Safety of vaginal erbium laser: A review of 113,000 patients treated in the past 8 years.

Background: Energy-based devices are becoming a popular option for minimally invasive vaginal procedures. The aim of this study was to obtain information on the frequency of occurrence of adverse effects (AEs) related to vaginal erbium laser (VEL™) treatment.Materials and methods: The global survey was conducted among practitioners using the non-ablative VEL™ (Fotona, Ljubljana, Slovenia). Users were invited to provide the number of patients treated with VEL™ and the number of observed laser-related AEs.Results: The survey was conducted from August 2018 to April 2019. Responses from 535 practitioners were collected, with a total of 113,174 patients treated in the period from 2012 to 2019. Out of 535 respondents, 160 (30%) shared detailed information about the indications they treated in a population of 62,727 patients, whereas 188 (35%) respondents provided information on the frequency of AEs observed in their treated population of 43,095 patients. All observed AEs were mild to moderate, transient and appeared with low frequencies.Conclusions: Minimally invasive thermal-only laser treatment using the non-ablative VEL™ procedures appears to be safe and the incidence of AEs is low

3-PHENACYLURIDINE-DERIVED HYPNOTICS: ANTHOLOGY, STRUCTUREACTIVITY RELATIONSHIPS AND SYNTHESIS OF SEVERAL ACYCLONUCLEOSIDE ANALOGUES

This work was supported by the Russian Foundation for Basic Research, project # 18-33-00421

Video-assisted thoracoscopic diagnosis of trapped lung in malignant pleural effusions

PURPOSE. The aim of this study is to present the role of video-assisted thoracoscopy to assess the ability of the lung to expand in malignant pleural effusions. METHODS. The survey was conducted for a 3-year period in 13 patients with histologically diagnosed malignant pleural effusion and trapped lung. In each of the patients video-assisted thoracoscopy was performed. RESULTS. Two reasons for trapped lung were identified. In 10 of the patients it was due to multiple metastatic nodules. In 3 cases the cause was a diffuse fibrotic involvement of the lung resulting from the metastatic process.CONCLUSIONS. Our research confirmed two causes of trapped lung in malignant pleural effusions: multiple metastases on the lung surface and diffuse lung fibrosis, induced by the metastatic process, with the increased role of multiple metastases on the lung surface

SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF THE NOVEL ISOTHIOBARBAMINE ANALOGUES WITH LOWERED BASICITY

This work was supported by the Russian Scientific Foundation, project № 19-13-00123

Aerosol Properties and Chemical Apportionment of Aerosol Optical Depth at Locations off the U.S. East Coast in July and August 2001

Airborne in situ measurements of vertical profiles of the aerosol light scattering coefficient, light absorption coefficient, and single scattering albedo (ω0) are presented for locations off the East Coast of the United States in July–August 2001. The profiles were obtained in relatively clean air, dominated by airflows that had passed over Canada and the Atlantic Ocean. Comparisons of aerosol optical depths (AODs) at 550 nm derived from airborne in situ and sun-photometer measurements agree, on average, to within 0.034 ± 0.021. A frequency distribution of ω0 measured in the atmospheric boundary layer off the coast yields an average value of ω0 = 0.96 ± 0.03 at 550 nm. Values for the mass scattering efficiencies of sulfate and total carbon (organic and black carbon) derived from a multiple linear regression are 6.0 ± 1.0 m2 (g SO=4)−1 and 2.6 ± 0.9 m2 (g C)−1, respectively. Measurements of sulfate and total carbon mass concentrations are used to estimate the contributions of these two major components of the submicron aerosol to the AOD. Mean percentage contributions to the AOD from sulfate, total carbon, condensed water, and absorbing aerosols are 38% ± 8%, 26% ± 9%, 32% ± 9%, and 4% ± 2%, respectively. The sensitivity of the above results to the assumed values of the hygroscopic growth factors for the particles are examined and it is found that, although the AOD derived from the in situ measurements can vary by as much as 20%, the average value of ω0 is not changed significantly. The results are compared with those obtained in the same region in 1996 under more polluted conditions

Intergenic interactions of SBNO1, NFAT5 AND GLT8D1 determine the susceptibility to knee osteoarthritis among Europeans of Russia

This study was conducted to examine the associations between genome-wide association studies (GWAS)-important single nucleotide polymorphisms (SNPs) and knee osteoarthritis (KOA) among Europeans of Russi

