Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders

Hippocampal output is increased in affective disorders and is mediated by increased glutamatergic input via N-methyl-D-aspartate (NMDA) receptor and moderated by antidepressant treatment. Activation of NMDA receptors by glutamate evokes the release of nitric oxide (NO) by the activation of neuronal nitric oxide synthase (nNOS). The human hippocampus contains a high density of NMDA receptors and nNOS-expressing neurons suggesting the existence of an NMDA-NO transduction pathway which can be involved in the pathogenesis of affective disorders. We tested the hypothesis that nNOS expression is increased in the human hippocampus from affectively ill patients. Immunocytochemistry was used to demonstrate nNOS-expressing neurons in sections obtained from the Stanley Consortium postmortem brain collection from patients with major depression (MD, N = 15), bipolar disorder (BD, N = 15), and schizophrenia (N = 15) and from controls (N = 15). nNOS-immunoreactive (nNOS-IR) and Nissl-stained neurons were counted in entorhinal cortex, hippocampal CA1, CA2, CA3, and CA4 subfields, and subiculum. The numbers of Nissl-stained neurons were very similar in different diagnostic groups and correlated significantly with the number of nNOS-IR neurons. Both the MD and the BD groups had greater number of nNOS-IR neurons/400 µm² in CA1 (mean ± SEM: MD = 9.2 ± 0.6 and BD = 8.4 ± 0.6) and subiculum (BD = 6.7 ± 0.4) when compared to control group (6.6 ± 0.5) and this was significantly more marked in samples from the right hemisphere. These changes were specific to affective disorders since no changes were seen in the schizophrenic group (6.7 ± 0.8). The results support the current view of the NMDA-NO pathway as a target for the pathophysiology of affective disorders and antidepressant drug development.Stanley FoundationCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES

Social welfare analysis of the Iberian electricity market accounting for carbon emission prices.

In this study, the authors analyse the social welfare impact of the integration of Portugal and Spain in the Iberian electricity market (MIBEL), taking into account the CO2 price for emissions trading. They model the impact of emissions trading on the daily clearing prices and generation scheduling, and its effects on the benefits of integration as a whole. They compare the impact of market integration in Portugal and Spain and show that the welfare impact of the MIBEL is dependent on the CO2 prices. From their analysis, they conclude high CO2 prices lead to a change in the merit order. Moreover, natural gas is the generation technology that most benefits from transmission constraints and from high CO2 prices, as in the base case it is mainly used as a peak technology. The authors have also found that increases in the CO2 prices do not lead to higher profits. Overall, the introduction of the MIBEL will increase social welfare by reducing generation costs and prices

Analysis of the optimal policy for managing strategic petroleum reserves under long-term uncertainty: the ASEAN case.

We examine the issue of petroleum stockpiling in the Association of Southeast Asian Nations (ASEAN), computing the optimal build-up and draw-down policies under different conditions. We study, in detail, the properties of petroleum prices, oil imports and production, and GDP, analyzing the impact of the planning horizon, discount rate and price elasticity of demand on the optimal policy. We use a finite horizon stochastic program (with varying branching) in which the policymaker minimizes the negative impacts of oil price increases on the GDP and the cost of holding the strategic petroleum reserve. We propose an inter-generational equity rule to compute the level of inventory in the final states of the decision tree. We find that ASEAN countries would benefit significantly from developing a strategic petroleum reserve, with net benefits ranging from US$25–125 billion. Our suggested target stockpile is consistent with the International Energy Agency's recommendation of holding stocks equal to 90 days of net imports

Suministro De La Demanda De Energía En El Procesamiento De Carne De Pollo Con Biogás

