-1ß mRNA was produced in the brain of rats subjected to permanent focal ischemia. Methods: Rat interleukin-1ß cDNA, synthesized from stimulated rat peritoneal macrophage RNA by reverse transcription and polymerase chain reaction and c10ned in plasmid Bluescript KS+, was used to evaluate the expression of interleukin-1ß mRNA in cerebral cortex from spontaneously hypertensive rats and normotensive rats subjected to permanent middle cerebral artery occlusion. Interleukin-1ß mRNA was quantified by Northern blot analysis and compared with rat macrophage RNA standard. To correct for gel loading, blots were also analyzed with cyclophilin cDNA, which encodes an abundant, conserved protein that was unchanged by the experimental conditions. Results: Interleukin-1ß mRNA produced in the ischemic zone was significantly increased from 6 hours to 120 hours, with a maximum of211±24% ofinterleukin-1ß reference standard, ie, 0.2 ng stimulated rat macrophage RNA, mRNA compared with the level in nonischemic cortices (4±2%) at 12 hours after ischemia (P<.OI; n=6). Interleukin-1ß mRNA at 12 hours after ischemia was markedly elevated in hypertensive rats over levels found in two normotensive rat strains. Neurological deficits were also apparent only in the hypertensive rats. Conclusions: Brain interleukin-1ß mRNA is elevated acutely after permanent focal ischemia and especially in hypertensive rats. These data suggest that this potent proinflammatory and procoagulant cytokine might have a role in brain damage following ischemia
Integrate and Fire Neural Networks, Piecewise Contractive Maps and Limit Cycles
We study the global dynamics of integrate and fire neural networks composed
of an arbitrary number of identical neurons interacting by inhibition and
excitation. We prove that if the interactions are strong enough, then the
support of the stable asymptotic dynamics consists of limit cycles. We also
find sufficient conditions for the synchronization of networks containing
excitatory neurons. The proofs are based on the analysis of the equivalent
dynamics of a piecewise continuous Poincar\'e map associated to the system. We
show that for strong interactions the Poincar\'e map is piecewise contractive.
Using this contraction property, we prove that there exist a countable number
of limit cycles attracting all the orbits dropping into the stable subset of
the phase space. This result applies not only to the Poincar\'e map under
study, but also to a wide class of general n-dimensional piecewise contractive
maps.Comment: 46 pages. In this version we added many comments suggested by the
referees all along the paper, we changed the introduction and the section
containing the conclusions. The final version will appear in Journal of
Mathematical Biology of SPRINGER and will be available at
http://www.springerlink.com/content/0303-681
The "Solar Model Problem" Solved by the Abundance of Neon in Stars of the Local Cosmos
The interior structure of the Sun can be studied with great accuracy using
observations of its oscillations, similar to seismology of the Earth. Precise
agreement between helioseismological measurements and predictions of
theoretical solar models has been a triumph of modern astrophysics (Bahcall et
al. 2005). However, a recent downward revision by 25-35% of the solar
abundances of light elements such as C, N, O and Ne (Asplund et al. 2004) has
broken this accordance: models adopting the new abundances incorrectly predict
the depth of the convection zone, the depth profiles of sound speed and
density, and the helium abundance (Basu Antia 2004, Bahcall et al. 2005). The
discrepancies are far beyond the uncertainties in either the data or the model
predictions (Bahcall et al. 2005b). Here we report on neon abundances relative
to oxygen measured in a sample of nearby solar-like stars from their X-ray
spectra. They are all very similar and substantially larger than the recently
revised solar value. The neon abundance in the Sun is quite poorly determined.
