Association Between ABO Blood Group With Parkinson’s Disease

AbstractBackground/Aims:Parkinson's disease  is a common  neurodegenerative disease that seen in adulthood. Most prevelant symptoms are  resting tremor, rigidity, bradykinesia ,gait disturbance, and postural abnormalities.Disorders related with  ABO  blood group are infectious disease(cholera,helicobacter pylori,echerichia coli),cardiovascular disease,malignancies and allergic status.We objectived to elucidate the association between ABO  blood group and Parkinson's disease Materials -Methods: We investigated  retrospectively the files of 264 adult patients  who were diagnosed with Parkinson's disease and had blood type between January 2008 and December 2018 in neurology outpatient clinics included in the study Results: Distribution of  blood groups in patients as follows : ARh(+): 94(%35,6), ARh(-):15(%5,7),BRh(+):44(%16,7),BRh(-):8(%3), ABRh(+):18(%6,8),  ABRh(-):4(%1,5),0Rh(+):71(%26,9),0Rh(-):10(%3,8) Conclusions: When we consider the pathogenesis of Parkinson’s Disease , we think  of  the antigenic structure of blood groups may be effective in this process

Doxycycline-induced esophagitis: Report of two cases and review of the literature

Although it is not so frequent in medical literature, drug-induced esophageal injury is important, because of its possible complications. Here, we reported two patients with ulcerative esophagitis secondary to doxycycline use. Both patients applied to outpatient clinic with retrosternal pain, odynofagia and dysphagia. Symptoms had been developed after three days of doxicycline treatment in the first patient, and after two days in the second patient. Upper gastrointestinal endoscopy revealed ulcers in patient 1 at the upper 1/3 segment of esophagus and in patient 2 at the middle 1/3 segment of esophagus. Based on the endoscopic findings, the patients were diagnosed as drug-induced esophageal injury resulting from doxycycline treatments. Doxycycline treatments were stopped and lansoprazole and sucralfate was started.

Pyoderma gangrenosum in a patient with Crohn’s disease: Case report and a review of the literature

Pyoderma gangrenosum is a rare neutrophilic noninfectious dermatose. Etiopathogenesis remains unclear, but in half of cases, there is an associated underlying disease. Inflammatory bowel disease is the most common underlying disorder. Systemic immunosuppressive or immunomodulator drugs and some topical agents are used in treatment of pyoderma gangrenosum. Systemic corticosteroids are the first-choice of treatment. We reported a case with Crohn’s disease associated with pyoderma gangrenosum. She was successfully treated with oral methyl prednisolon. The case was a 54-year-old woman who admitted to hospital because of erythematous, painful plaques on the right and left pretibial surfaces. She had a history of Crohn’s disease, diabetes mellitus, and hypertension. An elevated white blood cell count (13500/μL) and high erythrocyte sedimentation rate (120 mm/h) were detected. A regime of broad-spectrum antibiotics was started, but response was poor. Histopathological assessment of biopsy specimens showed necrosis, severe edema and erythrocyte extravasations in superficial dermis, regenerative changes in adjacent epithelium, and mixed inflammatory reaction surrounding necrosis in the inner part of the dermis. Based on these clinical and laboratory findings, poor response to antibiotics and underlying disease; her skin lesions were considered as pyoderma gangrenosum. Oral methylprednisolone was started and her skin lesions improved. The steroid dose was tapered and finally stopped under outpatient follow-up. In conclusion, our patient also showed that corticosteroids continue to be the first-choice therapy in pyoderma gangrenosum

Somali-Mogadişu'da Yapılan Üst Gastrointestinal Sistem Endoskopisi Sonuçlarının İlk ve Tek Analizi

