21 research outputs found
Reciprocal Interactions of Pit1 and GATA2 Mediate Signaling GradientâInduced Determination of Pituitary Cell Types
- Author
- Publication venue
- Cell Press.
- Publication date
- 28/05/1999
- Field of study
AbstractThe mechanisms by which transient gradients of signaling molecules lead to emergence of specific cell types remain a central question in mammalian organogenesis. Here, we demonstrate that the appearance of four ventral pituitary cell types is mediated via the reciprocal interactions of two transcription factors, Pit1 and GATA2, which are epistatic to the remainder of the cell typeâspecific transcription programs and serve as the molecular memory of the transient signaling events. Unexpectedly, this program includes a DNA bindingâindependent function of Pit1, suppressing the ventral GATA2-dependent gonadotrope program by inhibiting GATA2 binding to gonadotrope- but not thyrotrope-specific genes, indicating that both DNA bindingâdependent and âindependent actions of abundant determining factors contribute to generate distinct cell phenotypes
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie OâConnell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella DâArminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- BjĂžrn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
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- Brooke Wolford
- Brooke Wolford Sebastian Zoš llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
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- Chloe Fawns-Ritchie
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- Christine Stevens
- Christine Stevens
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- Patrick Turley
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- Pere Soler
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- Phil Tsao
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- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
- Pintip Suchartlikitwong
- Prabhu Arumugam
- Qin Qin Huang
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- Rafael de Cid
- Raffaele Bruno
- Raffaele Scala
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- Ravaglia Sabrina
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- Reedik Magi
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- Renzo Scaggiante
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- Richard H. Scott
- Richard J. Packer
- Rita Perna
- Roaa T. Halawani
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- Robert C. Green
- Robert Frithiof
- Robert P. Sebra
- Robert Warmerdam
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- Ron Do
- Rosangela Artuso
- Rossella Tita
- Rui Li
- Ruth J. F. Loos
- Ryan C. Thompson
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- Sabino Scolletta
- Sabrina Ravaglia
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- Saleh Alqahtani
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- Sam Bryant
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- Sameer Chavan
- Sameera AlJohani
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- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
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- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- SteÂŽ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- VeÂŽronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Ăyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- BirgegÄrd Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- ButtenschĂžn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- BĂŠkvad-Hansen Marie
- BĂŠkvad-Hansen Marie
- BĂžen Erlend
- BĂžrglum Anders D.
- BĂžrglum Anders D.
- BĂžrglum Anders D.
- BĂžrte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
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- Pato Carlos
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- Patrinos George P.
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- Penninx Brenda W. J. H.
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- Sorbi Sandro
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- Sriram Peruvemba
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- Stapley Todd
- Starnawska Anna
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- Stefansson Hreinn
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- Stefansson Kari
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- Thornton Laura M.
- Thornton Laura M.
- Tiemeier Henning
- Toma Claudio
- Tooney Paul
- Tortorella Alfonso
- Tozzi Federica
- Traylor Matthew
- Treasure Janet
- Treasure Janet
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
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- Trzaskowski Maciej
- Trzaskowski Maciej
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- Tsao Philip S.
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- Tsitsika Artemis
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- van Elburg Annemarie A.
- van Furth Eric F.
- van Hemert Albert M.
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- Vedder Helmut
- Vieta Eduard
- Viktorin Alexander
- Vilar-RibĂł Laura
- Villareal Gerardo
- Vincent John B.
- Vincent John B.
- Visscher Peter M.
- Völzke Henry
- Völzke Henry
- Wade Tracey D.
- Wagner Gudrun
- Waldman Irwin D.
- Wallbom Agnes
- Walters James T. R.
- Walters James T. R.
- Walton Esther
- Wang Yunpeng
- Ware Erin B.
- Wasserman Danuta
- Watson Hunna J.
- Watson Hunna J.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weickert Thomas W.
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann JĂŒrgen
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Whitbourne Stacey B.
- Whiteman David C.
- Whiteman David C.
- Whittle Jeffrey
- Whooley Mary
- Wichmann H. Erich
- Widen Elisabeth
- Willemsen Gonneke
- Williams Leanne M.
- Willour Virginia
- Wilson Peter
- Winsvold Bendik S.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Won Hong-Hee
- Woodside D. Blake
- Woodside D. Blake
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Yang
- Xi Hualin S.
- Xi Simon
- Xu Junzhe
- Xu Wei
- Yang Jian
- Yao Shuyang
- Yeh Shing Shing
- Yilmaz Zeynep
- Yilmaz Zeynep
- Young Allan H.
- Young Hannah
- Zablocki Clement J.
