ASSESSMENT OF INDICATIONS OF LOWER SEGMENT CESAREAN SECTION AT TERTIARY CARE CENTER: A RETROSPECTIVE STUDY

Background: Cesarean section (CS) is one of the most common and widely performed surgical procedures in obstetrics in India and Worldwide. It is mainly evolved as a lifesaving procedure for mother and fetus during the difficult delivery. To study, various indications for the lower segment CS at our tertiary care center were the objective of the present study. Methods: This is a descriptive, retrospective study of all the patients who were underwent CS in the Department of Obstetrics and Gynecology, Jhalawar Medical College, Jhalawar from January 1, 2021, to March 31, 2021 for the duration of 3 months. Data of patients who delivered by C-Section in our hospital during the defined study period were recorded and a statistical analysis was done for various indications of the lower segment CS (LSCS). Results: The total numbers of women delivered by CS over the study period were 806 among these 339 (42.05%) patients were primiparous and 467 (57.95%) were multiparous. 550 (68.23%) cases were from age group 20–25 years and 153 (18.98%) were had age group 26–30 years, 20 (2.48%) were from age group below 19 years, and 76 (10.29%) patients were above 31 years age. The previous LSCS was the leading indication to the LSCS (31.14%) followed fetal distress (13.88%), malpresentation 95 (11.78%) (including breech presentation in maximum women (86), transverse and oblique lie (9 each), and face presentation (3)) (11.78%), meconium stained liquor with fetal distress 60 (7.44%), severe oligohydramnios 48 (5.95%), non-progress of labor 32 (3.97%), cephalopelvic disproportion 23 (2.85%), pre-eclampsia 20 (2.48%), obstructed labor 19 (2.35%), big baby 19 (2.35%), pregnancy-induced hypertension 18 (2.23%), maternal request and post-dated pregnancy 15 (1.86%) each, gestational hypertension and eclampsia 11 (1.36%) each, placenta previa 10 (1.24%), induction failure 8 (0.99%), and intrauterine growth retardation and antepartum hemorrhage 7 (0.86%) and 14 (1.73%). Patients had other indications such as Abruptio placentae, gestational diabetes, twin pregnancy, uterine rupture, and deep transverse arrest. Conclusions: In this study, CS rate (40.68%) is found to be higher as compared to other studies and the WHO guidelines. CSs rate is high probably because Jhalawar Medical College, Jhalawar acts as a government tertiary care center. The previous LSCS was a common indication in 31.14% of mothers in present study. Besides, previous LSCS, fetal distress, malpresentation (Breech presentation/transverse lie, oblique lie, and face presentation) MSL with fetal distress, and severe oligohydramnios were the common indications for LSCS, which are seen in the present study

Influence of Internalized and Externalized Aggression on Students’ Academic Success

The current research aimed to identify the relationship of internalized (anger and hostility) and externalized (physical and verbal) aggression of students’ academic success. The specimen of the study was comprised of 200 undergraduate students (including 100 male and 100 female) of cities Rawalpindi and Islamabad. Two questionnaires were used for data collection. Buss-Perry Aggression Questionnaire (1992) was used to measure internalized and externalizes aggression, whereas Academic Motivational Scale was utilized for measuring students’ academic success. Data were analyzed by using descriptive statistics and Pearson correlation. Findings exposed that boys expressed more externalize aggression than girls and in educational setting girls performed much better than boys. Further findings exposed a negative but moderate relationship between externalized aggression and students’ academic performance and a weak correlation was found between internalize aggression and the academic performance of male students. The further result indicated a weak but negative correlation of internalizing aggression with academic performance of female students and a positive correlation of externalizing aggression with academic performance

Histopathological study of pancreatobiliary tumors in a tertiary care center: a 7 year study

Background: The aim of this study was to comprehensively analyse the histopathological spectrum of pancreatobiliary tumors with special reference to ampulla of Vater.Methods: The retrospective study was done for 5 years and a prospective study was carried out for 2 years in the Department of Pathology.Results: A total of 110 cases were included; 103 underwent a standard Whipple procedure and 7 underwent localised resection (partial pancreatectomy). The average age was 52.64 years (16-80 years) and males outnumbered females (3:2). Malignant (93.63%) lesions outweighed benign lesions (6.36%). Among malignant lesions, 71 (68.93%) were peri-ampullary, 15 (14.56%) were pancreatic, 11 (10.67%) were duodenal and only 6 (5.825%) were cholangiocarcinoma. The most common presenting feature was jaundice followed by pain in the abdomen. The mean tumor size was 2.38 cm (0.5-15cm). The pathological stage of most of the tumors was T2 (58.2%), followed by T3 (22.7%), T1 (11.8%) and T4 was only 1.8%. Proximal duodenal resection margin was free in 90.9%, distal duodenal resection margin was free in all cases, CBD resection margin was involved in only 2 cases (1.8%), while the pancreatic duct resection margin was involved in 2.7%. The nodal status was N0 in 61.8%, N1 in 23.6% and Nx in 9.1%.Conclusions: Adenocarcinoma (well differentiated-47.3%) is the most common histological variant of pancreatobiliary region

Research article Characterization of broad-spectrum biocontrol efficacy of Bacillus velezensis against Fusarium oxysporum in Triticum aestivum L.