Quality Management System in Stavropol Research Anti-Plague Institute

The analysis of the structure of quality management system and the areas of its activity is presented. Trends for its further improvement are defined

A critical evaluation of interlaboratory data on total, elemental, and isotopic carbon in the carbonaceous particle reference material, NIST SRM 1649a

Because of increased interest in the marine and atmospheric sciences in elemental carbon (EC), or black carbon (BC) or soot carbon (SC), and because of the difficulties in analyzing or even defining this pervasive component of particulate carbon, it has become quite important to have appropriate reference materials for intercomparison and quality control. The NIST "urban dust" Standard Reference Material? SRM 1649a is useful in this respect, in part because it comprises a considerable array of inorganic and organic species, and because it exhibits a large degree of (14C) isotopic heterogeneity, with biomass carbon source contributions ranging from about 2 % (essentially fossil aliphatic fraction) to about 32 % (polar fraction). A primary purpose of this report is to provide documentation for the new isotopic and chemical particulate carbon data for the most recent (31 Jan. 2001) SRM 1649a Certificate of Analysis. Supporting this is a critical review of underlying international intercomparison data and methodologies, provided by 18 teams of analytical experts from 11 institutions. Key results of the intercomparison are: (1) a new, Certified Value for total carbon (TC) in SRM 1649a; (2) 14C Reference Values for total carbon and a number of organic species, including for the first time 8 individual PAHs; and (3) elemental carbon (EC) Information Values derived from 13 analytical methods applied to this component. Results for elemental carbon, which comprised a special focus of the intercomparison, were quite diverse, reflecting the confounding of methodological-matrix artifacts, and methods that tended to probe more or less refractory regions of this universal, but ill-defined product of incomplete combustion. Availability of both chemical and 14C speciation data for SRM 1649a holds great promise for improved analytical insight through comparative analysis (e.g., fossil/ biomass partition in EC compared to PAH), and through application of the principle of isotopic mass balance.Carrie, L. A., Benner, B. A., Kessler, J. D., Klinedinst, D. B., Klouda, G. A., Marolf, J. V., . . . Schmid, H. (2002). A Critical Evaluation of Interlaboratory Data on Total, Elemental, and Isotopic Carbon in the Carbonaceous Particle Reference Material, NIST SRM 1649a. Journal of Research of the National Institute of Standards and Technology, 107(3), 279-298

Antiseptics and disinfectants for the treatment of bacterial vaginosis: a systematic review

Background: The study objective was to assess the available data on efficacy and tolerability of antiseptics and disinfectants in treating bacterial vaginosis (BV). Methods: A systematic search was conducted by consulting PubMed (1966-2010), CINAHL (1982-2010), IPA (1970-2010), and the Cochrane CENTRAL databases. Clinical trials were searched for by the generic names of all antiseptics and disinfectants listed in the Anatomical Therapeutic Chemical (ATC) Classification System under the code D08A. Clinical trials were considered eligible if the efficacy of antiseptics and disinfectants in the treatment of BV was assessed in comparison to placebo or standard antibiotic treatment with metronidazole or clindamycin and if diagnosis of BV relied on standard criteria such as Amsel\u27s and Nugent\u27s criteria. Results: A total of 262 articles were found, of which 15 reports on clinical trials were assessed. Of these, four randomised controlled trials (RCTs) were withheld from analysis. Reasons for exclusion were primarily the lack of standard criteria to diagnose BV or to assess cure, and control treatment not involving placebo or standard antibiotic treatment. Risk of bias for the included studies was assessed with the Cochrane Collaboration\u27s tool for assessing risk of bias. Three studies showed non-inferiority of chlorhexidine and polyhexamethylene biguanide compared to metronidazole or clindamycin. One RCT found that a single vaginal douche with hydrogen peroxide was slightly, though significantly less effective than a single oral dose of metronidazole. Conclusion: The use of antiseptics and disinfectants for the treatment of BV has been poorly studied and most studies are somehow methodologically flawed. There is insufficient evidence at present to advocate the use of these agents, although some studies suggest that some antiseptics may have equal efficacy compared to clindamycin or metronidazole. Further study is warranted with special regard to the long-term efficacy and safety of antiseptics and disinfectants for vaginal use