Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários

MODERN TECHNOLOGY ENHANCED ADAPTIVE AND COGNITIVE LEARNING IN THE VIRTUAL REALITY ENVIRONMENT

This text deals with the design of virtual reality systems. Infrastructure includes providing a powerful adaptive or cognitive learning to use the different levels of complexity that will be adapted for each student, empowering those who present more difficulties for learning. Smart devices and intelligent technologies create learning environments that respond to each learner’s profile and needs and offer conditions for realizing personalized and adaptive learning

Modern View in the Diagnosis and Treatment of Avascular Necrosis of the Femoral Head

Avascular necrosis of the femoral head is a serious disease, the relevance of which has not been lost to this day. With early detection and adequate therapy, the prognosis is favorable, but late diagnosis and lack of treatment lead to rapid destruction of the joint and disability of the patient. The purpose of this study is to provide information on modern diagnostic possibilities and a differentiated approach to the choice of treatment method depending on the stage of osteonecrosis

Modern View in the Diagnosis and Treatment of Avascular Necrosis of the Femoral Head

Avascular necrosis of the femoral head is a serious disease, the relevance of which has not been lost to this day. With early detection and adequate therapy, the prognosis is favorable, but late diagnosis and lack of treatment lead to rapid destruction of the joint and disability of the patient. The purpose of this study is to provide information on modern diagnostic possibilities and a differentiated approach to the choice of treatment method depending on the stage of osteonecrosis

Technology-based methods in the improvement of therapy compliance among ambulatory cardiac patients: one-year follow-up data

Aim. To assess the impact of automatic telephone survey with a differentiated reminder text, as well as of the survey combination with the self-control dairy, on the compliance with lipid-lowering and antihypertensive therapy and on therapy effectiveness during the longterm ambulatory follow-up. Material and methods. The study included 604 patients: 323 individuals with high or very high cardiovascular risk levels by SCORE scale and 281 participants with coronary heart disease (CHD). The patients were divided into two groups, according to their agreement to participate in the automatic telephone reminder survey (“Survey” and “Refusal”). All participants were also given a self-control diary. At baseline and one year later, the patients underwent general clinical examination, office blood pressure (BP) measurement, blood biochemistry assessment, and the measurement of therapy compliance (Morisky-Green test), anxiety, and depression levels (HADS scale). Results. The reduction in diastolic BP levels was significantly larger in the Survey group (p=0,04). This group also demonstrated a significantly larger decrease in the levels of total cholesterol (TCH) (p=0,0003) and low-density lipoprotein cholesterol (LDL-CH) (p=0,001), as well as a significantly larger increase in the levels of high-density lipoprotein cholesterol (HDL-CH) (p=0,04). The therapy compliance, assessed by the Morisky-Green test, improved in both groups; however, among CHD patients, a significant improvement was observed only in the Survey group (p<0,00001). The percentage of patients submitting their self-control diaries was higher for the Survey group (p<0,0001). Conclusion. The automatic telephone reminder method provides an opportunity to significantly increase the therapy compliance