Objective: There is’nt any study giving information about profiles of upper gastroin- testinal (GI) diseases in Somalia; this study has reported the analysis of upper endoscopic results from Mogadishu for the first time. In this study we aimed to evaluate the distributions of the upper gastrointestinal diseases in Mogadishu. Material and Methods: Three hundred six patients who un- derwent upper GI endoscopy between 01.01.2015 and 20.04.2017 at Mogadishu Recep Tayyip Er- doğan Somalia-Turkey Training and Research Hospital were included in this study. Patients grouped according to the age, gender and diagnoses and assessed. Results: Ninety-seven patients were female (31.7%), 209 patients were male (68.3%). Age range was 16-97 years (mean age 47.9 years). The rates of upper GI were 18.0% (55 cases) esophageal cancer (nearly all patients had ade- nocarcinoma, squamous type was very rare), 2.3% (7 cases) gastric adenocarcinoma, 44.1% (135) en- doscopic gastritis, 10.1% (31cases) peptic esophagitis, 4.3% (13 cases) duodenal ulcer, 4.3% (13 cases) bulbitis, 3.0% (9 cases) hiatal hernia, and 1.3% (4 cases) candidial esophagitis. 24 patients (7.8%) had normal endoscopic appearance. C o n c l u s i o n : In our study we showed that the prevalence of esopha- gial cancer was higher in Mogadishu than in those of western countries. We think that the high rate of esophagus cancers due to the use of “khat” named an anxiolytic plant, too hot rice eating, poor nutrition from fresh vegetables and fruits, and the meals cooked in coal fire. Reduction the khat chewing and the improvements in eating habits are mandatory in order to reduce esophageal can- cer cases.Amaç: Somali’de üst gastrointestinal sistem (GİS) hastalıklarının profili ile ilgili bilgi veren bir çalışma bulunmamaktadır. Bu çalışma Mogadişu’da üst GİS endoskopisi sonuçlarının analizi ile ilgilili ilk çalışmadır. Bu çalışmada Mogadişuda üst GİS hastalıklarının dağılımı ile ilgili ilk değer- lendirmeyi yapmayı amaçladık. Gereç ve Yöntemler: Çalışmaya 01.01.2015 ve 20.04.2017 tarihleri arasında Recep Tayyip Erdoğan Somali-Türk Eğitim Araştırma Hastanesinde Üst GIS endoskopisi yapılmış olan 306 hasta dahil edildi. Hastalar yaş, cinsiyet ve tanılarına göre gruplandırılarak de- ğerlendirildi. Bulgular: Çalışmada 97 hasta kadın (%31,7), 209 hasta erkekti (%68,3). Yaş aralığı 16- 97 (ortalama 47,9) yıl idi. 55 hastada (%18,0) özofagus kanseri (hastaların tama yakını adenokarsinom tipte olup, skuamöz hücreli karsinom tip nadirdi), 7 hastada (%2,3) mide kanseri, 135 hastada (%44,1) gastrit, 31’inde (%10,1) peptik özofajit, 13 hastada (%4,3) bulbusta ülser, 13’ünde (%4,3) bulbit, 9 hastada (%3,0) herni ve 4 hastada (%1,3) kandidial özofajit, 24 (%7,8) has- tada ise normal endoskopik bulgular saptandı. S o n u ç : Çalışmamızda Batı ülkelerine nazaran Mo- gadişu’da özofagus kanseri prevelansı daha yüksek olarak bulundu. Daha yüksek özofagus kanseri oranı görülmesinin nedeni olarak “khat” isimli anksiyolitik bitki çiğnenmesi ve sıcak pirinç yeme alışkanlığı, taze sebze-meyveden fakir beslenme ve kömür ateşinde yemek pişirme alışkanlığını dü- şünmekteyiz. “Khat” çiğnemenin azaltılması, yeme alışkanlıklarının iyileştirilmesi özofageal kan- serin azaltılmasında gereklidir

The short-term effects of Helicobacter pylori eradication on symptoms of functional dyspepsia

Objectives: Helicobacter pylori (H.pylori) infection is major etiologic factor of chronic active gastritis and peptic ulcer disease. Functional dyspepsia (FD) is defined as “persistent or recurrent abdominal pain or discomfort centered in the upper abdomen in patient who has no definite structural or biochemical explanation of their symptoms. It is uncertain whether treatment of H.pylori infection relieves symptoms in patients with FD. We searched short term effects of H.pylori eradication for symptoms in patients with FD.Material and method: We enrolled patients with dyspeptic symptoms which were diagnosed FD and satisfied en-rollment criteria of trial. Endoscopic biopsy was taken from each patient during upper gastrointestinal endoscopy. H.pylori infected patients were assigned to seven days of treatment with 30 mgr of lansoprozole twice daily, 1000 mg of amoksisilin twice daily, and 500 mg levofloxacin once daily. Patients were assessed whether treatment was suc-cessful or not by 14C urea breathe test after 6-8 week. Also pretreatment and post treatment symptom scores were questioned.Results: There were 99 female and 68 male patients. After treatment 114 patients (68%) was negative for H. pylori, 53 patients (32%) remained positive. Mean of age and proportion of sex was similar in H.pylori (+) and (-) groups. While 111 (97.4%) of H.pylori (-) patients’ symptom scores decreased, 38 (71.7%) of H.pylori (+) patients’ scores de-creased. There was significant differences between two groups (p=0.001).Conclusion: Eradication of H.pylori relieves the symptoms of functional dyspepsia. New trials for long term effect of H.pylori eradication on symptoms must be conducted in future