Fungi are the most important phytopathogens that cause yield losses. The mycotoxins released by fungi cause spoilage of stored food consumed by humans and feed supplied to animals. Fungi-antagonistic microbes are gaining attention as potential biocontrol agents (BCAs). This study was designed to isolate bacterial isolates from different crops and evaluate their in vitro antifungal assay against three phytopathogens, plant growth promoting (PGP) characteristics, molecular identification, and in vivo efficiency against the most devastating phytopathogenic fungus Fusarium oxysporum Schltdl. In the in vitro experiment, the 3 isolates BA, GL-1, and 5a out of 360 isolates showed more than 60% inhibitory activity against the selected fungi in this study. On the basis of 16S rRNA sequencing and phylogenetic analysis, BA isolate was identified as Bacillus velezensis. All three isolates produced indole acetic acid (IAA), hydrogen cyanide (HCN), and cellulase enzymes, while the BA and GL-1 isolates also produced siderophores and the BA isolate also produced ammonia. BA was selected on basis of not only Biocontrol efficacy but also maximum PGPR activity compared to GL-1 and 5a. In vivo assay, the isolate BA showed a significant decrease in disease severity caused by Fusarium oxysporum by 64.97% after 100 days of inoculation on wheat (FD-08) seedlings in a greenhouse assay and enhanced the shoot root height, fresh and dry mass. The wide-ranging antagonistic action of Bacillus velezensis isolated from the phyllosphere of wheat crops showed promising fungicidal and plant growth-promoting capabilities, suggesting it can be used as a biofungicide

Mitigating Salt-Induced Damages in Wheat with Foliar-Applied Nigella sativa Seed Extract: A Comprehensive Study

Nigella sativa, a medicinal plant, known for its diverse bioactive compounds, including antioxidants and phytohormones, have shown potential in mitigating salt stress in various plant species. Amongst naturally occurring plant growth stimulants, it has attained enormous attention being rich in thymoquinineand carvacrol in seeds for scavenging free radicals. This research aimed to investigate the effect of Nigella sativa seed extract (NSE) as foliar spray (0, 50, 100 and 150g seeds per liter each) on wheat growth under salt stress (0mM, 75mM and 150mM). Results revealed that salinity decreased growth attributes and accumulation of photosynthetic pigments. On the other hand, salinity stress boosted the contents of malondialdehyde, hydrogen peroxide, glycinebetaine, leaf free proline, Na+ and Cl-. Foliar application of NSEameliorated the negative effects of salinity to considerable extent by enhancing growth traits, chlorophyll contents, glycinebetaine and prolineand decreased Na+, Cl-,malondialdehyde andhydrogen peroxide. This research provides valuable insights into the potential use of NSE as natural and sustainable solution to alleviate salt stress in wheat crop. These findings contribute to the development of eco-friendly strategies for enhancing crop resilience in saline environments, ultimately addressing the global challenge of food security in the face of increasing soil salinity

What do adolescents perceive to be key features of an effective dementia education and awareness initiative?

The development of dementia friendly communities is a current global and national priority for the UK. As a response to policy, there have been a number of dementia awareness initiatives disseminated with the aim of reducing the stigma associated with a diagnosis of dementia. The inclusion of adolescents in such initiatives in imperative in order to sustain dementia friendly communities. With this is mind, the aim of this study was to establish the dementia education needs of adolescents and effective dissemination strategies to convey key messages. A total of 42 adolescents aged 12 to 18 years participated in eight focus group discussions. Key themes to emerge from discussions included: the importance of dementia awareness, topics of interest within dementia, preferred methods of learning, the inclusion of the person living with dementia and the use of social media. The findings of the study will enable the development of appropriate dementia awareness initiatives for adolescents and thus facilitate the sustainability of dementia friendly communities

Cushing syndrome in children: Pathophysiology, clinical features, diagnostic and therapeutic strategies

A rare condition called Cushing disease causes increased morbidity or mortality. Therapeutic methods such as anti-cortisol medications, bilateral adrenalectomy, or radiation procedures may therefore be required to prevent long-term dangers of hypercortisolism, such as hirsutism, moon face, facial plethora, and obesity. Endogenous hypercortisolism increases the risk of cardiovascular metabolic symptoms, osteoporosis, respiratory diseases, psychological difficulties, and infections while also having a high rate of morbidity or mortality. Significant fetal and mental complications during pregnancy are linked to Cushing syndrome. Early detection and treatment are essential. Except in the late trimester, surgery is the preferred method of treatment for Cushing syndrome during pregnancy, with medication therapy as a backup. Cushing syndrome is an endocrine illness that presents differently from other endocrine disorders, making it difficult for doctors to control

Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan : Evidence from two longitudinal cohort studies 15 years apart

Funding Information: Study 1 was funded through the Applied Diarrheal Disease Research Program at Harvard Institute for International Development with a grant from USAID (Project 936–5952, Cooperative Agreement # DPE-5952-A-00-5073-00), and the Aga Khan Health Service, Northern Areas and Chitral, Pakistan. Study 2 was funded by the Pakistan US S&T Cooperative Agreement between the Pakistan Higher Education Commission (HEC) (No.4–421/PAK-US/HEC/2010/955, grant to the Karakoram International University) and US National Academies of Science (Grant Number PGA-P211012 from NAS to the Fogarty International Center). The funding bodies had no role in the design of the study, data collection, analysis, interpretation, or writing of the manuscript. Publisher Copyright: © 2020 The Author(s).Peer reviewedPublisher PD

First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment

The LUX-ZEPLIN (LZ) experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LZ's first search for Weakly Interacting Massive Particles (WIMPs) with an exposure of 60 live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross-sections for WIMP masses above 9 GeV/c$^2$. The most stringent limit is set at 30 GeV/c$^2$, excluding cross sections above 5.9$\times 10^{-48}$ cm$^2$ at the 90\% confidence level.Comment: 9 pages, 6 figures. See https://tinyurl.com/LZDataReleaseRun1 for a data release related to this pape