If the Ne/O abundance in these stars is adopted for the Sun the models are
brought back into agreement with helioseismology measurements (Antia Basu 2005,
Bahcall et al. 2005c).Comment: 13 pages, 3 Figure
The direction of postural threat alters balance control when standing at virtual elevation
This is the author accepted manuscript. The final version is available from Springer via the DOI in this recordAvailability of Data and Material: All data are available here:
https://github.com/keithlohse/Gait_VR/tree/master/standing_balanceCode availability: All analysis code are available here:
https://github.com/keithlohse/Gait_VR/tree/master/standing_balanceAnxiogenic settings lead to reduced postural sway while standing, but anxiety-related balance may be
influenced by the location of postural threat in the environment. We predicted that the direction of threat
would elicit a parallel controlled manifold relative to the standing surface, and an orthogonal
uncontrolled manifold during standing. Altogether, 14 healthy participants (8 women, mean age = 27.5
yrs, SD = 8.2) wore a virtual reality (VR) headset and stood on a matched real-world walkway (2m x
40cm x 2cm) for 30s at ground level and simulated heights (elevated 15m) in two positions: (1) parallel
to walkway, lateral threat; and (2) perpendicular to walkway, anteroposterior threat. Inertial sensors
measured postural sway acceleration (e.g., 95% ellipse, root mean square (RMS) of acceleration), and a
wrist-worn monitor measured heart rate coefficient of variation (HR CV). Fully factorial linear-mixed
effect regressions (LMER) determined the effects of height and position. HR CV moderately increased
from low to high height (p = 0.050, g = 0.397). The Height x Position interaction approached
significance for sway area (95% ellipse; ß = -0.018, p = 0.062) and was significant for RMS (ß = -0.022,
p = 0.007). Post-hoc analyses revealed that frontal plane sway accelerations and RMS increased from
low to high elevation in parallel standing, but decreased when facing the threat during perpendicular
standing. Postural response to threat varies depending on the direction of threat, suggesting that the
control strategies used during standing are sensitive to the direction of threat.National Institutes of Health (NIH
Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults
Backgroun
Line-Up Elections: Parallel Voting with Shared Candidate Pool
We introduce the model of line-up elections which captures parallel or
sequential single-winner elections with a shared candidate pool. The goal of a
line-up election is to find a high-quality assignment of a set of candidates to
a set of positions such that each position is filled by exactly one candidate
and each candidate fills at most one position. A score for each
candidate-position pair is given as part of the input, which expresses the
qualification of the candidate to fill the position. We propose several voting
rules for line-up elections and analyze them from an axiomatic and an empirical
perspective using real-world data from the popular video game FIFA.Comment: Accepted to SAGT 202
Similarity solutions for unsteady shear-stress-driven flow of Newtonian and power-law fluids : slender rivulets and dry patches
Unsteady flow of a thin film of a Newtonian fluid or a non-Newtonian power-law fluid with power-law index N driven by a constant shear stress applied at the free surface, on a plane inclined at an angle α to the horizontal, is considered. Unsteady similarity solutions representing flow of slender rivulets and flow around slender dry patches are obtained. Specifically, solutions are obtained for converging sessile rivulets (0 < α < π/2) and converging dry patches in a pendent film (π/2 < α < π), as well as for diverging pendent rivulets and diverging dry patches in a sessile film. These solutions predict that at any time t, the rivulet and dry patch widen or narrow according to |x|3/2, and the film thickens or thins according to |x|, where x denotes distance down the plane, and that at any station x, the rivulet and dry patch widen or narrow like |t|−1, and the film thickens or thins like |t|−1, independent of N
Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo. SHP-2 function in cultured human umbilical vein and human dermal microvascular endothelial cells was inhibited by either silencing the protein expression with antisense-oligodesoxynucleotides or treatment with a pharmacological inhibitor (PtpI IV). SHP-2 inhibition impaired capillary-like structure formation (p < 0.01; n = 8) in vitro as well as new vessel growth ex vivo (p < 0.05; n = 10) and in vivo in the chicken chorioallantoic membrane (p < 0.01, n = 4). Additionally, SHP-2 knock-down abrogated fibroblast growth factor 2 (FGF-2)-dependent endothelial proliferation measured by MTT reduction ( p ! 0.01; n = 12). The inhibitory effect of SHP-2 knock-down on vessel growth was mediated by increased endothelial apoptosis ( annexin V staining, p ! 0.05, n = 9), which was associated with reduced FGF-2-induced phosphorylation of phosphatidylinositol 3-kinase (PI3-K), Akt and extracellular regulated kinase 1/2 (ERK1/2) and involved diminished ERK1/2 phosphorylation after PI3-K inhibition (n=3). These results suggest that SHP-2 regulates endothelial cell survival through PI3-K-Akt and mitogen-activated protein kinase pathways thereby strongly affecting new vessel formation. Thus, SHP-2 exhibits a pivotal role in angiogenesis and may represent an interesting target for therapeutic approaches controlling vessel growth. Copyright (C) 2007 S. Karger AG, Basel
Propagation of an Earth-directed coronal mass ejection in three dimensions
Solar coronal mass ejections (CMEs) are the most significant drivers of
adverse space weather at Earth, but the physics governing their propagation
through the heliosphere is not well understood. While stereoscopic imaging of
CMEs with the Solar Terrestrial Relations Observatory (STEREO) has provided
some insight into their three-dimensional (3D) propagation, the mechanisms
governing their evolution remain unclear due to difficulties in reconstructing
their true 3D structure. Here we use a new elliptical tie-pointing technique to
reconstruct a full CME front in 3D, enabling us to quantify its deflected
trajectory from high latitudes along the ecliptic, and measure its increasing
angular width and propagation from 2-46 solar radii (approximately 0.2 AU).
Beyond 7 solar radii, we show that its motion is determined by an aerodynamic
drag in the solar wind and, using our reconstruction as input for a 3D
magnetohydrodynamic simulation, we determine an accurate arrival time at the
Lagrangian L1 point near Earth.Comment: 5 figures, 2 supplementary movie
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