Клинические наблюдения гигантоклеточного гепатита у детей

Giant cell hepatitis is characterized, by inflammation and large multinucleated. hepatocytes in hepatic parenchyma It is an unusual hepatocytes response to various noxious stimuli, characterized, by presence of multinucleated cells in liver with generally dismal clinical outcome. Giant cell hepatitis is commonly reported, in neonatal and. infantile liver diseases but rarely in adults (postinfantile giant cell hepatitis). Giant cell hepatitis is associated, with many diseases, including drugs toxicity, viral and. autoimmune liver diseases, with autoimmune hepatitis being the most prevalent. We report some clinical cases of giant cell hepatitis with review of literature regarding various etiological agents and their respective prognostic outcome.Гигантоклеточный гепатит, характеризуется наличием воспалительного инфильтрата и гигантских многоядерных клеток в печеночной паренхиме. Гигантоклеточная трансформация представляет, собой необычный ответ, гепатоцитов на различные повреждающие факторы, обычно с неблагоприятным, клиническим, исходом. Гигантоклеточный гепатит, обычно наблюдается при неонатальных и инфантильных заболеваниях печени и редко у взрослых (постинфантильный гигантоклеточный гепатит). Гигантоклеточный гепатит, ассоциируется со многими заболеваниями, включая токсическое воздействие лекарственных средств, вирусные и аутоиммунные заболевания печени. Наиболее распространенным, является аутоиммунный гепатит. Мы сообщаем, о нескольких клинических случаях гигантоклеточного гепатита с обзором, литературы, относительно различных этиологических агентов и их соответствующих прогностических результатов

Fluorescent amino acids as versatile building blocks for chemical biology

Fluorophores have transformed the way we study biological systems, enabling non-invasive studies in cells and intact organisms, which increase our understanding of complex processes at the molecular level. Fluorescent amino acids have become an essential chemical tool because they can be used to construct fluorescent macromolecules, such as peptides and proteins, without disrupting their native biomolecular properties. Fluorescent and fluorogenic amino acids with unique photophysical properties have been designed for tracking protein–protein interactions in situ or imaging nanoscopic events in real time with high spatial resolution. In this Review, we discuss advances in the design and synthesis of fluorescent amino acids and how they have contributed to the field of chemical biology in the past 10 years. Important areas of research that we review include novel methodologies to synthesize building blocks with tunable spectral properties, their integration into peptide and protein scaffolds using site-specific genetic encoding and bioorthogonal approaches, and their application to design novel artificial proteins, as well as to investigate biological processes in cells by means of optical imaging. [Figure not available: see fulltext.]

An Investigation of Methanol Anomalous Diffusion in Mesoporous Silica

Methanol transport in mesoporous silica is investigated. It is demonstrated that usual approach based on the second Fick’s law fails describing the experimental kinetic data. Contrary, the solution of the time-fractional diffusion equation fits the experimental data in a fairly good manner. Obtained value of the fractional order reveals the presence of fast super-diffusive regime of transport.Keywords: diffusion, anomalous diffusion, fractional diffusion, super-diffusion, silica, methanol.</p

Water evaporation particularities in the process of forest fire extinguishing

Numerical simulation of water massif motion through the high temperature gases corresponding to the typical conditions of forest fires was carried out. Maximal values of part by volume of liquid evaporating from water massif under its motion through the flaming burning area were determined when solving the heat and mass transfer problem under the conditions of endothermic phase transformations. Influence of liquid phase transition heat on the heat and mass transfer conditions on the track of water massif was determined. The expediency of polydisperse interspaced in time and space atomization of water massifs under the large-scale (especially, forest fires) fire extinguishing was proved

ПОРІВНЯННЯ СПОСОБІВ КЕРУВАННЯ ПРОДУКТИВНІСТЮ НАСОСНИХ УСТАНОВОК СІЛЬСЬКОГОСПОДАРСЬКОГО ПРИЗНАЧЕННЯ

Calculations of watt-hour energy usage by agricultural pump plants are offered for three different control techniques: with throttling, with a water-tower, and with a frequency-controlled pump electric drive. Power and economic indexes of these variants are compared.Рассчитана потребляемая мощность насосных установок сельскохозяйственного назначения для трех различных способов управления данными установками: с дросселированием, с водонапорной башней и частотным управлением электрического двигателя насоса. Выполнено сравнение энергетических и экономических показателей этих вариантов.Запропоновано розрахунки споживаної потужності насосних установок сільськогосподарського призначення для трьох різних способів керування даними установками: з дроселюванням, з водонапірною баштою та частотним керуванням електричного двигуна насоса. Виконано кількісне порівняння енергетичних та економічних показників розглянутих варіантів

ПОРІВНЯННЯ СПОСОБІВ КЕРУВАННЯ ПРОДУКТИВНІСТЮ НАСОСНИХ УСТАНОВОК СІЛЬСЬКОГОСПОДАРСЬКОГО ПРИЗНАЧЕННЯ

Calculations of watt-hour energy usage by agricultural pump plants are offered for three different control techniques: with throttling, with a water-tower, and with a frequency-controlled pump electric drive. Power and economic indexes of these variants are compared.Рассчитана потребляемая мощность насосных установок сельскохозяйственного назначения для трех различных способов управления данными установками: с дросселированием, с водонапорной башней и частотным управлением электрического двигателя насоса. Выполнено сравнение энергетических и экономических показателей этих вариантов.Запропоновано розрахунки споживаної потужності насосних установок сільськогосподарського призначення для трьох різних способів керування даними установками: з дроселюванням, з водонапірною баштою та частотним керуванням електричного двигуна насоса. Виконано кількісне порівняння енергетичних та економічних показників розглянутих варіантів

Change in Ignition Characteristics Of Composite Liquid Fuel Droplet While Varying the Combustible Liquid Content

The features of heat and ignition of composite liquid fuel droplets in a heated (temperatures were 600–900 K) oxidant were investigated to develop modern recycling technologies of processing waste of coal, petroleum products, liquid fuels and combustible liquids. Compositions based on tailings of bituminous coal, used turbine and motor oils were considered. Ignition delay times of composite fuel droplets were defined. The influence scale of mass fraction of combustible liquid on droplet heat and ignition characteristics were identified

Change in Ignition Characteristics Of Composite Liquid Fuel Droplet While Varying the Combustible Liquid Content

The features of heat and ignition of composite liquid fuel droplets in a heated (temperatures were 600–900 K) oxidant were investigated to develop modern recycling technologies of processing waste of coal, petroleum products, liquid fuels and combustible liquids. Compositions based on tailings of bituminous coal, used turbine and motor oils were considered. Ignition delay times of composite fuel droplets were defined. The influence scale of mass fraction of combustible liquid on droplet heat and ignition characteristics were identified

EXPERIMENTAL STUDY ON EVAPORATION BEHAVIOR OF WATER DROPLET WITH METALLIC INCLUSION

We perform the experimental research on particularities of phase changes of heterogeneous droplets based on water with single metallic inclusions. We applied the metals and alloys which are typical of power engineering. Moreover, the lifetimes of 5-15 µl water droplets were determined. We also established the estimated proportion of phase change energies (vaporization) as well as those absorbed by water and metallic inclusions. Finally, we formulated the recommendations how to use the suspensions of water with metallic inclusions in cooling systems of hot surfaces of power engineering equipment, as well as high-temperature gas-vapor flows