The main use of electrical energy in the chicken meat processing unit is refrigeration. About 70% of the electricity is consumed in the compressors for the refrigeration system. Through this study, the energetic viability of using biogas from poultry litter in supplying the demand for the refrigeration process was found. The meat processing unit studied has the potential to process about a hundred and sixty thousand chickens a day. The potential biogas production from poultry litter is 60,754,298.91 m3.year-1. There will be a surplus of approximately 8,103 MWh per month of electric energy generated from biogas. An economic analysis was performed considering a planning horizon of 20 years and the discount rate of 12% per year. The economic analysis was performed considering scenario 1: sale of all electricity generated by the thermoelectric facility, and scenario 2: sale of the surplus electricity generated after complying with the demands of the refrigeration process and all other electrical energy and thermal energy use. Economic indicators obtained for scenarios 1 and 2 were favorable for the project implementation. © 2016, Revista Ingenieria e Investigacion - Editorial Board. All Rights reserved.36111812

Fractional Wave-diffusion Equation With Periodic Conditions

We study a time-space fractional wave-diffusion equation with periodic conditions using Laplace transforms and Fourier series and presenting its solution in terms of three-parameter Mittag-Leffler functions. As a particular case we recover a recent result. We also present some graphics associated with particular values of the parameters. © 2012 American Institute of Physics.5312Caputo, M., Carcione, J.M., Hysteresis cycles and fatigue criteria using anelastic models based on fractional derivatives (2011) Rheol. Acta, 50 (2), pp. 107-115. , 10.1007/s00397-010-0524-zMainardi, F., Spada, G., Creep, relaxation and viscosity properties for basic fractional models in rheology (2011) Eur. Phys. J. Spec. Top., 193, pp. 133-160. , 10.1140/epjst/e2011-01387-1, e-print arXiv:cond-mat.mtrl.sci1110.3400v1Mainardi, F., Mura, A., Pagnini, G., The M-Wright function in time-fractional diffusion processes: A tutorial survey (2010) Int. J. Differ. Equations, 2010, p. 104505. , 10.1155/2010/104505, e-print arXiv:org/abs/1004.2950(2011) Fractional Dynamics, Recent Advances, , J. Klafter, S. C. Lim, R. Metzler, edited by and (World Scientific, Singapore, )Costa, F.S., Fractional thermal systems (2011) International Conference on Multimedia Technology (ICMT), , E. Capelas de Oliveira, Hangzhou, China, 26-28 JulyOliveira, E., Costa, F.S., Vaz, J., The fractional Schrödinger equation for delta potentials (2010) J. Math. Phys., 51, p. 123517. , 10.1063/1.3525976Oliveira, E., Vaz, J., Tunneling in fractional quantum mechanics (2011) J. Phys. A: Math. Theor., 44, p. 185303. , 10.1088/1751-8113/44/18/185303Machado, J.T., Kiryakova, V., Mainardi, F., Recent history of fractional calculus (2011) Nonlinear Sci. Number. Simul., 16, pp. 1140-1153. , 10.1016/j.cnsns.2010.05.027Podlubny, I., (1999) Fractional Differential Equations, , (Academic, San Diego, )Kilbas, A.A., Srivastava, H.M., Trujillo, J.J., (2006) Theory and Applications of Fractional Differential Equations, 204. , J. Van Mill, and Mathematics Studies, edited by (Elsevier, Amsterdam, )Zhang, H., Liu, F., The fundamental solutions of the space, space-time Riesz fractional partial differential equations with periodic conditions (2007) Numer. Math. J. Chin. Univ., 16, pp. 181-192Prabhakar, T.R., A singular integral equation with generalized Mittag-Leffler function in the kernel (1971) Yokohama Math. J., 19, pp. 7-25Samko, S.G., Kilbas, A.A., Marichev, O.I., (1993) Fractional Integrals and Derivatives: Theory and Applications, , (Gordon and Breach, New York, )Mainardi, F., Luchko, Y., Pagnini, G., The fundamental solution of the space-time fractional diffusion equation (2001) Fract. Calc. & Appl. Anal., 4 (2), pp. 153-192. , e-print arXiv:cond-mat.stat.mech/0702419v1Camargo, R., Charnet, R., de Oliveira, E., On the fractional Green function (2009) J. Math. Phys., 50, p. 043514. , 10.1063/1.311948