- Zai Clement C.
- Zandi Peter P.
- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- AgĂŒero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
- Balaconis Mary K.
- Baldassarri Margherita
- Ball Catherine A.
- Baltzell Asher Haug
- Band Gavin
- Bandini Maria
- Baraka Dona
- Baras Aris
- Baratti Stefano
- Barbieri Chiara
- Barda B.
- Bargagli Elena
- Barhoush Eman
- Barnes Kathleen C.
- Baroni Silvia
- Bartels Meike
- Bassetti Matteo
- Batini Chiara
- Baya Nikolas
- Beck Andrew
- Beckmann Noam D.
- Bedini Josep L.
- Bee Catherine E.
- Beguin Yves
- Belbin Gillian M.
- Belhaj Yasmine
- Beligni Giada
- Belisle Alexandre
- Belli Mary Ann
- Below Jennifer
- Benetti Elisa
- Bennett David
- Bergantini Laura
- Bergomi Paola
- Berkowitz Nathan
- Bernardo David
- Biagio Antonio Di
- Bianchi Francesco
- Bibert Stéphanie
- Bibert Stéphanie
- Biesecker Les
- Biscarini Filippo
- Blay Natalia
- Bochud M.
- Bochud P. Y.
- Bochud P. Y.
- Bochud Pierre-Yves
- Bochud Pierre-Yves
- Boezen Marike
- Boillat Noémie
- Boillat-Blanco N.
- BottĂ Giordano
- Bouab Meriem
- Boughton Andrew P.
- Bouras K.
- Bradford Yuki
- Brahier T.
- Brassard Nathalie
- Breen Gerome
- Brenner Bluma
- Britvan Bari
- Brumpton Ben M.
- Bruno Raffaele
- Bruttini Mirella
- Bryant Sam
- Bryant Sam
- Buring Julie E.
- Busani Stefano
- Bussotti Maurizio
- Butler-Laporte Guillaume
- Butterworth Adam S.
- Buxbaum Joseph D.
- Caldarelli Gian Piero
- Callier Shawneequa
- Cameli Paolo
- Campbell Archie
- Campbell Archie
- Canaccini Anna
- Cantarini Luca
- Cantor Michael N.
- Capasso Mario
- Capitani Katia
- Cappelli Silvia
- Carella Massimo
- Carey Dave J.
- Carreras Anna
- Carriero Miriam Lucia
- Castaño-Vinyals Gemma
- Castelli Francesco
- Castori Marco
- Catena Emanuele
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- Ceri Stefano
- Cerny A.
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- Chan Georgia
- Chang Xiao
- Chang Xiao
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- Chen Hung-Hsin
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- Cho Judy H.
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- Chowdhury Maharun
- Chung Raymond
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- Chwialkowska Karolina
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- Coignet Marie
- Coiro Gabriella
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- Conticini Edoardo
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- Cortés Beatriz
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- Merla Giuseppe
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- Meuris Christelle
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- Petitjean Louis
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- Piacentini Paolo
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- Pigazzini Sara
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- Rafaels Nicholas
- Raggi Pamela
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- Rahmouni Souad
- Raimondi Francesco
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- Voide Cathy
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- Zucchi Patrizia
- Zyndorf Marissa
- Zöllner Sebastian
- Ă svold BjĂžrn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
peer reviewe
Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
- Author
- Publication venue
- The National Academy of Sciences
- Publication date
- 01/01/1999
- Field of study
Pax6, a highly conserved member of the paired homeodomain transcription factor family that plays essential roles in ocular, neural, and pancreatic development and effects asymmetric transient dorsal expression during pituitary development, with its expression extinguished before the ventral â dorsal appearance of specific cell types. Analysis of pituitary development in the Small eye and Pax6 â/â mouse mutants reveals that the dorsoventral axis of the pituitary gland becomes ventralized, with dorsal extension of the transcriptional determinants of ventral cell types, particularly PFrk. This ventralization is followed by a marked decrease in terminally differentiated dorsal somatotrope and lactotrope cell types and a marked increase in the expression of markers of the ventral thyrotrope cells and SF-1-expressing cells of gonadotrope lineage. We suggest that the transient dorsal expression of Pax6 is essential for establishing a sharp boundary between dorsal and ventral cell types, based on the inhibition of Shh ventral signals
Unselfish traits and social decision-making patterns characterize six populations of real-world extraordinary altruists
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2023
- Field of study
Here, the authors show that real-world extraordinary altruists, including heroic rescuers and altruistic kidney donors, are distinguished by unusually unselfish traits and decision-making patterns. This pattern was not predicted by a general sample of adults who were asked what traits would characterize altruists