Distribution of Colon Lesions in Elderly

Objective: Screening and surveillance for colon lesions is very important, particularly given the increased incidence of benign and malign colon diseases with age. The aim of this study was to determine the frequency and characteristics of colon lesions in an elderly population in Turkey. Materials and Methods: This retrospective study was conducted in the gastroenterology clinic of the Erciyes University Faculty of Medicine Hospital. The histopathological results and demographic characteristics of 1004 elderly patients who underwent a colonoscopy with a biopsy between 2015 and 2019 were retrospectively analyzed. Results: A total of 1004 elderly patients were included in the study. The findings revealed that 592 (58.9%) of the patients had polyps, 121 (12.05%) had colitis, 23 (2.3%) had ileitis, 88 (8.7%) had colon carcinoma, 2 (0.2%) had amyloidosis, 34 (3.4%) had other histopathological diagnoses (in order of frequency, melanosis coli, lipoma, solitary rectal ulcer, neuroendocrine tumor, leiomyoma, mantle cell lymphoma, marginal zone lymphoma and low grade dysplasia), and 22 patients had multiple synchronous pathologies. Conclusion: Colon pathology types and frequencies differ with advanced age. Appropriate colonoscopy screening programs and multiple histopathological sampling methods from each colon segment during colonoscopy offer early recognition of both benign and malignant colon lesions

Türkiyede atriyum fibrilasyonu epidemiyolojisi; çok merkezli AFTER çalışmasının ön sonuçları

Amaç: Atriyum fibrilasyonu (AF) klinik pratiğimizde en sık rastlanan ritm bozukluğu olup ülkemizde bu konuda yapılmış çok merkezli bir epidemiyolojik çalışma bulunmamaktadır. Bu çalışmanın amacı ülkemizde ilk kez yapılmış olan çok merkezli, ileriye dönük Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) çalışmasının kayıtlarından yararlanarak AFye klinik yönden yaklaşımımızı değerlendirmektir. Çalışma planı: Ülkemizde nüfus dağılımı göz önünde bulundurularak 17 ayrı üçüncü basamak merkezden, elektrokardiyografisinde en az bir defa AF atağı tespit edilmiş olan ardışık 2242 hasta çalışmaya alındı. Acil polikliniğine başvuran ya da yatmakta olan hastalar çalışmadan dışlandı. Hastaların epidemiyolojik verileri ve uygulanan tedaviler değerlendirildi. Bulgular: Çalışma popülasyonunu oluşturan hastaların %60ı kadındı, hastaların ortalama yaşı 66.812.3 yıl olarak saptandı. Türk nüfusunda en sık görülen AF tipi non-valvular AF (%78) olup, AFli hastaların %81i ısrarcı-kalıcı AFli idi. AFye en sık eşlik eden komorbid durum hipertansiyon (%67) olarak bulundu. Hastaların %15.3ünde inme, geçici iskemik atak ve sistemik tromboemboli hikayesi mevcut iken kanama öyküsü hastaların %11.2sinde kaydedildi. Çalışma süresinde hastaların %50si warfarin, %53ü de aspirin kullanıyordu. Oral antikoagülan ilaç kullanan hastaların %41.3ünde etkin INR düzeyi saptandı. Oral antikoagülan ilaç kullanmamanın en sık nedeni (%69) hekim ihmali olarak saptandı. Sonuç: Bu veriler klinik pratiğimizde özellikle AFli hastaların antitrombotik tedavileri konusunda daha dikkatli olunması gerektiğini göstermektedir.Objectives: Although atrial fibrillation (AF) is one of the most com- mon rhythm disorders observed in clinical practice, a multicenter epidemiological study has not been conducted in our country. This study aimed to assess our clinical approach to AF based upon the records of the first multicenter prospective Atrial Fibrillation in Tur- key: Epidemiologic Registry (AFTER) study. Study design: Taking into consideration the distribution of the population in our country, 2242 consecutive patients with at least one AF attack determined by electrocardiographic examination in 17 different tertiary health care centers were included in the study. Inpatients and patients that were admitted to emergency depart- ments were excluded from the study. Epidemiological data of the patients and the treatment administered were assessed. Results: The mean age of the patients was determined as 66.8±12.3 years with female patients representing 60% of the study popula- tion. While the most common AF type in the Turkish population was non-valvular AF (78%), persistent/permanent AF was determined in 81% of all patients. Hypertension (%67) was the most common co- morbidity in patients with AF. While a stroke or transient ischemic at- tack or history of systemic thromboembolism was detected in 15.3% of the patients, bleeding history was recorded in 11.2%. Also, 50% of the patients were on warfarin treatment and 53% were on aspi- rin treatment at the time of the study. The effective INR level was detected in 41.3% of the patients. The most frequent cause of not receiving anticoagulant therapy was physician neglect. Conclusion: These results demonstrate the necessity for improved quality of physician care of patients with AF, especially with regards to antithrombotic therapy