Effect of biliopancreatic diversion on sleep quality and daytime sleepiness in patients with obesity and type 2 diabetes

sem informaçãoThe poor quality of sleep and the deprivation thereof have been associated with disruption of metabolic homeostasis, favoring the development of obesity and type 2 diabetes (T2DM). We aimed to evaluate the influence of biliopancreatic diversion (BPD) surg616623627sem informaçãosem informaçãosem informaçã

The Fractional Schrödinger Equation For Delta Potentials

The fractional Schrödinger equation is solved for the delta potential and the double delta potential for all energies. The solutions are given in terms of Fox's H-function. © 2010 American Institute of Physics.5112Rangarajan, G., Ding, M., (2000) Phys. Lett. A, 273, p. 322. , 10.1016/S0375-9601(00)00518-1Mainardi, F., (1996) Appl. Math. Lett., 9, p. 23. , 10.1016/0893-9659(96)00089-4Duan, J.S., (2005) J. Math. Phys., 46, p. 013504. , 10.1063/1.1819524Figueiredo Camargo, R., Capelas de Oliveira, E., Vaz, J., (2009) J. Math. Phys., 50, p. 123518. , 10.1063/1.3269587Laskin, N., (2000) Phys. Lett. A, 268, p. 298. , 10.1016/S0375-9601(00)00201-2Laskin, N., (2000) Phys. Rev. E, 62, p. 3135. , 10.1103/PhysRevE.62.3135(1995) Lévy Flights and Related Topics in Physics, 450. , M.F.Shlesinger, G.M.Zaslavsky, U.Frisch, edited by and, Lecture Notes in Physics, (Springer, New York)Guo, X., Xu, M., (2006) J. Math. Phys., 47, p. 082104. , 10.1063/1.2235026Laskin, N., (2000) Chaos, 10, p. 780. , 10.1063/1.1050284Naber, M., (2004) J. Math. Phys., 45, p. 3339. , 10.1063/1.1769611Jeng, M., Xu, S.-L.-Y., Hawkins, E., Schwarz, J.M., (2010) J. Math. Phys., 51, p. 062102. , 10.1063/1.3430552Dong, J., Xu, M., (2007) J. Math. Phys., 48, p. 072105. , 10.1063/1.2749172Butzer, P.L., Westphal, U., (2000) Applications of Fractional Calculus in Physics, pp. 1-85. , R.Hilfer, and, "An introduction to fractional calculus," in, edited by (World Scientific, Singapore)Riesz, M., (1948) Acta Math., 81, p. 1. , 10.1007/BF02395016Gradshteyn, I.S., Ryzhik, I.M., (2007) Table of Integrals, Series, and Products, , 7th ed. (Academic Press, NY)Gasiorowicz, S., (2003) Quantum Physics, , 3rd ed. (Wiley, NY)Scott, T.C., Babb, J.F., Dalmano, A., Morgan, J.D., (1993) J. Chem. Phys., 99, p. 2841. , 10.1063/1.465193Mathai, A.M., Saxena, R.K., Haubold, H.J., (2009) The H-Function, , (Springer, NY)Braaksma, B.L.J., (1962) Compos. Math., 15, p. 239. , 2013, 1964Kilbas, A.A., Srivastava, H.M., Trujillo, J.J., (2006) Theory and Applications of Fractional Differential Equations, , (Elsevier, Amsterdam)Oberhettinger, F., (1974) Tables of Mellin Transforms, , (Springer-Verlag, Berlin)Churchill, R.V., (1960) Complex Variables and Applications, , (McGraw-Hill, NY)Podlubny, I., (1998) Fractional Differential Equations, , (Academic Press, San Diego