c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells

Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases. Direct activation of rDNA transcription by c-Myc is functionally conserved in rat cells, despite high divergence in non-coding rDNA sequences, suggesting that this coordinating role is likely to be a general within mammals. Upon re-feeding of starved cells, c-Myc activity enhances the efficiency of RNA Polymerase I and SL1/TIF-1B recruitment to the rDNA and rapidly induces higher order gene loop structures in rDNA chromatin that juxtapose upstream and downstream rDNA sequences. Furthermore c-Myc induced gene-loop formation in rDNA genes occurs independently of rDNA transcription, implying that it may be an early step in the re-programming of quiescent cells as they enter the growth cycle

Static and non-static quantum effects in two-dimensional dilaton gravity

We study backreaction effects in two-dimensional dilaton gravity. The backreaction comes from an $R^2$ term which is a part of the one-loop effective action arising from massive scalar field quantization in a certain approximation. The peculiarity of this term is that it does not contribute to the Hawking radiation of the classical black hole solution of the field equations. In the static case we examine the horizon and the physical singularity of the new black hole solutions. Studying the possibility of time dependence we see the generation of a new singularity. The particular solution found still has the structure of a black hole, indicating that non-thermal effects cannot lead, at least in this approximation, to black hole evaporation.Comment: 10 pages, no figure

A Max-Min Multiobjective Technique to Optimize Model Based Test Suite

Generally, quality software production seeks timely delivery with higher productivity at lower cost. Redundancy in a test suite raises the execution cost and wastes scarce project resources. In model-based testing, the testing process starts with earlier software developmental phases and enables fault detection in earlier phases. The redundancy in the test suites generated from models can be detected earlier as well and removed prior to its execution. The paper presents a novel max-min multiobjective technique incorporated into a test suite optimization framework to find a better trade-off between the intrinsically conflicting goals. For illustration two objectives i.e. coverage and size of a test suite were used however it can be extended to more objectives. The study is associated with model based testing and reports the results of the empirical analysis on four UML based synthetic as well as industrial Activity Diagram models

Climatology of water vapor in the upper troposphere and lower stratosphere determined from Sage 2 observations

The purpose of this paper is to present a vertically-resolved global climatology of water vapor in the upper troposphere and lower stratosphere based on multi-year SAGE 2 observations. Seasonally averaged zonal mean profiles are illustrated in terms of both mixing ration and relative humidity

Decoherent Scattering of Light Particles in a D-Brane Background

We discuss the scattering of two light particles in a D-brane background. It is known that, if one light particle strikes the D brane at small impact parameter, quantum recoil effects induce entanglement entropy in both the excited D brane and the scattered particle. In this paper we compute the asymptotic `out' state of a second light particle scattering off the D brane at large impact parameter, showing that it also becomes mixed as a consequence of quantum D-brane recoil effects. We interpret this as a non-factorizing contribution to the superscattering operator S-dollar for the two light particles in a Liouville D-brane background, that appears when quantum D-brane excitations are taken into account.Comment: 18 pages LATEX, one figure (incorporated

Effective dynamics of the closed loop quantum cosmology

In this paper we study dynamics of the closed FRW model with holonomy corrections coming from loop quantum cosmology. We consider models with a scalar field and cosmological constant. In case of the models with cosmological constant and free scalar field, dynamics reduce to 2D system and analysis of solutions simplify. If only free scalar field is included then universe undergoes non-singular oscillations. For the model with cosmological constant, different behaviours are obtained depending on the value of $\Lambda$. If the value of $\Lambda$ is sufficiently small, bouncing solutions with asymptotic de Sitter stages are obtained. However if the value of $\Lambda$ exceeds critical value $\Lambda_{\text{c}} =\frac{\sqrt{3}m^2_{\text{Pl}}}{2\pi\gamma^3} \simeq 21 m^2_{\text{Pl}}$ then solutions become oscillatory. Subsequently we study models with a massive scalar field. We find that this model possess generic inflationary attractors. In particular field, initially situated in the bottom of the potential, is driven up during the phase of quantum bounce. This subsequently leads to the phase of inflation. Finally we find that, comparing with the flat case, effects of curvature do not change qualitatively dynamics close to the phase of bounce. Possible effects of inverse volume corrections are also briefly discussed.Comment: 18 pages, 11 figure

Massless and Massive Three Dimensional Super Yang-Mills Theory and Mini-Twistor String Theory

We propose various ways of adding mass terms to three-dimensional twistor string theory. We begin with a review of mini-twistor space--the reduction of D=4 twistor space to D=3. We adapt the two proposals for twistor string theory, Witten's and Berkovits's, to D=3 super Yang-Mills theory. In Berkovits's model, we identify the enhanced R-symmetry. We then construct B-model topological string theories that, we propose, correspond to D=3 Yang-Mills theory with massive spinors and massive and massless scalars in the adjoint representation of the gauge group. We also analyze the counterparts of these constructions in Berkovits's model. Some of our constructions can be lifted to D=4, where infinitesimal mass terms correspond to VEVs of certain superconformal gravity fields.Comment: 69 pages; Typos correcte

Carbon Dioxide (CO2) Retrievals from Atmospheric Chemistry Experiment (ACE) Solar Occultation Measurements

The Atmospheric Chemistry Experiment ACE satellite (SCISAT-1) was launched into an inclined orbit on 12 August 2003 and is now recording high signal-to-noise 0.02 per centimeter resolution solar absorption spectra covering 750-4400 per centimeter (2.3-13 micrometers). A procedure has been developed for retrieving average dry air CO2 mole fractions (X(sub CO2)) in the altitude range 7-10 kilometers from the SCISAT-1 spectra. Using the N2 continuum absorption in a window region near 2500 per centimeter, altitude shifts are applied to the tangent heights retrieved in version 2.2 SCISAT-1 processing, while cloudy or aerosol-impacted measurements are eliminated. Monthly-mean XCO2 covering 60 S to 60 N latitude for February 2004 to March 2008 has been analyzed with consistent trends inferred in both hemispheres. The ACE XCO2 time series have been compared with previously-reported surface network measurements, predictions based on upper tropospheric aircraft measurements, and space-based measurements. The retrieved X(sub CO2) from the ACE-FTS spectra are higher on average by a factor of 1.07 plus or minus 0.025 in the northern hemisphere and by a factor of 1.09 plus or minus 0.019 on average in the southern hemisphere compared to surface station measurements covering the same time span. The ACE derived trend is approximately 0.2% per year higher than measured at surface stations during the same observation period