Türkiye’de atriyum fibrilasyonu epidemiyolojisi; çok merkezli AFTER çalışmasının ön sonuçları

Amaç: Atriyum fibrilasyonu (AF) klinik pratiğimizde en sık rastlanan ritm bozukluğu olup ülkemizde bu konuda yapılmış çok merkezli bir epidemiyolojik çalışma bulunmamaktadır. Bu çalışmanın amacı ülkemizde ilk kez yapılmış olan çok merkezli, ileriye dönük Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) çalışmasının kayıtlarından yararlanarak AF’ye klinik yönden yaklaşımımızı değerlendirmektir. Çalışma planı: Ülkemizde nüfus dağılımı göz önünde bulundurularak 17 ayrı üçüncü basamak merkezden, elektrokardiyografisinde en az bir defa AF atağı tespit edilmiş olan ardışık 2242 hasta çalışmaya alındı. Acil polikliniğine başvuran ya da yatmakta olan hastalar çalışmadan dışlandı. Hastaların epidemiyolojik verileri ve uygulanan tedaviler değerlendirildi. Bulgular: Çalışma popülasyonunu oluşturan hastaların %60’ı kadındı, hastaların ortalama yaşı 66.8±12.3 yıl olarak saptandı. Türk nüfusunda en sık görülen AF tipi non-valvular AF (%78) olup, AF’li hastaların %81’i ısrarcı-kalıcı AF’li idi. AF’ye en sık eşlik eden komorbid durum hipertansiyon (%67) olarak bulundu. Hastaların %15.3’ünde inme, geçici iskemik atak ve sistemik tromboemboli hikayesi mevcut iken kanama öyküsü hastaların %11.2’sinde kaydedildi. Çalışma süresinde hastaların %50’si warfarin, %53’ü de aspirin kullanıyordu. Oral antikoagülan ilaç kullanan hastaların %41.3’ünde etkin INR düzeyi saptandı. Oral antikoagülan ilaç kullanmamanın en sık nedeni (%69) hekim ihmali olarak saptandı. Sonuç: Bu veriler klinik pratiğimizde özellikle AF’li hastaların antitrombotik tedavileri konusunda daha dikkatli olunması gerektiğini göstermektedir.Objectives: Although atrial fibrillation (AF) is one of the most com- mon rhythm disorders observed in clinical practice, a multicenter epidemiological study has not been conducted in our country. This study aimed to assess our clinical approach to AF based upon the records of the first multicenter prospective Atrial Fibrillation in Tur- key: Epidemiologic Registry (AFTER) study. Study design: Taking into consideration the distribution of the population in our country, 2242 consecutive patients with at least one AF attack determined by electrocardiographic examination in 17 different tertiary health care centers were included in the study. Inpatients and patients that were admitted to emergency depart- ments were excluded from the study. Epidemiological data of the patients and the treatment administered were assessed. Results: The mean age of the patients was determined as 66.8±12.3 years with female patients representing 60% of the study popula- tion. While the most common AF type in the Turkish population was non-valvular AF (78%), persistent/permanent AF was determined in 81% of all patients. Hypertension (%67) was the most common co- morbidity in patients with AF. While a stroke or transient ischemic at- tack or history of systemic thromboembolism was detected in 15.3% of the patients, bleeding history was recorded in 11.2%. Also, 50% of the patients were on warfarin treatment and 53% were on aspi- rin treatment at the time of the study. The effective INR level was detected in 41.3% of the patients. The most frequent cause of not receiving anticoagulant therapy was physician neglect. Conclusion: These results demonstrate the necessity for improved quality of physician care of patients with AF, especially with regards to antithrombotic therapy